Sarah Nickels
YOU?
Author Swipe
View article: Author Correction: Integrating digital gait data with metabolomics and clinical data to predict outcomes in Parkinson’s disease
Author Correction: Integrating digital gait data with metabolomics and clinical data to predict outcomes in Parkinson’s disease Open
View article: The Parkinson’s disease-associated LRRK2-G2019S variant restricts serine metabolism, leading to microglial inflammation and dopaminergic neuron degeneration
The Parkinson’s disease-associated LRRK2-G2019S variant restricts serine metabolism, leading to microglial inflammation and dopaminergic neuron degeneration Open
A growing body of evidence implicates inflammation as a key hallmark in the pathophysiology of Parkinson’s disease (PD), with microglia playing a central role in mediating neuroinflammatory signaling in the brain. However, the molecular me…
View article: Reproducibility of PD patient-specific midbrain organoid data for in vitro disease modeling
Reproducibility of PD patient-specific midbrain organoid data for in vitro disease modeling Open
View article: Multi-cohort machine learning identifies predictors of cognitive impairment in Parkinson’s disease
Multi-cohort machine learning identifies predictors of cognitive impairment in Parkinson’s disease Open
View article: Reproducibility of PD patient-specific midbrain organoid data for in vitro disease modelling
Reproducibility of PD patient-specific midbrain organoid data for in vitro disease modelling Open
Midbrain organoids are advanced in vitro cellular models for disease modelling. They have been used successfully over the past decade for Parkinson’s disease (PD) research and drug development. The three-dimensional structure and multicell…
View article: Cystatin C Secretion in Blood Derivatives and Cellular Models of Idiopathic Parkinson’s Disease
Cystatin C Secretion in Blood Derivatives and Cellular Models of Idiopathic Parkinson’s Disease Open
Parkinson’s disease is an age‐related progressive neurodegenerative disorder. A large majority of Parkinson’s disease patients have an unknown etiology, which is classified as idiopathic Parkinson’s disease. Generating disease models direc…
View article: Mixed effects models but not t-tests or linear regression detect progression of apathy in Parkinson’s disease over seven years in a cohort: a comparative analysis
Mixed effects models but not t-tests or linear regression detect progression of apathy in Parkinson’s disease over seven years in a cohort: a comparative analysis Open
View article: Cardiovascular history and risk of idiopathic Parkinson’s disease: a cross-sectional observational study
Cardiovascular history and risk of idiopathic Parkinson’s disease: a cross-sectional observational study Open
View article: Gut microbiome is not associated with mild cognitive impairment in Parkinson’s disease
Gut microbiome is not associated with mild cognitive impairment in Parkinson’s disease Open
View article: Comprehensive blood metabolomics profiling of Parkinson’s disease reveals coordinated alterations in xanthine metabolism
Comprehensive blood metabolomics profiling of Parkinson’s disease reveals coordinated alterations in xanthine metabolism Open
Parkinson’s disease (PD) is a highly heterogeneous disorder influenced by several environmental and genetic factors. Effective disease-modifying therapies and robust early-stage biomarkers are still lacking, and an improved understanding o…
View article: Highly scalable and standardized organ-on-chip platform with TEER for biological barrier modeling
Highly scalable and standardized organ-on-chip platform with TEER for biological barrier modeling Open
The development of new therapies is hampered by the lack of predictive, and patient-relevant in vitro models. Organ-on-chip (OOC) technologies can potentially recreate physiological features and hold great promise for tissue and disease mo…
View article: Converging peripheral blood microRNA profiles in Parkinson's disease and progressive supranuclear palsy
Converging peripheral blood microRNA profiles in Parkinson's disease and progressive supranuclear palsy Open
MicroRNAs act via targeted suppression of messenger RNA translation in the DNA–RNA–protein axis. The dysregulation of microRNA(s) reflects the epigenetic changes affecting the cellular processes in multiple disorders. To understand the com…
View article: Impaired neuron differentiation in GBA-associated Parkinson’s disease is linked to cell cycle defects in organoids
Impaired neuron differentiation in GBA-associated Parkinson’s disease is linked to cell cycle defects in organoids Open
View article: Accurate long-read sequencing identified GBA1 as major risk factor in the Luxembourgish Parkinson’s study
Accurate long-read sequencing identified GBA1 as major risk factor in the Luxembourgish Parkinson’s study Open
Heterozygous variants in the glucocerebrosidase GBA1 gene are an increasingly recognized risk factor for Parkinson’s disease (PD). Due to the GBAP1 pseudogene, which shares 96% sequence homology with the GBA1 coding region, accurate varian…
View article: Omics data integration suggests a potential idiopathic Parkinson’s disease signature
Omics data integration suggests a potential idiopathic Parkinson’s disease signature Open
View article: Treating Parkinson’s Disease with Human Bone Marrow Mesenchymal Stem Cell Secretome: A Translational Investigation Using Human Brain Organoids and Different Routes of In Vivo Administration
Treating Parkinson’s Disease with Human Bone Marrow Mesenchymal Stem Cell Secretome: A Translational Investigation Using Human Brain Organoids and Different Routes of In Vivo Administration Open
