Explanipedia

Melanoma of the Choroid and Ciliary Body in Children: Remission of Metastatic Melanoma of the Choroid After Treatment With Chemotherapy and Immune Checkpoint Inhibition Open

Pia Tüller, Tobias Kiefer, Leyla Jabbarli, Kyriaki Papaioannou, Kathrin Schramm , et al. · 2025

Background Uveal melanoma is the most common malignant primary intraocular tumor in adults, associated with high mortality. Pediatric uveal melanoma generally has a more favorable course. However, when metastasis occurs, therapeutic option…

Other possibilities to consider before a diagnosis of intracranial hibernoma Open

Saskia Ting · 2025

Definition of parameters and thresholds to detect MYCN amplification in retinoblastomas Open

C. Bielefeld, Toraño-Zamudio Víctor Hugo, N. Sievers, Petra Ketteler, Eva Biewald , et al. · 2025

Retinoblastoma is a malignant childhood neoplasm where MYCN amplification defines a subset of tumors with worse prognosis. FISH (fluorescence in situ hybridization) represents a fast and reliable method to measure gene copy numbers in vari…

Managing Psychosis in Acute Intermittent Porphyria: A Case Report on Olanzapine Use Open

Cinly Ooi, Chao Tian Tang, Saskia Ting, Iris Rawtaer, Ho Teck Tan · 2025

Melanoma of the choroid and ciliary body in children: Remission of metastatic melanoma of the choroid after treatment with chemotherapy and immune checkpoint inhibition Open

Pia Tüller, Tobias Kiefer, Leyla Jabbarli, Kyriaki Papaioannou, Kathrin Schramm , et al. · 2025

In vitro model of retinoblastoma derived tumor and stromal cells for tumor microenvironment (TME) studies Open

Emily Alefeld, André Haase, Dario Van Meenen, Bettina Budeus, Oliver Dräger , et al. · 2024

Expression of the Large Aminoacid Transporter Slc7a5/Lat1 on Immune Cells is Enhanced in Primary Sclerosing Cholangitis-Associated Cholangiocarcinoma and Correlates with Poor Prognosis in Cholangiocarcinoma Open

Vittorio Branchi, Racha Hosni, Lukas Kiwitz, Susanna S. Ng, Gemma van der Voort , et al. · 2024

AI-based digital histopathology for perihilar cholangiocarcinoma: A step, not a jump Open

Dieter P. Hoyer, Saskia Ting, Nina A. Rogacka, Sven Koitka, René Hosch , et al. · 2023

AI-based digital pathology showed potential in PHCC prognosis prediction, though refinement is necessary for clinical relevance. Future research should focus on enhancing AI models and exploring novel approaches to improve PHCC patient pro…

PDGF, NGF, and EGF as main contributors to tumorigenesis in high-risk retinoblastoma Open

Karim Al-Ghazzawi, Michael Wessolly, Sami Dalbah, Petra Ketteler, Tobias Kiefer , et al. · 2023

Retinoblastoma (RB) is the most common form of eye cancer experienced in childhood. Its aggressive malignancy is associated with excellent survival rates in high-income countries; however, the prognosis in third-world countries is less fav…

Real-world clinical data and gene expression analysis of urothelial carcinoma for the prediction of immune checkpoint inhibitor therapy Open

Tibor Szarvas, M. Váradi, Örs Péter Horváth, Tamás Fazekas, Anita Csizmarik , et al. · 2023

Histology-Based Prediction of Therapy Response to Neoadjuvant Chemotherapy for Esophageal and Esophagogastric Junction Adenocarcinomas Using Deep Learning Open

Fabian Hörst, Saskia Ting, Sven‐Thorsten Liffers, Kelsey L. Pomykala, Katja Steiger , et al. · 2023

PURPOSE Quantifying treatment response to gastroesophageal junction (GEJ) adenocarcinomas is crucial to provide an optimal therapeutic strategy. Routinely taken tissue samples provide an opportunity to enhance existing positron emission to…

