Sarah Donegan
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View article: The impact of Cochrane Reviews that apply network meta-analysis in clinical guidelines: A systematic review
The impact of Cochrane Reviews that apply network meta-analysis in clinical guidelines: A systematic review Open
Background Systematic reviews, such as those prepared by Cochrane, are the strongest evidence on which to base recommendations in clinical guidelines. Network meta-analysis (NMA) can be used to combine the results of studies to compare mul…
View article: Best step-up treatments for children with uncontrolled asthma: a systematic review and network meta-analysis of individual participant data
Best step-up treatments for children with uncontrolled asthma: a systematic review and network meta-analysis of individual participant data Open
Background There is uncertainty about the best treatment option for children/adolescents with uncontrolled asthma despite inhaled corticosteroids (ICS) and international guidelines make different recommendations. We evaluated the pharmacol…
View article: Establishing the best step-up treatments for children with uncontrolled asthma despite inhaled corticosteroids: the EINSTEIN systematic review, network meta-analysis and cost-effectiveness analysis using individual participant data
Establishing the best step-up treatments for children with uncontrolled asthma despite inhaled corticosteroids: the EINSTEIN systematic review, network meta-analysis and cost-effectiveness analysis using individual participant data Open
Background There is no clear preferential option for initial step-up of treatment for children with uncontrolled asthma on inhaled corticosteroid. Objectives Evaluate the clinical effectiveness of pharmacological treatments to use in child…
View article: Table of Contents
Table of Contents Open
View article: Radiological features characterising indeterminate testes masses: a systematic review and meta‐analysis
Radiological features characterising indeterminate testes masses: a systematic review and meta‐analysis Open
Context The use of scrotal ultrasonography (SUS) has increased the detection rate of indeterminate testicular masses. Defining radiological characteristics that identify malignancy may reduce the number of men undergoing unnecessary radica…
View article: Using individual participant data to improve network meta-analysis projects
Using individual participant data to improve network meta-analysis projects Open
A network meta-analysis combines the evidence from existing randomised trials about the comparative efficacy of multiple treatments. It allows direct and indirect evidence about each comparison to be included in the same analysis, and prov…
View article: The management of anticoagulants in patients with atrial fibrillation and history of falls or risk of falls: The Liverpool AF-Falls Project. A systematic review and meta-analysis
The management of anticoagulants in patients with atrial fibrillation and history of falls or risk of falls: The Liverpool AF-Falls Project. A systematic review and meta-analysis Open
Funding Acknowledgements Type of funding sources: Private company. Main funding source(s): Johnson and Johnson Medical Background Atrial fibrillation affects an estimated 33 million individuals worldwide and a major cause of stroke, heart …
View article: The management of anticoagulants in patients with atrial fibrillation and history of falls or risk of falls: protocol for a systematic review and meta-analysis
The management of anticoagulants in patients with atrial fibrillation and history of falls or risk of falls: protocol for a systematic review and meta-analysis Open
View article: Interventions to prevent spontaneous preterm birth in women with singleton pregnancy who are at high risk: systematic review and network meta-analysis
Interventions to prevent spontaneous preterm birth in women with singleton pregnancy who are at high risk: systematic review and network meta-analysis Open
Objectives To compare the efficacy of bed rest, cervical cerclage (McDonald, Shirodkar, or unspecified type of cerclage), cervical pessary, fish oils or omega fatty acids, nutritional supplements (zinc), progesterone (intramuscular, oral, …
View article: Ontology of the apelinergic system in mouse pancreas during pregnancy and relationship with β-cell mass
Ontology of the apelinergic system in mouse pancreas during pregnancy and relationship with β-cell mass Open
View article: The Management of Anticoagulants in Patients With Atrial Fibrillation and History of Falls or Risk of Falls: The Liverpool Af-falls Project. Protocol for a Systematic Review and Meta-analysis
The Management of Anticoagulants in Patients With Atrial Fibrillation and History of Falls or Risk of Falls: The Liverpool Af-falls Project. Protocol for a Systematic Review and Meta-analysis Open
BackgroundAtrial fibrillation affects an estimated 33 million individuals worldwide and is a major cause of stroke, heart failure, and death. Anticoagulants substantially reduces risk of stroke but are also associated with an increased ris…
View article: EstablishINg the best STEp-up treatments for children with uncontrolled asthma despite INhaled corticosteroids (EINSTEIN): protocol for a systematic review, network meta-analysis and cost-effectiveness analysis using individual participant data (IPD)
EstablishINg the best STEp-up treatments for children with uncontrolled asthma despite INhaled corticosteroids (EINSTEIN): protocol for a systematic review, network meta-analysis and cost-effectiveness analysis using individual participant data (IPD) Open
