Sarah Alexander
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View article: The Emotion and Symptom‐Focused Engagement (EASE) Psychotherapeutic Intervention for Parents of Children With Acute Leukemia: A Feasibility Trial
The Emotion and Symptom‐Focused Engagement (EASE) Psychotherapeutic Intervention for Parents of Children With Acute Leukemia: A Feasibility Trial Open
Background Parents of children newly diagnosed with acute leukemia (AL) experience significant traumatic stress that adversely affects their well‐being, caregiving capacity, and family functioning. However, rigorous evidence of the feasibi…
View article: A testing time for gradient strips: an evaluation of ETEST for the antimicrobial susceptibility testing of Neisseria gonorrhoeae
A testing time for gradient strips: an evaluation of ETEST for the antimicrobial susceptibility testing of Neisseria gonorrhoeae Open
Introduction. Antimicrobial susceptibility testing (AST) of Neisseria gonorrhoeae isolates is recommended in the UK to ensure antimicrobial stewardship and detection of multi-drug and extensively resistant cases. In diagnostic and referenc…
View article: The impact of oncotype DX testing on adjuvant chemotherapy decision making in breast cancer with micrometastasis to the sentinel lymph node
The impact of oncotype DX testing on adjuvant chemotherapy decision making in breast cancer with micrometastasis to the sentinel lymph node Open
Introduction Oncotype-DX testing has reduced adjuvant chemotherapy use in breast cancer but there is limited evidence on patients with sentinel lymph node micrometastasis (SLNmi). This study aimed to evaluate the real-world use of Oncotype…
View article: Characterizing Difficulty and Life Disruption During B‐Acute Lymphoblastic Leukemia Therapy From the Perspective of Parents: A Survey Study
Characterizing Difficulty and Life Disruption During B‐Acute Lymphoblastic Leukemia Therapy From the Perspective of Parents: A Survey Study Open
Purpose Children with B‐acute lymphoblastic leukemia (B‐ALL) treated in resource‐intensive settings have a high likelihood of cure, but therapy is long, burdensome, and associated with substantial toxicities. Understanding parents’ percept…
View article: Reducing General Anesthesia for Lumbar Punctures in Pediatric Patients With Leukemia and Lymphoma, a Quality Improvement Project
Reducing General Anesthesia for Lumbar Punctures in Pediatric Patients With Leukemia and Lymphoma, a Quality Improvement Project Open
Purpose Curative therapy for most children with leukemia and lymphoma includes multiple lumbar punctures (LPs) for the administration of intrathecal chemotherapy, commonly facilitated with deep sedation or general anesthesia (GA). There is…
View article: “After a long day of play, I get tired and forget to unfurl my bednet”: a qualitative study exploring factors affecting insecticide-treated bednet use among school-aged children in eastern
“After a long day of play, I get tired and forget to unfurl my bednet”: a qualitative study exploring factors affecting insecticide-treated bednet use among school-aged children in eastern Open
BACKGROUND Despite widespread access to long-lasting insecticidal nets, infection with malaria parasites remains prevalent among African school-aged children. Though this group contributes significantly to malaria transmission, few studies…
View article: Baseline Characteristics of Parents Enrolled in Children's Oncology Group Study ACCL20N1CD: Financial Toxicity During Treatment for Pediatric Acute Lymphoblastic Leukemia in the United States
Baseline Characteristics of Parents Enrolled in Children's Oncology Group Study ACCL20N1CD: Financial Toxicity During Treatment for Pediatric Acute Lymphoblastic Leukemia in the United States Open
Background Costs to parents and associated financial distress may contribute to observed health disparities in pediatric oncology. We describe financial distress in a cohort of parents with children newly diagnosed with acute lymphoblastic…
View article: Attitudes Toward COVID‐19 Vaccination Among Pediatric Acute Lymphoblastic Leukemia Patients and Their Caregivers
Attitudes Toward COVID‐19 Vaccination Among Pediatric Acute Lymphoblastic Leukemia Patients and Their Caregivers Open
The COVID‐19 vaccine is indicated for children with acute lymphoblastic leukemia (ALL), yet patients and caregivers may have unique questions and concerns about vaccination. We surveyed children with ALL or their caregivers ( N = 44) to un…
View article: Current Treatment Strategies and Supportive Care Practices in the Care of Children and Adolescents With Mature B‐Cell Non‐Hodgkin Lymphoma: A Survey of Children's Oncology Group Institutions
Current Treatment Strategies and Supportive Care Practices in the Care of Children and Adolescents With Mature B‐Cell Non‐Hodgkin Lymphoma: A Survey of Children's Oncology Group Institutions Open
