Sascha Pahernik
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View article: Robotic-assisted pyeloplasty and percutaneous nephrolithotomy for simultaneous treatment of ureteropelvic junction obstruction and calyx stones: Initial series and stone-free outcomes
Robotic-assisted pyeloplasty and percutaneous nephrolithotomy for simultaneous treatment of ureteropelvic junction obstruction and calyx stones: Initial series and stone-free outcomes Open
View article: Transcript Markers from Urinary Extracellular Vesicles for Predicting Risk Reclassification of Prostate Cancer Patients on Active Surveillance
Transcript Markers from Urinary Extracellular Vesicles for Predicting Risk Reclassification of Prostate Cancer Patients on Active Surveillance Open
Serum prostate-specific antigen (PSA), its derivatives, and magnetic resonance tomography (MRI) lack sufficient specificity and sensitivity for the prediction of risk reclassification of prostate cancer (PCa) patients on active surveillanc…
View article: Durability of Functional Outcomes After MRI-Guided Transurethral Ultrasound Ablation of the Prostate
Durability of Functional Outcomes After MRI-Guided Transurethral Ultrasound Ablation of the Prostate Open
Long-term data on functional outcomes after MRI-guided transurethral ultrasound ablation (TULSA) are limited. We assess the 5-year post-TULSA durability of outcomes for patient-reported genitourinary function, bowel function, and adverse e…
View article: Personalized Prediction of Patient Radiation Exposure for Therapy of Urolithiasis: An Application and Comparison of Six Machine Learning Algorithms
Personalized Prediction of Patient Radiation Exposure for Therapy of Urolithiasis: An Application and Comparison of Six Machine Learning Algorithms Open
The prediction of radiation exposure is an important tool for the choice of therapy modality and becomes, as a component of patient-informed consent, increasingly important for both surgeon and patient. The final goal is the implementation…
View article: What would one of the greatest natural scientists and educators of the eighteenth century, Georg Christoph Lichtenberg, say about the current therapy management of patients with penile cancer?
What would one of the greatest natural scientists and educators of the eighteenth century, Georg Christoph Lichtenberg, say about the current therapy management of patients with penile cancer? Open
View article: Neural Networks Modeling for Prediction of Required Resources for Personalized Endourologic Treatment of Urolithiasis
Neural Networks Modeling for Prediction of Required Resources for Personalized Endourologic Treatment of Urolithiasis Open
When scheduling surgeries for urolithiasis, the lack of information about the complexity of procedures and required instruments can lead to mismanagement, cancellations of elective surgeries and financial risk for the hospital. The aim of …
View article: Single-Center Evaluation of Treatment Success Using Two Different Protocols for MRI–Guided Transurethral Ultrasound Ablation of Localized Prostate Cancer
Single-Center Evaluation of Treatment Success Using Two Different Protocols for MRI–Guided Transurethral Ultrasound Ablation of Localized Prostate Cancer Open
Objectives To assess differences in 24-month oncologic and functional outcomes in men with low to intermediate-risk prostate cancer treated with MRI-guided transurethral ultrasound ablation (TULSA) using intentionally conservative versus i…
View article: Modulating the Heat Sensitivity of Prostate Cancer Cell Lines In Vitro: A New Impact for Focal Therapies
Modulating the Heat Sensitivity of Prostate Cancer Cell Lines In Vitro: A New Impact for Focal Therapies Open
Focal therapies such as high-intensity focused ultrasound (HiFU) are an emerging therapeutic option for prostate cancer (PCA). Thermal or mechanical effects mediate most therapies. Moreover, locally administered drugs such as bicalutamide …
View article: Cardiopulmonary Bypass has No Significant Impact on Survival in Patients Undergoing Nephrectomy and Level III-IV Inferior Vena Cava Thrombectomy: Multi-Institutional Analysis
Cardiopulmonary Bypass has No Significant Impact on Survival in Patients Undergoing Nephrectomy and Level III-IV Inferior Vena Cava Thrombectomy: Multi-Institutional Analysis Open
The impact of cardiopulmonary bypass (CPB) usage in level III-IV tumor thrombectomy on surgical and oncologic outcomes is unknown. We sought to determine the impact of cardiopulmonary bypass (CPB) on overall and cancer specific survival, a…
