Sarah Staudt
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View article: Dissecting the metabolic signaling pathways by which microbial molecules drive the differentiation of regulatory B cells
Dissecting the metabolic signaling pathways by which microbial molecules drive the differentiation of regulatory B cells Open
The host-microbiome axis has been implicated in promoting anti-inflammatory immune responses. Yet, the underlying molecular mechanisms of commensal-mediated IL-10 production by regulatory B cells (Bregs) are not fully elucidated. Here, we …
View article: Metabolization of microbial postbiotic pentanoate drives anti-cancer CAR T cells
Metabolization of microbial postbiotic pentanoate drives anti-cancer CAR T cells Open
The microbiome is a complex host factor and key determinant of the outcome of antibody-based and cellular immunotherapy. Its postbiotics are a blend of soluble commensal byproducts that are released into the host environment and have been …
View article: Learning from the microbes: exploiting the microbiome to enforce T cell immunotherapy
Learning from the microbes: exploiting the microbiome to enforce T cell immunotherapy Open
The opportunities genetic engineering has created in the field of adoptive cellular therapy for cancer are accelerating the development of novel treatment strategies using chimeric antigen receptor (CAR) and T cell receptor (TCR) T cells. …