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View article: Ex-vivo validation of nine algorithms for quantifying infarcts with late gadolinium enhancement cardiovascular magnetic resonance
Ex-vivo validation of nine algorithms for quantifying infarcts with late gadolinium enhancement cardiovascular magnetic resonance Open
EWA, Heiberg-08, FWHM, and FACT all perform on par with manual delineation, however, Heiberg-08, and FWHM are not suitable for phase sensitive inversion recovery images. The technique used to measure infarct size should be disclosed in cli…
View article: Longitudinal assessment of myocardial edema following experimental acute myocardial infarction using a comprehensive CMR protocol
Longitudinal assessment of myocardial edema following experimental acute myocardial infarction using a comprehensive CMR protocol Open
Background Preclinical and clinical data following acute myocardial infarction (MI) and reperfusion have shown a bimodal pattern of edematous myocardium at risk (MaR) on cardiovascular magnetic resonance (CMR) imaging during the first week…
View article: Non-contrast-enhanced magnetic resonance imaging can be used to assess renal cortical and medullary volumes—A validation study
Non-contrast-enhanced magnetic resonance imaging can be used to assess renal cortical and medullary volumes—A validation study Open
Background Magnetic resonance imaging (MRI) biomarkers can diagnose and prognosticate kidney disease. Renal volume validation studies are however scarce, and measurements are limited by use of contrast agent or advanced post-processing. Pu…
View article: Decreased atrioventricular plane displacement after acute myocardial infarction yields a concomitant decrease in stroke volume
Decreased atrioventricular plane displacement after acute myocardial infarction yields a concomitant decrease in stroke volume Open
Acute myocardial infarction (AMI) can progress to heart failure, which has a poor prognosis. Normally, 60% of stroke volume (SV) is attributed to the longitudinal ventricular shortening and lengthening evident in the atrioventricular plane…
View article: Measuring extracellular volume fraction by MRI: First verification of values given by clinical sequences
Measuring extracellular volume fraction by MRI: First verification of values given by clinical sequences Open
Purpose To verify MR measurements of myocardial extracellular volume fraction (ECV) based on clinically applicable T1‐mapping sequences against ECV measurements by radioisotope tracer in pigs and to relate the results to those obtained in …
View article: Noninvasive Quantification of Pressure-Volume Loops From Brachial Pressure and Cardiovascular Magnetic Resonance
Noninvasive Quantification of Pressure-Volume Loops From Brachial Pressure and Cardiovascular Magnetic Resonance Open
Background: Pressure-volume (PV) loops provide a wealth of information on cardiac function but are not readily available in clinical routine or in clinical trials. This study aimed to develop and validate a noninvasive method to compute in…
View article: Modulations in extracellular calcium lead to H<sup>+</sup>-ATPase-dependent acid secretion: a clarification of PPI failure
Modulations in extracellular calcium lead to H<sup>+</sup>-ATPase-dependent acid secretion: a clarification of PPI failure Open
The H + ,K + -ATPase was identified as the primary proton secretory pathway in the gastric parietal cell and is the pharmacological target of agents suppressing acid secretion. Recently, we identified a second acid secretory protein expres…
View article: Importance of standardizing timing of hematocrit measurement when using cardiovascular magnetic resonance to calculate myocardial extracellular volume (ECV) based on pre- and post-contrast T1 mapping
Importance of standardizing timing of hematocrit measurement when using cardiovascular magnetic resonance to calculate myocardial extracellular volume (ECV) based on pre- and post-contrast T1 mapping Open
View article: Isolated pulmonary regurgitation causes decreased right ventricular longitudinal function and compensatory increased septal pumping in a porcine model
Isolated pulmonary regurgitation causes decreased right ventricular longitudinal function and compensatory increased septal pumping in a porcine model Open
Aim Longitudinal ventricular contraction is a parameter of cardiac performance with predictive power. Right ventricular (RV) longitudinal function is impaired in patients with free pulmonary regurgitation ( PR ) following corrective surger…
View article: Nanoparticles that deliver triplex-forming peptide nucleic acid molecules correct F508del CFTR in airway epithelium
Nanoparticles that deliver triplex-forming peptide nucleic acid molecules correct F508del CFTR in airway epithelium Open
Cystic fibrosis (CF) is a lethal genetic disorder most commonly caused by the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. It is not readily amenable to gene therapy because of its systemic natur…