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View article: Bulky Group Shaping Cyanine as an Efficient Photosensitizer: A Photo-Inducer for Photodynamic Immunotherapy
Bulky Group Shaping Cyanine as an Efficient Photosensitizer: A Photo-Inducer for Photodynamic Immunotherapy Open
View article: A Tumor Microenvironment Triggered Nanoplatform for Activatable Chemo-chemical Energy Dynamic Combined Therapy
A Tumor Microenvironment Triggered Nanoplatform for Activatable Chemo-chemical Energy Dynamic Combined Therapy Open
View article: The <scp>CsLOB1</scp> ‐ <scp>CsERF027</scp> Regulatory Module Positively Enhances Citrus Target Spot Disease Resistance by Regulating <scp>CsRAP2.3‐CsERF1</scp> Cascade
The <span>CsLOB1</span> ‐ <span>CsERF027</span> Regulatory Module Positively Enhances Citrus Target Spot Disease Resistance by Regulating <span>CsRAP2.3‐CsERF1</span> Cascade Open
Citrus target spot disease poses significant threats to the citrus industry. However, the molecular mechanisms underlying citrus resistance to Pseudofabraea citricarpa remain unexplored. In this study, we identified the LBD family gene CsL…
View article: A Photon‐Driven Unimolecular Immunostimulant for Self‐Amplified Pyroptosis and cGAS‐STING Pathway by Destroying the Pyroptosis Checkpoint
A Photon‐Driven Unimolecular Immunostimulant for Self‐Amplified Pyroptosis and cGAS‐STING Pathway by Destroying the Pyroptosis Checkpoint Open
Immunotherapy is a groundbreaking approach for clinically treating tumors, but its effectiveness is hindered by the tumor's immunosuppressive environment and lack of immune cell infiltration, enabling tumors to evade the immune system. Alt…
View article: A photoactivatable tumor‐targeting in situ nanovaccine for large‐volume tumor therapy
A photoactivatable tumor‐targeting in situ nanovaccine for large‐volume tumor therapy Open
The clinical application of tumor vaccines is hindered by challenges such as time‐consuming and costly production processes. In this context, in situ cancer vaccines represent a promising strategy by leveraging endogenous tumor antigens to…
View article: Cyclometalating Ligand Affords NIR Absorption in Ruthenium Enantiomers for Type-I Photodynamic Therapy
Cyclometalating Ligand Affords NIR Absorption in Ruthenium Enantiomers for Type-I Photodynamic Therapy Open
The development of NIR photosensitizers based on Ru complexes with Type-I process holds substantial promise for photodynamic therapy (PDT) of cancer, though this breakthrough remains unrealized to date. Herein, a pair of cyclometalated Ru …
View article: Unveiling the Power of Dark State Photocages: An Efficient Pathway to Triplet State Under Near‐Infrared Light Irradiation
Unveiling the Power of Dark State Photocages: An Efficient Pathway to Triplet State Under Near‐Infrared Light Irradiation Open
The photocage platform provides a synergistic approach to photodynamic therapy (PDT) and chemotherapy. Before light activation, both pro‐photosensitizers and pro‐drugs remain inert, ensuring safety. Upon near‐infrared (NIR) light irradiati…
View article: Precise Molecular Engineering of Heptamethine Cyanine‐Based Near‐Infrared Type‐I Photosensitizers for Pro‐Death Autophagy and Hypoxia‐Tolerant Antitumor Treatment
Precise Molecular Engineering of Heptamethine Cyanine‐Based Near‐Infrared Type‐I Photosensitizers for Pro‐Death Autophagy and Hypoxia‐Tolerant Antitumor Treatment Open
Heptamethine cyanine ( Cy7 ) dyes have excellent near‐infrared (NIR) fluorescence imaging capability but competitively inhibit the photodynamic therapy (PDT) effect, especially in hypoxic solid tumors. In this study, a series of aryl‐keton…
