Explanipedia

Degeneration and Impaired Resilience of Skull Bone and Hematopoietic Bone Marrow Open

Yang� Yang, Yonggang Fan, Sandhya Jain, Zhangfan Ding, Hanyu Liu , et al. · 2025

Bone marrow health is central to transplantations, blood formation, and cancer progression. However, the bone marrow niche deteriorates with age, impairing haematopoietic stem cell function. Contrary to a recent report 1 suggesting skull m…

Bone marrow adipocytes: key players in vascular niches, aging, and disease Open

Yonggang Fan, Mai Kamal Abd El-Khalek, Yuheng Zhang, Lu Liu, Qi Tian , et al. · 2025

Bone marrow adipocytes (BMAs) are emerging as metabolically active endocrine organs within the bone marrow microenvironment, engaging in extensive crosstalk with vascular niches, osteogenic cells, and hematopoietic compartments. In aging a…

Data from Transforming Cancer Therapy: Unlocking the Potential of Targeting Vascular and Stromal Cells in the Tumor Microenvironment Open

Lu Liu, Y. Zhang, Hanyu Liu, Jian Yang, Qi Tian , et al. · 2025

The tumor microenvironment (TME) orchestrates cancer progression by fostering a complex interplay between cancer cells and the surrounding cellular and acellular elements. Through dynamic interactions with cancer cells, vascular and stroma…

Supplementary Data from Transforming Cancer Therapy: Unlocking the Potential of Targeting Vascular and Stromal Cells in the Tumor Microenvironment Open

Lu Liu, Y. Zhang, Hanyu Liu, Jian Yang, Qi Tian , et al. · 2025

supplementary tables and text.

Transforming Cancer Therapy: Unlocking the Potential of Targeting Vascular and Stromal Cells in the Tumor Microenvironment Open

Lu Liu, Y. Zhang, Hanyu Liu, Jian Yang, Qi Tian , et al. · 2025

The tumor microenvironment (TME) orchestrates cancer progression by fostering a complex interplay between cancer cells and the surrounding cellular and acellular elements. Through dynamic interactions with cancer cells, vascular and stroma…

Lymphatic vessels in bone support regeneration after injury Open

Lincoln Biswas, Junyu Chen, Jessica De Angelis, Amit Singh, Charlotte Owen-Woods , et al. · 2023

Blood and lymphatic vessels form a versatile transport network and provide inductive signals to regulate tissue-specific functions. Blood vessels in bone regulate osteogenesis and hematopoiesis, but current dogma suggests that bone lacks l…

Estrogen enforces the integrity of blood vessels in the bone during pregnancy and menopause Open

Julia Rodrigues, Yi-Fang Wang, Amit Singh, Michelle Hendriks, Gopuraja Dharmalingam , et al. · 2022

High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging Open

Junyu Chen, Unnikrishnan Sivan, Sin Lih Tan, Luciana Lippo, Jessica De Angelis , et al. · 2021

3D tissue imaging reveals maladaptations of blood vessels in organ aging, fibrosis, and arthritis.

SUMIC: A Simple Ultrafast Multicolor Immunolabelling and Clearing Approach for Whole-Organ and Large Tissue 3D Imaging Open

Lincoln Biswas, Junyu Chen, Jessica De Angelis, Alexandros Chatzis, Jagdeep Nanchahal , et al. · 2021

High-resolution whole-organ imaging of cleared tissues captures cellular and molecular insights within the intact tissue and tumour microenvironments. However, current immunolabelling and clearing methods are complicated and time-consuming…

Blood Vessels and Vascular Niches in Bone Development and Physiological Remodeling Open

Michelle Hendriks, Saravana K. Ramasamy · 2020

Recent advances in our understanding of blood vessels and vascular niches in bone convey their critical importance in regulating bone development and physiology. The contribution of blood vessels in bone functions and remodeling has recent…

Decreased blood vessel density and endothelial cell subset dynamics during ageing of the endocrine system Open

Junyu Chen, Luciana Lippo, Rossella Labella, Sin Lih Tan, Brian D. Marsden , et al. · 2020

Bone Vasculature and Bone Marrow Vascular Niches in Health and Disease Open

Junyu Chen, Michelle Hendriks, Alexandros Chatzis, Saravana K. Ramasamy, Anjali P. Kusumbe · 2020

