Sarah Snoeck
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View article: Unique transcriptional profiles of adult human immature neurons in healthy aging, Alzheimer’s disease, and cognitive resilience
Unique transcriptional profiles of adult human immature neurons in healthy aging, Alzheimer’s disease, and cognitive resilience Open
The existence and functional significance of immature neurons in the adult human brain, particularly in the context of neurodegenerative disorders, remain controversial. While rodent studies have highlighted active roles for adult-born imm…
View article: NACC2, a molecular effector of miR-132 regulation at the interface between adult neurogenesis and Alzheimer’s disease
NACC2, a molecular effector of miR-132 regulation at the interface between adult neurogenesis and Alzheimer’s disease Open
The generation of new neurons at the hippocampal neurogenic niche, known as adult hippocampal neurogenesis (AHN), and its impairment, have been implicated in Alzheimer's disease (AD). MicroRNA-132 (miR-132), the most consistently downregul…
View article: Cellular and molecular mapping of human adult hippocampal neurogenesis in Alzheimer’s disease
Cellular and molecular mapping of human adult hippocampal neurogenesis in Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is a progressive, irreversible disorder accounting for 50‐70% of all dementia cases. Given the current lack of disease‐modifying therapies, systematic profiling of the cell type‐ and cell state‐specific …
View article: Synergetic microRNA delivery for therapeutic targeting in Alzheimer’s disease
Synergetic microRNA delivery for therapeutic targeting in Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is a complex multigenic disorder primarily defined by the presence of β‐amyloid‐containing plaques and Tau‐containing neurofibrillary tangles. To date, there is no available treatment and the failure of …
View article: Systematic assessment of microRNA‐132 therapeutic targeting in Alzheimer’s disease using iPSC‐derived neurons and microglia
Systematic assessment of microRNA‐132 therapeutic targeting in Alzheimer’s disease using iPSC‐derived neurons and microglia Open
Background Mapping the mechanistic heterogeneity and multifactorial nature of Alzheimer’s Disease (AD) is a key challenge for therapeutic development and the main reason why network biology and multi‐modal therapies begin to attract attent…
View article: Systematic assessment of microRNA‐132 therapeutic targeting in Alzheimer’s disease
Systematic assessment of microRNA‐132 therapeutic targeting in Alzheimer’s disease Open
Background Mapping the mechanistic heterogeneity and multifactorial nature of AD is a key challenge for therapeutic development and the main reason why network biology and multi‐modal therapies begin to attract attention also in AD researc…
View article: microRNA-132 regulates gene expression programs involved in microglial homeostasis
microRNA-132 regulates gene expression programs involved in microglial homeostasis Open
microRNA-132 (miR-132), a known neuronal regulator, is one of the most robustly downregulated microRNAs (miRNAs) in the brain of Alzheimer's disease (AD) patients. Increasing miR-132 in AD mouse brain ameliorates amyloid and Tau pathologie…
View article: Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer’s disease
Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer’s disease Open
View article: Impaired adult hippocampal neurogenesis in Alzheimer’s disease is mediated by microRNA-132 deficiency and can be restored by microRNA-132 replacement
Impaired adult hippocampal neurogenesis in Alzheimer’s disease is mediated by microRNA-132 deficiency and can be restored by microRNA-132 replacement Open
Summary Adult hippocampal neurogenesis (AHN) plays a crucial role in memory processes and is impeded in the brains of Alzheimer’s disease (AD) patients. However, the molecular mechanisms impacting AHN in AD brain are unknown. Here we ident…