Sasisekhar Bennuru
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View article: Wb5, a novel biomarker for monitoring efficacy and success of mass drug administration programs for Wuchereria bancrofti elimination
Wb5, a novel biomarker for monitoring efficacy and success of mass drug administration programs for Wuchereria bancrofti elimination Open
The success of mass drug administration at reducing the prevalence of lymphatic filariasis in endemic areas has led to an increased need for highly sensitive and specific diagnostic assays. To be useful in post-elimination surveillance in …
View article: Molecular Mimicry Drives Locally Produced Autoantibodies in Subarachnoid Neurocysticercosis
Molecular Mimicry Drives Locally Produced Autoantibodies in Subarachnoid Neurocysticercosis Open
Background Subarachnoid neurocysticercosis (SANCC) is a condition manifested by chronic meningitis induced by infection with Taenia solium. We sought to determine if there is evidence of autoantibody production in SANCC and whether local p…
View article: Optimized strategy for real-time qPCR detection of Onchocerca volvulus DNA in pooled Simulium sp. blackfly vectors
Optimized strategy for real-time qPCR detection of Onchocerca volvulus DNA in pooled Simulium sp. blackfly vectors Open
Background Onchocerca volvulus is a filarial parasite that is a major cause of dermatitis and blindness in endemic regions primarily in sub-Saharan Africa. Widespread efforts to control the disease caused by O . volvulus infection (onchoce…
View article: Improved NAAT assay for the diagnosis of onchocerciasis and its use for detection of circulating cell free DNA
Improved NAAT assay for the diagnosis of onchocerciasis and its use for detection of circulating cell free DNA Open
Mass drug administration (MDA) programs aimed at control and elimination of onchocerciasis relies on annual or semi-annual distribution of Ivermectin (IVM) that target the microfialarial (mf) stage of the parasite Onchocerca volvulus . The…
View article: Eosinophil trafficking in allergen-mediated pulmonary inflammation relies on IL-13–driven CCL-11 and CCL-24 production by tissue fibroblasts and myeloid cells
Eosinophil trafficking in allergen-mediated pulmonary inflammation relies on IL-13–driven CCL-11 and CCL-24 production by tissue fibroblasts and myeloid cells Open
View article: A Novel, Highly Sensitive Nucleic Acid Amplification Test Assay for the Diagnosis of Loiasis and its Use for Detection of Circulating Cell-Free DNA
A Novel, Highly Sensitive Nucleic Acid Amplification Test Assay for the Diagnosis of Loiasis and its Use for Detection of Circulating Cell-Free DNA Open
Mass drug administration programs targeting filarial infections depend on diagnostic tools that are sensitive and specific. The coendemicity of Loa loa with other filarial species often hampers the control programs. LL2634 was identified a…
View article: Unraveling cross-reactivity of anti-glycan IgG responses in filarial nematode infections
Unraveling cross-reactivity of anti-glycan IgG responses in filarial nematode infections Open
Parasitic nematodes responsible for filarial diseases cause chronic disablement in humans worldwide. Elimination programs have substantially reduced the rate of infection in certain areas, but limitations of current diagnostics for populat…
View article: A filarial parasite-encoded human IL-10 receptor antagonist reveals a novel strategy to modulate host responses
A filarial parasite-encoded human IL-10 receptor antagonist reveals a novel strategy to modulate host responses Open
Interleukin (IL)-10 is the primary cytokine driving the modulation of the host response in filarial infections. We performed binding assays with Brugia malayi antigen extracts and human IL-10R1. Bm5539 was the top-binding hit. We identifie…
View article: Bma-LAD-2, an Intestinal Cell Adhesion Protein, as a Potential Therapeutic Target for Lymphatic Filariasis
Bma-LAD-2, an Intestinal Cell Adhesion Protein, as a Potential Therapeutic Target for Lymphatic Filariasis Open
Brugia malayi is a parasitic nematode that can cause lymphatic filariasis, a debilitating disease prevalent in tropical and subtropical countries. Significant progress has been made toward eliminating the disease.
