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Identification of a translatable animal model for dry eye disease using comparative analysis of tear proteins across species Open
The pig exhibited the highest similarity to humans in tear protein analysis among non-primate mammals, suggesting that the porcine model may be the most translational for DED research.
View article: Genetic Risk of Reticular Pseudodrusen in Age-Related Macular Degeneration: <i>HTRA1</i> /lncRNA <i>BX842242.1</i> dominates, with no evidence for Complement Cascade involvement
Genetic Risk of Reticular Pseudodrusen in Age-Related Macular Degeneration: <i>HTRA1</i> /lncRNA <i>BX842242.1</i> dominates, with no evidence for Complement Cascade involvement Open
Age-related macular degeneration (AMD) is a multifactorial retinal disease with a large genetic risk contribution. Reticular pseudodrusen (RPD) is a sub-phenotype of AMD with a high risk of progression to late vision threatening AMD. In a …
View article: RG7774 (Vicasinabin), an orally bioavailable cannabinoid receptor 2 (CB2R) agonist, decreases retinal vascular permeability, leukocyte adhesion, and ocular inflammation in animal models
RG7774 (Vicasinabin), an orally bioavailable cannabinoid receptor 2 (CB2R) agonist, decreases retinal vascular permeability, leukocyte adhesion, and ocular inflammation in animal models Open
Introduction Preclinical studies suggest that cannabinoid receptor type 2 (CB2R) activation has a therapeutic effect in animal models on chronic inflammation and vascular permeability, which are key pathological features of diabetic retino…
Implications of Ocular Confounding Factors for Aqueous Humor Proteomic and Metabolomic Analyses in Retinal Diseases Open
Considering AH protein concentration, lens status, and phenylephrine/tropicamide administration as confounders is crucial for accurate interpretation of AH protein data.
View article: Corrigendum to “Fibrosis in neovascular age-related macular degeneration: a review of definitions based on clinical imaging” [Surv Ophthalmol 68 (2023) 835–848/5]
Corrigendum to “Fibrosis in neovascular age-related macular degeneration: a review of definitions based on clinical imaging” [Surv Ophthalmol 68 (2023) 835–848/5] Open
The authors regret that the cited reference on page 843 in the sentence "The recently published review of fibrosis (…)" should be "16" (not "61", as cited). The authors would like to apologize for any inconvenience caused. Fibrosis in neov…
LASER FLARE PHOTOMETRY IN PRIMARY RHEGMATOGENOUS RETINAL DETACHMENT Open
Purpose: Exploratory analysis associated with the prospective, multicenter, randomized PRIVENT trial. To characterize the associations between laser flare photometry and anatomical and epidemiological features of rhegmatogenous retinal det…
View article: Whole Genome Sequencing Identifies Novel Common and Low-Frequency Variants Associated With Age-Related Macular Degeneration
Whole Genome Sequencing Identifies Novel Common and Low-Frequency Variants Associated With Age-Related Macular Degeneration Open
We describe the largest WGS study in AMD to date. We confirmed previously identified associations and identified several novel associations that are worth exploring in further follow-up studies.
Correlation of Aqueous, Vitreous, and Serum Protein Levels in Patients With Retinal Diseases Open
This study further supports AH as a clinically suitable source of protein biomarkers in retinal diseases. In addition, the identified AH and VH correlations can inform the selection of protein biomarker candidates in future translational r…
View article: Hyperreflective Material Boundary Remodeling in Neovascular Age-Related Macular Degeneration
Hyperreflective Material Boundary Remodeling in Neovascular Age-Related Macular Degeneration Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Systemic Metabolomics in a Framework of Genetics and Lifestyle in Age-Related Macular Degeneration
Systemic Metabolomics in a Framework of Genetics and Lifestyle in Age-Related Macular Degeneration Open
Insights into the pathogenesis of age-related macular degeneration (AMD), a leading cause of blindness, point towards a complex interplay of genetic and lifestyle factors triggering various systemic pathways. This study aimed to characteri…
View article: Fibrosis in neovascular age-related macular degeneration: A review of definitions based on clinical imaging
Fibrosis in neovascular age-related macular degeneration: A review of definitions based on clinical imaging Open
Despite the success of antiangiogenic therapy in controlling exudation in neovascular age-related macular degeneration (nAMD), the involvement of the outer retina in fibrosis results in gradual vision loss over time. The development of dru…
INCREASING EVIDENCE FOR THE SAFETY OF FOVEA-INVOLVING HALF-DOSE PHOTODYNAMIC THERAPY FOR CHRONIC CENTRAL SEROUS CHORIORETINOPATHY Open
Purpose: A retrospective study was performed with data from the prospective randomized controlled trials, PLACE and SPECTRA, assessing the risk of foveal atrophy and the likelihood of structural and functional improvement on optical cohere…
View article: Intravitreal 5-Fluorouracil and Heparin to Prevent Proliferative Vitreoretinopathy
Intravitreal 5-Fluorouracil and Heparin to Prevent Proliferative Vitreoretinopathy Open
Rate of PVR did not differ between adjuvant therapy with 5-FU and LMWH and placebo treatment in eyes with RRD.