View article: Electrostatic Co‐Assembly of Cyanine Pair for Augmented Photoacoustic Imaging and Photothermal Therapy
Electrostatic Co‐Assembly of Cyanine Pair for Augmented Photoacoustic Imaging and Photothermal Therapy Open
Molecular phototheranostic dyes are of eminent interest for oncological diagnosis and imaging‐guided phototherapy. However, it remains challenging to develop photosensitizers (PSs) that simultaneously integrate high‐contrast photoacoustic …
View article: Spin Orbit Charge Transfer Enhances Intermolecular Hydrogen Atom Transfer Catalyzed Polymerization for Conductive Elastomers Syntheses
Spin Orbit Charge Transfer Enhances Intermolecular Hydrogen Atom Transfer Catalyzed Polymerization for Conductive Elastomers Syntheses Open
View article: Benzene Excimer Fluorescence in Dibenzophenanthroline Thin Film
Benzene Excimer Fluorescence in Dibenzophenanthroline Thin Film Open
View article: Dimerized Pentamethine Cyanines for Synergistically Boosting Photodynamic/Photothermal Therapy
Dimerized Pentamethine Cyanines for Synergistically Boosting Photodynamic/Photothermal Therapy Open
Photodynamic therapy (PDT) and photothermal therapy (PTT) have emerged promising applications in both fundamental research and clinical trials. However, it remains challenging to develop ideal photosensitizers (PSs) that concurrently integ…
View article: A self‐reinforced activatable photosensitizer prodrug enabling synergistic photodynamic and chemotherapy
A self‐reinforced activatable photosensitizer prodrug enabling synergistic photodynamic and chemotherapy Open
As a novel drug development paradigm, selective activation of prodrugs provides the potential for precise tumor chemotherapy, thereby presenting an opportunity for advancing cancer treatment. The combination of photodynamic therapy (PDT) a…
View article: A Highly Bright Near-Infrared Chemiluminescent Probe for Inflammation Imaging
A Highly Bright Near-Infrared Chemiluminescent Probe for Inflammation Imaging Open
View article: CCDC 2246197: Experimental Crystal Structure Determination
CCDC 2246197: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Aryl‐Modified Pentamethyl Cyanine Dyes at the C2’ Position: A Tunable Platform for Activatable Photosensitizers
Aryl‐Modified Pentamethyl Cyanine Dyes at the C2’ Position: A Tunable Platform for Activatable Photosensitizers Open
Pentamethyl cyanine dyes are promising fluorophores for fluorescence sensing and imaging. However, advanced biomedical applications require enhanced control of their excited‐state properties. Herein, a synthetic approach for attaching aryl…
View article: Highly Efficient Photosensitizers with Molecular Vibrational Torsion for Cancer Photodynamic Therapy
Highly Efficient Photosensitizers with Molecular Vibrational Torsion for Cancer Photodynamic Therapy Open
The development of highly effective photosensitizers (PSs) for photodynamic therapy remains a great challenge at present. Most PSs rely on the heavy-atom effect or the spin-orbit charge-transfer intersystem crossing (SOCT-ISC) effect to pr…
View article: A GPX4-targeted photosensitizer to reverse hypoxia-induced inhibition of ferroptosis for non-small cell lung cancer therapy
A GPX4-targeted photosensitizer to reverse hypoxia-induced inhibition of ferroptosis for non-small cell lung cancer therapy Open
A GPX4 targeted photosensitizer ENBS-ML210 was prepared to promote lipid peroxidation, which reversed the hypoxia-induced resistance of ferroptosis for non-small cell lung cancer therapy.
