Saray Garasa
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View article: Supplementary video 2 from Depletion of Conventional Type-1 Dendritic Cells in Established Tumors Suppresses Immunotherapy Efficacy
Supplementary video 2 from Depletion of Conventional Type-1 Dendritic Cells in Established Tumors Suppresses Immunotherapy Efficacy Open
Video S2
View article: Supplementary video 3 from Depletion of Conventional Type-1 Dendritic Cells in Established Tumors Suppresses Immunotherapy Efficacy
Supplementary video 3 from Depletion of Conventional Type-1 Dendritic Cells in Established Tumors Suppresses Immunotherapy Efficacy Open
Video S3
View article: Supplementary figures and methods from Depletion of Conventional Type-1 Dendritic Cells in Established Tumors Suppresses Immunotherapy Efficacy
Supplementary figures and methods from Depletion of Conventional Type-1 Dendritic Cells in Established Tumors Suppresses Immunotherapy Efficacy Open
Supplementary figures 1-5 Supplementary methods
View article: Supplementary Video S2 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Supplementary Video S2 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Supplementary Video S2. Time-lapse confocal microscopy of co-cultures of tumor spheroids covered by radiation-induced NETs and cytotoxic lymphocytes. HT29 tumor cell-spheroids stained with CMRA (red) were cocultured or not with 2 Gy-irradi…
View article: Supplementary Figure S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Supplementary Figure S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Supplementary Figure S1. Autocrine IL-8 is secreted upon low-dose g-irradiation.
View article: Supplementary Table S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Supplementary Table S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Supplementary Table S1. Description of the cohorts of patients undergoing radiotherapy.
View article: Supplementary Video S2 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Supplementary Video S2 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Supplementary Video S2. Time-lapse confocal microscopy of co-cultures of tumor spheroids covered by radiation-induced NETs and cytotoxic lymphocytes. HT29 tumor cell-spheroids stained with CMRA (red) were cocultured or not with 2 Gy-irradi…
View article: Supplementary Figure S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Supplementary Figure S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Supplementary Figure S1. Autocrine IL-8 is secreted upon low-dose g-irradiation.
View article: Supplementary Table S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Supplementary Table S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Supplementary Table S1. Description of the cohorts of patients undergoing radiotherapy.
View article: Supplementary Figure S2 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Supplementary Figure S2 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Supplementary Figure S2. Radiation-induced NETs increase metastases to the lung in a spontaneously metastatic model.
View article: Data from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Data from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Purpose:Patients with cancer frequently undergo radiotherapy in their clinical management with unintended irradiation of blood vessels and copiously irrigated organs in which polymorphonuclear leukocytes circulate. Following the observatio…
View article: Supplementary Figure S3 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Supplementary Figure S3 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Supplementary Figure S3. The serum protein thioredoxin blocks low-dose g-irradiation induced NETosis.
View article: Supplementary Video S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Supplementary Video S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Supplementary Video S1. Time-lapse confocal microscopy showing the induction of NETosis by low-dose y-irradiation of human neutrophils. 3D reconstruction of a z-stack time-lapse acquisition of pre-stained neutrophils (red) treated with the…
View article: Data from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Data from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Purpose:Patients with cancer frequently undergo radiotherapy in their clinical management with unintended irradiation of blood vessels and copiously irrigated organs in which polymorphonuclear leukocytes circulate. Following the observatio…
View article: Supplementary Figure S3 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Supplementary Figure S3 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Supplementary Figure S3. The serum protein thioredoxin blocks low-dose g-irradiation induced NETosis.
View article: Supplementary Figure S2 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Supplementary Figure S2 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Supplementary Figure S2. Radiation-induced NETs increase metastases to the lung in a spontaneously metastatic model.
