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View article: Motivational Interviewing: Addressing Interest Among Health Professions Students
Motivational Interviewing: Addressing Interest Among Health Professions Students Open
Background and Objectives: Motivational interviewing (MI) is a patient-centered approach to behavior change counseling that is used among health professionals across multiple disciplines. However, MI training has yet to be broadly offered …
View article: Regional Elective Day Procedure Centre Pilot- the solution to waiting lists and trainee deficit in the reshaping of services following COVID-19?
Regional Elective Day Procedure Centre Pilot- the solution to waiting lists and trainee deficit in the reshaping of services following COVID-19? Open
Inter-trust day surgery at a dedicated green site could successfully contribute to resuming and reforming surgical services, addressing the impact on mounting waiting lists with positive patient impact as well as providing an excellent tra…
View article: A qualitative evaluation of a multi-modal cancer prehabilitation programme for colorectal, head and neck and lung cancers patients
A qualitative evaluation of a multi-modal cancer prehabilitation programme for colorectal, head and neck and lung cancers patients Open
Background Growing evidence indicates patients’ survivorship outcomes can be enhanced through active engagement in a multi-modal cancer prehabilitation programme (MCPP), although this intervention is not uniformly embedded as a standard of…
View article: Supplementary Figure 1 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 1 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplementary Figure S1. Experimental design and quality control analysis for Methyl-Seq data. (A) FVB mice were bred to become pregnant (parous, P) and underwent a complete pregnancy (Pr), lactation (L), and Involution (I). Animals were t…
View article: Supplementary Figure 4 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 4 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Figure S4. Full representation of CpG methylation analysis in the confirmation of Methyl-Seq DNA methylation by bisulfite sequencing. (A) The percent methylation for each CpG site after bisulfite sequencing on mammary gland ge…
View article: Supplementary Figure 2 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 2 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Figure S2. All samples from both time points were used in a hierarchal clustering analysis. 10 samples at the early time point and 11 samples at the late time point were included.(E=early, L=late, P=parous, NP=nulliparous)
View article: Supplementary Figure 3 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 3 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Figure S3. Mapping efficiency was above 50 for all samples in both time points. One sample was an outlier in the early time point (P12) and one at the late time point (NP4) and were removed from further analysis. Both Pearson …
View article: Supplementary Figure Legends from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure Legends from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
All Supplementary Figure legends are included in this document.
View article: Data from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Data from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
The most effective natural prevention against breast cancer is an early first full-term pregnancy. Understanding how the protective effect is elicited will inform the development of new prevention strategies. To better understand the role …
View article: Supplementary Figure 9 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 9 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Fig S9. Differentially methylated regions of IGF pathway genes align with histone methylation sites. The UCSC Genome Browser was used to align the Irs1, Igf1, and Igfbp4 with other epigenetic modifications. The red bars indica…
View article: Supplementary Table 1 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Table 1 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Primers used for quantitative PCR and bisulfite sequencing.
View article: Supplementary Figure 8 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 8 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Fig S8. Hypermethylation of the Igf1r aligns with sites of histone methylation. (A) The UCSC Genome Browser was used to align the Igf1r with other epigenetic modifications. The red bar indicates the region of differential DNA …
View article: Supplementary Figure 5 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 5 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Fig S5. Imprinted genes display approximately 50% DNA methylation. Gene regions known to be imprinted were chosen to confirm the validity of the Methyl-Seq assay. For each gene a β value was calculated for each window. The fre…
View article: Supplementary Figure 9 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 9 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Fig S9. Differentially methylated regions of IGF pathway genes align with histone methylation sites. The UCSC Genome Browser was used to align the Irs1, Igf1, and Igfbp4 with other epigenetic modifications. The red bars indica…
View article: Supplementary Figure 5 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 5 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Fig S5. Imprinted genes display approximately 50% DNA methylation. Gene regions known to be imprinted were chosen to confirm the validity of the Methyl-Seq assay. For each gene a β value was calculated for each window. The fre…
View article: Supplementary Figure 1 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 1 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplementary Figure S1. Experimental design and quality control analysis for Methyl-Seq data. (A) FVB mice were bred to become pregnant (parous, P) and underwent a complete pregnancy (Pr), lactation (L), and Involution (I). Animals were t…
View article: Supplementary Figure 3 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 3 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Figure S3. Mapping efficiency was above 50 for all samples in both time points. One sample was an outlier in the early time point (P12) and one at the late time point (NP4) and were removed from further analysis. Both Pearson …
View article: Supplementary Figure Legends from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure Legends from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
All Supplementary Figure legends are included in this document.
