Sarah Tosato
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View article: Digital mental health in Italy: findings from the multicentric DIGIT-PSY study
Digital mental health in Italy: findings from the multicentric DIGIT-PSY study Open
Introduction Despite an increasing interest in upscaling the digitalization process in mental health care services, there is still a gap in a deeper knowledge of the main barriers and facilitators allowing a capillary and consolidated impl…
View article: Interplay Between Childhood Maltreatment, Subclinical Post‐Traumatic Stress Symptoms, and <scp>IQ</scp>: Findings From the <scp>EU</scp>‐<scp>GEI</scp> Multicentre Case–Control Study
Interplay Between Childhood Maltreatment, Subclinical Post‐Traumatic Stress Symptoms, and <span>IQ</span>: Findings From the <span>EU</span>‐<span>GEI</span> Multicentre Case–Control Study Open
Introduction Evidence suggests that childhood maltreatment affects cognitive performance in both patients with psychosis and community controls. However, the interplay between childhood maltreatment, post‐traumatic stress symptoms (PTSS), …
View article: Gender differences in psychological features and determinates of quality of life in axial spondyloarthritis and psoriatic arthritis: a cross-sectional study
Gender differences in psychological features and determinates of quality of life in axial spondyloarthritis and psoriatic arthritis: a cross-sectional study Open
The study indicates that female patients with axial spondyloarthritis and psoriatic arthritis experience worse scores in psychological variables compared to men. Additionally, women's quality of life is significantly lower when compared to…
View article: Peritraumatic Distress Affected the Course of Depressive Symptoms During the COVID-19 Pandemic Lockdown in Subjects with Affective and Anxiety Disorders
Peritraumatic Distress Affected the Course of Depressive Symptoms During the COVID-19 Pandemic Lockdown in Subjects with Affective and Anxiety Disorders Open
In western countries, the COVID-19 pandemic represented a unique scenario of a global threat of contagion of a life-threatening illness, as confirmed by the need for exceptional and never adopted measures represented by national lockdowns.…
View article: A Genome-Wide Association Study of First-Episode Psychosis: A Genetic Exploration in an Italian Cohort
A Genome-Wide Association Study of First-Episode Psychosis: A Genetic Exploration in an Italian Cohort Open
Background: Psychosis, particularly schizophrenia (SZ), is influenced by genetic and environmental factors. The neurodevelopmental hypothesis suggests that genetic factors affect neuronal circuit connectivity during perinatal periods, henc…
View article: Environmental risk factors for schizophrenia spectrum disorders around the globe: a mapping review of the literature
Environmental risk factors for schizophrenia spectrum disorders around the globe: a mapping review of the literature Open
Aims There is a substantial body of literature on environmental risk associated with schizophrenia. Most research has largely been conducted in Europe and North America, with little representation of the rest of the world; hence generalisa…
View article: Cognitive presentation at psychosis onset through premorbid deterioration and exposure to environmental risk factors
Cognitive presentation at psychosis onset through premorbid deterioration and exposure to environmental risk factors Open
Background Previous studies identified clusters of first-episode psychosis (FEP) patients based on cognition and premorbid adjustment. This study examined a range of socio-environmental risk factors associated with clusters of FEP, aiming …
View article: Polygenic and Polyenvironment Interplay in Schizophrenia-Spectrum Disorder and Affective Psychosis; the EUGEI First Episode Study
Polygenic and Polyenvironment Interplay in Schizophrenia-Spectrum Disorder and Affective Psychosis; the EUGEI First Episode Study Open
Background Multiple genetic and environmental risk factors play a role in the development of both schizophrenia-spectrum disorders and affective psychoses. How they act in combination is yet to be clarified. Methods We analyzed 573 first e…
View article: The impact of schizophrenia genetic load and heavy cannabis use on the risk of psychotic disorder in the EU-GEI case-control and UK Biobank studies
The impact of schizophrenia genetic load and heavy cannabis use on the risk of psychotic disorder in the EU-GEI case-control and UK Biobank studies Open
Background The association between cannabis and psychosis is established, but the role of underlying genetics is unclear. We used data from the EU-GEI case-control study and UK Biobank to examine the independent and combined effect of heav…
