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View article: Early weight gain predicts nutritional recovery in children with sickle cell anemia and severe acute malnutrition in Nigeria
Early weight gain predicts nutritional recovery in children with sickle cell anemia and severe acute malnutrition in Nigeria Open
Introduction Malnutrition in children with sickle cell anemia (SCA) is associated with higher rates of hospitalizations and early mortality, particularly in low-income settings such as northern Nigeria. However, there are no established gu…
View article: Including malnourished siblings in treatment improves nutritional outcomes for children with sickle cell anemia in Northern Nigeria: Results from a feasibility trial
Including malnourished siblings in treatment improves nutritional outcomes for children with sickle cell anemia in Northern Nigeria: Results from a feasibility trial Open
Best treatment approaches for malnutrition in children with sickle cell anemia (SCA) remain underexplored. We hypothesized that (1) children with SCA (CwSCA) enrolled in a malnutrition trial alongside their non-SCA siblings would experienc…
View article: The Genetic Architecture of Congenital Diarrhea and Enteropathy
The Genetic Architecture of Congenital Diarrhea and Enteropathy Open
We have characterized the broad genetic architecture of CODE disorders in a large case series of patients and identified three novel genes associated with CODEs. (Funded by the National Institutes of Health and others.).
View article: Impact of Food Insecurity on Malnutrition Treatment Response in Nigerian Children With Sickle Cell Anemia and Severe Acute Malnutrition
Impact of Food Insecurity on Malnutrition Treatment Response in Nigerian Children With Sickle Cell Anemia and Severe Acute Malnutrition Open
Background In this planned ancillary analysis of our completed clinical trial, we hypothesized that among older children with sickle cell anemia (SCA) and severe acute malnutrition, those with higher levels of food insecurity would have lo…
View article: Diet management in congenital diarrheas and enteropathies – general concepts and disease-specific approach, a narrative review
Diet management in congenital diarrheas and enteropathies – general concepts and disease-specific approach, a narrative review Open
Congenital diarrheas and enteropathies (CODE) are a group of rare, heterogenous, monogenic disorders that lead to chronic diarrhea in infancy. Definitive treatment is rarely available, and supportive treatment is the mainstay. Nutritional …
View article: A human milk oligosaccharide prevents intestinal inflammation in adulthood via modulating gut microbial metabolism
A human milk oligosaccharide prevents intestinal inflammation in adulthood via modulating gut microbial metabolism Open
Observational evidence suggests that human milk oligosaccharides (HMOs) promote the growth of commensal bacteria in early life and adulthood. However, the mechanisms by which HMOs benefit health through modulation of gut microbial homeosta…
View article: Impact of maternal depression on malnutrition treatment outcomes in older children with sickle cell anemia
Impact of maternal depression on malnutrition treatment outcomes in older children with sickle cell anemia Open
Background Malnutrition and sickle cell anemia (SCA) result in high childhood mortality rates. Although maternal depression is an established risk factor for malnutrition in younger children, little is known about its impact on treatment r…
View article: Identification of a functional peptide of a probiotic bacterium-derived protein for the sustained effect on preventing colitis
Identification of a functional peptide of a probiotic bacterium-derived protein for the sustained effect on preventing colitis Open
Several probiotic-derived factors have been identified as effectors of probiotics for exerting beneficial effects on the host. However, there is a paucity of studies to elucidate mechanisms of their functions. p40, a secretory protein, is …
View article: Risk factors in underweight older children with sickle cell anemia: a comparison of low- to high-income countries
Risk factors in underweight older children with sickle cell anemia: a comparison of low- to high-income countries Open
Previously, we demonstrated that older children with sickle cell anemia (SCA) living in Nigeria are at increased risk of death if they are underweight (weight-for-age z score < −1). We now conducted a cross-sectional study in low- and h…
View article: Epidemiology of Maternal Nutritional Status and Risk of Adverse Birth Outcomes in Undernourished Mothers with Sickle Cell Disease: A Systematic Review and Meta-Analysis Protocol
Epidemiology of Maternal Nutritional Status and Risk of Adverse Birth Outcomes in Undernourished Mothers with Sickle Cell Disease: A Systematic Review and Meta-Analysis Protocol Open
In pregnancies complicated by sickle cell disease (SCD), the maternal-fetal dyad is at high risk for mortality and morbidity. In healthy pregnancies, maternal nutritional status is a critical factor for the healthy growth and development o…
View article: Feasibility trial for the management of severe acute malnutrition in older children with sickle cell anemia in Nigeria
Feasibility trial for the management of severe acute malnutrition in older children with sickle cell anemia in Nigeria Open
Children with sickle cell anemia (SCA) living in Nigeria are at an increased risk of malnutrition, which contributes to increased morbidity and mortality. However, evidence-based guidelines for managing malnutrition in children with SCA ar…
View article: Fecal microbiota transplantation for the treatment of recurrent <i>Clostridioides difficile</i> (<i>Clostridium difficile</i>)
