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Supplementary Figure from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2<sup>+</sup> Breast Tumor Microenvironment Open

Dimitrios N. Sidiropoulos, Christine I. Rafie, Julie K. Jang, Sofi Castanon, Aaron G. Baugh , et al. · 2023

Supplementary Figure from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2⁺ Breast Tumor Microenvironment

Data from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2<sup>+</sup> Breast Tumor Microenvironment Open

Dimitrios N. Sidiropoulos, Christine I. Rafie, Julie K. Jang, Sofi Castanon, Aaron G. Baugh , et al. · 2023

Therapeutic combinations to alter immunosuppressive, solid tumor microenvironments (TME), such as in breast cancer, are essential to improve responses to immune checkpoint inhibitors (ICI). Entinostat, an oral histone deacetylase inhibitor…

Supplementary Data from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2<sup>+</sup> Breast Tumor Microenvironment Open

Dimitrios N. Sidiropoulos, Christine I. Rafie, Julie K. Jang, Sofi Castanon, Aaron G. Baugh , et al. · 2023

Supplementary Data from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2⁺ Breast Tumor Microenvironment

Supplementary Data from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2<sup>+</sup> Breast Tumor Microenvironment Open

Dimitrios N. Sidiropoulos, Christine I. Rafie, Julie K. Jang, Sofi Castanon, Aaron G. Baugh , et al. · 2023

Supplementary Data from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2⁺ Breast Tumor Microenvironment

Supplementary Data from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2<sup>+</sup> Breast Tumor Microenvironment Open

Dimitrios N. Sidiropoulos, Christine I. Rafie, Julie K. Jang, Sofi Castanon, Aaron G. Baugh , et al. · 2023

Supplementary Data from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2⁺ Breast Tumor Microenvironment

Supplementary Data from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2<sup>+</sup> Breast Tumor Microenvironment Open

Dimitrios N. Sidiropoulos, Christine I. Rafie, Julie K. Jang, Sofi Castanon, Aaron G. Baugh , et al. · 2023

Supplementary Data from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2⁺ Breast Tumor Microenvironment

Supplementary Data from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2<sup>+</sup> Breast Tumor Microenvironment Open

Dimitrios N. Sidiropoulos, Christine I. Rafie, Julie K. Jang, Sofi Castanon, Aaron G. Baugh , et al. · 2023

Supplementary Data from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2⁺ Breast Tumor Microenvironment

Data from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2<sup>+</sup> Breast Tumor Microenvironment Open

Dimitrios N. Sidiropoulos, Christine I. Rafie, Julie K. Jang, Sofi Castanon, Aaron G. Baugh , et al. · 2023

Therapeutic combinations to alter immunosuppressive, solid tumor microenvironments (TME), such as in breast cancer, are essential to improve responses to immune checkpoint inhibitors (ICI). Entinostat, an oral histone deacetylase inhibitor…

Supplementary Data from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2<sup>+</sup> Breast Tumor Microenvironment Open

Dimitrios N. Sidiropoulos, Christine I. Rafie, Julie K. Jang, Sofi Castanon, Aaron G. Baugh , et al. · 2023

Supplementary Data from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2⁺ Breast Tumor Microenvironment

Supplementary Data from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2<sup>+</sup> Breast Tumor Microenvironment Open

Dimitrios N. Sidiropoulos, Christine I. Rafie, Julie K. Jang, Sofi Castanon, Aaron G. Baugh , et al. · 2023

Supplementary Data from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2⁺ Breast Tumor Microenvironment

Supplementary Data from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2<sup>+</sup> Breast Tumor Microenvironment Open

Dimitrios N. Sidiropoulos, Christine I. Rafie, Julie K. Jang, Sofi Castanon, Aaron G. Baugh , et al. · 2023

Supplementary Data from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2⁺ Breast Tumor Microenvironment

Supplementary Figure from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2<sup>+</sup> Breast Tumor Microenvironment Open

