Satish Gopal
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View article: Figure S1 from A Genomic Analysis of Esophageal Squamous Cell Carcinoma in Eastern Africa
Figure S1 from A Genomic Analysis of Esophageal Squamous Cell Carcinoma in Eastern Africa Open
Supplementary Figure S1. Measurement of RNA Quantity and Quality using PAXgene tissue container vs. RNAlater.
View article: Shared genomic features of HIV+ diffuse large B-cell lymphoma in two African cohorts
Shared genomic features of HIV+ diffuse large B-cell lymphoma in two African cohorts Open
View article: First Decade of the National Cancer Institute's Affordable Cancer Technologies Program: Accelerating Translational Technology Research and Development for Cancer Globally
First Decade of the National Cancer Institute's Affordable Cancer Technologies Program: Accelerating Translational Technology Research and Development for Cancer Globally Open
Since 2014, the National Cancer Institute Affordable Cancer Technologies (ACTs) program has supported a broad research portfolio focused on the development and validation of new technologies for global cancer control. ACTs projects are con…
View article: Cancer immunotherapy clinical trials to support urgently needed access in low- and middle-income countries: a report from the SITC global access and impact committee
Cancer immunotherapy clinical trials to support urgently needed access in low- and middle-income countries: a report from the SITC global access and impact committee Open
Cancer is rapidly on the rise as a cause of morbidity and mortality in low- and middle-income countries (LMICs). However, despite the increasing importance of immune checkpoint inhibitors (ICIs) as a pillar of cancer therapy, access in the…
View article: Pediatric Malignant Tumors in Malawi: A Diagnostic Report From the Kamuzu Central Hospital Pathology Laboratory 2011–2020
Pediatric Malignant Tumors in Malawi: A Diagnostic Report From the Kamuzu Central Hospital Pathology Laboratory 2011–2020 Open
Background In 2011, a partnership between Kamuzu Central Hospital (KCH) and the University of North Carolina (UNC) led to the opening of the first diagnostic pathology laboratory in Lilongwe, Malawi's capital. Procedure A retrospective cas…
View article: Barriers and Opportunities for Cancer Clinical Trials in Low- and Middle-Income Countries
Barriers and Opportunities for Cancer Clinical Trials in Low- and Middle-Income Countries Open
Importance Clinical trials represent the gold standard to test the safety and efficacy of new or updated approaches to treatments that will inform quality cancer care. However, cancer trials enroll few patients in low- and middle-income co…
View article: Global perspectives on patient-centered outcomes: advancing patient-centered cancer clinical trials globally
Global perspectives on patient-centered outcomes: advancing patient-centered cancer clinical trials globally Open
Patient-centered clinical trials prioritize the patient experience and outcomes that matter most to those affected by cancer. By centering on patient values and experiences, patient-centered outcomes research generates evidence to inform p…
View article: HIV and prior exposure to antiretroviral therapy alter tumour composition and tumour: T‐cell associations in diffuse large B‐cell lymphoma
HIV and prior exposure to antiretroviral therapy alter tumour composition and tumour: T‐cell associations in diffuse large B‐cell lymphoma Open
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of lymphoma worldwide, accounting for up to 40% of new non-Hodgkin Lymphoma (NHL) globally. People living with HIV are up to 17 times more likely to develop NHL, and as such,…
View article: Aetiology, susceptibility and outcomes of fever in patients receiving chemotherapy in Malawi: a prospective study
Aetiology, susceptibility and outcomes of fever in patients receiving chemotherapy in Malawi: a prospective study Open
Objectives: To evaluate causes of fever, including resistance patterns, in patients undergoing cancer treatment in Malawi. Methods: In this prospective cohort study, enrolled patients undergoing chemotherapy at Kamuzu Central Hospital in L…
View article: Update on pathology laboratory development and research in advancing regional cancer care in Malawi
Update on pathology laboratory development and research in advancing regional cancer care in Malawi Open
The pathology laboratory at Kamuzu Central Hospital (KCH) in Lilongwe, Malawi was established in 2011. We published our initial experiences in laboratory development and telepathology in 2013 and 2016, respectively. The purpose of this pap…
View article: Figure S2 from A Genomic Analysis of Esophageal Squamous Cell Carcinoma in Eastern Africa
Figure S2 from A Genomic Analysis of Esophageal Squamous Cell Carcinoma in Eastern Africa Open
Supplementary Figure S2. Expression of Mutsig CV genes in cohorts from Tanzania (Panel A) and Malawi (Panel B).
View article: Figure S2 from A Genomic Analysis of Esophageal Squamous Cell Carcinoma in Eastern Africa
Figure S2 from A Genomic Analysis of Esophageal Squamous Cell Carcinoma in Eastern Africa Open
Supplementary Figure S2. Expression of Mutsig CV genes in cohorts from Tanzania (Panel A) and Malawi (Panel B).
View article: Data from A Genomic Analysis of Esophageal Squamous Cell Carcinoma in Eastern Africa
Data from A Genomic Analysis of Esophageal Squamous Cell Carcinoma in Eastern Africa Open
Background: Esophageal squamous cell carcinoma (ESCC) comprises 90% of all esophageal cancer cases globally and is the most common histology in low-resource settings. Eastern Africa has a disproportionately high incidence of ESCC. Methods:…
View article: Figure S1 from A Genomic Analysis of Esophageal Squamous Cell Carcinoma in Eastern Africa
Figure S1 from A Genomic Analysis of Esophageal Squamous Cell Carcinoma in Eastern Africa Open
Supplementary Figure S1. Measurement of RNA Quantity and Quality using PAXgene tissue container vs. RNAlater.