View article: Data from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Data from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
The most effective natural prevention against breast cancer is an early first full-term pregnancy. Understanding how the protective effect is elicited will inform the development of new prevention strategies. To better understand the role …
View article: Supplementary Data 1 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Data 1 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Data 1. This spreadsheet contains the results of the differential methylation analysis, the meta-analysis and the pathway analysis. In the meta-analysis sheets, the first 3 columns represent the chromosomal locations, followed…
View article: Supplementary Figure 7 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 7 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Fig S7. Igf1r is central to a top signaling network in Ingenuity pathway analysis. Ingenuity pathway analysis (IPA) identified this signaling network to be significantly altered by DNA methylation. The hyper and hypomethylated…
View article: Supplementary Figure 6 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 6 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Figure S6. Supervised hierarchical clustering and cell type content analysis. (A) Heatmaps displaying supervised hierarchical clustering of hypermethylated and hypomethylated windows including dendrograms (Red=Methylated, Gree…
View article: Supplementary Figure 6 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 6 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Figure S6. Supervised hierarchical clustering and cell type content analysis. (A) Heatmaps displaying supervised hierarchical clustering of hypermethylated and hypomethylated windows including dendrograms (Red=Methylated, Gree…
View article: Supplementary Figure 2 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 2 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Figure S2. All samples from both time points were used in a hierarchal clustering analysis. 10 samples at the early time point and 11 samples at the late time point were included.(E=early, L=late, P=parous, NP=nulliparous)
View article: Supplementary Data 1 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Data 1 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Data 1. This spreadsheet contains the results of the differential methylation analysis, the meta-analysis and the pathway analysis. In the meta-analysis sheets, the first 3 columns represent the chromosomal locations, followed…
View article: Supplementary Figure 4 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 4 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Figure S4. Full representation of CpG methylation analysis in the confirmation of Methyl-Seq DNA methylation by bisulfite sequencing. (A) The percent methylation for each CpG site after bisulfite sequencing on mammary gland ge…
View article: Supplementary Figure 8 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 8 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Fig S8. Hypermethylation of the Igf1r aligns with sites of histone methylation. (A) The UCSC Genome Browser was used to align the Igf1r with other epigenetic modifications. The red bar indicates the region of differential DNA …
View article: Supplementary Figure 7 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Figure 7 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Supplemental Fig S7. Igf1r is central to a top signaling network in Ingenuity pathway analysis. Ingenuity pathway analysis (IPA) identified this signaling network to be significantly altered by DNA methylation. The hyper and hypomethylated…
View article: Supplementary Table 1 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition
Supplementary Table 1 from Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of <i>Igf1r</i> That Persists Long after Parturition Open
Primers used for quantitative PCR and bisulfite sequencing.
View article: A qualitative evaluation of a multi-modal cancer prehabilitation programme for colorectal, head and neck and lung cancers patients
A qualitative evaluation of a multi-modal cancer prehabilitation programme for colorectal, head and neck and lung cancers patients Open
Background Growing evidence indicates patients’ survivorship outcomes can be enhanced through active engagement in a multi-modal cancer prehabilitation programme (MCPP), although this intervention is not uniformly embedded as a standard of…