Dimitrios N. Sidiropoulos, Christine I. Rafie, Julie K. Jang, Sofi Castanon, Aaron G. Baugh , et al. · 2023

Supplementary Figure from Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2⁺ Breast Tumor Microenvironment

Supplementary Table S8 (xlsx) from Circulating Tumor Cells Exhibit Metastatic Tropism and Reveal Brain Metastasis Drivers Open

Rémi Klotz, Amal Thomas, Teng Teng, Sung Min Han, Oihana Iriondo , et al. · 2023

List of upregulated genes associated with brain tropism in CTCs

Data from Inhibition of Megakaryocyte Differentiation by Antibody–Drug Conjugates (ADCs) is Mediated by Macropinocytosis: Implications for ADC-induced Thrombocytopenia Open

Hui Zhao, Sara Gulesserian, Sathish Kumar Ganesan, Jimmy Ou, Karen Morrison , et al. · 2023

Thrombocytopenia is a common adverse event in cancer patients treated with antibody–drug conjugates (ADC), including AGS-16C3F, an ADC targeting ENPP3 (ectonucleotide pyrophosphatase/phosphodiesterase-3) and trastuzumab emtansine (T-DM1). …

Data from Circulating Tumor Cells Exhibit Metastatic Tropism and Reveal Brain Metastasis Drivers Open

Rémi Klotz, Amal Thomas, Teng Teng, Sung Min Han, Oihana Iriondo , et al. · 2023

Hematogenous metastasis is initiated by a subset of circulating tumor cells (CTC) shed from primary or metastatic tumors into the blood circulation. Thus, CTCs provide a unique patient biopsy resource to decipher the cellular subpopulation…

Supplementary Table S4 (xlsx) from Circulating Tumor Cells Exhibit Metastatic Tropism and Reveal Brain Metastasis Drivers Open

Rémi Klotz, Amal Thomas, Teng Teng, Sung Min Han, Oihana Iriondo , et al. · 2023

List of differentially expressed genes in brain stromal cells after tumor formation

Supplementary Tables from Circulating Tumor Cells Exhibit Metastatic Tropism and Reveal Brain Metastasis Drivers Open

Rémi Klotz, Amal Thomas, Teng Teng, Sung Min Han, Oihana Iriondo , et al. · 2023

Includes supplementary tables S1, S2, S5, S6, S7 and S9

Supplementary Table S4 (xlsx) from Circulating Tumor Cells Exhibit Metastatic Tropism and Reveal Brain Metastasis Drivers Open

Rémi Klotz, Amal Thomas, Teng Teng, Sung Min Han, Oihana Iriondo , et al. · 2023

List of differentially expressed genes in brain stromal cells after tumor formation

Supplementary Figures from Circulating Tumor Cells Exhibit Metastatic Tropism and Reveal Brain Metastasis Drivers Open

Rémi Klotz, Amal Thomas, Teng Teng, Sung Min Han, Oihana Iriondo , et al. · 2023

File includes supplementary figures S1 to S5

Supplementary methods, legends, Figures S1-S5, and Tables S1-S2 from Inhibition of Megakaryocyte Differentiation by Antibody–Drug Conjugates (ADCs) is Mediated by Macropinocytosis: Implications for ADC-induced Thrombocytopenia Open

Hui Zhao, Sara Gulesserian, Sathish Kumar Ganesan, Jimmy Ou, Karen Morrison , et al. · 2023

Fig. S1. Structure of AGS-16C3F; Figure S2. ENPP3 was not expressed in megakaryocytes; Figure S3. AGS-16C3F did not affect platelet activation; Figure S4. Maturing MKs did not express ENPP3; Figure S5. Fc blocker inhibited FcγRIIA pathway …

Supplemental data from A Potential Mechanism for ADC-Induced Neutropenia: Role of Neutrophils in Their Own Demise Open

Hui Zhao, Sara Gulesserian, Maria Christina Malinao, Sathish Kumar Ganesan, James Song , et al. · 2023

