Sarah J. Nelson
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View article: Bravery Shame and Identity in the LIS Classroom
Bravery Shame and Identity in the LIS Classroom Open
In contrast to a “safe space” a “brave space” allows and encourages challenging discussions. In a brave space, all members of the group recognize that they may be uncomfortable. It is possible that some people will cause harm, and that tha…
View article: Enhancing Multicenter Trials With the Trial Innovation Network's Initial Consultation Process
Enhancing Multicenter Trials With the Trial Innovation Network's Initial Consultation Process Open
This qualitative study describes the Trial Innovation Network's initial consultation process, which provides researchers with resources and recommendations to address complex aspects of planning and conducting clinical trials.
View article: Insights from the trial innovation network’s initial consultation process
Insights from the trial innovation network’s initial consultation process Open
Multicenter clinical trials are essential for evaluating interventions but often face significant challenges in study design, site coordination, participant recruitment, and regulatory compliance. To address these issues, the National Inst…
View article: Leveraging the Expertise of the CTSA Program to Increase the Impact and Efficiency of Clinical Trials
Leveraging the Expertise of the CTSA Program to Increase the Impact and Efficiency of Clinical Trials Open
Importance Multicenter clinical trials play a critical role in the translational processes that enable new treatments to reach all people and improve public health. However, conducting multicenter randomized clinical trials (mRCT) presents…
View article: Podium Presentation Title: Biomechanical Changes in the Ankle Joint After Syndesmosis and Deltoid Injury and Subsequent Repairs
Podium Presentation Title: Biomechanical Changes in the Ankle Joint After Syndesmosis and Deltoid Injury and Subsequent Repairs Open
View article: Examining The Association Between Pain Catastrophizing And Depression In Hispanic Vs Non-Hispanic White Youth With Chronic Pain
Examining The Association Between Pain Catastrophizing And Depression In Hispanic Vs Non-Hispanic White Youth With Chronic Pain Open
View article: Data from Changes in Pyruvate Metabolism Detected by Magnetic Resonance Imaging Are Linked to DNA Damage and Serve as a Sensor of Temozolomide Response in Glioblastoma Cells
Data from Changes in Pyruvate Metabolism Detected by Magnetic Resonance Imaging Are Linked to DNA Damage and Serve as a Sensor of Temozolomide Response in Glioblastoma Cells Open
Recent findings show that exposure to temozolomide (TMZ), a DNA-damaging drug used to treat glioblastoma (GBM), can suppress the conversion of pyruvate to lactate. To understand the mechanistic basis for this effect and its potential utili…
View article: Transforming place-based management within watersheds in Fiji: the Watershed Interventions for Systems Health project
Transforming place-based management within watersheds in Fiji: the Watershed Interventions for Systems Health project Open
Watersheds offer opportunities for place-based interventions to transform systems health via preventative versus reactive approaches to management that achieve multiple co-benefits for public and environmental health. The Watershed Interve…
View article: Rationale and design of a multisite randomized clinical trial examining an integrated behavioral treatment for veterans with co-occurring chronic pain and opioid use disorder: The pain and opioids integrated treatment in veterans (POSITIVE) trial
Rationale and design of a multisite randomized clinical trial examining an integrated behavioral treatment for veterans with co-occurring chronic pain and opioid use disorder: The pain and opioids integrated treatment in veterans (POSITIVE) trial Open
ClinicalTrials.gov Identifier: NCT04648228.
