Sarun Juengpanich
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View article: Correction: Trends in the applications of artificial intelligence in fatty liver diseases
Correction: Trends in the applications of artificial intelligence in fatty liver diseases Open
View article: Microneedle Patch for In Situ Neutrophil Monitoring
Microneedle Patch for In Situ Neutrophil Monitoring Open
Monitoring neutrophil levels plays an essential role in diagnosing infections and various diseases, as well as for managing specific treatments such as chemotherapy and radiotherapy. However, the traditional complete blood count technique …
View article: Cachexia-related consequences of glycemic metabolism: A multivariable and two-step Mendelian randomization study
Cachexia-related consequences of glycemic metabolism: A multivariable and two-step Mendelian randomization study Open
Background: Cachexia is a global burden that is caused by chronic diseases such as cancer. It is characterized by inflammation and progressive loss of muscle and adipose tissue, aggravating the patient’s health. Glycemic metabolism disorde…
View article: Lipid metabolism in tumor-infiltrating regulatory T cells: perspective to precision immunotherapy
Lipid metabolism in tumor-infiltrating regulatory T cells: perspective to precision immunotherapy Open
View article: Adavosertib-encapsulated metal-organic frameworks for p53-mutated gallbladder cancer treatment via synthetic lethality
Adavosertib-encapsulated metal-organic frameworks for p53-mutated gallbladder cancer treatment via synthetic lethality Open
Adavosertib (ADA) is a WEE1 inhibitor that exhibits a synthetic lethal effect on p53-mutated gallbladder cancer (GBC). However, drug resistance due to DNA damage response compensation pathways and high toxicity limits further applications.…
View article: Research progress and future prospects in glucose oxidase-like activity of Au NPs
Research progress and future prospects in glucose oxidase-like activity of Au NPs Open
With the advancement of scientific research, an increasing number of studies on metal nanozymes, particularly Au NPs, have been conducted. They possess glucose oxidase (GOD)-like activity and peroxidase (POD)-like activity, with GOD-like a…
View article: Pre-activated nanoparticles with persistent luminescence for deep tumor photodynamic therapy in gallbladder cancer
Pre-activated nanoparticles with persistent luminescence for deep tumor photodynamic therapy in gallbladder cancer Open
View article: Adhesive cryogel particles for bridging confined and irregular tissue defects
Adhesive cryogel particles for bridging confined and irregular tissue defects Open
Background Reconstruction of damaged tissues requires both surface hemostasis and tissue bridging. Tissues with damage resulting from physical trauma or surgical treatments may have arbitrary surface topographies, making tissue bridging ch…
View article: Inhibition of AMPK/PFKFB3 mediated glycolysis synergizes with penfluridol to suppress gallbladder cancer growth
Inhibition of AMPK/PFKFB3 mediated glycolysis synergizes with penfluridol to suppress gallbladder cancer growth Open
View article: Enhanced Recovery Care vs. Traditional Care in Laparoscopic Hepatectomy: A Systematic Review and Meta-Analysis
Enhanced Recovery Care vs. Traditional Care in Laparoscopic Hepatectomy: A Systematic Review and Meta-Analysis Open
Background Enhanced recovery care could alleviate surgical stress and accelerate the recovery rates of patients. Previous studies showed the benefits of enhanced recovery after surgery program in liver surgery, but the exact role in laparo…
View article: DNA damage response inhibition‐based combination therapies in cancer treatment: Recent advances and future directions
DNA damage response inhibition‐based combination therapies in cancer treatment: Recent advances and future directions Open
DNA molecules are subject to various lesions that can be detrimental to the cells. DNA damage response (DDR) pathways encompass a variety of mechanisms that cells employ in response to DNA damage. While DDR promotes genomic stability in no…
View article: Bortezomib‐Encapsulated Dual Responsive Copolymeric Nanoparticles for Gallbladder Cancer Targeted Therapy
Bortezomib‐Encapsulated Dual Responsive Copolymeric Nanoparticles for Gallbladder Cancer Targeted Therapy Open
Gallbladder cancer (GBC) is a rare but the most malignant type of biliary tract tumor. It is usually diagnosed at an advanced stage and conventional treatments are unsatisfactory. As a proteasome inhibitor, bortezomib (BTZ) exhibits excell…
View article: Biologic therapy for Crohn’s disease over the last 3 decades
Biologic therapy for Crohn’s disease over the last 3 decades Open
The bibliometric analysis emphasized the key contributions to the development of the specialized field. These data would provide useful research insights into biologic therapy for CD for clinicians and researchers.
