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View article: Plasma brain-derived tau: analytical and clinical validation of the first commercial immunoassay
Plasma brain-derived tau: analytical and clinical validation of the first commercial immunoassay Open
Background: Brain-derived tau (BD-tau) is a promising blood-based biomarker for neurodegeneration/brain injury in neurodegenerative and acute neurological disorders. However, widespread use is hampered by lack of commercial assays. Methods…
View article: Pharmacokinetic analysis of morphine-3-glucuronide after acute morphine intravenous bolus administration to rats with traumatic brain injury
Pharmacokinetic analysis of morphine-3-glucuronide after acute morphine intravenous bolus administration to rats with traumatic brain injury Open
View article: Identifying a Biological Signature of Trauma-Related Neurodegeneration Following Repeated Traumatic Brain Injuries Compared with Healthy Controls
Identifying a Biological Signature of Trauma-Related Neurodegeneration Following Repeated Traumatic Brain Injuries Compared with Healthy Controls Open
The objective of this study was to compare participants at-risk for trauma-related neurodegeneration to a healthy control group on outcomes associated with Alzheimer's disease (AD), such as subjective symptoms, neurocognitive performance, …
View article: Detection of Injury Biomarkers in Sweat of Collegiate Athletes Pre- and Post-Football Season: A Pilot Study
Detection of Injury Biomarkers in Sweat of Collegiate Athletes Pre- and Post-Football Season: A Pilot Study Open
The sports medicine community and society at large have recognized traumatic brain injury (TBI) as a major public health concern. It is estimated that more than 150 million youths have played football in the United States. As an alternativ…
View article: Viral-mediated increased hippocampal neurogranin modulate synapses at one month in a rat model of controlled cortical impact
Viral-mediated increased hippocampal neurogranin modulate synapses at one month in a rat model of controlled cortical impact Open
View article: Viral-mediated increased hippocampal neurogranin modulate synapses at one month in a rat model of controlled cortical impact.
Viral-mediated increased hippocampal neurogranin modulate synapses at one month in a rat model of controlled cortical impact. Open
Reductions of neurogranin (Ng), a calcium-sensitive calmodulin-binding protein, result in significant impairment across various hippocampal-dependent learning and memory tasks. Conversely, increasing levels of Ng facilitates synaptic plast…
View article: Experimental traumatic brain injury increases epichaperome formation
Experimental traumatic brain injury increases epichaperome formation Open
View article: Temporal-specific sex and injury-dependent changes on neurogranin-associated synaptic signaling after controlled cortical impact in rats
Temporal-specific sex and injury-dependent changes on neurogranin-associated synaptic signaling after controlled cortical impact in rats Open
Extensive effort has been made to study the role of synaptic deficits in cognitive impairment after traumatic brain injury (TBI). Neurogranin (Ng) is a calcium-sensitive calmodulin (CaM)-binding protein essential for Ca2+/CaM-de…
View article: Repetitive head impacts and chronic traumatic encephalopathy are associated with TDP-43 inclusions and hippocampal sclerosis
Repetitive head impacts and chronic traumatic encephalopathy are associated with TDP-43 inclusions and hippocampal sclerosis Open
View article: Assessment of behavioral, neuroinflammatory, and histological responses in a model of rat repetitive mild fluid percussion injury at 2 weeks post-injury
Assessment of behavioral, neuroinflammatory, and histological responses in a model of rat repetitive mild fluid percussion injury at 2 weeks post-injury Open
Repetitive mild traumatic brain injury (rmTBI) is a prominent public health concern, with linkage to debilitating chronic sequelae. Developing reliable and well-characterized preclinical models of rmTBI is imperative in the investigation o…
View article: All-Trans Retinoic Acid Dose Response to Evaluate Therapeutic Effects on Cognition and Hippocampal Protein Expression after Controlled Cortical Impact
All-Trans Retinoic Acid Dose Response to Evaluate Therapeutic Effects on Cognition and Hippocampal Protein Expression after Controlled Cortical Impact Open
View article: Tau seeding in chronic traumatic encephalopathy parallels disease severity
Tau seeding in chronic traumatic encephalopathy parallels disease severity Open
View article: CCL2 is associated with microglia and macrophage recruitment in chronic traumatic encephalopathy
CCL2 is associated with microglia and macrophage recruitment in chronic traumatic encephalopathy Open
