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View article: Management and survival of patients with cancer of unknown primary discussed by a French national multidisciplinary tumour board: a retrospective analysis
Management and survival of patients with cancer of unknown primary discussed by a French national multidisciplinary tumour board: a retrospective analysis Open
View article: Clinical and biological factors associated with response to immune checkpoint inhibitors in advanced sarcomas: IMPRESARC, a French retrospective multicenter cohort study
Clinical and biological factors associated with response to immune checkpoint inhibitors in advanced sarcomas: IMPRESARC, a French retrospective multicenter cohort study Open
Background Immune checkpoint inhibitors (ICIs) in unselected sarcomas yield limited response rates and tumor control. Long‐term responders have however been reported, suggesting a critical challenge in refining patient selection, by identi…
View article: Outcome of patients with curative-intent treatment for primary pulmonary sarcoma: Results from an international multicenter retrospective study
Outcome of patients with curative-intent treatment for primary pulmonary sarcoma: Results from an international multicenter retrospective study Open
View article: Trabectedin in the Treatment of Soft Tissue Sarcoma: Real-world Data on Effectiveness, Safety, and Financial Implications from a European Comprehensive Cancer Centre
Trabectedin in the Treatment of Soft Tissue Sarcoma: Real-world Data on Effectiveness, Safety, and Financial Implications from a European Comprehensive Cancer Centre Open
Background Soft tissue sarcomas (STS) comprise over 150 histological subtypes, with advanced cases showing poor prognosis (5-year survival <10%). Trabectedin, a synthetic alkaloid, is frequently used after anthracycline-based chemotherapy …
View article: Driving dynamical inner-heliosphere models with in-situ solar-wind observations
Driving dynamical inner-heliosphere models with in-situ solar-wind observations Open
View article: Clinical presentation, management and outcome of 11132 patients with liposarcoma: a population-based study from the NETSARC+ registry
Clinical presentation, management and outcome of 11132 patients with liposarcoma: a population-based study from the NETSARC+ registry Open
View article: Activation of lysosomal iron triggers ferroptosis in cancer
Activation of lysosomal iron triggers ferroptosis in cancer Open
Iron catalyses the oxidation of lipids in biological membranes and promotes a form of cell death called ferroptosis1. Defining where this chemistry occurs in the cell can inform the design of drugs capable of inducing or inhibit…
View article: Regorafenib combined with irinotecan as second-line treatment in metastatic gastro-oesophageal adenocarcinomas: results of PRODIGE 58–UCGI35–REGIRI Unicancer randomised phase II study
Regorafenib combined with irinotecan as second-line treatment in metastatic gastro-oesophageal adenocarcinomas: results of PRODIGE 58–UCGI35–REGIRI Unicancer randomised phase II study Open
The study was stopped early because of limited efficacy and increased toxicities in the REGIRI arm, possibly due to drug interactions. No optimal sub-population that could benefit from a REGIRI regimen exposure was identified.
View article: Prospective observational study to assess the performance accuracy of clinical decision rules in children presenting to emergency departments with possible cervical spine injuries: the Study of Neck Injuries in Children (SONIC)
Prospective observational study to assess the performance accuracy of clinical decision rules in children presenting to emergency departments with possible cervical spine injuries: the Study of Neck Injuries in Children (SONIC) Open
Introduction Paediatric cervical spine injury (CSI) is uncommon but can have devastating consequences. Many children, however, present to emergency departments (EDs) for the assessment of possible CSI. While imaging can be used to determin…
View article: 166P Development of patient-derived tumor organoids from cancers of unknown primary carcinomas to guide clinical decision making (OCAPI)
166P Development of patient-derived tumor organoids from cancers of unknown primary carcinomas to guide clinical decision making (OCAPI) Open
View article: Clinical description and development of a prognostic score for neurofibromatosis type 1 (NF1)-associated GISTs: a retrospective study from the NETSARC+
Clinical description and development of a prognostic score for neurofibromatosis type 1 (NF1)-associated GISTs: a retrospective study from the NETSARC+ Open
View article: Cognitive Outcomes and Delirium After Cardiac Neurodevelopmental Program Implementation for Children With Congenital Heart Disease
Cognitive Outcomes and Delirium After Cardiac Neurodevelopmental Program Implementation for Children With Congenital Heart Disease Open
Importance A recent advisory from the American Heart Association delineated the potential benefits of developmental care for hospitalized children with congenital heart disease (CHD) and a critical gap in research evaluating the associatio…
View article: Liposarcomas: Natural History of 11132 Patients from the NETSARC Nationwide Registry
Liposarcomas: Natural History of 11132 Patients from the NETSARC Nationwide Registry Open
View article: Cellular origin and clonal evolution of human dedifferentiated liposarcoma
Cellular origin and clonal evolution of human dedifferentiated liposarcoma Open
View article: A metabolic crosstalk between liposarcoma and muscle sustains tumor growth
A metabolic crosstalk between liposarcoma and muscle sustains tumor growth Open
