Sarah Wagner
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View article: EPA guidance on lifestyle interventions for adults with severe mental illness: A meta-review of the evidence
EPA guidance on lifestyle interventions for adults with severe mental illness: A meta-review of the evidence Open
There is growing interest in lifestyle interventions as stand-alone and add-on therapies in mental health care due to their potential benefits for both physical and mental health outcomes. We evaluated lifestyle interventions focusing on p…
View article: The relationship between blood–brain barrier dysfunction and neurocognitive impairments in first-episode psychosis: findings from a retrospective chart analysis
The relationship between blood–brain barrier dysfunction and neurocognitive impairments in first-episode psychosis: findings from a retrospective chart analysis Open
Background Even before the onset of psychotic symptoms, individuals with schizophrenia display cognitive impairments. Simultaneously, increasing amounts of individuals exhibit dysfunction of the blood–brain barrier (BBB). However, the impa…
View article: Analysis of cervical HPV infections among unvaccinated young adult women to inform vaccine strategies in this age group: the Costa Rica HPV Vaccine Trial
Analysis of cervical HPV infections among unvaccinated young adult women to inform vaccine strategies in this age group: the Costa Rica HPV Vaccine Trial Open
Introduction Human papillomavirus (HPV) vaccines protect against incident HPV infections, which cause cervical cancer. Objectives We estimated the prevalence and incidence of HPV infections in young adult women to understand the impact of …
View article: Rationale and design of a double-blind randomized non-inferiority clinical trial to evaluate one or two doses of vaccine against human papillomavirus including an epidemiologic survey to estimate vaccine efficacy: The Costa Rica ESCUDDO trial
Rationale and design of a double-blind randomized non-inferiority clinical trial to evaluate one or two doses of vaccine against human papillomavirus including an epidemiologic survey to estimate vaccine efficacy: The Costa Rica ESCUDDO trial Open
HPV vaccination of adolescent girls is the most effective measure to prevent cervical cancer. The World Health Organization recommends that adolescent girls receive two doses of vaccine but only a small proportion of girls from regions wit…
View article: Age‐specific prevalence of human papillomavirus and abnormal cytology at baseline in a diverse statewide prospective cohort of individuals undergoing cervical cancer screening in Mississippi
Age‐specific prevalence of human papillomavirus and abnormal cytology at baseline in a diverse statewide prospective cohort of individuals undergoing cervical cancer screening in Mississippi Open
Background Mississippi (MS) has among the highest rates of cervical cancer incidence and mortality in the United States, with disproportionately higher rates among Blacks compared to Whites. Here, we evaluate the prevalence of high‐risk hu…
View article: Recovering genotypes and phenotypes using allele-specific genes
Recovering genotypes and phenotypes using allele-specific genes Open
With the recent increase in RNA sequencing efforts using large cohorts of individuals, surveying allele-specific gene expression is becoming increasingly frequent. Here, we report that, despite not containing explicit variant information, …
View article: Risk Factors for Non–Human Papillomavirus (HPV) Type 16/18 Cervical Infections and Associated Lesions Among HPV DNA–Negative Women Vaccinated Against HPV-16/18 in the Costa Rica Vaccine Trial
Risk Factors for Non–Human Papillomavirus (HPV) Type 16/18 Cervical Infections and Associated Lesions Among HPV DNA–Negative Women Vaccinated Against HPV-16/18 in the Costa Rica Vaccine Trial Open
Background Factors that lead human papillomavirus (HPV) infections to persist and progress to cancer are not fully understood. We evaluated co-factors for acquisition, persistence, and progression of non–HPV-16/18 infections among HPV-vacc…
View article: Recovering genomes and phenotypes using allele-specific gene expression
Recovering genomes and phenotypes using allele-specific gene expression Open
With the recent increase in RNA sequencing efforts using large cohorts of individuals, studying allele-specific gene expression is becoming increasingly important. Here, we report that, despite not containing explicit variant information, …
View article: Toward pollen sterility in German chamomile (<i>Matricaria chamomilla</i>)–Conventional breeding approaches of cytoplasmic/genic male sterility and chemical emasculation
Toward pollen sterility in German chamomile (<i>Matricaria chamomilla</i>)–Conventional breeding approaches of cytoplasmic/genic male sterility and chemical emasculation Open
Pollen sterility (PS) in mother lines is crucial for hybrid crossings in plant breeding. 21 di‐ (2 x ) and tetraploid (4 x ) accessions of the hermaphroditic chamomile were screened for spontaneous, thermic or gametocide induced PS. Two cr…
View article: Put your "best" foot forward: comparing and contrasting various marching techniques
Put your "best" foot forward: comparing and contrasting various marching techniques Open
The art of marching band requires attention to detail and dedication to uniformity. When
\nperforming, members of a marching ensemble strive to move and play as one. To this end, every
\nensemble must define a marching technique: how the m…
View article: Storing and analyzing a genome on a blockchain
Storing and analyzing a genome on a blockchain Open
The genomic characterization of individuals promises to be immensely useful for biomedical research and healthcare. However, a critical barrier to expanding personal genome sequencing is achieving secure, high-integrity storage of raw data…
View article: Immune Response Following Quadrivalent Human Papillomavirus Vaccination in Women After Hematopoietic Allogeneic Stem Cell Transplant
Immune Response Following Quadrivalent Human Papillomavirus Vaccination in Women After Hematopoietic Allogeneic Stem Cell Transplant Open
ClinicalTrials.gov Identifier: NCT01092195.
