Satish Iyengar
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View article: Visual Imagery and Spectrum Symptoms of Depression and Hypomania Differentially Modulate Brain Responses during Emotional Face Anticipation and Encoding
Visual Imagery and Spectrum Symptoms of Depression and Hypomania Differentially Modulate Brain Responses during Emotional Face Anticipation and Encoding Open
Background Depressive (DD) and bipolar (BD) disorders are characterized by biases in anticipating and encoding emotional information. Depressive traits are linked to negative affective biases, while hypomanic features are associated with h…
View article: Distinct white matter fiber density patterns in bipolar and depressive disorders: Insights from fixel-based analysis
Distinct white matter fiber density patterns in bipolar and depressive disorders: Insights from fixel-based analysis Open
Our findings highlight distinct and overlapping white matter alterations in BD and DD. Furthermore, FD in key tracts may serve as a predictor of future symptom trajectories, supporting the potential clinical utility of FD as a biomarker fo…
View article: Maximum and minimum activity in inpatient adolescents with Bipolar Disorders: Daily-Variability classification of actigraphy pattern with artificial intelligence
Maximum and minimum activity in inpatient adolescents with Bipolar Disorders: Daily-Variability classification of actigraphy pattern with artificial intelligence Open
Measures of daily activity may be objective markers to help differentiate adolescent bipolar disorder (BD). We used chart reviewed actigraphy data collected from 2014 to 2023, and AI methods to classify well-characterized inpatient adolesc…
View article: Distinct White Matter Fiber Density Patterns in Bipolar and Depressive Disorders: Insights from Fixel-Based Analysis
Distinct White Matter Fiber Density Patterns in Bipolar and Depressive Disorders: Insights from Fixel-Based Analysis Open
Background Differentiating Bipolar (BD) and depressive (DD) disorders remains challenging in clinical practice due to overlapping symptoms. Our study employs fixel-based analysis (FBA) to examine fiber-specific white matter differences in …
View article: Addressing Zero-Inflated Scores in Self-Reported Psychiatric Questionnaires: Utilizing Synthetic Minority Over-Sampling Technique (SMOTE) to Classify Mood and Energy Based on Extreme Activity Levels for Adolescents with Bipolar and ADHD
Addressing Zero-Inflated Scores in Self-Reported Psychiatric Questionnaires: Utilizing Synthetic Minority Over-Sampling Technique (SMOTE) to Classify Mood and Energy Based on Extreme Activity Levels for Adolescents with Bipolar and ADHD Open
Accurate classification of bipolar disorder (BD) and attention deficit hyperactivity disorder (ADHD) in adolescents is challenging due to symptom overlap and the prevalence of zero-inflated bias in self-report questionnaires. This study te…
View article: Person-level contributions of bipolar polygenic risk score to the prediction of new-onset bipolar disorder in at-risk offspring
Person-level contributions of bipolar polygenic risk score to the prediction of new-onset bipolar disorder in at-risk offspring Open
View article: The relationship between the size and asymmetry of the lateral ventricles and cortical myelin content in individuals with mood disorders
The relationship between the size and asymmetry of the lateral ventricles and cortical myelin content in individuals with mood disorders Open
Background Although enlargement of the lateral ventricles was previously observed in individuals with mood disorders, the link between ventricular size and asymmetry with other indices of brain structure remains underexplored. In this stud…
View article: Validation of a youth suicide risk calculator in an adult sample with bipolar disorder
Validation of a youth suicide risk calculator in an adult sample with bipolar disorder Open
View article: 3.5 Validation of the Youth Suicide Risk Calculator in an Adult Sample with Bipolar Disorder
3.5 Validation of the Youth Suicide Risk Calculator in an Adult Sample with Bipolar Disorder Open
BackgroundBipolar disorder (BD) conveys the highest risk of suicide of all mental disorders. We sought to externally validate a risk calculator (RC) of suicide attempts developed in youth with BD from the Course and Outcome of Bipolar Yout…
View article: Quantifying Distances between Non-elliptical Clusters to Enhance the Identification of Meaningful Emotional Reactivity Subtypes
Quantifying Distances between Non-elliptical Clusters to Enhance the Identification of Meaningful Emotional Reactivity Subtypes Open
Coordinated emotional responses across psychophysiological and subjective indices is a cornerstone of adaptive emotional functioning. Using clustering to identify cross-diagnostic subgroups with similar emotion response profiles may sugges…
View article: Early indicators of bipolar risk in preschool offspring of parents with bipolar disorder
Early indicators of bipolar risk in preschool offspring of parents with bipolar disorder Open
Background Offspring of parents with bipolar disorder (BD‐I/II) are at increased risk to develop the disorder. Previous work indicates that bipolar spectrum disorder (BPSD) is often preceded by mood/anxiety symptoms. In school‐age offsprin…
View article: Working memory updating in individuals with bipolar and unipolar depression: fMRI study
Working memory updating in individuals with bipolar and unipolar depression: fMRI study Open
