Sarah Partridge
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View article: Call to action: British and Irish hypertension society position statement on blood pressure treatment thresholds and targets
Call to action: British and Irish hypertension society position statement on blood pressure treatment thresholds and targets Open
In this position statement the British and Irish Hypertension Society (BIHS) present a review of the current evidence for blood pressure (BP) treatment thresholds and targets. The BIHS recommend initiating pharmacological antihypertensive …
View article: British and Irish Hypertension Society response to ‘RAAS inhibitors in pregnancy, breastfeeding and women of childbearing potential: a review of national and international clinical practice guidelines’
British and Irish Hypertension Society response to ‘RAAS inhibitors in pregnancy, breastfeeding and women of childbearing potential: a review of national and international clinical practice guidelines’ Open
In their review of clinical practice guidelines on the use of renin-angiotensin-aldosterone system (RAAS) inhibitors, Greenlees and Delles call for more explicit advice on the use of these drugs among women of childbearing potential, durin…
View article: The use of pembrolizumab monotherapy for the management of head and neck squamous cell carcinoma (<scp>HNSCC</scp>) in the <scp>UK</scp>
The use of pembrolizumab monotherapy for the management of head and neck squamous cell carcinoma (<span>HNSCC</span>) in the <span>UK</span> Open
Pembrolizumab has received approval in the UK as first‐line monotherapy for recurrent and/or metastatic HNSCC (R/M HNSCC) following the results of the KEYNOTE‐048 trial, which demonstrated a longer overall survival (OS) in comparison to th…
View article: The Hammersmith Score Optimises Patient Selection and Predicts for Overall Survival in Early-Phase Cancer Trial Participants Independent of Tumour Burden
The Hammersmith Score Optimises Patient Selection and Predicts for Overall Survival in Early-Phase Cancer Trial Participants Independent of Tumour Burden Open
Introduction: As tumour response rates are increasingly demonstrated in early-phase cancer trials (EPCT), optimal patient selection and accurate prognostication are paramount. Hammersmith Score (HS), a simple prognostic index derived on ro…
View article: A systematic literature review on the clinical efficacy of low dose naltrexone and its effect on putative pathophysiological mechanisms among patients diagnosed with fibromyalgia
A systematic literature review on the clinical efficacy of low dose naltrexone and its effect on putative pathophysiological mechanisms among patients diagnosed with fibromyalgia Open
The strength of evidence from randomized controlled trials to support the use of LDN among patients with fibromyalgia is low. Two small studies suggest ESR and cytokines may be involved in the mechanism by which LDN exerts its effects. Two…
View article: Management of hypertensive crisis: British and Irish Hypertension Society Position document
Management of hypertensive crisis: British and Irish Hypertension Society Position document Open
Patients with hypertensive emergencies, malignant hypertension and acute severe hypertension are managed heterogeneously in clinical practice. Initiating anti-hypertensive therapy and setting BP goal in acute settings requires important co…
View article: Direction of attentional focus in prosthetic training: Current practice and potential for improving motor learning in individuals with lower limb loss
Direction of attentional focus in prosthetic training: Current practice and potential for improving motor learning in individuals with lower limb loss Open
Objective Adopting an external focus of attention has been shown to benefit motor performance and learning. However, the potential of optimizing attentional focus for improving prosthetic motor skills in lower limb prosthesis (LLP) users h…
View article: Malignant Salivary Gland Tumours - a single centre experience
Malignant Salivary Gland Tumours - a single centre experience Open
Objectives: Salivary gland malignancies are an uncommon and heterogeneous group of cancers. We report our experience of clinicopathological variables that affect survival in patients treated by curative intent with surgery at a UK institut…
View article: Association of Prior Antibiotic Treatment With Survival and Response to Immune Checkpoint Inhibitor Therapy in Patients With Cancer
Association of Prior Antibiotic Treatment With Survival and Response to Immune Checkpoint Inhibitor Therapy in Patients With Cancer Open
Despite being limited by sample size, geographic origin, and the lack of correlative analyses on patients' gut microbiota, this study suggests that pATB therapy but not cATB therapy is associated with a worse treatment response and OS in u…