Sarah O’Brien
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1437 Single cell profiling of pancreatic ductal adenocarcinoma tumor microenvironment in response to Flt3 ligand reveals molecular and cellular interaction between dendritic cell lineage and cancer associated fibroblasts Open
Background Pancreatic ductal adenocarcinoma (PDAC) has an environment characterized by heterogeneity in cancer associated fibroblasts (CAF) as well as an immune desert phenotype. It is well-established that dendritic cells (DCs) which are …
902 Comprehensive multi-omics meta-analysis of pancreatic cancer mouse models and human PDAC data sets identifies unique cancer-associated fibroblast subsets Open
Background Pancreatic ductal adenocarcinoma (PDAC) is resistant to many available therapies including immunotherapy because of its highly complex tumor microenvironment (TME). PDAC TME consists of a significant proportion of stromal cells,…