Saran Lotfollahzadeh
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View article: A Murine Model of Cardiovascular-Kidney-Metabolic Syndrome Demonstrates Compromised Limb Function in the Ischemic Hind Limb
A Murine Model of Cardiovascular-Kidney-Metabolic Syndrome Demonstrates Compromised Limb Function in the Ischemic Hind Limb Open
Background: Cardiovascular-Kidney-metabolic (CKM) syndrome is a public health problem in the US and results in premature CVD at a relatively preserved GFR. The molecular mediators of CKM are poorly understood, partly due to the lack of a r…
View article: Dietary tryptophan augments cancer-associated venous thrombogenicity mitigated by indoleamine 2,3-dioxygenase 1 inhibition
Dietary tryptophan augments cancer-associated venous thrombogenicity mitigated by indoleamine 2,3-dioxygenase 1 inhibition Open
Studies related to cardio-oncology remain a high priority, considering that venous thromboembolism (VTE) in cancer survivors is the second most common cause of death. Although diet-derived metabolites are emerging as contributors to VTE, t…
View article: Corrigendum to “Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity” [Mol Metabol 73 (July 2023) 101744]
Corrigendum to “Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity” [Mol Metabol 73 (July 2023) 101744] Open
View article: Tryptophan metabolism reprogramming contributes to the prothrombotic milieu in mice and humans infected with SARS-CoV-2
Tryptophan metabolism reprogramming contributes to the prothrombotic milieu in mice and humans infected with SARS-CoV-2 Open
SARS-CoV-2 infection disturbs the coagulation balance in the blood, triggering thrombosis and contributing to organ failure. The role of prothrombotic metabolites in COVID-19-associated coagulopathy remains elusive. Leveraging K18-hACE2 mi…
View article: A murine model of cardiovascular-kidney-metabolic syndrome demonstrates compromised limb function in the ischemic hind limb
A murine model of cardiovascular-kidney-metabolic syndrome demonstrates compromised limb function in the ischemic hind limb Open
s Background Cardiovascular-Kidney-metabolic (CKM) syndrome is a public health problem involving > 90% of the US and results in premature CVD at a relatively preserved GFR. The molecular mediators of CKM are poorly understood, partly due t…
View article: External validation of a novel cancer-associated venous thromboembolism risk assessment score in a safety-net hospital
External validation of a novel cancer-associated venous thromboembolism risk assessment score in a safety-net hospital Open
View article: Aryl Hydrocarbon Receptor Pathway Augments Peritoneal Fibrosis in a Murine CKD Model Exposed to Peritoneal Dialysate
Aryl Hydrocarbon Receptor Pathway Augments Peritoneal Fibrosis in a Murine CKD Model Exposed to Peritoneal Dialysate Open
Key Points CKD and high glucose–containing peritoneal dialysate alter peritoneal membrane contributing to peritoneal dialysis failure, with a poorly understood mechanism. CKD milieu activates the aryl hydrocarbon receptor pathway in the su…
View article: Early Kidney Transplantation or Conversion to Peritoneal Dialysis after First-Time Arteriovenous Access Creation
Early Kidney Transplantation or Conversion to Peritoneal Dialysis after First-Time Arteriovenous Access Creation Open
View article: End Organ Affection in Sickle Cell Disease
End Organ Affection in Sickle Cell Disease Open
Sickle cell disease is an orphan disease affecting ethnic minorities and characterized by profound systemic manifestations. Although around 100,000 individuals with SCD are living in the US, the exact number of individuals is unknown, and …
View article: Alleviating iatrogenic effects of paclitaxel via antiinflammatory treatment
Alleviating iatrogenic effects of paclitaxel via antiinflammatory treatment Open
Background: Paclitaxel (PTX) is touted as an essential medicine due to its extensive use as a chemotherapeutic agent for various cancers and an antiproliferative agent for endovascular applications. Emerging studies in cardio-oncology impl…
View article: JoVE Video Dataset
JoVE Video Dataset Open
An erratum was issued for: A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice. The Authors section was updated from:
View article: Two methods of isolation of rat aortic smooth muscle cells with high yield
Two methods of isolation of rat aortic smooth muscle cells with high yield Open
Vascular smooth muscle cells (VSMCs) are an integral part of blood vessels and are the focus of intensive research in vascular biology, translational research, and cardiovascular diseases. Though immortalized vascular smooth muscle cell li…
View article: Calreticulin Regulates SARS-CoV-2 Spike Protein Turnover and Modulates SARS-CoV-2 Infectivity
Calreticulin Regulates SARS-CoV-2 Spike Protein Turnover and Modulates SARS-CoV-2 Infectivity Open
Cardiovascular complications are major clinical hallmarks of acute and post-acute coronavirus disease 2019 (COVID-19). However, the mechanistic details of SARS-CoV-2 infectivity of endothelial cells remain largely unknown. Here, we demonst…
View article: Tryptophan Metabolites Target Transmembrane and Immunoglobulin Domain-Containing 1 Signaling to Augment Renal Tubular Injury
Tryptophan Metabolites Target Transmembrane and Immunoglobulin Domain-Containing 1 Signaling to Augment Renal Tubular Injury Open
View article: Epidemiology of Cancer-Associated Venous Thromboembolism in Patients With Solid and Hematologic Neoplasms in the Veterans Affairs Health Care System
Epidemiology of Cancer-Associated Venous Thromboembolism in Patients With Solid and Hematologic Neoplasms in the Veterans Affairs Health Care System Open
Importance Identifying changes in epidemiologic patterns of the incidence and risk of cancer-associated thrombosis (CAT), particularly with evolving cancer-directed therapy, is essential for risk stratification. Objective To assess the inc…
View article: Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity
Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity Open
Our findings identified Minar2 as a novel physiological negative regulator of mTORC1 with a key role in obesity and metabolic disorders. Impaired expression or activation of MINAR2 could lead to obesity and obesity-associated diseases.