View article: Cannabis use and cognitive biases in people with first-episode psychosis and their siblings
Cannabis use and cognitive biases in people with first-episode psychosis and their siblings Open
Background Cannabis use and familial vulnerability to psychosis have been associated with social cognition deficits. This study examined the potential relationship between cannabis use and cognitive biases underlying social cognition and f…
View article: The effect of polygenic risk score and childhood adversity on transdiagnostic symptom dimensions at first-episode psychosis: evidence for an affective pathway to psychosis
The effect of polygenic risk score and childhood adversity on transdiagnostic symptom dimensions at first-episode psychosis: evidence for an affective pathway to psychosis Open
View article: Methylomic signature of current cannabis use in two first-episode psychosis cohorts
Methylomic signature of current cannabis use in two first-episode psychosis cohorts Open
The rising prevalence and legalisation of cannabis worldwide have underscored the need for a comprehensive understanding of its biological impact, particularly on mental health. Epigenetic mechanisms, specifically DNA methylation, have gai…
View article: Gender differences in clinical features and quality of life of patients with axial spondyloarthritis and psoriatic arthritis
Gender differences in clinical features and quality of life of patients with axial spondyloarthritis and psoriatic arthritis Open
Objective. The aim of the current study was to compare the clinical and treatment characteristics and dimensions of health-related quality of life between female and male patients with axial spondyloarthritis (SpA) and psoriatic arthritis …
View article: The contribution of cannabis use to the increased psychosis risk among minority ethnic groups in Europe
The contribution of cannabis use to the increased psychosis risk among minority ethnic groups in Europe Open
Background We examined whether cannabis use contributes to the increased risk of psychotic disorder for non-western minorities in Europe. Methods We used data from the EU-GEI study (collected at sites in Spain, Italy, France, the United Ki…
View article: The effect of polygenic risk score and childhood adversity experiences on transdiagnostic symptom dimensions at first-episode psychosis: evidence for an affective pathway to psychosis
The effect of polygenic risk score and childhood adversity experiences on transdiagnostic symptom dimensions at first-episode psychosis: evidence for an affective pathway to psychosis Open
Background Childhood adversity is associated with various clinical dimensions in psychosis; however, how genetic vulnerability shapes the adversity associated psychopathological signature is yet to be clarified. Methods Using data from the…
View article: Longitudinal trajectories of psychosocial functioning in patients with pre-existing mental disorders after one year of COVID-19 pandemic
Longitudinal trajectories of psychosocial functioning in patients with pre-existing mental disorders after one year of COVID-19 pandemic Open
View article: Variation of subclinical psychosis across 16 sites in Europe and Brazil: findings from the multi-national EU-GEI study
Variation of subclinical psychosis across 16 sites in Europe and Brazil: findings from the multi-national EU-GEI study Open
Background Incidence of first-episode psychosis (FEP) varies substantially across geographic regions. Phenotypes of subclinical psychosis (SP), such as psychotic-like experiences (PLEs) and schizotypy, present several similarities with psy…
View article: Diminished social motivation in early psychosis is associated with polygenic liability for low vitamin D
Diminished social motivation in early psychosis is associated with polygenic liability for low vitamin D Open
Insufficiency of vitamin D levels often occur in individuals with schizophrenia and first-episode psychosis (FEP). However, it is unknown whether this represents a biological predisposition, or it is essentially driven by illness-related a…
View article: The interplay between mentalization, personality traits and burnout in psychiatry training: Results from a large multicenter controlled study
The interplay between mentalization, personality traits and burnout in psychiatry training: Results from a large multicenter controlled study Open
Background A better characterization of educational processes during psychiatry training is needed, both to foster personal resilience and occupational proficiency. Methods An adequate coverage of medical residents at the national level wa…
View article: Methylomic signature of current cannabis use in two first-episode psychosis cohorts
Methylomic signature of current cannabis use in two first-episode psychosis cohorts Open
