Sarah Lensen
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View article: Modern management of the menopause: Are we measuring what matters?
Modern management of the menopause: Are we measuring what matters? Open
View article: Elective egg freezers’ disposition decisions pathways
Elective egg freezers’ disposition decisions pathways Open
As disposition decisions are individual and personal, the study highlights the importance of counselling for elective egg freezers when considering disposition options. The development of support tools is recommended to help patients navig…
View article: Endometrial receptivity testing for assisted reproductive technologies
Endometrial receptivity testing for assisted reproductive technologies Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of endometrial receptivity testing in women undergoing assisted reproductive technologies.
View article: O-289 FIIX study: A multicentre, non-inferiority, randomised controlled trial comparing in vitro fertilisation (IVF) to intrauterine insemination with ovarian stimulation (IUI-OS) in couples with unexplained infertility
O-289 FIIX study: A multicentre, non-inferiority, randomised controlled trial comparing in vitro fertilisation (IVF) to intrauterine insemination with ovarian stimulation (IUI-OS) in couples with unexplained infertility Open
Study question In couples with unexplained infertility, are four cycles of IUI-OS comparable to one complete cycle of IVF for the outcome of live birth? Summary answer IUI-OS was inferior to IVF. Approximately one in two couples had a live…
View article: P-541 The psychosocial and behavioural consequences of anti-müllerian hormone (AMH) testing on women
P-541 The psychosocial and behavioural consequences of anti-müllerian hormone (AMH) testing on women Open
Study question What are the psychosocial and behavioural consequences of anti-müllerian hormone (AMH) testing in women without a history of infertility? Summary answer AMH testing influenced emotional well-being and reproductive decision-m…
View article: Assessing the feasibility and impact of clinical trial trustworthiness checks via an application to Cochrane Reviews: Stage 2 of the INSPECT-SR project
Assessing the feasibility and impact of clinical trial trustworthiness checks via an application to Cochrane Reviews: Stage 2 of the INSPECT-SR project Open
Systematic reviews collate evidence from randomized controlled trials (RCTs) to find out whether health interventions are safe and effective. However, it is now recognized that the findings of some RCTs are not genuine, and some of these s…
View article: Development and validation of a gonadotropin dose selection model for optimized ovarian stimulation in IVF/ICSI: an individual participant data meta-analysis
Development and validation of a gonadotropin dose selection model for optimized ovarian stimulation in IVF/ICSI: an individual participant data meta-analysis Open
BACKGROUND The ovarian response to gonadotropin stimulation varies widely among women, and could impact the probability of live birth as well as treatment risks. Many studies have evaluated the impact of different gonadotropin starting dos…
View article: Assessing the feasibility and impact of clinical trial trustworthiness checks via an application to Cochrane Reviews: Stage 2 of the INSPECT-SR project
Assessing the feasibility and impact of clinical trial trustworthiness checks via an application to Cochrane Reviews: Stage 2 of the INSPECT-SR project Open
Background The aim of the INSPECT-SR project is to develop a tool to identify problematic RCTs in systematic reviews. In Stage 1 of the project, a list of potential trustworthiness checks was created. The checks on this list must be evalua…
View article: A survey of experts to identify methods to detect problematic studies: stage 1 of the INveStigating ProblEmatic Clinical Trials in Systematic Reviews project
A survey of experts to identify methods to detect problematic studies: stage 1 of the INveStigating ProblEmatic Clinical Trials in Systematic Reviews project Open
A comprehensive list of trustworthiness checks has been produced. The checks will be evaluated to determine which should be included in the INSPECT-SR tool.