View article: The Trial Innovation Network Liaison Team: building a national clinical and translational community of practice
The Trial Innovation Network Liaison Team: building a national clinical and translational community of practice Open
In 2016, the National Center for Advancing Translational Science launched the Trial Innovation Network (TIN) to address barriers to efficient and informative multicenter trials. The TIN provides a national platform, working in partnership …
View article: Approaches for enhancing the informativeness and quality of clinical trials: Innovations and principles for implementing multicenter trials from the Trial Innovation Network
Approaches for enhancing the informativeness and quality of clinical trials: Innovations and principles for implementing multicenter trials from the Trial Innovation Network Open
One challenge for multisite clinical trials is ensuring that the conditions of an informative trial are incorporated into all aspects of trial planning and execution. The multicenter model can provide the potential for a more informative e…
View article: 4MS AGE-FRIENDLY HEALTHCARE INITIATIVE IMPLEMENTATION ON AN ACUTE CARE FOR ELDERS UNIT
4MS AGE-FRIENDLY HEALTHCARE INITIATIVE IMPLEMENTATION ON AN ACUTE CARE FOR ELDERS UNIT Open
Although evidence supports 4Ms [Medication, Mentation, What Matters Most (WMM), Mobility] care for older adults, successful implementation at an academic hospital is not well described. The aim of this study was to describe the implementat…
View article: A 44-Year-Old Woman with Dyspnea and Hemoptysis in the Setting of Remote Bariatric Surgery
A 44-Year-Old Woman with Dyspnea and Hemoptysis in the Setting of Remote Bariatric Surgery Open
View article: Recruitment and retention for chronic pain clinical trials: a narrative review
Recruitment and retention for chronic pain clinical trials: a narrative review Open
Opioid misuse is at a crisis level. In response to this epidemic, the National Institutes of Health has funded $945 million in research through the Helping to End Addiction Long-term (HEAL) Pain Management Initiative, including funding to …
View article: No Difference in Return to Duty Between Minimally Invasive, Percutaneous Achilles Tendon Repair and Nonoperative Functional Rehabilitation in Active Duty Military Members
No Difference in Return to Duty Between Minimally Invasive, Percutaneous Achilles Tendon Repair and Nonoperative Functional Rehabilitation in Active Duty Military Members Open
Category: Sports; Trauma; Other Introduction/Purpose: Achilles tendon ruptures are common injuries in the active duty US military population. Timely rehabilitation has critical importance in force readiness. There remains debate about opti…
View article: Selecting EHR-driven recruitment strategies: An evidence-based decision guide
Selecting EHR-driven recruitment strategies: An evidence-based decision guide Open
Participant recruitment for research is a persistent bottleneck that can be improved by leveraging electronic health records (EHRs). Despite emerging evidence for various EHR-driven approaches, guidance for those attempting to select and u…
View article: What we wish every investigator knew: Top 4 recruitment and retention recommendations from the Recruitment Innovation Center
What we wish every investigator knew: Top 4 recruitment and retention recommendations from the Recruitment Innovation Center Open
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View article: EHR-based cohort assessment for multicenter RCTs: a fast and flexible model for identifying potential study sites
EHR-based cohort assessment for multicenter RCTs: a fast and flexible model for identifying potential study sites Open
Objective The Recruitment Innovation Center (RIC), partnering with the Trial Innovation Network and institutions in the National Institutes of Health-sponsored Clinical and Translational Science Awards (CTSA) Program, aimed to develop a se…
View article: The Recruitment Innovation Center: Developing novel, person-centered strategies for clinical trial recruitment and retention
The Recruitment Innovation Center: Developing novel, person-centered strategies for clinical trial recruitment and retention Open
Clinical trials continue to face significant challenges in participant recruitment and retention. The Recruitment Innovation Center (RIC), part of the Trial Innovation Network (TIN), has been funded by the National Center for Advancing Tra…
View article: 4113 Infusing a CTSA Program with Causal Pathway Thinking to Transform Evaluation from Operations to Impacts
4113 Infusing a CTSA Program with Causal Pathway Thinking to Transform Evaluation from Operations to Impacts Open
OBJECTIVES/GOALS: Innovations with positive health impact are a high priority for NCATS and CTSAs. Program design that uses the Causal Pathway approach incorporates performance indicators that assess impact. We applied Causal Pathway think…