Impact of encorafenib on survival of patients with BRAFV600E-mutant metastatic colorectal cancer in a real-world setting Open

M. Zurloh, Moritz Goetz, Tobias Herold, Jürgen Treckmann, P. M. Markus , et al. · 2023

Purpose Patients with BRAF V600E -mutant metastatic colorectal cancer (mCRC) have a dismal prognosis. The best strategies in these patients remain elusive. Against this background, we report the clinical course of patients with BRAF V600E …

Impact of encorafenib on survival of patients with BRAF V600E -mutant metastatic colorectal cancer in a real-world setting Open

Marie Zurloh, Moritz Goetz, Thomas Herold, Jürgen Treckmann, P. M. Markus , et al. · 2023

Purpose: Patients with BRAF V600E mutant metastatic colorectal cancer (mCRC) have a dismal prognosis. The best strategies in these patients remain elusive. Against this background, we report the clinical course of patients with BRAF V600E …

Valuing vicinity: Memory attention framework for context-based semantic segmentation in histopathology Open

Oliver Ester, Fabian Hörst, Constantin Seibold, Julius Keyl, Saskia Ting , et al. · 2023

The segmentation of histopathological whole slide images into tumourous and non-tumourous types of tissue is a challenging task that requires the consideration of both local and global spatial contexts to classify tumourous regions precise…

Histology-based Prediction of Therapy Response to Neoadjuvant Chemotherapy for Esophageal and Esophagogastric Junction Adenocarcinomas Using Deep Learning Open

Fabian Hörst, Saskia Ting, Sven‐Thorsten Liffers, Kelsey L. Pomykala, Katja Steiger , et al. · 2023

Background Quantifying treatment response to gastroesophageal junction (GEJ) adenocarcinomas is crucial to provide optimal therapeutic strategy. Routinely taken tissue samples provide an opportunity to enhance existing PET/CT-based therapy…

The impact of oxygen supply and erythrocytes during normothermic kidney perfusion Open

Charlotte von Horn, Hristo Zlatev, Bastian Lüer, Laura Malkus, Saskia Ting , et al. · 2023

The influence of erythrocytes and oxygen concentration on kidneys during long-term normothermic kidney perfusion is under debate. This study compares acellular and erythrocyte-based NMP with focus on oxygen delivery to the tissue as well a…

Valuing vicinity: Memory attention framework for context-based semantic segmentation in histopathology Open

Oliver Ester, Fabian Hörst, Constantin Seibold, Julius Keyl, Saskia Ting , et al. · 2023

Adjuvant therapy for children treated by enucleation at diagnosis of retinoblastoma Open

Yelena Diarra, Christina Brockmeyer, Karen Fischhuber, Isabel Hülsenbeck, Saskia Ting , et al. · 2023

Supplementary Material for: Clinical outcome and treatment sequences of patients with advanced pancreatic cancer treated with contemporary chemotherapy protocols Open

J. Roehrle, Stefan Kasper, Treckmann J.-W., P. M. Markus, Brigitte Schumacher , et al. · 2023

Introduction Systemic therapy is firmly established in patients with advanced or metastatic pancreatic ductal adenocarcinoma (PDAC). Clinical efficacy is still modest and options are limited. Combination therapy protocols such as FOLFIRINO…

Deep learning‐based assessment of body composition and liver tumour burden for survival modelling in advanced colorectal cancer Open

Julius Keyl, René Hosch, Aaron Berger, Oliver Ester, Tobias Greiner , et al. · 2022

Background Personalized therapy planning remains a significant challenge in advanced colorectal cancer care, despite extensive research on prognostic and predictive markers. A strong correlation of sarcopenia or overall body composition an…

18F-PSMA Cerenkov Luminescence and Flexible Autoradiography Imaging in a Prostate Cancer Mouse Model and First Results of a Radical Prostatectomy Feasibility Study in Men Open

Pedro Fragoso Costa, Lukas Püllen, Claudia Kesch, Ulrich Krafft, Stephan Tschirdewahn , et al. · 2022

