Explanipedia

Antigen dependency delineates memory and exhausted CD8 T cells 4050 Open

Jenny Krause, Meagan R. Rollins, Noah Veis Gavil, Sathi Wijeyesinghe, Olivia Smith , et al. · 2025

Description Antigen experienced T cell subsets are heterogenous, and can be described based on their phenotype, function, and migration properties. Whether antigen stimulation regulates the migration, survival, differentiation, or developm…

LN CD8+ resident memory T cells demonstrate unexpected abundance, exhibit biased migration upon recall, and orchestrate intranodal recall responses 4178 Open

Olivia Smith, Marco K nzli, Milcah C. Scott, Vineet Joag, Abraham J. Matar , et al. · 2025

Description For over six decades, LNs have been considered sites of lymphocyte recirculation, with central memory T cells (TCM) assuming the role of primary surveillants. We and others have identified CD8+ memory T cells that establish res…

Tissue-resident B cells orchestrate macrophage polarisation and function Open

Ondřej Suchánek, John R. Ferdinand, Zewen Kelvin Tuong, Sathi Wijeyesinghe, Anita Chandra , et al. · 2023

Chronic antigen in solid tumors drives a distinct program of T cell residence Open

Noah Veis Gavil, Milcah C. Scott, Eyob Weyu, Olivia Smith, Stephen O’Flanagan , et al. · 2023

Analyses of healthy tissue reveal signatures that identify resident memory CD8 + T cells (T RM ), which survey tissues without recirculating. The density of T RM phenotype cells within solid tumors correlates favorably with prognosis, sugg…

Tissue-resident memory T cells trigger rapid exudation and local antibody accumulation Open

Pamela C. Rosato, Sahar Lotfi‐Emran, Vineet Joag, Sathi Wijeyesinghe, Clare F. Quarnstrom , et al. · 2023

Route of self-amplifying mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells Open

Marco Künzli, Stephen O’Flanagan, Madeleine LaRue, Poulami Talukder, Thamotharampillai Dileepan , et al. · 2022

Respiratory tract resident memory T cells (T RM ), typically generated by local vaccination or infection, can accelerate control of pulmonary infections that evade neutralizing antibody. It is unknown whether mRNA vaccination establishes r…

1027 Chronic antigen in solid tumors drives a distinct program of T cell residence Open

Noah Veis Gavil, Milcah C. Scott, Eyob Weyu, Olivia Smith, Stephen O’Flanagan , et al. · 2022

Background Resident-memory T cells (T_RM) permanently reside in tissues, surveying local environments without recirculating. Surface protein expression (e.g. CD69, CD103) and transcriptional signatures from infection models are u…

Novel Lymphocytic Choriomeningitis Virus Strain Sustains Abundant Exhausted Progenitor CD8 T Cells without Systemic Viremia Open

Lalit K. Beura, Milcah C. Scott, Mark Pierson, Vineet Joag, Sathi Wijeyesinghe , et al. · 2022

Lymphocytic choriomeningitis virus (LCMV) is the prototypic arenavirus and a natural mouse pathogen. LCMV-Armstrong, an acutely resolved strain, and LCMV-clone 13, a mutant that establishes chronic infection, have provided contrasting infe…

Route of self-amplifying mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells Open

Marco Künzli, Stephen O’Flanagan, Madeleine LaRue, Poulami Talukder, Thamotharampillai Dileepan , et al. · 2022

Respiratory tract resident memory T cells (Trm), typically generated by local vaccination or infection, can accelerate control of pulmonary infections that evade neutralizing antibody. It is unknown whether mRNA vaccination establishes res…

Correction to: Functional virus‑specific memory T cells survey glioblastoma Open

Jianfang Ning, Noah Veis Gavil, Shaoping Wu, Sathi Wijeyesinghe, Eyob Weyu , et al. · 2022

Mice with diverse microbial exposure histories as a model for preclinical vaccine testing Open

Jessica K. Fiege, Katharine E. Block, Mark Pierson, Hezkiel A. Nanda, Frances K. Shepherd , et al. · 2021

Therapeutic activation of virus-specific resident memory T cells within the glioblastoma microenvironment Open

Jianfang Ning, Noah Veis Gavil, Shaoping Wu, Sathi Wijeyesinghe, Eyob Weyu , et al. · 2021

Glioblastoma multiforme (GBM) is among the most aggressive, treatment resistant cancers, and despite standard of care surgery, radiation and chemotherapy, is invariably fatal. GBM is marked by local and systemic immunosuppression, contribu…

