Explanipedia

Association of genetically-predicted placental gene expression with adult blood pressure traits Open

Jacklyn N. Hellwege, Sarah Stallings, Jacqueline A. Piekos, Elizabeth A. Jasper, David M. Aronoff , et al. · 2023

Objective: Blood pressure is a complex, polygenic trait, and the need to identify prehypertensive risks and new gene targets for blood pressure control therapies or prevention continues. We hypothesize a developmental origins model of bloo…

Assessing patient-level knowledge of precision medicine in a community health center setting Open

Sarah Stallings, Jennifer Richmond, Juan Canedo, Katina Beard, Kemberlee Bonnet , et al. · 2023

Development and Validation of the Perceptions of Research Trustworthiness Scale to Measure Trust Among Minoritized Racial and Ethnic Groups in Biomedical Research in the US Open

Sarah Stallings, Jennifer Cunningham‐Erves, Carleigh Frazier, Jabari Ichimura, Thelma C. Hurd , et al. · 2022

Importance Historically, trust in biomedical research has been lower among minoritized racial and ethnic groups who are underrepresented in and excluded from research, with the same groups experiencing worse health outcomes. Unfortunately,…

Development and pilot implementation of guidelines for culturally tailored research recruitment materials for African Americans and Latinos Open

Jennifer Cunningham‐Erves, Sheila V. Kusnoor, Victoria Villalta‐Gil, Sarah Stallings, Jabari Ichimura , et al. · 2022

Design and implementation of a massive open online course on enhancing the recruitment of minorities in clinical trials – Faster Together Open

Sheila V. Kusnoor, Victoria Villalta‐Gil, Margo Michaels, Yvonne Joosten, Tiffany Israel , et al. · 2021

Background Racial and ethnic minorities are often underrepresented in clinical trials, threatening the generalizability of trial results. Several factors may contribute to underrepresentation of minorities in clinical trials, including lac…

Determinants of stage at diagnosis of HPV-related cancer including area deprivation and clinical factors Open

Rohini Chakravarthy, Sarah Stallings, Digna R. Velez Edwards, Sifang Kathy Zhao, Douglas Conway , et al. · 2020

Background Collecting social determinants of health in electronic health records is time-consuming. Meanwhile, an Area Deprivation Index (ADI) aggregates sociodemographic information from census data. The objective of this study was to asc…

Factors influencing precision medicine knowledge and attitudes Open

Rohini Chakravarthy, Sarah Stallings, Michael Williams, Megan Hollister, Mario Davidson , et al. · 2020

Precision medicine holds great promise for improving health and reducing health disparities that can be most fully realized by advancing diversity and inclusion in research participants. Without engaging underrepresented groups, precision …

Patient Stories Can Make a Difference in Patient-Centered Research Design Open

Laurie L. Novak, Sheba George, Kenneth A. Wallston, Yvonne Joosten, Tiffany Israel , et al. · 2020

Amid increasing interest in improving the patient-centeredness of research, new forms of engagement are emerging that enable researchers to get input from community members on research goals, methods, and implementation. This input often i…

Factors Influencing Precision Medicine Knowledge and Attitudes Open

Rohini Chakravarthy, Sarah Stallings, Michael Williams, Megan Hollister, Mario Davidson , et al. · 2020

Precision medicine holds great promise for improving health and reducing health disparities that can be most fully realized by advancing diversity and inclusion in research participants. Without engaging underrepresented groups, precision …

Determinants of Trustworthiness to Conduct Medical Research: Findings from Focus Groups Conducted with Racially and Ethnically Diverse Adults Open

Derek M. Griffith, Emily C. Jaeger, Erin M. Bergner, Sarah Stallings, Consuelo H. Wilkins · 2020

Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin Open

Yongmei Liu, Sridharan Raghavan, Nisa M. Maruthur, Edmond K. Kabagambe, Jae‐Young Hong , et al. · 2020

Knowledge of the genetic basis of the type 2 diabetes (T2D)-related quantitative traits fasting glucose (FG) and insulin (FI) in African ancestry (AA) individuals has been limited. In non-diabetic subjects of AA (n = 20,209) and European a…

Comparing Methods to Make Research More Patient Centered Open

Consuelo H. Wilkins, Sarah Stallings, Sarah Stallings, Victoria Villalta‐Gil, Mckenzie Houston , et al. · 2019

What was the research about?Currently many researchers get input on their research projects from other researchers.But researchers want their work to be more patient centered, or relevant to patients' preferences, needs, and values.To do t…

A taxonomy of impacts on clinical and translational research from community stakeholder engagement Open

Sarah Stallings, Alaina Boyer, Yvonne Joosten, Laurie L. Novak, Al Richmond , et al. · 2019

Background Community engagement is increasingly recognized as a valuable tool in clinical and translational research; however, the impact of engagement is not fully understood. No standard nomenclature yet exists to clearly define how rese…

Heritability and genome-wide association study of benign prostatic hyperplasia (BPH) in the eMERGE network Open

Jacklyn N. Hellwege, Sarah Stallings, Eric S. Torstenson, Robert J. Carroll, Kenneth M. Borthwick , et al. · 2019