View article: Analysis of hemopexin plasma levels in patients with age-related macular degeneration.
Analysis of hemopexin plasma levels in patients with age-related macular degeneration. Open
In this study, HPX levels were not associated with AMD or AMD-associated variants at the CFH locus. The finding of a previous pQTL study that variants at the CFH locus were associated with HPX levels was also not confirmed in this study.
EFFICACY OF HALF-DOSE PHOTODYNAMIC THERAPY VERSUS HIGH-DENSITY SUBTHRESHOLD MICROPULSE LASER FOR TREATING PIGMENT EPITHELIAL DETACHMENTS IN CHRONIC CENTRAL SEROUS CHORIORETINOPATHY Open
Purpose: Comparing the effect of half-dose photodynamic therapy and high-density subthreshold micropulse laser treatment on retinal pigment epithelial detachments (PEDs) in chronic central serous chorioretinopathy. Methods: This study incl…
View article: Semi-Quantitative Multiplex Profiling of the Complement System Identifies Associations of Complement Proteins with Genetic Variants and Metabolites in Age-Related Macular Degeneration
Semi-Quantitative Multiplex Profiling of the Complement System Identifies Associations of Complement Proteins with Genetic Variants and Metabolites in Age-Related Macular Degeneration Open
Age-related macular degeneration (AMD) is a major cause of vision loss among the elderly in the Western world. The complement system has been identified as one of the main AMD disease pathways. We performed a comprehensive expression analy…
Systemic complement levels in patients with age-related macular degeneration carrying rare or low-frequency variants in the <i>CFH</i> gene Open
Age-related macular degeneration (AMD) is a major cause of vision loss among the elderly in the Western world. Genetic variants in the complement factor H (CFH) gene are associated with AMD, but the functional consequences of many of these…
Common haplotypes at the CFH locus and low-frequency variants in CFHR2 and CFHR5 associate with systemic FHR concentrations and age-related macular degeneration Open
Age-related macular degeneration (AMD) is the principal cause of blindness in the elderly population. A strong effect on AMD risk has been reported for genetic variants at the CFH locus, encompassing complement factor H (CFH) and the compl…
Long‐term follow‐up of chronic central serous chorioretinopathy after successful treatment with photodynamic therapy or micropulse laser Open
Purpose To describe the treatment outcomes and recurrence risk of chronic central serous chorioretinopathy (cCSC) in patients who had complete resolution of subretinal fluid (SRF) after either primary half‐dose photodynamic therapy (PDT) o…
Genetic and environmental risk factors for reticular pseudodrusen in the EUGENDA study. Open
RPD share a variety of genetic and nongenetic risk factors with AMD. Future AMD grading systems should integrate RPD as an important risk phenotype.
Increased pro-MMP9 plasma levels are associated with neovascular age-related macular degeneration and with the risk allele of rs142450006 near <i>MMP9</i>. Open
The results of our MMP9 analyses indicate that nAMD patients have on average higher systemic MMP9 levels than control individuals, and that this is partly driven by the rs142450006 variant near MMP9. This finding might be an interesting st…
The Effect of Genetic Variants Associated With Age-Related Macular Degeneration Varies With Age Open
Effect sizes and MAF of genetic risk factors for late AMD differed among the age groups. These results could guide future work on AMD risk assessment in older individuals.