Sarmad Mehmood
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View article: Plasma extrachromosomal circular <scp>DNA</scp> as a biomarker in <scp>EGFR</scp> ‐targeted therapy of non‐small cell lung cancer
Plasma extrachromosomal circular <span>DNA</span> as a biomarker in <span>EGFR</span> ‐targeted therapy of non‐small cell lung cancer Open
The genomic instability associated with cancer can result in the formation of extrachromosomal circular DNA (eccDNA), which contributes to tumor heterogeneity, gene amplification, tumor evolution, and drug resistance. However, most studies…
View article: KRAS and BRAF genetic alterations in lung cancer: A case − control study
KRAS and BRAF genetic alterations in lung cancer: A case − control study Open
Context: Lung cancer (LC) is one of the most critical neoplastic abnormalities, having globally a high mortality rate. Knowledge about its genetic mutations and their association with clinically pathological features of LC is very importan…
View article: An mRNA-based reverse-vaccinology strategy to stimulate the immune response against Nipah virus in humans using fusion glycoproteins
An mRNA-based reverse-vaccinology strategy to stimulate the immune response against Nipah virus in humans using fusion glycoproteins Open
The zoonotic pathogen, Nipah virus, is considered a potential healthcare threat due to its high mortality rates and detrimental symptoms like encephalitis. Ribavirin, an antiviral drug helps in overcoming the number of casualties and reduc…
View article: A recurrent rare intronic variant in <scp><i>CAPN3</i></scp> alters <scp>mRNA</scp> splicing and causes autosomal recessive limb‐girdle muscular dystrophy‐1 in three Pakistani pedigrees
A recurrent rare intronic variant in <span><i>CAPN3</i></span> alters <span>mRNA</span> splicing and causes autosomal recessive limb‐girdle muscular dystrophy‐1 in three Pakistani pedigrees Open
Autosomal recessive limb‐girdle muscular dystrophy‐1 (LGMDR1) is an autosomal recessive disorder characterized by progressive weakness of the proximal limb and girdle muscles. Biallelic mutations in CAPN3 are reported frequently to cause L…
View article: Identification and in silico analysis of GALNS mutations causing Morquio A syndrome in eight consanguineous families
Identification and in silico analysis of GALNS mutations causing Morquio A syndrome in eight consanguineous families Open
Genetic deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS) due to mutations in the GALNS gene results in the pathogenesis of Morquio A syndrome. To date, more than 200 mutations have been reported in GALNS, resulting in variab…