View article: Supplementary Video S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Supplementary Video S1 from Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Supplementary Video S1. Time-lapse confocal microscopy showing the induction of NETosis by low-dose y-irradiation of human neutrophils. 3D reconstruction of a z-stack time-lapse acquisition of pre-stained neutrophils (red) treated with the…
View article: Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps
Low-Dose Ionizing γ-Radiation Elicits the Extrusion of Neutrophil Extracellular Traps Open
Purpose: Patients with cancer frequently undergo radiotherapy in their clinical management with unintended irradiation of blood vessels and copiously irrigated organs in which polymorphonuclear leukocytes circulate. Following the observati…
View article: Intratumoral co‐injection of <scp>NK</scp> cells and <scp>NKG2A</scp>‐neutralizing monoclonal antibodies
Intratumoral co‐injection of <span>NK</span> cells and <span>NKG2A</span>‐neutralizing monoclonal antibodies Open
View article: Intratumoral immunotherapy with mRNAs encoding chimeric protein constructs encompassing IL-12, CD137 agonists, and TGF-β antagonists
Intratumoral immunotherapy with mRNAs encoding chimeric protein constructs encompassing IL-12, CD137 agonists, and TGF-β antagonists Open
Intratumoral immunotherapy strategies for cancer based on interleukin-12 (IL-12)-encoding cDNA and mRNA are under clinical development in combination with anti-PD-(L)1 monoclonal antibodies. To make the most of these approaches, we have co…
View article: Intratumoral neoadjuvant immunotherapy based on the BO-112 viral RNA mimetic
Intratumoral neoadjuvant immunotherapy based on the BO-112 viral RNA mimetic Open
BO-112 is a poly I:C-based viral mimetic that exerts anti-tumor efficacy when intratumorally delivered in mouse models. Intratumoral BO-112 synergizes in mice with systemic anti-PD-1 mAbs and this combination has attained efficacy in PD1-r…
View article: Data from A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα, and IL-1β
Data from A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα, and IL-1β Open
Interleukin-8 (CXCL8) produced in the tumor microenvironment correlates with poor response to checkpoint inhibitors and is known to chemoattract and activate immunosuppressive myeloid leukocytes. In human cancer, IL8 mRNA levels cor…
View article: Supplementary Figure from A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα, and IL-1β
Supplementary Figure from A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα, and IL-1β Open
Supplementary Figure from A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα, and IL-1β
View article: Supplementary Figure from A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα, and IL-1β
Supplementary Figure from A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα, and IL-1β Open
Supplementary Figure from A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα, and IL-1β
View article: Data from A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα, and IL-1β
Data from A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα, and IL-1β Open
Interleukin-8 (CXCL8) produced in the tumor microenvironment correlates with poor response to checkpoint inhibitors and is known to chemoattract and activate immunosuppressive myeloid leukocytes. In human cancer, IL8 mRNA levels cor…
View article: Supplementary Table 3 from CD137 (4-1BB) Costimulation Modifies DNA Methylation in CD8<sup>+</sup> T Cell–Relevant Genes
Supplementary Table 3 from CD137 (4-1BB) Costimulation Modifies DNA Methylation in CD8<sup>+</sup> T Cell–Relevant Genes Open
Primer sequences
View article: Supplementary Table 1 from CD137 (4-1BB) Costimulation Modifies DNA Methylation in CD8<sup>+</sup> T Cell–Relevant Genes
Supplementary Table 1 from CD137 (4-1BB) Costimulation Modifies DNA Methylation in CD8<sup>+</sup> T Cell–Relevant Genes Open
DNA methylation array results with urelumab
View article: Supplemental Figures 1-10 from Mitochondrial Morphological and Functional Reprogramming Following CD137 (4-1BB) Costimulation
Supplemental Figures 1-10 from Mitochondrial Morphological and Functional Reprogramming Following CD137 (4-1BB) Costimulation Open
Figure S1 shows that CD8 T cells with high mitochondrial transmembrane potential after CD137 stimulation have enlarged mitochondria. Fig S2 shows that CD137 induced mitochondrial changes are not due to enrichment of specific CD8 T cells su…
View article: supplementary figure 1 from CD137 (4-1BB) Costimulation Modifies DNA Methylation in CD8<sup>+</sup> T Cell–Relevant Genes
supplementary figure 1 from CD137 (4-1BB) Costimulation Modifies DNA Methylation in CD8<sup>+</sup> T Cell–Relevant Genes Open
No change in memory naive proportions and their DNA methylation in relevant genes
View article: Data from Mitochondrial Morphological and Functional Reprogramming Following CD137 (4-1BB) Costimulation
Data from Mitochondrial Morphological and Functional Reprogramming Following CD137 (4-1BB) Costimulation Open
T and NK lymphocytes express CD137 (4-1BB), a costimulatory receptor of the TNFR family whose function is exploitable for cancer immunotherapy. Mitochondria regulate the function and survival of T lymphocytes. Herein, we show that CD137 co…