View article: Evaluation of Durability of a Single Dose of the Bivalent HPV Vaccine: The CVT Trial
Evaluation of Durability of a Single Dose of the Bivalent HPV Vaccine: The CVT Trial Open
Background The authors investigated the durability of vaccine efficacy (VE) against human papillomavirus (HPV)16 or 18 infections and antibody response among nonrandomly assigned women who received a single dose of the bivalent HPV vaccine…
View article: Durability of Cross-Protection by Different Schedules of the Bivalent HPV Vaccine: The CVT Trial
Durability of Cross-Protection by Different Schedules of the Bivalent HPV Vaccine: The CVT Trial Open
Background The Costa Rica HPV Vaccine Trial has documented cross-protection of the bivalent HPV vaccine against HPV31/33/45 up to 7 years after vaccination, even with one dose of the vaccine. However, the durability of such protection rema…
View article: Evaluation of TypeSeq, a Novel High-Throughput, Low-Cost, Next-Generation Sequencing-Based Assay for Detection of 51 Human Papillomavirus Genotypes
Evaluation of TypeSeq, a Novel High-Throughput, Low-Cost, Next-Generation Sequencing-Based Assay for Detection of 51 Human Papillomavirus Genotypes Open
Background Human papillomaviruses (HPV) cause over 500 000 cervical cancers each year, most of which occur in low-resource settings. Human papillomavirus genotyping is important to study natural history and vaccine efficacy. We evaluated T…
View article: Development of the TypeSeq Assay for Detection of 51 Human Papillomavirus Genotypes by Next-Generation Sequencing
Development of the TypeSeq Assay for Detection of 51 Human Papillomavirus Genotypes by Next-Generation Sequencing Open
We have developed a new human papillomavirus (HPV) genotyping assay for detection of 51 HPV genotypes by next-generation sequencing (NGS). The TypeSeq assay consists of 3 PCR steps that equalize viral load and each type’s amplicon copies p…
View article: FIRE DEPARTMENT SUPPORT AND PHYSICAL ACTIVITY OF VOLUNTEER FIREFIGHTERS: A CROSS-SECTIONAL EXAMINATION
FIRE DEPARTMENT SUPPORT AND PHYSICAL ACTIVITY OF VOLUNTEER FIREFIGHTERS: A CROSS-SECTIONAL EXAMINATION Open
Greater health and fitness of volunteer firefighters protects them from cardiovascular disease-related deaths, reduces risk of injury, and improves job performance, which subsequently provides better protection for the majority of the U.S.…
View article: Low-cost HPV testing and the prevalence of cervical infection in asymptomatic populations in Guatemala
Low-cost HPV testing and the prevalence of cervical infection in asymptomatic populations in Guatemala Open
In this sample of cancer free women in Guatemala, HPV16 was the most prevalent HR type in Guatemala and the age-specific prevalence curve peaked in younger ages. Women in the 30-59-year age groups had a prevalence of HR-HPV of 8%, however,…
View article: Low-cost HPV testing and the prevalence of cervical infection in asymptomatic populations in Guatemala
Low-cost HPV testing and the prevalence of cervical infection in asymptomatic populations in Guatemala Open
Background A low cost and accurate method for detecting high-risk (HR) HPV is important to permit HPV testing for cervical cancer prevention. We validated a low-cost commercially available HPV method (H13, Hybribio, Hong Kong) and determin…
View article: When patients fail UNAIDS’ last 90 ‐ the “failure cascade” beyond 90‐90‐90 in rural Lesotho, Southern Africa: a <i>prospective cohort study</i>
When patients fail UNAIDS’ last 90 ‐ the “failure cascade” beyond 90‐90‐90 in rural Lesotho, Southern Africa: a <i>prospective cohort study</i> Open
Introduction : HIV‐infected individuals on first‐line antiretroviral therapy (ART) in resource‐limited settings who do not achieve the last “90” (viral suppression) enter a complex care cascade: enhanced adherence counselling (EAC), repeti…
View article: Vegetative and generative maintenance of self-incompatibility in six accessions of German chamomile
Vegetative and generative maintenance of self-incompatibility in six accessions of German chamomile Open
Self-incompatible (SI) plants are able to form ideal mother lines for hybrid crossing in hermaphroditic plants, assuring fertilization from the desired father line. To find out suitable ways to maintain SI was the aim of this study. Among …
View article: Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41
Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41 Open
Genome-wide association studies have identified multiple renal cell carcinoma (RCC) susceptibility loci. Here, we use regional imputation and bioinformatics analysis of the 12p12.1 locus to identify the single-nucleotide polymorphism (SNP)…
View article: Vegetative and generative maintenance of self-incompatibility in six accessions of German chamomile
Vegetative and generative maintenance of self-incompatibility in six accessions of German chamomile Open
Self-incompatible (SI) plants are able to form ideal mother lines for hybrid crossing in hermaphroditic plants, assuring fertilization from the desired father line. To find out suitable ways to maintain SI was the aim of this study. Among …