View article: Five-year outcomes from a prospective phase I study of MRI-guided transurethral ultrasound ablation in men with localized prostate cancer
Five-year outcomes from a prospective phase I study of MRI-guided transurethral ultrasound ablation in men with localized prostate cancer Open
View article: Renal cell carcinoma with inferior vena cava involvement: Prognostic effect of tumor thrombus consistency on cancer specific survival: Tumor Thrombus Consistency and Survival
Renal cell carcinoma with inferior vena cava involvement: Prognostic effect of tumor thrombus consistency on cancer specific survival: Tumor Thrombus Consistency and Survival Open
Renal cell carcinoma forming a venous tumor thrombus (VTT) in the inferior vena cava (IVC) has a poor prognosis. Recent investigations have been focused on prognostic markers of survival. Thrombus consistency (TC) has been proposed to be o…
View article: Association of an organ transplant-based approach with a dramatic reduction in postoperative complications following radical nephrectomy and tumor thrombectomy in renal cell carcinoma
Association of an organ transplant-based approach with a dramatic reduction in postoperative complications following radical nephrectomy and tumor thrombectomy in renal cell carcinoma Open
View article: Clinical characteristics, treatment outcomes and potential novel therapeutic options for patients with neuroendocrine carcinoma of the prostate
Clinical characteristics, treatment outcomes and potential novel therapeutic options for patients with neuroendocrine carcinoma of the prostate Open
EP in first-line shows notable ORR, however limited PFS. For second-line therapy, topotecan, FOLFIRI, enzalutamide, abiraterone and immune checkpoint blockade are treatment options. Prostatic carcinoids can be treated in analogy to well di…
View article: Correlation between genomic index lesions and mpMRI and 68Ga-PSMA-PET/CT imaging features in primary prostate cancer
Correlation between genomic index lesions and mpMRI and 68Ga-PSMA-PET/CT imaging features in primary prostate cancer Open
View article: Clinical characteristics, treatment outcomes and potential novel therapeutic options for patients with neuroendocrine carcinoma of the prostate (NEPC)
Clinical characteristics, treatment outcomes and potential novel therapeutic options for patients with neuroendocrine carcinoma of the prostate (NEPC) Open
Background: Neuroendocrine Carcinomas of the prostate (NEPCs) are rare tumors with poor prognosis. While platinum and etoposide based chemotherapy regimens (PE) are commonly applied in first-line for advanced disease, clinical-grade eviden…
View article: Ablation energies for focal treatment of prostate cancer
Ablation energies for focal treatment of prostate cancer Open
View article: Genomic features of renal cell carcinoma with venous tumor thrombus
Genomic features of renal cell carcinoma with venous tumor thrombus Open
View article: Survival outcomes of patients with germ cell tumors treated with high-dose chemotherapy for refractory or relapsing disease
Survival outcomes of patients with germ cell tumors treated with high-dose chemotherapy for refractory or relapsing disease Open
HDCT/ASCT offers a potential curative strategy for patients with relapsed GCT. Improvement is still needed in patients with intermediate, high, and very high IPFSG risk group.
View article: MP30-03 MRI-GUIDED TRANSURETHRAL ULTRASOUND ABLATION IN PATIENTS WITH LOCALIZED PROSTATE CANCER: 3-YEAR OUTCOMES OF A PROSPECTIVE PHASE I STUDY
MP30-03 MRI-GUIDED TRANSURETHRAL ULTRASOUND ABLATION IN PATIENTS WITH LOCALIZED PROSTATE CANCER: 3-YEAR OUTCOMES OF A PROSPECTIVE PHASE I STUDY Open
You have accessJournal of UrologyProstate Cancer: Localized: Ablative Therapy I1 Apr 2018MP30-03 MRI-GUIDED TRANSURETHRAL ULTRASOUND ABLATION IN PATIENTS WITH LOCALIZED PROSTATE CANCER: 3-YEAR OUTCOMES OF A PROSPECTIVE PHASE I STUDY Joseph…
View article: Prospective Single Center Trial of Next-Generation Sequencing Analysis in Metastatic Renal Cell Cancer: the MORE-TRIAL
Prospective Single Center Trial of Next-Generation Sequencing Analysis in Metastatic Renal Cell Cancer: the MORE-TRIAL Open
This study is aiming at exploring genetic profiles with prognostic and predictive value in metastatic renal cell cancer patients. Clonal evolution facilitating resistance to systemic treatment will be investigated by repeat biopsies.