Bone vasculature and bone marrow vascular niches supply oxygen, nutrients, and secrete angiocrine factors required for the survival, maintenance, and self-renewal of stem and progenitor cells. In the skeletal system, vasculature creates nu…

Author response for "Bone vasculature and bone marrow vascular niches in health and disease" Open

Junyu Chen, Michelle Hendriks, Alexandros Chatzis, Saravana K. Ramasamy, Anjali P. Kusumbe · 2020

Author response for "Bone vasculature and bone marrow vascular niches in health and disease" Open

Junyu Chen, Michelle Hendriks, Alexandros Chatzis, Saravana K. Ramasamy, Anjali P. Kusumbe · 2020

Angiocrine signals regulate quiescence and therapy resistance in bone metastasis Open

Amit Singh, Vimal Veeriah, Pengjun Xi, Rossella Labella, Junyu Chen , et al. · 2019

Bone provides supportive microenvironments for hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) and is a frequent site of metastasis. While incidences of bone metastases increase with age, the properties of the bone marrow…

Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML Open

Delfim Duarte, Edwin D. Hawkins, Olufolake Akinduro, Heather Ang, Katia De Filippo , et al. · 2017

Correction: Corrigendum: Regulation of monocyte cell fate by blood vessels mediated by Notch signalling Open

Jaba Gamrekelashvili, Roberto Giagnorio, Jasmin Jussofie, Oliver Soehnlein, Johan Duchêne , et al. · 2017

Nature Communications 7: Article number: 12597 (2016); Published: 31 August 2016; Updated: 3 May 2017 The authors inadvertently omitted Christine Häger, who was involved in the initial characterization of Notch mutant mice presented in thi…

Flow Dynamics and HSPC Homing in Bone Marrow Microvessels Open

M. Gabriele Bixel, Anjali P. Kusumbe, Saravana K. Ramasamy, Kishor K. Sivaraj, Stefan Butz , et al. · 2017

Structure and Functions of Blood Vessels and Vascular Niches in Bone Open

Saravana K. Ramasamy · 2017

Bone provides nurturing microenvironments for an array of cell types that coordinate important physiological functions of the skeleton, such as energy metabolism, mineral homeostasis, osteogenesis, and haematopoiesis. Endothelial cells for…

Confocal/two-photon microscopy in studying colonisation of cancer cells in bone using xenograft mouse models Open

Gloria Allocca, Anjali P. Kusumbe, Saravana K. Ramasamy, Ning Wang · 2016

Confocal and two-photon microscopy has been widely used in bone research to not only produce high quality, three-dimensional images but also to provide valuable structural and quantitative information. In this article, we describe step-by-…

Blood flow controls bone vascular function and osteogenesis Open

Saravana K. Ramasamy, Anjali P. Kusumbe, Maria Schiller, Dagmar Zeuschner, M. Gabriele Bixel , et al. · 2016

Correction: Corrigendum: Age-dependent modulation of vascular niches for haematopoietic stem cells Open

Anjali P. Kusumbe, Saravana K. Ramasamy, Tomer Itkin, Maarja Andaloussi Mäe, Urs H. Langen , et al. · 2016

Regulation of monocyte cell fate by blood vessels mediated by Notch signalling Open

Jaba Gamrekelashvili, Roberto Giagnorio, Jasmin Jussofie, Oliver Soehnlein, Johan Duchêne , et al. · 2016

Regulation of Hematopoiesis and Osteogenesis by Blood Vessel–Derived Signals Open

Saravana K. Ramasamy, Anjali P. Kusumbe, Tomer Itkin, Shiri Gur‐Cohen, Tsvee Lapidot , et al. · 2016

In addition to their conventional role as a versatile transport system, blood vessels provide signals controlling organ development, regeneration, and stem cell behavior. In the skeletal system, certain capillaries support perivascular ost…

Erratum: Corrigendum: Distinct bone marrow blood vessels differentially regulate haematopoiesis Open

Tomer Itkin, Shiri Gur‐Cohen, Joel A. Spencer, Amir Schajnovitz, Saravana K. Ramasamy , et al. · 2016

Distinct bone marrow blood vessels differentially regulate haematopoiesis Open

Tomer Itkin, Shiri Gur‐Cohen, Joel A. Spencer, Amir Schajnovitz, Saravana K. Ramasamy , et al. · 2016

Saravana K. Ramasamy YOU? Author Swipe