Treatment strategies of mature B‐cell non‐Hodgkin lymphoma (B‐NHL) have been investigated in cooperative group settings to balance toxicity and cure. A survey of institutions participating in the Children's Oncology Group (COG) was complet…
View article: Prevention and Management of Infectious Complications in Pediatric Patients With Cancer: A Survey Assessment of Current Practices Across Children's Oncology Group Institutions
Prevention and Management of Infectious Complications in Pediatric Patients With Cancer: A Survey Assessment of Current Practices Across Children's Oncology Group Institutions Open
Introduction While clinical practice guidelines (CPGs) for pediatric oncology infection prophylaxis and management exist, few data describe actual management occurring at pediatric oncology centers. Methods An electronic survey querying in…
View article: Blinatumomab in Standard-Risk B-Cell Acute Lymphoblastic Leukemia in Children
Blinatumomab in Standard-Risk B-Cell Acute Lymphoblastic Leukemia in Children Open
Adding blinatumomab to combination chemotherapy in patients with newly diagnosed childhood standard-risk B-cell ALL of average or higher risk of relapse significantly improved disease-free survival. (Funded by the National Institutes of He…
View article: Ceftriaxone-resistant <i>Neisseria gonorrhoeae</i> detected in England, 2015–24: an observational analysis
Ceftriaxone-resistant <i>Neisseria gonorrhoeae</i> detected in England, 2015–24: an observational analysis Open
Objectives Since June 2022, there has been a rise in the number of ceftriaxone-resistant Neisseria gonorrhoeae cases detected in England (n = 15), of which a third were XDR. We describe the demographic and clinical details of the recent ca…
View article: Ceftriaxone-resistant<i>Neisseria gonorrhoeae</i>detected in England, 2015 to 2024; an observational study
Ceftriaxone-resistant<i>Neisseria gonorrhoeae</i>detected in England, 2015 to 2024; an observational study Open
Background Since June 2022, there has been a rise in the number of ceftriaxone resistant Neisseria gonorrhoeae cases detected in England (n = 15), of which one third were extensively-drug resistant (XDR). We describe the demographic and cl…
View article: Editorial: Non-cellular immunotherapies in pediatric malignancies
Editorial: Non-cellular immunotherapies in pediatric malignancies Open
Citation: Alexander S, Harker-Murray P and Hayashi RJ (2024) Editorial: Non-cellular immunotherapies in pediatric malignancies. Front. Immunol. 15:1379278. doi: 10.3389/fimmu.2024.1379278
View article: A Potential Paradigm for the Robust and Systematic Prioritisation of Assets in Academic-Led, Multi-Industry Collaborative Trials in Rare Populations (Glo-BNHL)
A Potential Paradigm for the Robust and Systematic Prioritisation of Assets in Academic-Led, Multi-Industry Collaborative Trials in Rare Populations (Glo-BNHL) Open
Overview Given the rarity of children and adolescents with relapsed and refractory (r/r) B-cell Non-Hodgkin Lymphoma (B-NHL) and the large number of potential agents in development for adult mature B-cell malignancies, there is urgent need…
View article: Children's Oncology Group's 2023 blueprint for research: Non‐Hodgkin lymphoma
Children's Oncology Group's 2023 blueprint for research: Non‐Hodgkin lymphoma Open
Pediatric non‐Hodgkin lymphoma (NHL) includes over 30 histologies (many with subtypes), with approximately 800 cases per year in the United States. Improvements in survival in NHL over the past 5 decades align with the overall success of t…
View article: “It Just Made Me Feel Better": Qualitative Examination of the Implementation of a Novel Virtual Psychosocial Support Program for Adolescents with Cancer
“It Just Made Me Feel Better": Qualitative Examination of the Implementation of a Novel Virtual Psychosocial Support Program for Adolescents with Cancer Open
Purpose Adolescents with cancer routinely report feelings of isolation and exclusion, including from medical decision-making. To address this problem and support adolescents, we designed and implemented the novel, virtual, weekly Teens4Tee…
View article: SARS‐CoV‐2 infections in patients enrolled on the Children's Oncology Group standard‐risk B‐cell acute lymphoblastic leukemia trial, AALL1731
SARS‐CoV‐2 infections in patients enrolled on the Children's Oncology Group standard‐risk B‐cell acute lymphoblastic leukemia trial, AALL1731 Open
Hematologic malignancy is a risk factor for severe coronavirus disease 2019 (COVID‐19) in adults; however, data specific to children with leukemia are limited. High‐quality infectious adverse event data from the ongoing Children's Oncology…
View article: “IT JUST MADE ME FEEL BETTER”: QUALITATIVE EXAMINATION OF THE IMPLEMENTATION OF A NOVEL VIRTUAL PSYCHOSOCIAL SUPPORT PROGRAM FOR ADOLESCENTS WITH CANCER