View article: Photoredox catalysis may be a general mechanism in photodynamic therapy
Photoredox catalysis may be a general mechanism in photodynamic therapy Open
Elucidating the underlying photochemical mechanisms of action (MoA) of photodynamic therapy (PDT) may allow its efficacy to be improved and could set the stage for the development of new classes of PDT photosensitizers. Here, we provide ev…
View article: Enhancing Intersystem Crossing by Intermolecular Dimer-Stacking of Cyanine as Photosensitizer for Cancer Therapy
Enhancing Intersystem Crossing by Intermolecular Dimer-Stacking of Cyanine as Photosensitizer for Cancer Therapy Open
Open AccessCCS ChemistryRESEARCH ARTICLE7 Nov 2022Enhancing Intersystem Crossing by Intermolecular Dimer-Stacking of Cyanine as Photosensitizer for Cancer Therapy Haiqiao Huang, Dandan Ma, Qiang Liu, Daipeng Huang, Xueze Zhao, Qichao Yao, …
View article: Photodynamic inheritance from methylene blue to carbon dots against reduction, aggregation, and DNA interference
Photodynamic inheritance from methylene blue to carbon dots against reduction, aggregation, and DNA interference Open
View article: Light‐triggered dePEGylation with decreasing the diameter of hydroxyapatite nanocarriers for enhanced cellular uptake and tumor penetration
Light‐triggered dePEGylation with decreasing the diameter of hydroxyapatite nanocarriers for enhanced cellular uptake and tumor penetration Open
PEGylation of nano‐drug delivery systems (NDDSs) has been investigated to overcome the side effect of conventional chemotherapy including improving pharmacokinetics by prolonging drug circulation, reducing immune clearance and premature dr…
View article: Single-Molecule Förster Resonance Energy Transfer-Based Photosensitizer for Synergistic Photodynamic/Photothermal Therapy
Single-Molecule Förster Resonance Energy Transfer-Based Photosensitizer for Synergistic Photodynamic/Photothermal Therapy Open
Photosensitizers (PSs) inevitably release a large amount of energy in the form of fluorescence during photodynamic therapy (PDT). However, under the premise of satisfying fluorescence imaging, a large amount of energy is lost, which limits…
View article: New Cy5 photosensitizers for cancer phototherapy: a low singlet–triplet gap provides high quantum yield of singlet oxygen
New Cy5 photosensitizers for cancer phototherapy: a low singlet–triplet gap provides high quantum yield of singlet oxygen Open
The electron-withdrawing group at the meso -position of Thio-Cy5 could dramatically reduce the singlet–triplet energy gap, and speed up the intersystem crossing process.
View article: Activation of apoptosis by rationally constructing NIR amphiphilic AIEgens: surmounting the shackle of mitochondrial membrane potential for amplified tumor ablation
Activation of apoptosis by rationally constructing NIR amphiphilic AIEgens: surmounting the shackle of mitochondrial membrane potential for amplified tumor ablation Open
In this contribution, based on a “step-by-step” molecular design strategy, a novel NIR amphiphilic AIEgen TPA-S-TPP with a triplet lifetime of 11.43 μs and surmounting the shackle of MMP was successfully fabricated for amplified tumor abla…
View article: An APN-activated NIR photosensitizer for cancer photodynamic therapy and fluorescence imaging
An APN-activated NIR photosensitizer for cancer photodynamic therapy and fluorescence imaging Open
View article: CCDC 1916150: Experimental Crystal Structure Determination
CCDC 1916150: Experimental Crystal Structure Determination Open
View article: CCDC 1916151: Experimental Crystal Structure Determination
CCDC 1916151: Experimental Crystal Structure Determination Open
View article: CCDC 1916152: Experimental Crystal Structure Determination
CCDC 1916152: Experimental Crystal Structure Determination Open
View article: Development of a novel anti-tumor theranostic platform: a near-infrared molecular upconversion sensitizer for deep-seated cancer photodynamic therapy
Development of a novel anti-tumor theranostic platform: a near-infrared molecular upconversion sensitizer for deep-seated cancer photodynamic therapy Open
Upconversion-based photon-initiated therapeutic modalities, photodynamic therapy (PDT) in particular, have shown significant clinical potential in deep-seated tumor treatment.