View article: Inhibition of AMPK/PFKFB3 Mediated Glycolysis Synergizes with Penfluridol to Suppress Gallbladder Cancer Growth
Inhibition of AMPK/PFKFB3 Mediated Glycolysis Synergizes with Penfluridol to Suppress Gallbladder Cancer Growth Open
Background Penfluridol (PF) is an FDA approved antipsychotic drug, which shows anticancer activity recently. However, the anticancer effects and underlying mechanisms of PF on gallbladder cancers (GBCs) is not well-established. Methods Her…
View article: Comparison of Outcomes After Primary Laparoscopic Versus Open Approach for T1b/T2 Gallbladder Cancer
Comparison of Outcomes After Primary Laparoscopic Versus Open Approach for T1b/T2 Gallbladder Cancer Open
Objectives The primary laparoscopic approach (PLA) for T1b/T2 gallbladder cancer (GBC) remains contradicted. We aimed to compare the perioperative and long-term outcomes after PLA versus open approach (OA) for T1b/T2 GBC. Methods Patients …
View article: Targeting mutant p53 for cancer therapy: direct and indirect strategies
Targeting mutant p53 for cancer therapy: direct and indirect strategies Open
TP53 is a critical tumor-suppressor gene that is mutated in more than half of all human cancers. Mutations in TP53 not only impair its antitumor activity, but also confer mutant p53 protein oncogenic properties. The p53-targeted therapy ap…
View article: Artificial intelligence in gastroenterology and hepatology: Status and challenges
Artificial intelligence in gastroenterology and hepatology: Status and challenges Open
Originally proposed by John McCarthy in 1955, artificial intelligence (AI) has achieved a breakthrough and revolutionized the processing methods of clinical medicine with the increasing workloads of medical records and digital images. Doct…
View article: Development and Validation of a Nomogram for Predicting Survival in Gallbladder Cancer Patients With Recurrence After Surgery
Development and Validation of a Nomogram for Predicting Survival in Gallbladder Cancer Patients With Recurrence After Surgery Open
Background The management of gallbladder cancer (GBC) patients with recurrence who need additional therapy or intensive follow-up remains controversial. Therefore, we aim to develop a nomogram to predict survival in GBC patients with recur…
View article: Supplementary Material for: Clinical-Radiomic Analysis for Pretreatment Prediction of Objective Response to First Transarterial Chemoembolization in Hepatocellular Carcinoma
Supplementary Material for: Clinical-Radiomic Analysis for Pretreatment Prediction of Objective Response to First Transarterial Chemoembolization in Hepatocellular Carcinoma Open
Background: The preoperative selection of patients with intermediate-stage hepatocellular carcinoma (HCC) who are likely to have an objective response to first transarterial chemoembolization (TACE) remains challenging.
View article: Clinical-Radiomic Analysis for Pretreatment Prediction of Objective Response to First Transarterial Chemoembolization in Hepatocellular Carcinoma
Clinical-Radiomic Analysis for Pretreatment Prediction of Objective Response to First Transarterial Chemoembolization in Hepatocellular Carcinoma Open
Background: The preoperative selection of patients with intermediate-stage hepatocellular carcinoma (HCC) who are likely to have an objective response to first transarterial chemoembolization (TACE) remains challenging.
View article: Development of synthetic lethality in cancer: molecular and cellular classification
Development of synthetic lethality in cancer: molecular and cellular classification Open
Recently, genetically targeted cancer therapies have been a topic of great interest. Synthetic lethality provides a new approach for the treatment of mutated genes that were previously considered unable to be targeted in traditional genoty…
View article: Laparoscopic procedure is associated with lower morbidity for simultaneous resection of colorectal cancer and liver metastases: an updated meta-analysis
Laparoscopic procedure is associated with lower morbidity for simultaneous resection of colorectal cancer and liver metastases: an updated meta-analysis Open
View article: Advances in synthetic lethality for cancer therapy: cellular mechanism and clinical translation
Advances in synthetic lethality for cancer therapy: cellular mechanism and clinical translation Open
View article: Clinical-radiomics analysis for preoperative prediction of objective response to transarterial chemoembolization in hepatocellular carcinoma
Clinical-radiomics analysis for preoperative prediction of objective response to transarterial chemoembolization in hepatocellular carcinoma Open
View article: Deep learning for cost-effective accurate diagnosis of liver tumor based-on magnetic resonance imaging and clinical information: a retrospective study
Deep learning for cost-effective accurate diagnosis of liver tumor based-on magnetic resonance imaging and clinical information: a retrospective study Open
View article: Classification and mutation prediction based on histopathology H&E images in liver cancer using deep learning
Classification and mutation prediction based on histopathology H&E images in liver cancer using deep learning Open
Hepatocellular carcinoma (HCC) is the most common subtype of liver cancer, and assessing its histopathological grade requires visual inspection by an experienced pathologist. In this study, the histopathological H&E images from the Genomic…
View article: Deep Learning for Accurate Diagnosis of Liver Tumor Based on Magnetic Resonance Imaging and Clinical Data
Deep Learning for Accurate Diagnosis of Liver Tumor Based on Magnetic Resonance Imaging and Clinical Data Open
Background: Early-stage diagnosis and treatment can improve survival rates of liver cancer patients. Dynamic contrast-enhanced MRI provides the most comprehensive information for differential diagnosis of liver tumors. However, MRI …
View article: Laparoscopic surgery for early gallbladder carcinoma: A systematic review and meta-analysis
Laparoscopic surgery for early gallbladder carcinoma: A systematic review and meta-analysis Open
This systematic review and meta-analysis confirms that laparoscopic surgery is a safe and feasible alternative to open surgery with comparable survival and operation-related outcomes for early GBC.
View article: Prognostic factors and predictors of postoperative adjuvant transcatheter arterial chemoembolization benefit in patients with resected hepatocellular carcinoma
Prognostic factors and predictors of postoperative adjuvant transcatheter arterial chemoembolization benefit in patients with resected hepatocellular carcinoma Open
FHR and Barcelona Clinic Liver Cancer stages were regarded as prognostic factors for OS. Moreover, high FHR and the absence of MVI were important predictive factors, which can be used to assist clinicians in selecting which patients could …
View article: Role of cellular, molecular and tumor microenvironment in hepatocellular carcinoma: Possible targets and future directions in the regorafenib era
Role of cellular, molecular and tumor microenvironment in hepatocellular carcinoma: Possible targets and future directions in the regorafenib era Open
Hepatocellular carcinoma (HCC) remains as one of the major causes of cancer‐related mortality, despite the recent development of new therapeutic options. Regorafenib, an oral multikinase inhibitor, is the first systemic therapy that has a …