View article: Risk factors of long-term postoperative renal function after partial nephrectomy in a solitary kidney
Risk factors of long-term postoperative renal function after partial nephrectomy in a solitary kidney Open
The effect of warm ischemia time (WIT) on longterm renal function after partial nephrectomy remains controversial. In this retrospectively cohort study, 75 solitary kidney patients were included and the effects of warm ischemia time, preop…
View article: Impact of lymph node dissection at the time of radical nephrectomy with tumor thrombectomy on oncological outcomes: Results from the International Renal Cell Carcinoma-Venous Thrombus Consortium (IRCC-VTC)
Impact of lymph node dissection at the time of radical nephrectomy with tumor thrombectomy on oncological outcomes: Results from the International Renal Cell Carcinoma-Venous Thrombus Consortium (IRCC-VTC) Open
View article: Prognostic relevance of androgen receptor expression in renal cell carcinomas
Prognostic relevance of androgen receptor expression in renal cell carcinomas Open
Patients affected by AR-positive tumors exhibit a favorable prognosis by multiple Cox regression, while loss of AR expression is related to aggressive disease. Therefore, assessing AR expression offers valuable prognostic information that …
View article: Patient-specific molecular alterations are associated with metastatic clear cell renal cell cancer progressing under tyrosine kinase inhibitor therapy
Patient-specific molecular alterations are associated with metastatic clear cell renal cell cancer progressing under tyrosine kinase inhibitor therapy Open
The availability of tyrosine kinase inhibitors (TKI) during the past ten years has led to improved response and overall survival of patients suffering from metastatic clear cell renal cell carcinoma (ccRCC). However, most of these tumors w…
View article: Prognostic and discriminative power of the 7th TNM classification for patients with surgically treated papillary renal cell carcinoma: results of a multi-institutional validation study (CORONA subtype project)
Prognostic and discriminative power of the 7th TNM classification for patients with surgically treated papillary renal cell carcinoma: results of a multi-institutional validation study (CORONA subtype project) Open
The 2010 TNM staging system can be reliably applied to papRCC patients and allows certain prognostic discrimination.
View article: Outcome of papillary versus clear cell renal cell carcinoma varies significantly in non-metastatic disease
Outcome of papillary versus clear cell renal cell carcinoma varies significantly in non-metastatic disease Open
Well-documented reports of patients’ experiences with different treatments are important for helping localised prostate cancer (LPC) patients choose among the available treatment options.To document differences in patient-reported outcomes…
View article: Quality of life and functional outcome after infravesical desobstruction and HIFU treatment for localized prostate cancer
Quality of life and functional outcome after infravesical desobstruction and HIFU treatment for localized prostate cancer Open
HIFU treatment for localized prostate cancer shows acceptable oncological safety. Quality of life after HIFU is better than in the general population and ranges within those of standard treatment options compared to literature. HIFU seems …
View article: Collecting Duct (Bellini Duct) Renal Cell Carcinoma: Oncologic Outcome and Therapeutic Management
Collecting Duct (Bellini Duct) Renal Cell Carcinoma: Oncologic Outcome and Therapeutic Management Open
Objectives: To evaluate treatment and prognosis of collecting duct renal cell carcinoma (CDRCC) in three institutions. Methods: The data of CDRCC patients were collected retrospectively from 3 participating institutions. Results: A total o…
View article: Efficacy of Cabazitaxel Treatment in Metastatic Castration Resistant Prostate Cancer in Second and Later Lines. An Experience from Two German Centers
Efficacy of Cabazitaxel Treatment in Metastatic Castration Resistant Prostate Cancer in Second and Later Lines. An Experience from Two German Centers Open
Purpose: Several new treatment options for patients with metastatic castration resistant prostate cancer (mCRPC) have been approved within the last years - among them cabazitaxel (CAB), abiraterone acetate, enzalutamide, and radium-…
View article: Paraganglioma of the Seminal Vesicle Case Report and Review of the Literature
Paraganglioma of the Seminal Vesicle Case Report and Review of the Literature Open
Background: The present case report describes an extremely rare case of a norepinephrine secreting extraadrenal paraganglioma (PGL) located in the seminal vesicle. Case Presentation: A 36-year-old patient had si…