Sascha Brückmann
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View article: Intratumoral regulatory T cells are associated with treatment response to neoadjuvant chemotherapy and prognosis in gastroesophageal adenocarcinoma
Intratumoral regulatory T cells are associated with treatment response to neoadjuvant chemotherapy and prognosis in gastroesophageal adenocarcinoma Open
Gastroesophageal junction (GEJ) adenocarcinoma is an increasingly common cancer with complex biology and poor prognosis. The treatment strategy for locally advanced tumors involves multimodal treatment with perioperative chemotherapy. Howe…
View article: Efficacy of targeted therapy in lung cancer with rare ALK fusions
Efficacy of targeted therapy in lung cancer with rare ALK fusions Open
Paradigms about anaplastic lymphoma kinase (ALK)-driven non-small cell lung cancer (NSCLC) have been shaped by EML4::ALK. There is little evidence on the remaining patients, presenting with a plethora of other fusion partners (rare ALK). W…
View article: Algorithm-based intraoperative diagnosis of liver tumors using infrared spectroscopy
Algorithm-based intraoperative diagnosis of liver tumors using infrared spectroscopy Open
Liver cancer, including hepatocellular carcinoma (HCC), cholangiocellular carcinoma (CCC), and metastases, presents diagnostic challenges during surgery due to its infiltrative nature. Accurate intraoperative classification and margin asse…
View article: Trans-bronchial forceps biopsy for COVID-19 related diffuse parenchymal lung abnormalities
Trans-bronchial forceps biopsy for COVID-19 related diffuse parenchymal lung abnormalities Open
View article: Correlation of microscopic tumor extension with tumor microenvironment in esophageal cancer patients
Correlation of microscopic tumor extension with tumor microenvironment in esophageal cancer patients Open
Objective In the era of image-guided adaptive radiotherapy, definition of the clinical target volume (CTV) is a challenge in various solid tumors, including esophageal cancer (EC). Many tumor microenvironmental factors, e.g., tumor cell pr…
View article: NCT/DKFZ MASTER handbook of interpreting whole-genome, transcriptome, and methylome data for precision oncology
NCT/DKFZ MASTER handbook of interpreting whole-genome, transcriptome, and methylome data for precision oncology Open
Analysis of selected cancer genes has become an important tool in precision oncology but cannot fully capture the molecular features and, most importantly, vulnerabilities of individual tumors. Observational and interventional studies have…
View article: Response to (K)RAS<sup>G12C</sup> and EGFR Inhibition in a Patient With <i>NRAS</i><sup>G12C</sup>-Mutated Rectal Cancer
Response to (K)RAS<sup>G12C</sup> and EGFR Inhibition in a Patient With <i>NRAS</i><sup>G12C</sup>-Mutated Rectal Cancer Open
View article: Direct image to subtype prediction for brain tumors using deep learning
Direct image to subtype prediction for brain tumors using deep learning Open
Background Deep Learning (DL) can predict molecular alterations of solid tumors directly from routine histopathology slides. Since the 2021 update of the World Health Organization (WHO) diagnostic criteria, the classification of brain tumo…
View article: Metabolomics, machine learning and immunohistochemistry to predict succinate dehydrogenase mutational status in phaeochromocytomas and paragangliomas
Metabolomics, machine learning and immunohistochemistry to predict succinate dehydrogenase mutational status in phaeochromocytomas and paragangliomas Open
Phaeochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumours with a hereditary background in over one‐third of patients. Mutations in succinate dehydrogenase (SDH) genes increase the risk for PPGLs and several other tumour…