Sarah A. McLaughlin
YOU?
Author Swipe
View article: Proteomic analysis of small extracellular vesicles from lymphatic affluents in developing premetastatic niche in melanoma
Proteomic analysis of small extracellular vesicles from lymphatic affluents in developing premetastatic niche in melanoma Open
Melanoma is an aggressive form of skin cancer that often metastasizes through lymph nodes (LNs). Lymphatic small extracellular vesicles (sEVs) derived from melanoma play a crucial role in establishing a premetastatic niche (PMN) within the…
View article: A STAT1-GBP1 axis modulates epithelial proliferation in postpartum breast tissue by repressing CDKI expression
A STAT1-GBP1 axis modulates epithelial proliferation in postpartum breast tissue by repressing CDKI expression Open
These findings identify a STAT1-GBP1 axis that enhances postpartum epithelial proliferation by repressing CDKI expression. This mechanism may help to explain the heightened vulnerability observed after childbirth and highlights potential b…
View article: Cancer related lymphedema
Cancer related lymphedema Open
Lymphedema is a prevalent, incurable, and morbid condition with the potential to degrade the health and quality of life of patients living with cancer and beyond cancer. Effective long term control requires coordination by an interdiscipli…
View article: Imaging-based Surgical Site Infection Detection Using Artificial Intelligence
Imaging-based Surgical Site Infection Detection Using Artificial Intelligence Open
Objective: To develop an artificial intelligence–based pipeline to assess and triage patient-submitted postoperative wound images. Background: The rise of outpatient surgeries, remote monitoring, and patient-submitted wound images via onli…
View article: Abstract 1578 TMT-based quantitative proteomic analysis of lymphatic exosomes reveals pathways involved in sentinel lymph node remodeling in melanoma
Abstract 1578 TMT-based quantitative proteomic analysis of lymphatic exosomes reveals pathways involved in sentinel lymph node remodeling in melanoma Open
View article: Environmental and Biological Drivers of Root Exudation
Environmental and Biological Drivers of Root Exudation Open
Root exudation is the process by which plants release organic and inorganic metabolites from their roots into the surrounding soil. Root exudation is a dynamic process and shapes plant–environment interactions at the root–soil interface. L…
View article: Melanoma-derived cytokines and extracellular vesicles are interlinked with macrophage immunosuppression
Melanoma-derived cytokines and extracellular vesicles are interlinked with macrophage immunosuppression Open
Cytokines play a crucial role in mediating cell communication within the tumor microenvironment (TME). Tumor-associated macrophages are particularly influential in the regulation of immunosuppressive cytokines, thereby supporting tumor met…
View article: Lnc-RAINY regulates genes involved in radiation susceptibility through DNA:DNA:RNA triplex-forming interactions and has tumor therapeutic potential in lung cancers
Lnc-RAINY regulates genes involved in radiation susceptibility through DNA:DNA:RNA triplex-forming interactions and has tumor therapeutic potential in lung cancers Open
View article: Distinct metabolite profiles in tissues and exudates of a monocot and dicot shaped by the environment
Distinct metabolite profiles in tissues and exudates of a monocot and dicot shaped by the environment Open
Plants exhibit remarkable plasticity in response to environmental changes. Understanding how plants adapt to diverse environmental conditions through changes in their metabolite profiles can provide insights into their adaptive strategies …
View article: Future Fertility Among Pediatric Cancer Patients: Experiences and Perspectives of Health Workers in a Low Resource Setting
Future Fertility Among Pediatric Cancer Patients: Experiences and Perspectives of Health Workers in a Low Resource Setting Open
PURPOSE While fertility preservation for childhood and adolescent cancer patients is considered standard of care in the high-resource settings, it is rarely offered in low-resource settings. This study explores the experiences and perspect…
View article: Impact of a Multidisciplinary Service Line and Program for Transcatheter Device Closure of the Neonatal Ductus Arteriosus
Impact of a Multidisciplinary Service Line and Program for Transcatheter Device Closure of the Neonatal Ductus Arteriosus Open
Objective– Outline a quality initiative establishing an institutional service line for neonatal transcatheter device closure of the patent ductus arteriosus (TDC-PDA). Study Design – A retrospective descriptive observational study surround…
View article: D89. Nipple Areolar Malposition versus Ideal Position after Nipple-Sparing Mastectomy Reconstruction
D89. Nipple Areolar Malposition versus Ideal Position after Nipple-Sparing Mastectomy Reconstruction Open
PURPOSE: Malposition of the nipple areolar complex (NAC) is a non-optimal complication of nipple-sparing mastectomy (NSM) reconstruction, NSM that preserves the NAC and surrounding skin and results in both a more naturally appearing recons…
View article: A Versatile Glass Jar System for Semihydroponic Root Exudate Profiling
A Versatile Glass Jar System for Semihydroponic Root Exudate Profiling Open
Root exudates shape the plant-soil interface, are involved in nutrient cycling and modulate interactions with soil organisms. Root exudates are dynamic and shaped by biological, environmental, and experimental conditions. Due to their wide…
View article: Feasibility and Clinical Utility of Prediction Models for Breast Cancer–Related Lymphedema Incorporating Racial Differences in Disease Incidence