View article: Figure S1 from A Genomic Analysis of Esophageal Squamous Cell Carcinoma in Eastern Africa
Figure S1 from A Genomic Analysis of Esophageal Squamous Cell Carcinoma in Eastern Africa Open
Supplementary Figure S1. Measurement of RNA Quantity and Quality using PAXgene tissue container vs. RNAlater.
View article: Aetiology, susceptibility and outcomes of fever in patients receiving chemotherapy in Malawi: a prospective study
Aetiology, susceptibility and outcomes of fever in patients receiving chemotherapy in Malawi: a prospective study Open
Objectives To evaluate causes of fever, including resistance patterns, in patients undergoing cancer treatment in Malawi. Methods In this prospective cohort study, enrolled patients undergoing chemotherapy at Kamuzu Central Hospital in Lil…
View article: Understanding Global Lived Experiences to Advance Oncology Care in Low- and Middle-Income Countries
Understanding Global Lived Experiences to Advance Oncology Care in Low- and Middle-Income Countries Open
View article: How I treat Burkitt lymphoma in children, adolescents, and young adults in sub-Saharan Africa
How I treat Burkitt lymphoma in children, adolescents, and young adults in sub-Saharan Africa Open
Burkitt lymphoma (BL) is the most common pediatric cancer in sub-Saharan Africa (SSA), and also occurs frequently among adolescents and young adults (AYAs), often associated with HIV. Treating BL in SSA poses particular challenges. Althoug…
View article: Ending Tribalism in Global Oncology
Ending Tribalism in Global Oncology Open
My recent experiences suggest there is broad consensus that global health is important and that this is a settled issue, despite seeming not so settled at times during the last year. Foremost among these experiences was the opportunity to …
View article: Mature outcomes and prognostic indices in diffuse large B-cell lymphoma in Malawi: a prospective cohort
Mature outcomes and prognostic indices in diffuse large B-cell lymphoma in Malawi: a prospective cohort Open
Outcomes for diffuse large B-cell lymphoma (DLBCL) in sub-Saharan Africa (SSA) are poorly described. We report mature data from one of the first prospective SSA cohorts. Patients aged ≥18 years with DLBCL were enrolled in Malawi 2013-2017.…
View article: Frequent HIV and Young Age Among Individuals With Diverse Cancers at a National Teaching Hospital in Malawi
Frequent HIV and Young Age Among Individuals With Diverse Cancers at a National Teaching Hospital in Malawi Open
Purpose Cancer surveillance provides a critical evidence base to guide cancer control efforts, yet population-based coverage in Africa is sparse. Hospital-based registries may help fill this need by providing local epidemiologic data to gu…
View article: Lymphoma and Pathology in Sub-Saharan Africa Current Approaches and Future Directions
Lymphoma and Pathology in Sub-Saharan Africa Current Approaches and Future Directions Open
View article: Global Health: What's in It for Us?
Global Health: What's in It for Us? Open
Last April, my 7-year-old daughter had cerebral malaria in Malawi, where my family and I live. Given the international discussion about the value of engaging beyond one’s borders in today’s world, I have been thinking a lot about why as an…
View article: A prospective description of HIV-associated multicentric Castleman disease in Malawi
A prospective description of HIV-associated multicentric Castleman disease in Malawi Open
Despite high burden of Kaposi sarcoma (KS) and HIV, multicentric Castleman disease (MCD) is rarely reported in sub-Saharan Africa (SSA). A pathology series in Uganda demonstrated latency-associated nuclear antigen (LANA) and viral interleu…
View article: Kaposi's sarcoma in Malawi
Kaposi's sarcoma in Malawi Open
Kaposi’s sarcoma (KS) is the leading cancer in much of sub-Saharan Africa [1]. HIV has resulted in a dramatic increase in KS throughout the region, due to high overlapping prevalence of HIV and the etiologic agent of KS, Kaposi’s sarcoma-a…
View article: Practical Successes in Telepathology Experiences in Africa
Practical Successes in Telepathology Experiences in Africa Open
View article: Guidelines for sub-Saharan Africa: a call for evidence
Guidelines for sub-Saharan Africa: a call for evidence Open
View article: Discovering' primary effusion lymphoma in Malawi
Discovering' primary effusion lymphoma in Malawi Open
Primary effusion lymphoma (PEL) is a rare non-Hodgkin lymphoma (NHL) associated with human herpesvirus 8 (HHV8) and increased incidence among HIV-positive individuals. PEL rarely presents as solid tumor masses, or extracavitary PEL (EPEL).…
View article: Accurate Real-Time Diagnosis of Lymphoproliferative Disorders in Malawi Through Clinicopathologic Teleconferences
Accurate Real-Time Diagnosis of Lymphoproliferative Disorders in Malawi Through Clinicopathologic Teleconferences Open
OBJECTIVES: The incidence of lymphoproliferative disorders (LPDs) is increasing in sub-Saharan Africa (SSA) due to population growth, aging, and human immunodeficiency virus (HIV). Despite significant burden, resources for diagnosis and tr…
View article: Hodgkin lymphoma, HIV, and Epstein–Barr virus in Malawi: Longitudinal results from the Kamuzu Central Hospital Lymphoma study
Hodgkin lymphoma, HIV, and Epstein–Barr virus in Malawi: Longitudinal results from the Kamuzu Central Hospital Lymphoma study Open
BACKGROUND: Contemporary descriptions of classical Hodgkin lymphoma (cHL) are lacking from sub-Saharan Africa where human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) are prevalent. METHODS: We describe a prospective cHL cohor…