Introduction Asthma affects millions of children worldwide—1.1 million children in the UK. Asthma symptoms cannot be cured but can be controlled with low-dose inhaled corticosteroids (ICSs) in the majority of individuals. Treatment with a …
View article: Altered pancreas remodeling following glucose intolerance in pregnancy in mice
Altered pancreas remodeling following glucose intolerance in pregnancy in mice Open
Gestational diabetes mellitus increases the risk of dysglycemia postpartum, in part, due to pancreatic β-cell dysfunction. However, no histological evidence exists comparing endocrine pancreas after healthy and glucose-intolerant pregnanci…
View article: Interventions to prevent spontaneous preterm birth in high-risk women with singleton pregnancy: a systematic review and network meta-analysis
Interventions to prevent spontaneous preterm birth in high-risk women with singleton pregnancy: a systematic review and network meta-analysis Open
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To compare the efficacy of current, relevant interventions to prevent preterm birth in women with singleton pregnancy and high individual risk of spont…
View article: EVALUATION OF NOVEL ORAL ANTICOAGULANT PRESCRIPTION PATTERNS IN A TERTIARY CARE CLINIC
EVALUATION OF NOVEL ORAL ANTICOAGULANT PRESCRIPTION PATTERNS IN A TERTIARY CARE CLINIC Open
View article: Public health deworming programmes for soil-transmitted helminths in children living in endemic areas
Public health deworming programmes for soil-transmitted helminths in children living in endemic areas Open
Public health programmes to regularly treat all children with deworming drugs do not appear to improve height, haemoglobin, cognition, school performance, or mortality. We do not know if there is an effect on school attendance, since the e…
View article: Assessing the consistency assumptions underlying network meta‐regression using aggregate data
Assessing the consistency assumptions underlying network meta‐regression using aggregate data Open
When numerous treatments exist for a disease (Treatments 1, 2, 3, etc), network meta‐regression (NMR) examines whether each relative treatment effect (eg, mean difference for 2 vs 1, 3 vs 1, and 3 vs 2) differs according to a covariate (eg…
View article: Interpretation of subgroup analyses in systematic reviews: A tutorial
Interpretation of subgroup analyses in systematic reviews: A tutorial Open
View article: Graphs of study contributions and covariate distributions for network meta‐regression
Graphs of study contributions and covariate distributions for network meta‐regression Open
Background Meta‐regression results must be interpreted taking into account the range of covariate values of the contributing studies. Results based on interpolation or extrapolation may be unreliable. In network meta‐regression (NMR) model…
View article: Network meta‐analysis including treatment by covariate interactions: Consistency can vary across covariate values
Network meta‐analysis including treatment by covariate interactions: Consistency can vary across covariate values Open
Background Many reviews aim to compare numerous treatments and report results stratified by subgroups (eg, by disease severity). In such cases, a network meta‐analysis model including treatment by covariate interactions can estimate the re…
View article: Is Dengue Vector Control Deficient in Effectiveness or Evidence?: Systematic Review and Meta-analysis
Is Dengue Vector Control Deficient in Effectiveness or Evidence?: Systematic Review and Meta-analysis Open
This review and meta-analysis demonstrate the remarkable paucity of reliable evidence for the effectiveness of any dengue vector control method. Standardised studies of higher quality to evaluate and compare methods must be prioritised to …
View article: Cluster Randomised Trials in Cochrane Reviews: Evaluation of Methodological and Reporting Practice
Cluster Randomised Trials in Cochrane Reviews: Evaluation of Methodological and Reporting Practice Open
The methodological and reporting practices in Cochrane reviews incorporating C-RCTs could be greatly improved, particularly with regard to analyses. Criteria developed as part of the current study could be used by review authors or editors…
View article: A systematic review of placebo‐controlled trials of topiramate: How useful is a multiple‐indications review for evaluating the adverse events of an antiepileptic drug?
A systematic review of placebo‐controlled trials of topiramate: How useful is a multiple‐indications review for evaluating the adverse events of an antiepileptic drug? Open
Summary Objective Topiramate ( TPM ) is an antiepileptic drug that is also used for other indications (e.g., migraine). Adverse event ( AE ) data from epilepsy trials could be supplemented by data from trials in other indications. Combinin…
View article: Deworming drugs for soil-transmitted intestinal worms in children: effects on nutritional indicators, haemoglobin, and school performance
Deworming drugs for soil-transmitted intestinal worms in children: effects on nutritional indicators, haemoglobin, and school performance Open
Treating children known to have worm infection may have some nutritional benefits for the individual. However, in mass treatment of all children in endemic areas, there is now substantial evidence that this does not improve average nutriti…
View article: Exploring Treatment by Covariate Interactions Using Subgroup Analysis and Meta-Regression in Cochrane Reviews: A Review of Recent Practice
Exploring Treatment by Covariate Interactions Using Subgroup Analysis and Meta-Regression in Cochrane Reviews: A Review of Recent Practice Open
Interaction analyses in Cochrane Reviews can be substantially improved. The proposed criteria can be used to help guide the reporting and conduct of analyses.