View article: Women’s interest, knowledge, and attitudes relating to anti-Mullerian hormone testing: a randomized controlled trial
Women’s interest, knowledge, and attitudes relating to anti-Mullerian hormone testing: a randomized controlled trial Open
STUDY QUESTION What is the impact of co-designed, evidence-based information regarding the anti-Mullerian hormone (AMH) test on women’s interest in having the test? SUMMARY ANSWER Women who viewed the evidence-based information about the A…
View article: The most impactful endometriosis symptom: An international, cross‐sectional, two‐round survey study
The most impactful endometriosis symptom: An international, cross‐sectional, two‐round survey study Open
Introduction There is considerable variation in the types of symptoms experienced by people living with endometriosis, and it is unclear which symptoms impact people the most. This study aimed to identify the specific symptoms that are “mo…
View article: The “most bothersome symptom” construct: A qualitative study of Australians living with endometriosis
The “most bothersome symptom” construct: A qualitative study of Australians living with endometriosis Open
Introduction “Improvement in the most bothersome symptom” was recently selected as a core outcome for endometriosis intervention trials. This study aimed to explore the applicability of the construct of “symptom bother” in representing the…
View article: A survey of experts to identify methods to detect problematic studies: Stage 1 of the INSPECT-SR Project
A survey of experts to identify methods to detect problematic studies: Stage 1 of the INSPECT-SR Project Open
Background Randomised controlled trials (RCTs) inform healthcare decisions. Unfortunately, some published RCTs contain false data, and some appear to have been entirely fabricated. Systematic reviews are performed to identify and synthesis…
View article: Protocol for the development of a tool (INSPECT-SR) to identify problematic randomised controlled trials in systematic reviews of health interventions
Protocol for the development of a tool (INSPECT-SR) to identify problematic randomised controlled trials in systematic reviews of health interventions Open
Introduction Randomised controlled trials (RCTs) inform healthcare decisions. It is now apparent that some published RCTs contain false data and some appear to have been entirely fabricated. Systematic reviews are performed to identify and…
View article: Attitudes, knowledge and practice regarding the <scp>anti‐müllerian</scp> hormone test among general practitioners and reproductive specialists: A cross‐sectional study
Attitudes, knowledge and practice regarding the <span>anti‐müllerian</span> hormone test among general practitioners and reproductive specialists: A cross‐sectional study Open
Objective To describe clinicians' attitudes, knowledge and practice relating to the anti‐müllerian hormone (AMH) test. Design Cross‐sectional nationwide survey. Setting Australia. Population or Sample A total of 362 general practitioners (…
View article: Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro fertilisation plus intracytoplasmic sperm injection (IVF/ICSI)
Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro fertilisation plus intracytoplasmic sperm injection (IVF/ICSI) Open
We did not find that tailoring the FSH dose in any particular ORT population (low, normal, high ORT) affected live birth/ongoing pregnancy rates, but we could not rule out differences, due to sample size limitations. Low-certainty evidence…
View article: What do women undergoing <i>in vitro</i> fertilization (IVF) understand about their chance of IVF success?
What do women undergoing <i>in vitro</i> fertilization (IVF) understand about their chance of IVF success? Open
STUDY QUESTION How well informed are Australian women who undergo IVF about their chances of having a baby? SUMMARY ANSWER Only one in four women estimated their individual chance of success with IVF accurately, with most women overestimat…
View article: Correlations among Core Outcomes in Menopause-recommended vasomotor symptom outcomes in MsFLASH trials
Correlations among Core Outcomes in Menopause-recommended vasomotor symptom outcomes in MsFLASH trials Open
Objective This study aimed to advance understanding of vasomotor symptom (VMS) outcomes measurement using pooled data from three Menopause Strategies Finding Lasting Answers to Symptoms and Health (MsFLASH) trials. Methods Participants sel…
View article: Protocol for the development of a tool (INSPECT-SR) to identify problematic randomised controlled trials in systematic reviews of health interventions
Protocol for the development of a tool (INSPECT-SR) to identify problematic randomised controlled trials in systematic reviews of health interventions Open