The rising prevalence and legalization of cannabis worldwide have underscored the need for a comprehensive understanding of its biological impact, particularly on mental health. Epigenetic mechanisms, specifically DNA methylation, have gai…
View article: The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study
The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study Open
View article: Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case–control study
Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case–control study Open
Background Childhood adversity and cannabis use are considered independent risk factors for psychosis, but whether different patterns of cannabis use may be acting as mediator between adversity and psychotic disorders has not yet been expl…
View article: The association between reasons for first using cannabis, later pattern of use, and risk of first-episode psychosis: the EU-GEI case–control study
The association between reasons for first using cannabis, later pattern of use, and risk of first-episode psychosis: the EU-GEI case–control study Open
Background While cannabis use is a well-established risk factor for psychosis, little is known about any association between reasons for first using cannabis (RFUC) and later patterns of use and risk of psychosis. Methods We used data from…
View article: Exploring the mediation of DNA methylation across the epigenome between childhood adversity and First Episode of Psychosis—findings from the EU-GEI study
Exploring the mediation of DNA methylation across the epigenome between childhood adversity and First Episode of Psychosis—findings from the EU-GEI study Open
View article: Post-migration trajectories and psychopathological vulnerability
Post-migration trajectories and psychopathological vulnerability Open
Background Psychosis rates are higher among some migrant groups. We hypothesized that psychosis in migrants is associated with cumulative social disadvantage during different phases of migration. Methods We used data from the EUropean Netw…
View article: COMT but Not 5HTTLPR Gene Is Associated with Depression in First-Episode Psychosis: The Role of Stressful Life Events
COMT but Not 5HTTLPR Gene Is Associated with Depression in First-Episode Psychosis: The Role of Stressful Life Events Open
Serotonergic and dopaminergic systems are involved in the regulation of mood and reactivity to psychological stress. This study explores, in a sample of first episode psychosis (FEP) patients, whether more severe depressive symptoms were f…
View article: Development and Validation of Predictive Model for a Diagnosis of First Episode Psychosis Using the Multinational EU-GEI Case–control Study and Modern Statistical Learning Methods
Development and Validation of Predictive Model for a Diagnosis of First Episode Psychosis Using the Multinational EU-GEI Case–control Study and Modern Statistical Learning Methods Open
Background and Hypothesis It is argued that availability of diagnostic models will facilitate a more rapid identification of individuals who are at a higher risk of first episode psychosis (FEP). Therefore, we developed, evaluated, and val…
View article: Clinical and psychological characteristics associated with negative beliefs and concerns about treatment necessity in rheumatic diseases
Clinical and psychological characteristics associated with negative beliefs and concerns about treatment necessity in rheumatic diseases Open
Identifying factors that influence problematic beliefs and behaviors related to pharmacotherapy may be useful for clinicians to improve the patients’ adherence. The study aims to assess patients’ beliefs about the necessity and concerns re…
View article: Exploring the mediation of DNA methylation across the epigenome between childhood adversity and First Episode of Psychosis – findings from the EU-GEI study
Exploring the mediation of DNA methylation across the epigenome between childhood adversity and First Episode of Psychosis – findings from the EU-GEI study Open
Studies conducted in psychotic disorders have shown that DNA-methylation (DNAm) is sensitive to the impact of Childhood Adversity (CA). However, whether it mediates the association between CA and psychosis is yet to be explored. Epigenome-…
View article: Child maltreatment, migration and risk of first-episode psychosis: results from the multinational EU-GEI study
Child maltreatment, migration and risk of first-episode psychosis: results from the multinational EU-GEI study Open
Background Child maltreatment (CM) and migrant status are independently associated with psychosis. We examined prevalence of CM by migrant status and tested whether migrant status moderated the association between CM and first-episode psyc…