Feasibility and Clinical Utility of Prediction Models for Breast Cancer–Related Lymphedema Incorporating Racial Differences in Disease Incidence Open
Importance Breast cancer–related lymphedema (BCRL) is a common complication of axillary lymph node dissection (ALND) but can also develop after sentinel lymph node biopsy (SLNB). Several models have been developed to predict the risk of di…
View article: Integration of multiomics data shows down regulation of mismatch repair and tubulin pathways in triple-negative chemotherapy-resistant breast tumors
Integration of multiomics data shows down regulation of mismatch repair and tubulin pathways in triple-negative chemotherapy-resistant breast tumors Open
Background Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. Patients with TNBC are primarily treated with neoadjuvant chemotherapy (NAC). The response to NAC is prognostic, with reductions in overall survi…
View article: D18. Risk of Breast Cancer-Related Lymphedema: Development and Validation of a Clinically-Relevant, Patient-facing Prediction Model
D18. Risk of Breast Cancer-Related Lymphedema: Development and Validation of a Clinically-Relevant, Patient-facing Prediction Model Open
PURPOSE: Breast cancer related lymphedema (BCRL) may be prevented with immediate lymphatic reconstruction (ILR). However, prioritizing patients for ILR based on risk is not possible since current predictive models include obscure datapoint…
View article: Supplementary Figure 1 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer
Supplementary Figure 1 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer Open
Supplementary Figure 1 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer
View article: Supplementary Table 2 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer
Supplementary Table 2 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer Open
Supplementary Table 2 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer
View article: Supplementary Table 3 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer
Supplementary Table 3 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer Open
Supplementary Table 3 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer
View article: Supplementary Table 1 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer
Supplementary Table 1 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer Open
Supplementary Table 1 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer
View article: Supplementary Table 4 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer
Supplementary Table 4 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer Open
Supplementary Table 4 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer
View article: Supplementary Table 1 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer
Supplementary Table 1 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer Open
Supplementary Table 1 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer
View article: Supplementary Table 3 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer
Supplementary Table 3 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer Open
Supplementary Table 3 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer
View article: Supplementary Table 4 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer
Supplementary Table 4 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer Open
Supplementary Table 4 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer
View article: Supplementary Table 2 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer
Supplementary Table 2 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer Open
Supplementary Table 2 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer
View article: Supplementary Figure 1 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer
Supplementary Figure 1 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer Open
Supplementary Figure 1 from Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer
View article: The core metabolome and root exudation dynamics of three phylogenetically distinct plant species
The core metabolome and root exudation dynamics of three phylogenetically distinct plant species Open
Root exudates are plant-derived, exported metabolites likely shaping root-associated microbiomes by acting as nutrients and signals. However, root exudation dynamics are unclear and thus also, if changes in exudation are reflected in chang…
View article: Additional file 2 of Integration of multiomics data shows down regulation of mismatch repair and tubulin pathways in triple-negative chemotherapy-resistant breast tumors
Additional file 2 of Integration of multiomics data shows down regulation of mismatch repair and tubulin pathways in triple-negative chemotherapy-resistant breast tumors Open
Additional file 2. Supplementary Tables.
View article: Prospective Surveillance with Compression for Subclinical Lymphedema: Symptoms, Skin, and Quality-of-Life Outcomes
Prospective Surveillance with Compression for Subclinical Lymphedema: Symptoms, Skin, and Quality-of-Life Outcomes Open
Background: Patients underwent a compression (sleeve and gauntlet) intervention for subclinical breast cancer-related lymphedema (S-BCRL). Physical, emotional, and quality-of-life (QoL) outcomes were examined. Associations of…
View article: Risk factors for breast cancer–related lymphedema in patients undergoing 3 years of prospective surveillance with intervention
Risk factors for breast cancer–related lymphedema in patients undergoing 3 years of prospective surveillance with intervention Open
Background To evaluate risk factors (treatment‐related, comorbidities, and lifestyle) for breast cancer–related lymphedema (BCRL) within the context of a Prospective Surveillance and Early Intervention (PSEI) model of care for subclinical …