“IT JUST MADE ME FEEL BETTER”: QUALITATIVE EXAMINATION OF THE IMPLEMENTATION OF A NOVEL VIRTUAL PSYCHOSOCIAL SUPPORT PROGRAM FOR ADOLESCENTS WITH CANCER Open
Background: Adolescents with cancer routinely report feelings of isolation and exclusion, including from medical decision-making. To address this problem and support adolescents, we designed and implemented into clinical practice the novel…
View article: Guideline for the Management of Fever and Neutropenia in Pediatric Patients With Cancer and Hematopoietic Cell Transplantation Recipients: 2023 Update
Guideline for the Management of Fever and Neutropenia in Pediatric Patients With Cancer and Hematopoietic Cell Transplantation Recipients: 2023 Update Open
PURPOSE To update a clinical practice guideline (CPG) for the empiric management of fever and neutropenia (FN) in pediatric patients with cancer and hematopoietic cell transplantation recipients. METHODS The International Pediatric Fever a…
View article: Crizotinib in Combination With Chemotherapy for Pediatric Patients With ALK+ Anaplastic Large-Cell Lymphoma: The Results of Children's Oncology Group Trial ANHL12P1
Crizotinib in Combination With Chemotherapy for Pediatric Patients With ALK+ Anaplastic Large-Cell Lymphoma: The Results of Children's Oncology Group Trial ANHL12P1 Open
PURPOSE Arm crizotinib (CZ) of the Children's Oncology Group trial ANHL12P1 (ClinicalTrials.gov identifier: NCT01979536 ) examined the efficacy and toxicity of adding CZ to standard chemotherapy for children with newly diagnosed, nonlocali…
View article: Traumatic stress symptoms in family caregivers of patients with acute leukaemia: protocol for a multisite mixed methods, longitudinal, observational study
Traumatic stress symptoms in family caregivers of patients with acute leukaemia: protocol for a multisite mixed methods, longitudinal, observational study Open
Introduction The diagnosis, progression or recurrence of cancer is often highly traumatic for family caregivers (FCs), but systematic assessments of distress and approaches for its prevention and treatment are lacking. Acute leukaemia (AL)…
View article: Prospective Evaluation of the Fungitell® (1→3) <scp>Beta‐D‐Glucan</scp> Assay as a Diagnostic Tool for Invasive Fungal Disease in Pediatric Allogeneic Hematopoietic Cell Transplantation: A Report from the Children's Oncology Group
Prospective Evaluation of the Fungitell® (1→3) <span>Beta‐D‐Glucan</span> Assay as a Diagnostic Tool for Invasive Fungal Disease in Pediatric Allogeneic Hematopoietic Cell Transplantation: A Report from the Children's Oncology Group Open
Background Invasive fungal disease (IFD) is a major source of morbidity and mortality for hematopoietic cell transplant (HCT) recipients. Non‐invasive biomarkers, such as the beta‐D‐glucan assay, may improve the diagnosis of IFD. The objec…
View article: Inclusion of a core patient-reported outcomes battery in adolescent and young adult cancer clinical trials
Inclusion of a core patient-reported outcomes battery in adolescent and young adult cancer clinical trials Open
Disparities in care, treatment-related toxicity and health-related quality of life (HRQoL) for adolescents and young adults (AYAs, aged 15-39 years) with cancer are under-addressed partly because of limited collection of patient-reported o…
View article: Answers to common questions about COVID‐19 vaccines in children with cancer
Answers to common questions about COVID‐19 vaccines in children with cancer Open
Background The SARS‐CoV‐2 outbreak in 2020 evolved into a global pandemic, and COVID‐19 vaccines became rapidly available, including for pediatric patients. However, questions emerged that challenged vaccine acceptance and use. We aimed to…
View article: Issue Information
Issue Information Open
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View article: Improving infectious adverse event reporting for children and adolescents enrolled in clinical trials for acute lymphoblastic leukemia: A report from the Children's Oncology Group
Improving infectious adverse event reporting for children and adolescents enrolled in clinical trials for acute lymphoblastic leukemia: A report from the Children's Oncology Group Open
Infections cause substantial morbidity for children with acute lymphoblastic leukemia (ALL). Therefore, accurate characterization of infectious adverse events (AEs) reported on clinical trials is imperative to defining, comparing, and mana…
View article: Should Victorian Studies Be Posthuman? A Panel Discussion
Should Victorian Studies Be Posthuman? A Panel Discussion Open
What might posthumanist approaches to the study of literature and culture offer Victorian studies? Sarah Alexander, Miranda Butler, Bruce Clarke, Tamara Ketabgian, Amy Wong, and Dongshin Yi offer insights drawn from a range of methodologie…