Parkinson’s disease (PD) is the most common movement disorder, characterized by the progressive loss of dopaminergic neurons from the nigrostriatal system. Currently, there is no treatment that retards disease progression or reverses damag…
View article: Highly scalable and standardized organ-on-chip platform with TEER for biological barrier modeling
Highly scalable and standardized organ-on-chip platform with TEER for biological barrier modeling Open
The development of new therapies is hampered by the lack of predictive, and patient-relevant in vitro models. Organ-on-chip (OOC) technologies can potentially recreate physiological features and hold great promise for tissue and disease mo…
View article: Publisher Correction: Age at onset as stratifier in idiopathic Parkinson’s disease – effect of ageing and polygenic risk score on clinical phenotypes
Publisher Correction: Age at onset as stratifier in idiopathic Parkinson’s disease – effect of ageing and polygenic risk score on clinical phenotypes Open
View article: Age at onset as stratifier in idiopathic Parkinson’s disease – effect of ageing and polygenic risk score on clinical phenotypes
Age at onset as stratifier in idiopathic Parkinson’s disease – effect of ageing and polygenic risk score on clinical phenotypes Open
Several phenotypic differences observed in Parkinson’s disease (PD) patients have been linked to age at onset (AAO). We endeavoured to find out whether these differences are due to the ageing process itself by using a combined dataset of i…
View article: Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality
Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality Open
The human brain is a complex, three‐dimensional structure. To better recapitulate brain complexity, recent efforts have focused on the development of human‐specific midbrain organoids. Human iPSC‐derived midbrain organoids consist of diffe…
View article: Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression
Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression Open
Human brain organoid models that recapitulate the physiology and complexity of the human brain have a great potential for in vitro disease modeling, in particular for neurodegenerative diseases, such as Parkinson disease. In the present st…
View article: Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality
Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality Open
The human brain is a complex, three-dimensional structure. To better recapitulate brain complexity, recent efforts have focused on the development of human specific midbrain organoids. Human iPSC-derived midbrain organoids consist of diffe…
View article: The Parkinson’s-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1
The Parkinson’s-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1 Open
Increasing evidence suggests that neurodevelopmental alterations might contribute to increase the susceptibility to develop neurodegenerative diseases. We investigate the occurrence of developmental abnormalities in dopaminergic neurons in…
View article: A new brain organoid model to study Parkinson’s Disease
A new brain organoid model to study Parkinson’s Disease Open
Human midbrain organoid models represent a new tool to study the underlaying etiology of Parkinson’s disease in physiological conditions.
View article: Synaptic decline precedes dopaminergic neuronal loss in human midbrain organoids harboring a triplication of the <i>SNCA</i> gene
Synaptic decline precedes dopaminergic neuronal loss in human midbrain organoids harboring a triplication of the <i>SNCA</i> gene Open
1. Abstract Increased levels of the protein alpha-synuclein (α-syn) are associated with the development of neurodegenerative diseases like Parkinson’s disease (PD). In physiological conditions, α-syn modulates synaptic plasticity, neurogen…
View article: Neuronal hyperactivity in a LRRK2-G2019S cellular model of Parkinson’s Disease
Neuronal hyperactivity in a LRRK2-G2019S cellular model of Parkinson’s Disease Open
Monogenic Parkinson’s Disease can be caused by a mutation in the leucine-rich repeat kinase 2 (LRRK2) gene, causing a late-onset autosomal dominant inherited form of Parkinson’s Disease. The function of the LRRK2 gene is incompletely under…
View article: Is serine racemase (SRR) a second hit target for LRRK2-G2019S induced Parkinson’s disease?
Is serine racemase (SRR) a second hit target for LRRK2-G2019S induced Parkinson’s disease? Open
To date, at least 7 million people are suffering from Parkinson’s disease (PD) worldwide, which is the second most prevalent, age-associated, and progressive neurodegenerative disorder (Tysnes and Storstein, 2017). Given the accelerated gl…
View article: Parkinson’s disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions
Parkinson’s disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions Open
Background Parkinson’s disease (PD) is a systemic disease clinically defined by the degeneration of dopaminergic neurons in the brain. While alterations in the gut microbiome composition have been reported in PD, their functional consequen…
View article: Reproducible generation of human midbrain organoids for in vitro modeling of Parkinson’s disease
Reproducible generation of human midbrain organoids for in vitro modeling of Parkinson’s disease Open
View article: Machine learning-assisted neurotoxicity prediction in human midbrain organoids
Machine learning-assisted neurotoxicity prediction in human midbrain organoids Open
The here described model is a valuable tool for advanced in vitro PD modeling and to test putative neurotoxic compounds.