View article: Alleviating iatrogenic effects of paclitaxel via anti-inflammatory treatment
Alleviating iatrogenic effects of paclitaxel via anti-inflammatory treatment Open
Background Paclitaxel is touted as an essential medicine due to its extensive use as a chemotherapeutic for various cancers and an antiproliferative agent for restenosis. Due to recent concerns related to long-term mortality, paclitaxel (P…
View article: The Renal Manifestations of SARS-CoV-2: A Guide for Family Physicians
The Renal Manifestations of SARS-CoV-2: A Guide for Family Physicians Open
COVID-19 is a devastating systemic disease characterized by multisystem involvement driven by exuberant hyperinflammatory and dysregulations in coagulation. In COVID-19 patients, renal failure contributes to morbidity and mortality, and it…
View article: Prevalence of Central Venous Stenosis among Black and White ESKD Patients with Dysfunctional Dialysis Access.
Prevalence of Central Venous Stenosis among Black and White ESKD Patients with Dysfunctional Dialysis Access. Open
In the United States, significant racial and ethnic disparities exist in chronic kidney disease (CKD) and its management. Hemodialysis constitutes the main stay of renal replacement therapy for end-stage kidney disease (ESKD), which is ini…
View article: PRMT4-mediated arginine methylation promotes tyrosine phosphorylation of VEGFR-2 and regulates filopodia protrusions
PRMT4-mediated arginine methylation promotes tyrosine phosphorylation of VEGFR-2 and regulates filopodia protrusions Open
View article: Pharmacologic Manipulation of Late SV40 Factor Suppresses Wnt Signaling and Inhibits Growth of Allogeneic and Syngeneic Colon Cancer Xenografts
Pharmacologic Manipulation of Late SV40 Factor Suppresses Wnt Signaling and Inhibits Growth of Allogeneic and Syngeneic Colon Cancer Xenografts Open
View article: Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells
Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells Open
Significance Human angiotensin-converting enzyme 2 (ACE2) is the most widely known entry receptor for SARS-CoV-2. The possible involvement of other cellular components in viral entry mechanisms remains unknown. Vimentin is expressed in hum…
View article: Tryptophan metabolites suppress the Wnt pathway and promote adverse limb events in chronic kidney disease
Tryptophan metabolites suppress the Wnt pathway and promote adverse limb events in chronic kidney disease Open
Chronic kidney disease (CKD) imposes a strong and independent risk for peripheral artery disease (PAD). While solutes retained in CKD patients (uremic solutes) inflict vascular damage, their role in PAD remains elusive. Here, we show that …
View article: Indoleamine 2,3-dioxygenase-1, a Novel Therapeutic Target for Post-Vascular Injury Thrombosis in CKD
Indoleamine 2,3-dioxygenase-1, a Novel Therapeutic Target for Post-Vascular Injury Thrombosis in CKD Open
Significance Statement Patients with CKD are at a markedly higher risk of thrombosis after vascular procedures. Uremic solutes, such as indoxyl sulfate and kynurenine, are important contributors to this complication through tissue factor (…
View article: Microbial contamination of home nebulizers in children with cystic fibrosis and clinical implication on the number of pulmonary exacerbations
Microbial contamination of home nebulizers in children with cystic fibrosis and clinical implication on the number of pulmonary exacerbations Open
View article: Pitfalls in the Diagnosis of Acute Appendicitis in Tehran Children’s Hospital
Pitfalls in the Diagnosis of Acute Appendicitis in Tehran Children’s Hospital Open
Background: Appendicitis is the inflammation of the appendix. In spite of advances in the diagnosis and management of acute appendicitis, its morbidity is still significant. Despite widespread use of ultrasonography, computed tomography (C…
View article: Recurrent Aspiration Pneumonia in a Missed Case of Broncho-Esophageal Fistula with Repaired Esophageal Atresia: Usefulness of Fiberoptic Bronchoscopy: A Case Report
Recurrent Aspiration Pneumonia in a Missed Case of Broncho-Esophageal Fistula with Repaired Esophageal Atresia: Usefulness of Fiberoptic Bronchoscopy: A Case Report Open
: Broncho-esophageal fistula (BEF) is a rare congenital anomaly affecting the respiratory and upper gastrointestinal tract. The rarity makes its timely diagnosis very challenging. This study presents a rare case of missed congenital BEF in…
View article: Thoracotomy versus Video-Assisted Thoracoscopy in Pediatric Empyema
Thoracotomy versus Video-Assisted Thoracoscopy in Pediatric Empyema Open
Our results indicate that VATS was not only less invasive than thoracotomy, but also showed promising results, such as an earlier discharge from the hospital and fewer postoperative complications.
View article: Rare Presentation of Total Ileocolic Intussusception with Rectal Prolapse in a Child
Rare Presentation of Total Ileocolic Intussusception with Rectal Prolapse in a Child Open
View article: Congenital Pouch Colon with Anorectal Malformation: A Report of One Case
Congenital Pouch Colon with Anorectal Malformation: A Report of One Case Open