Cutting Edge: Nucleocapsid Vaccine Elicits Spike-Independent SARS-CoV-2 Protective Immunity Open

William E. Matchett, Vineet Joag, J. Michael Stolley, Frances K. Shepherd, Clare F. Quarnstrom , et al. · 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. Neutralizing Abs target the receptor binding domain of the spike (S) protein, a focus of successful vaccine efforts. Concerns have arise…

Nucleocapsid vaccine elicits spike-independent SARS-CoV-2 protective immunity Open

William E. Matchett, Vineet Joag, J. Michael Stolley, Frances K. Shepherd, Clare F. Quarnstrom , et al. · 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. Neutralizing antibodies target the receptor binding domain of the spike (S) protein, a focus of successful vaccine efforts. Concerns hav…

Expansible residence decentralizes immune homeostasis Open

Sathi Wijeyesinghe, Lalit K. Beura, Mark Pierson, J. Michael Stolley, Omar A. Adam , et al. · 2021

Cutting Edge: Mouse SARS-CoV-2 Epitope Reveals Infection and Vaccine-Elicited CD8 T Cell Responses Open

Vineet Joag, Sathi Wijeyesinghe, J. Michael Stolley, Clare F. Quarnstrom, Thamotharampillai Dileepan , et al. · 2021

The magnitude of SARS-CoV-2–specific T cell responses correlates inversely with human disease severity, suggesting T cell involvement in primary control. Whereas many COVID-19 vaccines focus on establishing humoral immunity to viral spike …

Retrograde migration supplies resident memory T cells to lung-draining LN after influenza infection Open

J. Michael Stolley, Timothy S. Johnston, Andrew G. Soerens, Lalit K. Beura, Pamela C. Rosato , et al. · 2020

Numerous observations indicate that resident memory T cells (TRM) undergo unusually rapid attrition within the lung. Here we demonstrate that contraction of lung CD8+ T cell responses after influenza infection is contemporized with egress …

MO064TISSUE-RESIDENT B CELLS DETERMINE SUSCEPTIBILITY TO URINARY TRACT INFECTION BY ORCHESTRATING MACROPHAGE POLARISATION Open

Ondřej Suchánek, Sathi Wijeyesinghe, John R. Ferdinand, Zewen Kelvin Tuong, Anita Chandra , et al. · 2020

Background Urinary tract infection (UTI) is an important clinical problem. More than half of women and 1 in 10 men will be affected during their lifetime. Many of these affect the lower urinary tract but recurrent pyelonephritis can lead t…

Developmental plasticity allows outside-in immune responses by resident memory T cells Open

Raíssa Fonseca, Lalit K. Beura, Clare F. Quarnstrom, Hazem E. Ghoneim, Yiping Fan , et al. · 2020

Integrating resident memory into T cell differentiation models Open

Pamela C. Rosato, Sathi Wijeyesinghe, J. Michael Stolley, David Masopust · 2020

The Impact of TCR Signal Strength on Resident Memory T Cell Formation during Influenza Virus Infection Open

Jessica K. Fiege, Ian A. Stone, Elizabeth J. Fay, Matthew W. Markman, Sathi Wijeyesinghe , et al. · 2019

Resident memory T cells (TRM) in the lung are vital for heterologous protection against influenza A virus (IAV). Environmental factors are necessary to establish lung TRM; however, the role of T cell–intrinsic factors like TCR signal stren…

Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy Open

Pamela C. Rosato, Sathi Wijeyesinghe, J. Michael Stolley, Christine E Nelson, Rachel L. Davis , et al. · 2019

Identification and characterization of HIV-specific resident memory CD8 <sup>+</sup> T cells in human lymphoid tissue Open

Marcus Buggert, Son Nguyen, Gonzalo Salgado-Montes de, Bertram Bengsch, Samuel Darko , et al. · 2018

Current paradigms of CD8 + T cell–mediated protection in HIV infection center almost exclusively on studies of peripheral blood, which is thought to provide a window into immune activity at the predominant sites of viral replication in lym…

T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells Open

Lalit K. Beura, Sathi Wijeyesinghe, Emily A. Thompson, Marissa Macchietto, Pamela C. Rosato , et al. · 2018

Intravital mucosal imaging of CD8+ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory Open

Lalit K. Beura, Jason S. Mitchell, Emily A. Thompson, Jason M. Schenkel, Javed Mohammed , et al. · 2018

Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β Open

Javed Mohammed, Lalit K. Beura, Aleh Bobr, Brian Astry, Brian Chicoine , et al. · 2016

Sathi Wijeyesinghe YOU? Author Swipe