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View article: TMET-15. INVESTIGATING THE IL4I1-AHR AXIS IN GLIOBLASTOMA METABOLISM
TMET-15. INVESTIGATING THE IL4I1-AHR AXIS IN GLIOBLASTOMA METABOLISM Open
Glioblastoma (GB) is the most frequent and malignant form of primary brain tumors in adults. Despite multi-modal therapy consisting of surgery, radio- and chemotherapy, tumors recur and overall survival remains poor. Previously, we identif…
View article: Pharmacological Improvement of Cystic Fibrosis Transmembrane Conductance Regulator Function Rescues Airway Epithelial Homeostasis and Host Defense in Children with Cystic Fibrosis
Pharmacological Improvement of Cystic Fibrosis Transmembrane Conductance Regulator Function Rescues Airway Epithelial Homeostasis and Host Defense in Children with Cystic Fibrosis Open
Rationale: Pharmacological improvement of cystic fibrosis transmembrane conductance regulator (CFTR) function with elexacaftor/tezacaftor/ivacaftor (ETI) provides unprecedented improvements in lung function and other clinical outcomes in p…
View article: Directed acyclic graph for epidemiological studies in childhood food allergy: Construction, user's guide, and application
Directed acyclic graph for epidemiological studies in childhood food allergy: Construction, user's guide, and application Open
Understanding modifiable prenatal and early life causal determinants of food allergy is important for the prevention of the disease. Randomized clinical trials studying environmental and dietary determinants of food allergy may not always …
View article: Undiagnosed Pediatric Elevated Blood Pressure Is Characterized by Induction of Proinflammatory and Cytotoxic Mediators
Undiagnosed Pediatric Elevated Blood Pressure Is Characterized by Induction of Proinflammatory and Cytotoxic Mediators Open
BACKGROUND: Inflammatory processes have been suggested as a culprit of vascular damage in pediatric hypertension. We aimed to investigate transcriptional changes of immune modulators and determine their association with office blood pressu…
View article: Global hypomethylation in childhood asthma identified by genome‐wide DNA‐methylation sequencing preferentially affects enhancer regions
Global hypomethylation in childhood asthma identified by genome‐wide DNA‐methylation sequencing preferentially affects enhancer regions Open
Background Childhood asthma is a result of a complex interaction of genetic and environmental components causing epigenetic and immune dysregulation, airway inflammation and impaired lung function. Although different microarray based EWAS …
View article: The MTORC1-AHR pathway sustains translation and autophagy in tumours under tryptophan stress
The MTORC1-AHR pathway sustains translation and autophagy in tumours under tryptophan stress Open
Tumours face tryptophan (Trp) depletion, but the mechanisms sustaining protein biosynthesis under Trp stress remain unclear. We report that Trp stress increases the levels of the translation repressor EIF4EBP1. Yet, at the same time, EIF4E…
View article: 165 PAHR: the pan-cancer AHR signature pipeline
165 PAHR: the pan-cancer AHR signature pipeline Open
Background The ligand-activated transcription factor, AHR (aryl hydrocarbon receptor) is an important regulator of different biological process including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility, and immune mod…
View article: <i>ELF5</i> is a respiratory epithelial cell-specific risk gene for severe COVID-19
<i>ELF5</i> is a respiratory epithelial cell-specific risk gene for severe COVID-19 Open
Despite two years of intense global research activity, host genetic factors that predispose to a poorer prognosis and severe course of COVID-19 infection remain poorly understood. Here, we identified eight candidate protein mediators of CO…
View article: Pre-activated anti-viral innate immunity in the upper airways controls early SARS-CoV-2 infection in children
Pre-activated anti-viral innate immunity in the upper airways controls early SARS-CoV-2 infection in children Open
Children are consistently reported to have reduced SARS-CoV-2 infection rates and a substantially lower risk for developing severe COVID-19. However, the molecular mechanisms underlying protection against COVID-19 in younger age groups rem…
View article: Prenatal paraben exposure and atopic dermatitis‐related outcomes among children
Prenatal paraben exposure and atopic dermatitis‐related outcomes among children Open