Fecal microbiota transplantation for the treatment of recurrent <i>Clostridioides difficile</i> (<i>Clostridium difficile</i>) Open
In immunocompetent adults with rCDI, FMT likely leads to a large increase in the resolution of recurrent Clostridioides difficile infection compared to alternative treatments such as antibiotics. There was no conclusive evidence regarding …
View article: Fecal transplantation for treatment of inflammatory bowel disease
Fecal transplantation for treatment of inflammatory bowel disease Open
FMT may increase the proportion of people with active UC who achieve clinical and endoscopic remission. The evidence was very uncertain about whether use of FMT in people with active UC impacted the risk of serious adverse events or improv…
View article: Modeling of a Novel Patient-Based MYO5B Point Mutation Reveals Insights Into MVID Pathogenesis
Modeling of a Novel Patient-Based MYO5B Point Mutation Reveals Insights Into MVID Pathogenesis Open
Microvillus inclusion disease (MVID) is a congenital disorder that presents with severe secretory diarrhea, typically within the first few hours of life. Inactivating mutations of myosin VB (MYO5B) cause MVID, which usually requires lifeti…
View article: Underweight children older than 5 years with sickle cell anemia are at risk for early mortality in a low-resource setting
Underweight children older than 5 years with sickle cell anemia are at risk for early mortality in a low-resource setting Open
Undernutrition is a risk factor for under-5 mortality and is also postulated to be a risk factor for mortality in older children and adults with sickle cell anemia (SCA). We tested the hypothesis that underweight is associated with mortali…
View article: Multichannel magnetogastrogram: a clinical marker for pediatric chronic nausea
Multichannel magnetogastrogram: a clinical marker for pediatric chronic nausea Open
Pediatric chronic nausea is a difficult-to-measure subjective complaint that requires objective diagnosis, clinical assessment, and individualized treatment plans. Our study demonstrates that multichannel MGG used in conjunction with custo…
View article: Development and Validation of Web-Based Tool to Predict Lamina Propria Fibrosis in Eosinophilic Esophagitis
Development and Validation of Web-Based Tool to Predict Lamina Propria Fibrosis in Eosinophilic Esophagitis Open
INTRODUCTION: Approximately half of esophageal biopsies from patients with eosinophilic esophagitis (EoE) contain inadequate lamina propria, making it impossible to determine the lamina propria fibrosis (LPF). This study aimed to develop a…
View article: The effect of chronic nausea on gastric slow wave spatiotemporal dynamics in children
The effect of chronic nausea on gastric slow wave spatiotemporal dynamics in children Open
Background Chronic nausea in adolescents with functional gastrointestinal disorders is an increasingly reported but poorly understood symptom that negatively affects quality of life. Functional gastrointestinal disorders are known to corre…
View article: Novel Insights Into Tissue-Specific Biochemical Alterations in Pediatric Eosinophilic Esophagitis Using Raman Spectroscopy
Novel Insights Into Tissue-Specific Biochemical Alterations in Pediatric Eosinophilic Esophagitis Using Raman Spectroscopy Open
INTRODUCTION: Elucidating esophageal biochemical composition in eosinophilic esophagitis (EoE) can offer novel insights into its pathogenesis, which remains unclear. Using Raman spectroscopy, we profiled and compared the biochemical compos…
View article: The Financial Burden of an Undiagnosed Congenital Diarrhea Disorder
The Financial Burden of an Undiagnosed Congenital Diarrhea Disorder Open
Congenital diarrheal disorders (CDD) are a group of rare conditions with diverse pathophysiologies that are often associated with significant morbidity or mortality. Most are caused by monogenic disorders that lead to intestinal epithelial…
P039 CLINICAL HYPNOSIS IN PEDIATRIC CROHN’S DISEASE: A RANDOMIZED CONTROLLED TRIAL Open
Background Crohn’s disease (CD) is a chronic, immune-mediated condition associated with abdominal pain, psychological comorbidities, and reduced quality of life (QoL), even in remission. Clinical hypnosis, involving focused relaxation and …
View article: CYP2C19 Phenotype and Risk of Proton Pump Inhibitor–Associated Infections
CYP2C19 Phenotype and Risk of Proton Pump Inhibitor–Associated Infections Open
PPI therapy is associated with higher infection rates in children with normal CYP2C19 function than in those with increased CYP2C19 function, highlighting this adverse effect of PPI therapy and the relevance of CYP2C19 genotypes to PPI the…
View article: The Salivary Microbiome Is Altered in Children With Eosinophilic Esophagitis and Correlates With Disease Activity
The Salivary Microbiome Is Altered in Children With Eosinophilic Esophagitis and Correlates With Disease Activity Open
OBJECTIVES: Eosinophilic esophagitis (EoE) is an allergen-mediated inflammatory disease affecting the esophagus. Although microbial communities may affect the host immune responses, little is known about the role of the microbiome in EoE. …
View article: Production of a Functional Factor, p40, by Lactobacillus rhamnosus GG Is Promoted by Intestinal Epithelial Cell-Secreted Extracellular Vesicles
Production of a Functional Factor, p40, by Lactobacillus rhamnosus GG Is Promoted by Intestinal Epithelial Cell-Secreted Extracellular Vesicles Open
The symbiotic relationship between the gut microbiome and the host provides a nutrient-rich environment for gut microbes and has beneficial effects on host health. Although the composition of the gut microbiome is known to be influenced by…