View article: Putative dendritic correlates of chronic traumatic encephalopathy: A preliminary quantitative Golgi exploration
Putative dendritic correlates of chronic traumatic encephalopathy: A preliminary quantitative Golgi exploration Open
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder that is associated with repetitive head impacts. Neuropathologically, it is defined by the presence of perivascular hyperphosphorylated tau aggregates in cortical tissu…
View article: Author response for "Putative dendritic correlates of chronic traumatic encephalopathy: A preliminary quantitative Golgi exploration"
Author response for "Putative dendritic correlates of chronic traumatic encephalopathy: A preliminary quantitative Golgi exploration" Open
View article: Author response for "Putative dendritic correlates of chronic traumatic encephalopathy: A preliminary quantitative Golgi exploration"
Author response for "Putative dendritic correlates of chronic traumatic encephalopathy: A preliminary quantitative Golgi exploration" Open
View article: Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E ε4 genotype
Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E ε4 genotype Open
Alzheimer disease (AD) is a chronic neurodegenerative disease with a multitude of contributing genetic factors, many of which are related to inflammation. The apolipoprotein E (APOE) ε 4 allele is the most common genetic risk factor for AD…
View article: Presenilin 1 increases association with synaptotagmin 1 during normal aging
Presenilin 1 increases association with synaptotagmin 1 during normal aging Open
Presenilin 1 (PS1), the catalytic component of gamma secretase, associates with synaptotagmin 1 (Syt-1). This interaction is decreased in the brains of patients with sporadic Alzheimer's disease. However, it remains unclear how this intera…
View article: Neurogranin Protein Expression Is Reduced after Controlled Cortical Impact in Rats
Neurogranin Protein Expression Is Reduced after Controlled Cortical Impact in Rats Open
Traumatic brain injury (TBI) is known to cause short- and long-term synaptic changes in the brain, possibly underlying downstream cognitive impairments. Neuronal levels of neurogranin, a calcium-sensitive calmodulin-binding protein essenti…
View article: Variation in TMEM106B in chronic traumatic encephalopathy
Variation in TMEM106B in chronic traumatic encephalopathy Open
The genetic basis of chronic traumatic encephalopathy (CTE) is poorly understood. Variation in transmembrane protein 106B (TMEM106B) has been associated with enhanced neuroinflammation during aging and with TDP-43-related neurodegenerative…
View article: Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports
Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports Open
Traumatic brain injury has been associated with increased risk of Parkinson disease and parkinsonism, and parkinsonism and Lewy body disease (LBD) can occur with chronic traumatic encephalopathy (CTE). To test whether contact sports and CT…
View article: Pathogenic PS1 phosphorylation at Ser367
Pathogenic PS1 phosphorylation at Ser367 Open
The high levels of serine (S) and threonine (T) residues within the Presenilin 1 (PS1) N-terminus and in the large hydrophilic loop region suggest that the enzymatic function of PS1/γ-secretase can be modulated by its ‘phosphorylated’ and …
View article: Author response: Pathogenic PS1 phosphorylation at Ser367
Author response: Pathogenic PS1 phosphorylation at Ser367 Open
Full text Figures and data Side by side Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract The high levels of serine (S) an…
View article: Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta
Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta Open
Our findings identify Syt1 as a novel Ca(2+)-sensitive PS1 modulator that could regulate synaptic Aβ, opening avenues for novel and selective synapse targeting therapeutic strategies.
View article: Additional file 7: of Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta
Additional file 7: of Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta Open
Supporting data values. The file presents individual values recorded in the experiments where nâ
View article: Additional file 2: of Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta
Additional file 2: of Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta Open
Proteins identified in mass spectrometry screen of mouse brain lysates for novel PS1 calcium-dependent interactors. Synaptotagmin 1 (Syt1) was detected in high calcium condition (calcium +) when GST-PS1 L6-7 and GST-PS1 NT recombinant pept…
View article: Oxidative stress and lipid peroxidation are upstream of amyloid pathology
Oxidative stress and lipid peroxidation are upstream of amyloid pathology Open