View article: Localization and RNA Interference-Driven Inhibition of a Brugia malayi-Encoded Interleukin-5 Receptor Binding Protein
Localization and RNA Interference-Driven Inhibition of a Brugia malayi-Encoded Interleukin-5 Receptor Binding Protein Open
A molecule we termed Brugia malayi IL-5 receptor (IL-5R) binding protein (BmIL5Rbp; also known as Bm8757) was identified from B. malayi filarial worms and found to inhibit human interleukin-5 (IL-5) binding to its human receptor competitiv…
View article: Bma-LAD-2, an intestinal cell adhesion protein, as a potential therapeutic target for lymphatic filariasis
Bma-LAD-2, an intestinal cell adhesion protein, as a potential therapeutic target for lymphatic filariasis Open
Lymphatic filariasis (LF) is a debilitating disease that afflicts over 70 million people worldwide. It is caused by the parasitic nematodes Wuchereria bancrofti , Brugia malayi , and Brugia timori . While efforts to eliminate LF have seen …
View article: Localization and RNAi-driven inhibition of a Brugia malayi encoded Interleukin-5 Receptor Binding protein
Localization and RNAi-driven inhibition of a Brugia malayi encoded Interleukin-5 Receptor Binding protein Open
A molecule termed BmIL5Rbp (aka Bm8757) was identified from Brugia malayi filarial worms and found to competitively inhibit human IL-5 binding to its human receptor. After the expression and purification of a recombinant BmIL5Rbp and gener…
View article: Insights into the L3 to L4 developmental program through proteomics
Insights into the L3 to L4 developmental program through proteomics Open
The establishment of infection with the lymphatic dwelling filarial parasites is dependent on the infectivity and subsequent development of the infective larvae (L3) within the human host to later stages (L4, adults) that require several d…
View article: House dust mite sensitization drives cross-reactive immune responses to homologous helminth proteins
House dust mite sensitization drives cross-reactive immune responses to homologous helminth proteins Open
The establishment of type 2 responses driven by allergic sensitization prior to exposure to helminth parasites has demonstrated how tissue-specific responses can protect against migrating larval stages, but, as a consequence, allow for imm…
View article: Extracellular vesicles released from the filarial parasite Brugia malayi downregulate the host mTOR pathway
Extracellular vesicles released from the filarial parasite Brugia malayi downregulate the host mTOR pathway Open
We have previously shown that the microfilarial (mf) stage of Brugia malayi can inhibit the mammalian target of rapamycin (mTOR; a conserved serine/threonine kinase critical for immune regulation and cellular growth) in human dendritic cel…
View article: Molecular evidence of hybridization between pig and human Ascaris indicates an interbred species complex infecting humans
Molecular evidence of hybridization between pig and human Ascaris indicates an interbred species complex infecting humans Open
Human ascariasis is a major neglected tropical disease caused by the nematode Ascaris lumbricoides . We report a 296 megabase (Mb) reference-quality genome comprised of 17,902 protein-coding genes derived from a single, representative Asca…
View article: Author response: Molecular evidence of hybridization between pig and human Ascaris indicates an interbred species complex infecting humans
Author response: Molecular evidence of hybridization between pig and human Ascaris indicates an interbred species complex infecting humans Open
View article: Characterization of glycan determinants that mediate recognition of the major Wuchereria bancrofti circulating antigen by diagnostic antibodies
Characterization of glycan determinants that mediate recognition of the major Wuchereria bancrofti circulating antigen by diagnostic antibodies Open
View article: Extensive hybridization between pig and human<i>Ascaris</i>identifies a highly interbred species complex infecting humans
Extensive hybridization between pig and human<i>Ascaris</i>identifies a highly interbred species complex infecting humans Open
Human ascariasis is a major neglected tropical disease caused by the nematode Ascaris lumbricoides . We report a 296 megabase (Mb) reference quality genome comprised of 17902 protein-coding genes derived from a single, representative Ascar…