Benign prostatic hyperplasia (BPH) results in a significant public health burden due to the morbidity caused by the disease and many of the available remedies. As much as 70% of men over 70 will develop BPH. Few studies have been conducted…

Enrichment sampling for a multi-site patient survey using electronic health records and census data Open

Nathaniel D. Mercaldo, Kyle B. Brothers, David Carrell, Ellen Wright Clayton, John J. Connolly , et al. · 2018

Objective We describe a stratified sampling design that combines electronic health records (EHRs) and United States Census (USC) data to construct the sampling frame and an algorithm to enrich the sample with individuals belonging to rarer…

Development and validation of the Person-Centeredness of Research Scale Open

Consuelo H. Wilkins, Victoria Villalta‐Gil, Mckenzie M Houston, Yvonne Joosten, Alan Richmond , et al. · 2018

Aim: Person-centeredness shifts the focus of healthcare and research to the needs and priorities of patients and communities, and may improve health outcomes. There are no instruments available, however, with which we can assess the degree…

A Multilevel Approach to Stakeholder Engagement in the Formulation of a Clinical Data Research Network Open

Alaina Boyer, Alecia M. Fair, Yvonne Joosten, Rowena J Dolor, Neely Williams , et al. · 2018

Objectives: To ensure meaningful engagement of stakeholders (patients, clinicians, and communities) in developing the Mid-South Clinical Data Research Network (MS-CDRN), we implemented a comprehensive, multilevel approach: (1) identify bar…

A case study evaluating the portability of an executable computable phenotype algorithm across multiple institutions and electronic health record environments Open

Jennifer A. Pacheco, Luke V. Rasmussen, Richard C. Kiefer, Thomas R. Campion, Peter Speltz , et al. · 2018

Electronic health record (EHR) algorithms for defining patient cohorts are commonly shared as free-text descriptions that require human intervention both to interpret and implement. We developed the Phenotype Execution and Modeling Archite…

Amphibians and Reptiles of United States Department of Defense Installations Open

Christopher E. Petersen, Robert E. Lovich, Sarah Stallings · 2018

The U.S. Department of Defense (DoD) occupies approximately 10.1 million ha of land within the U.S. spanning most ecosystems contained therein. To date, no comprehensive agency-wide inventory of amphibian and reptile species has been compi…

P4472Targeted sequencing of 80 pharmacogenes reveals evidence for pleiotropic effects on serum LDL cholesterol levels Open

Nikta Dadkhah Nikroo, Maya Safarova, Erin Austin, Mariza de Andrade, R. Li , et al. · 2017

Healthcare Provider Education to Support Integration of Pharmacogenomics in Practice: The Emerge Network Experience Open

Carolyn R. Rohrer Vitek, Noura S. Abul‐Husn, John J. Connolly, Andrea L. Hartzler, Terrie Kitchner , et al. · 2017

Ten organizations within the Electronic Medical Records and Genomics Network developed programs to implement pharmacogenomic sequencing and clinical decision support into clinical settings. Recognizing the importance of informed prescriber…

Concordance between Research Sequencing and Clinical Pharmacogenetic Genotyping in the eMERGE-PGx Study Open

Laura J. Rasmussen‐Torvik, Berta Almoguera, Kimberly F. Doheny, Robert R. Freimuth, Allan Gordon , et al. · 2017

Conducting a large, multi-site survey about patients’ views on broad consent: challenges and solutions Open

Maureen E. Smith, Saskia C. Sanderson, Kyle B. Brothers, Melanie F. Myers, Jennifer B. McCormick , et al. · 2016

Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin Open

Yongmei Liu, Sridharan Raghavan, Nisa M. Maruthur, Edmond K. Kabagambe, Jaeyoung Hong , et al. · 2016

Association of Arrhythmia-Related Genetic Variants With Phenotypes Documented in Electronic Medical Records Open

Sara L. Van Driest, Quinn S. Wells, Sarah Stallings, William S. Bush, Allan Gordon , et al. · 2016

Among laboratories experienced in genetic testing for cardiac arrhythmia disorders, there was low concordance in designating SCN5A and KCNH2 variants as pathogenic. In an unselected population, the putatively pathogenic genetic variants we…

When Participants in Genomic Research Grow Up: Contact and Consent at the Age of Majority Open

Kyle B. Brothers, Ingrid A. Holm, Janet E. Childerhose, Armand H. Matheny Antommaria, Barbara A. Bernhardt , et al. · 2015

Penetrance of Hemochromatosis in HFE Genotypes Resulting in p.Cys282Tyr and p.[Cys282Tyr];[His63Asp] in the eMERGE Network Open

Carlos J. Gallego, Amber Burt, Agnes S. Sundaresan, Zi Ye, C. Shaw , et al. · 2015

Hereditary hemochromatosis (HH) is a common autosomal-recessive disorder associated with pathogenic HFE variants, most commonly those resulting in p.Cys282Tyr and p.His63Asp. Recommendations on returning incidental findings of HFE variants…

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