View article: Factors governing the performance of Auxiliary Nurse Midwives in India: A study in Pune district
Factors governing the performance of Auxiliary Nurse Midwives in India: A study in Pune district Open
Focusing on the tasks of ANMs with technical inputs alone is insufficient to achieve the full potential of ANMs in a changing context. Systematic efforts tackling factors governing ANMs in their workplaces can produce a useful cadre, that …
View article: NIMG-42. RECURRENT TUMOR AND TREATMENT-INDUCED EFFECTS HAVE DIFFERENT MR SIGNATURES IN CONTRAST ENHANCING AND NON-ENHANCING LESIONS OF HIGH-GRADE GLIOMAS
NIMG-42. RECURRENT TUMOR AND TREATMENT-INDUCED EFFECTS HAVE DIFFERENT MR SIGNATURES IN CONTRAST ENHANCING AND NON-ENHANCING LESIONS OF HIGH-GRADE GLIOMAS Open
INTRODUCTION It is estimated that 25 to 35% of patients experience treatment-induced effects that can mimic recurrent high-grade gliomas. This diagnostic challenge is complicated by the coexistence of treatment-related changes and recurren…
View article: Tumor cell phenotype and heterogeneity differences in IDH1 mutant vs wild-type gliomas
Tumor cell phenotype and heterogeneity differences in IDH1 mutant vs wild-type gliomas Open
Glioma is recognized to be a highly heterogeneous CNS malignancy, whose diverse cellular composition and cellular interactions have not been well characterized. To gain new clinical- and biological-insights into the genetically-bifurcated …
View article: Methodological consensus on clinical proton MRS of the brain: Review and recommendations
Methodological consensus on clinical proton MRS of the brain: Review and recommendations Open
Proton MRS ( 1 H MRS) provides noninvasive, quantitative metabolite profiles of tissue and has been shown to aid the clinical management of several brain diseases. Although most modern clinical MR scanners support MRS capabilities, routine…
View article: An example of medical device-based projection of clinical trial enrollment: Use of electrocardiographic data to identify candidates for a trial in acute coronary syndromes
An example of medical device-based projection of clinical trial enrollment: Use of electrocardiographic data to identify candidates for a trial in acute coronary syndromes Open
Background: To identify potential participants for clinical trials, electronic health records (EHRs) are searched at potential sites. As an alternative, we investigated using medical devices used for real-time diagnostic decisions for tria…
View article: ATIM-22. PROGNOSTIC VALUE OF PTEN LOSS IN NEWLY DIAGNOSED GBM PATIENTS TREATED WITH AUTOLOGOUS HEAT SHOCK PROTEIN VACCINE
ATIM-22. PROGNOSTIC VALUE OF PTEN LOSS IN NEWLY DIAGNOSED GBM PATIENTS TREATED WITH AUTOLOGOUS HEAT SHOCK PROTEIN VACCINE Open
INTRODUCTION: The safety and efficacy of a heat shock protein peptide complex- 96 vaccine (HSPPC-96, Prophage) has been previously studied in phase II single-arm trials for the treatment of newly diagnosed and recurrent glioblastoma (GBM).…
View article: NIMG-11. DIFFERENTIATING TREATMENT-INDUCED EFFECTS FROM TRUE RECURRENT HIGH GRADE GLIOMA USING MULTIPARAMETRIC MRI TECHNIQUES
NIMG-11. DIFFERENTIATING TREATMENT-INDUCED EFFECTS FROM TRUE RECURRENT HIGH GRADE GLIOMA USING MULTIPARAMETRIC MRI TECHNIQUES Open
Recurrent high grade gliomas (rHGG) are difficult to diagnose accurately as they are often confounded with treatment-induced effects (TxE) because on conventional T1w and T2w anatomical MR imaging these two phenomena appear identical. This…
View article: NIMG-08. REPRODUCIBILITY OF HYPERPOLARIZED C-13 METABOLIC IMAGING IN PATIENTS WITH GLIOMA
NIMG-08. REPRODUCIBILITY OF HYPERPOLARIZED C-13 METABOLIC IMAGING IN PATIENTS WITH GLIOMA Open
As a non-invasive method for probing in vivo metabolism, hyperpolarized carbon-13 metabolic imaging may enhance the diagnostic assessment of response-to-treatment in patients with glioma. Having demonstrated the feasibility of applying thi…
View article: COMP-05. EVALUATION OF A DEEP LEARNING ARCHITECTURE FOR MRI PREDICTION OF IDH, 1p19q AND TERT IN GLIOMA PATIENTS
COMP-05. EVALUATION OF A DEEP LEARNING ARCHITECTURE FOR MRI PREDICTION OF IDH, 1p19q AND TERT IN GLIOMA PATIENTS Open
Recent studies have highlighted the importance of using molecular biomarkers (IDH, 1p19q, TERT) to group gliomas that have similar clinical behavior, response to therapy, and outcome. An emerging hypothesis is that glioma specific genetic …
View article: NIMG-24. DIFFUSION MRI PRECURSORS TO PROGRESSION IN GRADE II AND III GLIOMA
NIMG-24. DIFFUSION MRI PRECURSORS TO PROGRESSION IN GRADE II AND III GLIOMA Open
The goal of this project is to identify serial advanced imaging markers that can reveal tumor progression in grade II and III gliomas prior to the to the onset of new contrast enhancement or the expansion of FLAIR abnormality. Nineteen low…