View article: Studies on the development of Orally Disintegrating Tablets of Irbesartan
Studies on the development of Orally Disintegrating Tablets of Irbesartan Open
View article: Intestinal UDP-glucuronosyltransferase as a potential target for the treatment and prevention of lymphatic filariasis
Intestinal UDP-glucuronosyltransferase as a potential target for the treatment and prevention of lymphatic filariasis Open
Lymphatic filariasis (LF), a morbid disease caused by the tissue-invasive nematodes Wuchereria bancrofti, Brugia malayi, and Brugia timori, affects millions of people worldwide. Global eradication efforts have significantly reduced worldwi…
View article: Integrating Multiple Biomarkers to Increase Sensitivity for the Detection of Onchocerca volvulus Infection
Integrating Multiple Biomarkers to Increase Sensitivity for the Detection of Onchocerca volvulus Infection Open
Background Serological assessments for human onchocerciasis are based on IgG4 reactivity against the OV-16 antigen, with sensitivities of 60-80%. We have previously identified 7 novel proteins that could improve serodiagnosis. Methods IgG4…
View article: Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum
Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum Open
The newly identified mouse models for onchocerciasis will enable the development of O. volvulus specific biomarkers, screening for new therapeutic approaches and potentially studying the human immune response to infection with O. volvulus.
View article: Ligand binding properties of two Brugia malayi fatty acid and retinol (FAR) binding proteins and their vaccine efficacies against challenge infection in gerbils
Ligand binding properties of two Brugia malayi fatty acid and retinol (FAR) binding proteins and their vaccine efficacies against challenge infection in gerbils Open
Parasitic nematodes produce an unusual class of fatty acid and retinol (FAR)-binding proteins that may scavenge host fatty acids and retinoids. Two FARs from Brugia malayi (Bm-FAR-1 and Bm-FAR-2) were expressed as recombinant proteins, and…
View article: Similarities and differences between helminth parasites and cancer cell lines in shaping human monocytes: Insights into parallel mechanisms of immune evasion
Similarities and differences between helminth parasites and cancer cell lines in shaping human monocytes: Insights into parallel mechanisms of immune evasion Open
A number of features at the host-parasite interface are reminiscent of those that are also observed at the host-tumor interface. Both cancer cells and parasites establish a tissue microenvironment that allows for immune evasion and may ref…
View article: Tackling Hypotheticals in Helminth Genomes
Tackling Hypotheticals in Helminth Genomes Open
View article: Mining Filarial Genomes for Diagnostic and Therapeutic Targets
Mining Filarial Genomes for Diagnostic and Therapeutic Targets Open
View article: Insights Into Onchocerca volvulus Population Biology Through Multilocus Immunophenotyping
Insights Into Onchocerca volvulus Population Biology Through Multilocus Immunophenotyping Open
We have developed a serologically based immunophenotyping approach to study Onchocerca volvulus (Ov) population diversity. Using genomic sequence data and polymerase chain reaction-based genotyping, we identified nonsynonymous single-nucle…
View article: Discovery of Specific Antigens That Can Predict Microfilarial Intensity in <i>Loa loa</i> Infection
Discovery of Specific Antigens That Can Predict Microfilarial Intensity in <i>Loa loa</i> Infection Open
Antigen-based immunoassays are currently needed for point-of-care quantification of Loa loa microfilariae (mf). Coupling transcriptomic approaches with bioinformatic analysis, we have identified 11 specific putative proteins (coding mRNAs)…
View article: Stage-Specific Transcriptome and Proteome Analyses of the Filarial Parasite Onchocerca volvulus and Its <i>Wolbachia</i> Endosymbiont
Stage-Specific Transcriptome and Proteome Analyses of the Filarial Parasite Onchocerca volvulus and Its <i>Wolbachia</i> Endosymbiont Open
Onchocerciasis (river blindness) is a neglected tropical disease that has been successfully targeted by mass drug treatment programs in the Americas and small parts of Africa. Achieving the long-term goal of elimination of onchocerciasis, …