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View article: ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury
ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury Open
View article: ANXA7 Regulates Platelet Lipid Metabolism and Ca <sup>2+</sup> Release in Arterial Thrombosis
ANXA7 Regulates Platelet Lipid Metabolism and Ca <sup>2+</sup> Release in Arterial Thrombosis Open
Rationale: Platelet activation after contact to subendothelial collagen leads to acute arterial thrombosis. ANXA7 (Annexin A7) is a phospholipid-binding protein participating in the regulation of intracellular Ca 2+ and exocytosis. Objecti…
View article: Human Platelets Take up Anti-VEGF Agents
Human Platelets Take up Anti-VEGF Agents Open
Purpose. Growing evidence suggests different systemic exposure of anti-vascular endothelial growth factor (anti-VEGF) agents with repeated intravitreal application. Since the penetration of anti-VEGF agents through vascular barrier was rep…
View article: Annexin A7 is a critical regulator of Ca2+ mobilization and lipid metabolism during platelet activation and arterial thrombosis
Annexin A7 is a critical regulator of Ca2+ mobilization and lipid metabolism during platelet activation and arterial thrombosis Open
Background Platelet activation after contact to subendothelial collagen following atherosclerotic plaque rupture can lead to arterial thrombosis with acute thrombotic vascular occlusion. Annexin A7 (AnxA7) is an intracellular Ca2+- and pho…
View article: P4403Inhibitory mechanisms of very low dose rivaroxaban in non-ST-elevation myocardial infarction
P4403Inhibitory mechanisms of very low dose rivaroxaban in non-ST-elevation myocardial infarction Open
View article: Identification of key lipids critical for platelet activation by comprehensive analysis of the platelet lipidome
Identification of key lipids critical for platelet activation by comprehensive analysis of the platelet lipidome Open
Key Points First quantitative analysis of dynamic platelet lipidome modulation reveals key lipids altered in platelet activation. Lipidomics in a knockout approach unravel SMPD1 as a powerful modulator of platelet lipidome and activation v…
View article: Inhibitory mechanisms of very low–dose rivaroxaban in non–ST-elevation myocardial infarction
Inhibitory mechanisms of very low–dose rivaroxaban in non–ST-elevation myocardial infarction Open
Key Points VLD rivaroxaban significantly reduces platelet-dependent thrombin generation and thrombus formation on top of DAPT in patients with ACS. Adjunctive treatment with VLD rivaroxaban additionally reduced TG and thrombus formation in…
View article: CK2β regulates thrombopoiesis and Ca2+-triggered platelet activation in arterial thrombosis
CK2β regulates thrombopoiesis and Ca2+-triggered platelet activation in arterial thrombosis Open
Key Points CK2β is critically required for thrombopoiesis by regulating tubulin polymerization, MK fragmentation, and proplatelet formation. CK2β facilitates inositol triphosphate–mediated increase of cytosolic Ca2+ and is essential for pl…
View article: P6040Extracellular cyclophilin a augments platelet-dependent thrombosis and thrombo-inflammation without affecting physiological hemostasis
P6040Extracellular cyclophilin a augments platelet-dependent thrombosis and thrombo-inflammation without affecting physiological hemostasis Open
Introduction: Cyclophilin A (CyPA) is a ubiquitously expressed chaperon protein that contains PPIase activity and regulates intracellular functions, like protein folding and Ca2+ signaling.Upon activation CyPA is released into the extracel…
View article: 3132Casein Kinase 2 is a critical regulator of platelet Ca2+ signaling and activation in arterial thrombosis
3132Casein Kinase 2 is a critical regulator of platelet Ca2+ signaling and activation in arterial thrombosis Open
View article: P6264SGK1 deficiency protects from neointima formation via reduction of Ca2+-dependent VSMC migration
P6264SGK1 deficiency protects from neointima formation via reduction of Ca2+-dependent VSMC migration Open
View article: Doxepin inhibits GPVI-dependent platelet Ca<sup>2+</sup>signaling and collagen-dependent thrombus formation
Doxepin inhibits GPVI-dependent platelet Ca<sup>2+</sup>signaling and collagen-dependent thrombus formation Open
Platelet adhesion, activation, and aggregation are essential for primary hemostasis, but are also critically involved in the development of acute arterial thrombotic occlusion. Stimulation of the collagen receptor glycoprotein VI (GPVI) le…
View article: Extracellular Cyclophilin A Augments Platelet-Dependent Thrombosis and Thromboinflammation
Extracellular Cyclophilin A Augments Platelet-Dependent Thrombosis and Thromboinflammation Open
Cyclophilin A (CyPA) is involved in the pathophysiology of several inflammatory and cardiovascular diseases. To our knowledge, there is no specific inhibitor targeting extracellular CyPA without affecting other extracellular cyclophilins o…
View article: Alternative Splicing Substantially Diversifies the Transcriptome during Early Photomorphogenesis and Correlates with the Energy Availability in Arabidopsis
Alternative Splicing Substantially Diversifies the Transcriptome during Early Photomorphogenesis and Correlates with the Energy Availability in Arabidopsis Open
Plants use light as source of energy and information to detect diurnal rhythms and seasonal changes. Sensing changing light conditions is critical to adjust plant metabolism and to initiate developmental transitions. Here, we analyzed tran…