View article: Metastatic renal cell carcinoma with occult primary: a multicenter prospective cohort
Metastatic renal cell carcinoma with occult primary: a multicenter prospective cohort Open
View article: Activation of lysosomal iron triggers ferroptosis in cancer
Activation of lysosomal iron triggers ferroptosis in cancer Open
View article: Abstract 4627: Metastatic renal cell carcinoma with occult primary: Clinical and biological evidence for a new entity of cancers of unknown primary that beneficiates from tissue-tailored treatment
Abstract 4627: Metastatic renal cell carcinoma with occult primary: Clinical and biological evidence for a new entity of cancers of unknown primary that beneficiates from tissue-tailored treatment Open
Background: Cancers of unknown primary (CUP) is a heterogenous group of malignancies characterized by distant metastases in the absence of detectable primary. Specifics subgroups of CUP that share similarities with cancers of known primary…
View article: 59MO COTESARC – A multicentre, phase I-II clinical trial evaluating the combination of MEK and PDL-1 inhibitors in patients (pts) with advanced soft tissue sarcoma (STS): Results from complex (CG) and simple genomic (SG) STS cohorts
59MO COTESARC – A multicentre, phase I-II clinical trial evaluating the combination of MEK and PDL-1 inhibitors in patients (pts) with advanced soft tissue sarcoma (STS): Results from complex (CG) and simple genomic (SG) STS cohorts Open
Immune checkpoint inhibitor (ICI) effectiveness in unselected STS remains underwhelming but biological rationale suggest that MEK inhibitor combination may enhance response in advanced STS. COTESARC is a multicenter, open-label, phase I-II…
View article: Improved nationwide survival of sarcoma patients with a network of reference centers
Improved nationwide survival of sarcoma patients with a network of reference centers Open
View article: Fusion-negative rhabdomyosarcoma 3D organoids to predict effective drug combinations: A proof-of-concept on cell death inducers
Fusion-negative rhabdomyosarcoma 3D organoids to predict effective drug combinations: A proof-of-concept on cell death inducers Open
Rhabdomyosarcoma (RMS) is the main form of pediatric soft-tissue sarcoma. Its cure rate has not notably improved in the last 20 years following relapse, and the lack of reliable preclinical models has hampered the design of new therapies. …
View article: Ejecta Evolution Following a Planned Impact into an Asteroid: The First Five Weeks
Ejecta Evolution Following a Planned Impact into an Asteroid: The First Five Weeks Open
The impact of the Double Asteroid Redirection Test spacecraft into Dimorphos, moon of the asteroid Didymos, changed Dimorphos’s orbit substantially, largely from the ejection of material. We present results from 12 Earth-based facilities i…
View article: Sclerosing Epithelioid Fibrosarcoma (SEF) versus Low Grade Fibromyxoid Sarcoma (LGFMS): Presentation and outcome in the nationwide NETSARC+ series of 330 patients over 13 years
Sclerosing Epithelioid Fibrosarcoma (SEF) versus Low Grade Fibromyxoid Sarcoma (LGFMS): Presentation and outcome in the nationwide NETSARC+ series of 330 patients over 13 years Open
Although sharing close molecular alterations, SEF and LGFMS have a different natural history, clinical presentation and outcome, with a higher risk of metastatic relapse in SEF. Survival after relapse is longer than with other sarcomas, an…
View article: Ejecta Evolution Following a Planned Impact into an Asteroid: The First Five Weeks
Ejecta Evolution Following a Planned Impact into an Asteroid: The First Five Weeks Open
The impact of the DART spacecraft into Dimorphos, moon of the asteroid Didymos, changed Dimorphos' orbit substantially, largely from the ejection of material. We present results from twelve Earth-based facilities involved in a world-wide c…
View article: 1928P Differential presentation and outcome of sclerosing epithelioid fibrosarcoma (SEF) vs low grade fibromyxoid sarcoma (LGFMS): The nationwide series of 330 patients in NETSARC since 2010
1928P Differential presentation and outcome of sclerosing epithelioid fibrosarcoma (SEF) vs low grade fibromyxoid sarcoma (LGFMS): The nationwide series of 330 patients in NETSARC since 2010 Open
View article: 1555P Cell-free DNA analysis in patients with metastatic gastroesophageal adenocarcinoma: Preliminary results of the REGIRI - PRODIGE 58 ancillary study
1555P Cell-free DNA analysis in patients with metastatic gastroesophageal adenocarcinoma: Preliminary results of the REGIRI - PRODIGE 58 ancillary study Open
View article: 1927P Epithelioid hemangio-endothelioma (EHE) in NETSARC: The nationwide series of 267 patients over 12 years
1927P Epithelioid hemangio-endothelioma (EHE) in NETSARC: The nationwide series of 267 patients over 12 years Open
View article: Leiomyosarcoma and liposarcoma in young patients: The national netsarc+ network experience
Leiomyosarcoma and liposarcoma in young patients: The national netsarc+ network experience Open
Background: Leiomyosarcoma (LMS) and liposarcoma (LPS) are ultra-rare sarcomas in pediatric (0–18 years) and young adult (19−30) populations. We aimed to analyze their clinical characteristics at these young ages and to determine whether t…
View article: Epithelioid hemangio-endothelioma (EHE) in NETSARC: The nationwide series of 267 patients over 12 years
Epithelioid hemangio-endothelioma (EHE) in NETSARC: The nationwide series of 267 patients over 12 years Open
View article: A druggable copper-signalling pathway that drives inflammation
A druggable copper-signalling pathway that drives inflammation Open