Figure S1. Chemical structures of MMAF, MMAE and 13C5-MMAE. The asterisks indicate where Carbon-13 isotope has replaced Carbon-12; Figure S2. Expression of CD32 on mature neutrophils. Circulating neutrophils (AllCell) were incubated with a…

Supplementary methods, legends, Figures S1-S5, and Tables S1-S2 from Inhibition of Megakaryocyte Differentiation by Antibody–Drug Conjugates (ADCs) is Mediated by Macropinocytosis: Implications for ADC-induced Thrombocytopenia Open

Hui Zhao, Sara Gulesserian, Sathish Kumar Ganesan, Jimmy Ou, Karen Morrison , et al. · 2023

Fig. S1. Structure of AGS-16C3F; Figure S2. ENPP3 was not expressed in megakaryocytes; Figure S3. AGS-16C3F did not affect platelet activation; Figure S4. Maturing MKs did not express ENPP3; Figure S5. Fc blocker inhibited FcγRIIA pathway …

Data from A Potential Mechanism for ADC-Induced Neutropenia: Role of Neutrophils in Their Own Demise Open

Hui Zhao, Sara Gulesserian, Maria Christina Malinao, Sathish Kumar Ganesan, James Song , et al. · 2023

Neutropenia is a common adverse event in cancer patients treated with antibody–drug conjugates (ADC) and we aimed to elucidate the potential mechanism of this toxicity. To investigate whether ADCs affect neutrophil production from bone mar…

Data from A Potential Mechanism for ADC-Induced Neutropenia: Role of Neutrophils in Their Own Demise Open

Hui Zhao, Sara Gulesserian, Maria Christina Malinao, Sathish Kumar Ganesan, James Song , et al. · 2023

Neutropenia is a common adverse event in cancer patients treated with antibody–drug conjugates (ADC) and we aimed to elucidate the potential mechanism of this toxicity. To investigate whether ADCs affect neutrophil production from bone mar…

Supplementary Tables from Circulating Tumor Cells Exhibit Metastatic Tropism and Reveal Brain Metastasis Drivers Open

Rémi Klotz, Amal Thomas, Teng Teng, Sung Min Han, Oihana Iriondo , et al. · 2023

Includes supplementary tables S1, S2, S5, S6, S7 and S9

Data from Circulating Tumor Cells Exhibit Metastatic Tropism and Reveal Brain Metastasis Drivers Open

Rémi Klotz, Amal Thomas, Teng Teng, Sung Min Han, Oihana Iriondo , et al. · 2023

Hematogenous metastasis is initiated by a subset of circulating tumor cells (CTC) shed from primary or metastatic tumors into the blood circulation. Thus, CTCs provide a unique patient biopsy resource to decipher the cellular subpopulation…

Supplementary Table S3 (xlsx) from Circulating Tumor Cells Exhibit Metastatic Tropism and Reveal Brain Metastasis Drivers Open

Rémi Klotz, Amal Thomas, Teng Teng, Sung Min Han, Oihana Iriondo , et al. · 2023

List of unique genes upregulated in CTC-derived brain metastases

Supplementary Table S3 (xlsx) from Circulating Tumor Cells Exhibit Metastatic Tropism and Reveal Brain Metastasis Drivers Open

Rémi Klotz, Amal Thomas, Teng Teng, Sung Min Han, Oihana Iriondo , et al. · 2023

List of unique genes upregulated in CTC-derived brain metastases

Supplementary Table S8 (xlsx) from Circulating Tumor Cells Exhibit Metastatic Tropism and Reveal Brain Metastasis Drivers Open

Rémi Klotz, Amal Thomas, Teng Teng, Sung Min Han, Oihana Iriondo , et al. · 2023

List of upregulated genes associated with brain tropism in CTCs

Supplementary Figures from Circulating Tumor Cells Exhibit Metastatic Tropism and Reveal Brain Metastasis Drivers Open

Rémi Klotz, Amal Thomas, Teng Teng, Sung Min Han, Oihana Iriondo , et al. · 2023

File includes supplementary figures S1 to S5

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