Sasikumar J. Soumya
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View article: <b>Multitarget-Directed Multiple Ligands in Anti-VEGF Resistant Glioblastoma Therapeutics: An in Silico Approach to Identify Potential Phytochemicals</b>
<b>Multitarget-Directed Multiple Ligands in Anti-VEGF Resistant Glioblastoma Therapeutics: An in Silico Approach to Identify Potential Phytochemicals</b> Open
Angiogenesis is an important process in tumor progression. Vascular endothelial growth factor (VEGF) is the key factor regulating angiogenesis, and hence, anti-VEGF therapy is considered a useful therapeutic approach in tumor conditions. H…
View article: Multi-target and natural product-based multi-drug approach for anti-VEGF resistance in glioblastoma
Multi-target and natural product-based multi-drug approach for anti-VEGF resistance in glioblastoma Open
Glioblastoma (GBM) remains a formidable challenge in neuro-oncology due to its aggressive nature and propensity for therapeutic resistance. Anti-vascular endothelial growth factor (VEGF) therapies, although promising, often encounter resis…
View article: Chrysin inhibits adipogenesis by modulating PPARγ: <i>in silico</i> and <i>in vitro</i> studies
Chrysin inhibits adipogenesis by modulating PPARγ: <i>in silico</i> and <i>in vitro</i> studies Open
Adipose tissue is the major storage site of lipids and plays a vital role in energy homeostasis. Adipogenesis is a well-regulated process wherein preadipocytes differentiate into adipocytes. It requires the sequential activation of numerou…
View article: Multiple Targets Directed Multiple Ligands: An In Silico and In Vitro Approach to Evaluating the Effect of Triphala on Angiogenesis
Multiple Targets Directed Multiple Ligands: An In Silico and In Vitro Approach to Evaluating the Effect of Triphala on Angiogenesis Open
Angiogenesis is critical in both physiological and pathological conditions and targeting angiogenesis is a promising strategy for the development of therapies against cancer; however, cells develop resistance to anti-angiogenic therapy, ne…
View article: VEGF-A/VEGFR2 signaling network in endothelial cells relevant to angiogenesis
VEGF-A/VEGFR2 signaling network in endothelial cells relevant to angiogenesis Open
Vascular endothelial growth factor-A (VEGF-A) is essential for endothelial cell functions associated with angiogenesis. Signal transduction networks initiated by VEGFA/VEGFR2, the most prominent ligand-receptor complex in the VEGF system, …