Introduction Randomised controlled trials (RCTs) inform healthcare decisions. It is now apparent that some published RCTs contain false data and some appear to have been entirely fabricated. Systematic reviews are performed to identify and…
View article: Patient and professional perspectives about using in vitro fertilisation add-ons in the UK and Australia: a qualitative study
Patient and professional perspectives about using in vitro fertilisation add-ons in the UK and Australia: a qualitative study Open
Objectives In vitro fertilisation (IVF) add-ons are additional procedures offered alongside an IVF cycle with the aim of improving live birth rates. They are controversial because of the paucity of evidence to support their efficacy and sa…
View article: Endometrial scratching in women undergoing IVF/ICSI: an individual participant data meta-analysis
Endometrial scratching in women undergoing IVF/ICSI: an individual participant data meta-analysis Open
BACKGROUND In IVF/ICSI treatment, the process of embryo implantation is the success rate-limiting step. Endometrial scratching has been suggested to improve this process, but it is unclear if this procedure increases the chance of implanta…
View article: Community awareness and use of anti-Müllerian hormone testing in Australia: a population survey of women
Community awareness and use of anti-Müllerian hormone testing in Australia: a population survey of women Open
STUDY QUESTION What is the anti-Mullerian hormone (AMH) test usage, awareness, and perceived reasons for testing in a representative community sample of women in Australia? SUMMARY ANSWER : Among women aged 18–55 years, 13% had heard about…
View article: P-562 Elective egg freezers’ disposition decisions: A qualitative study
P-562 Elective egg freezers’ disposition decisions: A qualitative study Open
Study question What are the factors that influence elective egg freezers’ (EEF) disposition decisions towards their surplus frozen oocytes? Summary answer Achieving motherhood or dealing with grief if motherhood was not achieved, the compl…
View article: ‘It all depends on why it’s red’: qualitative interviews exploring patient and professional views of a traffic light system for in vitro fertilisation add-ons
‘It all depends on why it’s red’: qualitative interviews exploring patient and professional views of a traffic light system for in vitro fertilisation add-ons Open
In vitro fertilisation (IVF) add-ons are techniques, medicines, or procedures used in addition to standard IVF with the aim of improving the chance of success. The United Kingdom’s IVF regulator, the Human Fertilisation Embryology Authorit…
View article: How do IVF patients interpret claims about fertility treatments? A randomised survey experiment
How do IVF patients interpret claims about fertility treatments? A randomised survey experiment Open
Trials evaluating the efficacy of IVF and various treatment options often focus on upstream outcome measures, improvements which may not translate into clinical outcome improvements. A cross-sectional online survey was distributed globally…
View article: Is the use of IVF add-on treatments driven by patients or clinics? Findings from a UK patient survey
Is the use of IVF add-on treatments driven by patients or clinics? Findings from a UK patient survey Open
There are conflicting narratives over what drives demand for add-ons. We undertook an online survey of IVF patients to determine whether patients perceive that use of IVF add-ons is driven by patients or practitioners. People who underwent…
View article: Barriers to reproductive treatments in Australia
Barriers to reproductive treatments in Australia Open
Recognition of the impact of barriers such as age to achieving reproductive goals remains the highest priority for GPs. This will help them to broach this topic with patients, carry out a timely evaluation or provide referral, as well as d…
View article: Endometrial injury for pregnancy following sexual intercourse or intrauterine insemination
Endometrial injury for pregnancy following sexual intercourse or intrauterine insemination Open
Evidence is insufficient to show whether there is a difference in live birth/ongoing pregnancy between endometrial injury and no intervention/a sham procedure in women undergoing IUI or attempting to conceive via sexual intercourse. The po…
View article: Table of Contents
Table of Contents Open
View article: Creativity in lockdown: Understanding how music and the arts supported mental health during the COVID-19 pandemic by age group
Creativity in lockdown: Understanding how music and the arts supported mental health during the COVID-19 pandemic by age group Open
Recent research has indicated that many people around the world turned to artistic creative activities (ACAs) to support their mental health during COVID-19 lockdowns. However, studies have also shown that the negative psychosocial impacts…