Background Parabens, widely used as preservatives in cosmetics, foods, and other consumer products, are suspected of contributing to allergy susceptibility. The detection of parabens in the placenta or amniotic fluid raised concerns about …
View article: Pre-activated anti-viral innate immunity in the upper airways controls early SARS-CoV-2 infection in children
Pre-activated anti-viral innate immunity in the upper airways controls early SARS-CoV-2 infection in children Open
This dataset comprises single-cell RNA-Seq data of nasopharyngeal samples of of adults and children with COVID-19 (n=24 and n=21, respectively) and SARS-CoV-2-negative controls in each age group (n=23 and 18, respectively).An in-depth desc…
View article: Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma
Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma Open
Tryptophan (Trp)-catabolic enzymes (TCEs) produce metabolites that activate the aryl hydrocarbon receptor (AHR) and promote tumor progression and immunosuppression in glioblastoma. As therapies targeting TCEs or AHR become available, a bet…
View article: Single-cell sequencing reveals pre-activated anti-viral innate immunity as control of early SARS-CoV-2 infection in children
Single-cell sequencing reveals pre-activated anti-viral innate immunity as control of early SARS-CoV-2 infection in children Open
This dataset comprises single-cell RNA-Seq data of nasopharyngeal samples of COVID-19 patients and 16 healthy controls, for a total of 48 samples. 25 COVID-19 patients and 10 controls were diagnosed with hypertension and treated with eithe…
View article: Delayed viral clearance and exacerbated airway hyperinflammation in hypertensive COVID-19 patients
Delayed viral clearance and exacerbated airway hyperinflammation in hypertensive COVID-19 patients Open
In COVID-19, hypertension and cardiovascular diseases have emerged as major risk factors for critical disease progression. Concurrently, the impact of the main anti-hypertensive therapies, angiotensin-converting enzyme inhibitors (ACEi) an…
View article: We are what we experienced before birth: Lessons from epigenetics
We are what we experienced before birth: Lessons from epigenetics Open
It is commonly accepted that environmental factors play a pivotal role in the development of respiratory diseases like asthma by persistently perturbing disease-related regulatory pathways. Such perturbations in particular during the highl…
View article: Cross-talk between the airway epithelium and activated immune cells defines severity in COVID-19
Cross-talk between the airway epithelium and activated immune cells defines severity in COVID-19 Open
The clinical course of COVID-19 is highly variable, however, underlying host factors and determinants of severe disease are still unknown. Based on single-cell transcriptomes of nasopharyngeal and bronchial samples from clinically well-cha…
View article: G3BP1 tethers the TSC complex to lysosomes and suppresses mTORC1 in the absence of stress granules
G3BP1 tethers the TSC complex to lysosomes and suppresses mTORC1 in the absence of stress granules Open
Summary G3BP1 (Ras GTPase-activating protein-binding protein 1) is widely recognized as a core component of stress granules (SG), non-membranous RNA-protein-assemblies required for cellular survival under stress. We report that in the abse…
View article: COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis
COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis Open
Single-cell RNA-Seq of airway samples of COVID-19 patients and healthy controlsThis dataset comprises single-cell RNA-Seq data of nasopharyngeal, protected specimen brush, and bronchial lavage samples of 19 COVID-19 patients (eight moderat…
View article: COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis
COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis Open
Single-cell RNA-Seq of airway samples of COVID-19 patients and healthy controlsThis dataset comprises single-cell RNA-Seq data of nasopharyngeal, protected specimen brush, and bronchial lavage samples of 19 COVID-19 patients (eight moderat…
View article: Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19
Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19 Open
This dataset comprises single-cell RNA-Seq data of nasopharyngeal samples of 32 COVID-19 patients and 16 healthy controls, for a total of 48 samples. 25 COVID-19 patients and 10 controls were diagnosed with hypertension and treated with ei…