Intraoperative identification of positive resection margins (PRMs) in high-risk prostate cancer (PC) needs improvement. Cerenkov luminescence imaging (CLI) with ⁶⁸Ga-PSMA-11 is promising, although limited by low residual activit…

A prognostic systemic inflammation score (SIS) in patients with advanced intrahepatic cholangiocarcinoma Open

M. Maßmann, Jürgen Treckmann, P. M. Markus, Brigitte Schumacher, David Albers , et al. · 2022

Predictive value of molecular subtypes and APOBEC3G for adjuvant chemotherapy in urothelial bladder cancer Open

Csilla Oláh, Henning Reis, Michèle J. Hoffmann, Fabian Mairinger, Saskia Ting , et al. · 2022

Objective Although targeted approaches have become available in second‐ and third‐line settings, platinum‐based chemotherapy remains the standard first‐line treatment for advanced muscle‐invasive bladder cancer (MIBC). Therefore, the predi…

Clinical Decision Support for Axillary Lymph Node Staging in Newly Diagnosed Breast Cancer Patients Based on18F-FDG PET/MRI and Machine Learning Open

Janna Morawitz, Benjamin Sigl, Christian Rubbert, Nils Martin Bruckmann, Frederic Dietzel , et al. · 2022

In addition to its high prognostic value, the involvement of axillary lymph nodes in breast cancer patients also plays an important role in therapy planning. Therefore, an imaging modality that can determine nodal status with high accuracy…

OTHR-34. Identifying mechanisms of microglia-tumor cell interactions in retinoblastoma Open

Anike Pohlmann, Teresa Gerling, Carolin Walter, Viktoria Melcher, Flavia W. de Faria , et al. · 2022

BACKGROUND: Treatment-related long-term sequelae and chemotherapy resistance diminish the success of retinoblastoma (RB) treatment. To unravel the mechanisms leading to tumor progression and resistance we examined the intratumoral cellular…

Anterior chamber enhancement predicts optic nerve infiltration in retinoblastoma Open

Katerina Deike‐Hofmann, Paula von Lampe, Maija Eerikaeinen, Saskia Ting, Sabrina Schlüter , et al. · 2022

Objectives As described recently, intravenously injected gadolinium-based contrast agent (GBCA) penetrates into the anterior eye chamber (AC) and is drained from the retina to the distal optic nerve (ON) along perivascular spaces, which se…

Multiparametric 18F-FDG PET/MRI-Based Radiomics for Prediction of Pathological Complete Response to Neoadjuvant Chemotherapy in Breast Cancer Open

Lale Umutlu, Julian Kirchner, Nils Martin Bruckmann, Janna Morawitz, Gerald Antoch , et al. · 2022

Background: The aim of this study was to assess whether multiparametric 18F-FDG PET/MRI-based radiomics analysis is able to predict pathological complete response in breast cancer patients and hence potentially enhance pretherapeutic patie…

Adjuvant Therapy for Children with Primary Enucleation of Retinoblastoma: A Report from a Prospective Multicenter Observational Study Open

Yelena Diarra, Christina Brockmeyer, Karen Fischhuber, Isabel Hülsenbeck, Saskia Ting , et al. · 2022

Long-Term Results after Intraocular Surgery in Treated Retinoblastoma Eyes Open

Philipp Rating, Norbert Bornfeld, Sabrina Schlüter, Henrike Westekemper, Tobias Kiefer , et al. · 2022

Introduction: The aim of the study was to analyze the results of intraocular surgery in treated retinoblastoma eyes and to assess the long-term results with a priority on local recurrences, secondary enucleation, and metastas…

Optimisation of the Chicken Chorioallantoic Membrane Assay in Uveal Melanoma Research Open

Ekaterina Sokolenko, Utta Berchner‐Pfannschmidt, Saskia Ting, Kurt Werner Schmid, Nikolaos E. Bechrakis , et al. · 2021

The treatment of uveal melanoma and its metastases has not evolved sufficiently over the last decades in comparison to other tumour entities, posing a great challenge in the field of ocular oncology. Despite improvements in the conventiona…

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