Sarah Mowery
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View article: Specific binding sites on Rhesus rotavirus capsid protein dictate the method of endocytosis inducing the murine model of biliary atresia
Specific binding sites on Rhesus rotavirus capsid protein dictate the method of endocytosis inducing the murine model of biliary atresia Open
In this study, we have determined that the presence of the “SRL” peptide on RRV alters its method of endocytosis and intracellular trafficking through viral binding to heat shock cognate 70 protein. This initiates an inflammatory pathway t…
View article: Rhesus rotavirus receptor‐binding site affects high mobility group box 1 release, altering the pathogenesis of experimental biliary atresia
Rhesus rotavirus receptor‐binding site affects high mobility group box 1 release, altering the pathogenesis of experimental biliary atresia Open
Biliary atresia (BA) is a neonatal inflammatory cholangiopathy that requires surgical intervention by Kasai portoenterostomy to restore biliary drainage. Even with successful portoenterostomy, most patients diagnosed with BA progress to en…
View article: High Mobility Group Box 1 Release by Cholangiocytes Governs Biliary Atresia Pathogenesis and Correlates With Increases in Afflicted Infants
High Mobility Group Box 1 Release by Cholangiocytes Governs Biliary Atresia Pathogenesis and Correlates With Increases in Afflicted Infants Open
Background and Aims Biliary atresia (BA) is a devastating cholangiopathy of infancy. Upon diagnosis, surgical reconstruction by Kasai hepatoportoenterostomy (HPE) restores biliary drainage in a subset of patients, but most patients develop…
View article: Assessment of the role of FGF15 in mediating the metabolic outcomes of murine vertical sleeve gastrectomy
Assessment of the role of FGF15 in mediating the metabolic outcomes of murine vertical sleeve gastrectomy Open
In the absence of an intact fibroblast growth factor 15 (FGF15) signaling pathway, murine vertical sleeve gastrectomy results in weight loss without all its anticipated metabolic benefits. In the absence of an intact FGF15 signaling pathwa…
View article: Rotavirus Reassortant–Induced Murine Model of Liver Fibrosis Parallels Human Biliary Atresia
Rotavirus Reassortant–Induced Murine Model of Liver Fibrosis Parallels Human Biliary Atresia Open
Background and Aims Biliary atresia (BA) is a devastating neonatal cholangiopathy that progresses to fibrosis and end‐stage liver disease by 2 years of age. Portoenterostomy may reestablish biliary drainage, but, despite drainage, virtuall…
View article: Collagen COL22A1 maintains vascular stability and mutations in <i>COL22A1</i> are potentially associated with intracranial aneurysms
Collagen COL22A1 maintains vascular stability and mutations in <i>COL22A1</i> are potentially associated with intracranial aneurysms Open
Collagen XXII (COL22A1) is a quantitatively minor collagen, which belongs to the family of fibril-associated collagens with interrupted triple helices. Its biological function has been poorly understood. Here, we used a genome-editing appr…
View article: A Point Mutation in the Rhesus Rotavirus VP4 Protein Generated through a Rotavirus Reverse Genetics System Attenuates Biliary Atresia in the Murine Model
A Point Mutation in the Rhesus Rotavirus VP4 Protein Generated through a Rotavirus Reverse Genetics System Attenuates Biliary Atresia in the Murine Model Open
Rotavirus infection is one of the most common causes of diarrheal illness in humans. In neonatal mice, rhesus rotavirus (RRV) can induce biliary atresia (BA), a disease resulting in inflammatory obstruction of the extrahepatic biliary trac…
View article: Fibroblast growth factor 21 correlates with weight loss after vertical sleeve gastrectomy in adolescents
Fibroblast growth factor 21 correlates with weight loss after vertical sleeve gastrectomy in adolescents Open
Objective Vertical sleeve gastrectomy (VSG) results in weight loss and increased bile acids (BA) and fibroblast growth factor 19 (FGF19) levels. FGF21 shares essential cofactors with FGF19, but its physiology early post‐VSG has not been as…