Understanding neurobiological characteristics of cognitive dysfunction in distinct psychiatric disorders remains challenging. In this secondary data analysis, we examined neurobiological differences in brain response during working memory …
View article: The interaction between depression diagnosis and BMI is related to altered activation pattern in the right inferior frontal gyrus and anterior cingulate cortex during food anticipation
The interaction between depression diagnosis and BMI is related to altered activation pattern in the right inferior frontal gyrus and anterior cingulate cortex during food anticipation Open
Background Depression and overweight/obesity often cooccur but the underlying neural mechanisms for this bidirectional link are not well understood. Methods In this functional magnetic resonance imaging study, we scanned 54 individuals dia…
View article: Quantifying Distances Between Clusters with Elliptical or Non-Elliptical Shapes
Quantifying Distances Between Clusters with Elliptical or Non-Elliptical Shapes Open
Finite mixture models that allow for a broad range of potentially non-elliptical cluster distributions is an emerging methodological field. Such methods allow for the shape of the clusters to match the natural heterogeneity of the data, ra…
View article: White Matter Correlates of Early-Onset Bipolar Illness and Predictors of One-Year Recurrence of Depression in Adults with Bipolar Disorder
White Matter Correlates of Early-Onset Bipolar Illness and Predictors of One-Year Recurrence of Depression in Adults with Bipolar Disorder Open
Diffusion Magnetic Resonance Imaging (dMRI) studies have reported abnormalities in emotion regulation circuits in BD; however, no study has examined the contribution of previous illness on these mechanisms. Using global probabilistic tract…
View article: White matter predictors of worsening of subthreshold hypomania severity in non-bipolar young adults parallel abnormalities in individuals with bipolar disorder
White matter predictors of worsening of subthreshold hypomania severity in non-bipolar young adults parallel abnormalities in individuals with bipolar disorder Open
View article: Care team and practice-level implementation strategies to optimize pediatric collaborative care: study protocol for a cluster-randomized hybrid type III trial
Care team and practice-level implementation strategies to optimize pediatric collaborative care: study protocol for a cluster-randomized hybrid type III trial Open
Background Implementation facilitation is an effective strategy to support the implementation of evidence-based practices (EBPs), but our understanding of multilevel strategies and the mechanisms of change within the “black box” of impleme…
View article: Higher socioeconomic status and less parental psychopathology improve prognosis in youths with bipolar disorder
Higher socioeconomic status and less parental psychopathology improve prognosis in youths with bipolar disorder Open
View article: The role of sleep quality on white matter integrity and concussion symptom severity in adolescents
The role of sleep quality on white matter integrity and concussion symptom severity in adolescents Open
Poor quality of sleep following concussion is associated with widespread lower integrity of major white matter tracts, that in turn helped to explain post-concussion symptom severity in 12-17.9-year-old adolescents. The effect of sleep on …
View article: Role of Polygenic Risk Score in the Familial Transmission of Bipolar Disorder in Youth
Role of Polygenic Risk Score in the Familial Transmission of Bipolar Disorder in Youth Open
The findings of this study add to the extant clinical validation of BD in youth. Parental BD and offspring BD PRS independently associated with the risk of BD in offspring. Although this is promising, the association of BD PRS was relative…
View article: A Statewide Randomized Controlled Trial to Compare Three Models for Implementing Parent Child Interaction Therapy
A Statewide Randomized Controlled Trial to Compare Three Models for Implementing Parent Child Interaction Therapy Open
Through the use of a randomized controlled design and community implementation, this study contributes to the current understanding of the impact of training design on implementation of PCIT. Results also indicate that although in-person t…
View article: White Matter Abnormalities Associated With Prolonged Recovery in Adolescents Following Concussion
White Matter Abnormalities Associated With Prolonged Recovery in Adolescents Following Concussion Open
Background: Concussion symptoms in adolescents typically resolve within 4 weeks. However, 20 – 30% of adolescents experience a prolonged recovery. Abnormalities in tracts implicated in visuospatial attention and emotional regulation (i.e.,…
View article: Neural function during emotion regulation and future depressive symptoms in youth at risk for affective disorders
Neural function during emotion regulation and future depressive symptoms in youth at risk for affective disorders Open
View article: A Longitudinal Study of Psychiatric Disorders in Offspring of Parents With Bipolar Disorder From Preschool to Adolescence
A Longitudinal Study of Psychiatric Disorders in Offspring of Parents With Bipolar Disorder From Preschool to Adolescence Open
View article: Natural language processing and machine learning of electronic health records for prediction of first-time suicide attempts
Natural language processing and machine learning of electronic health records for prediction of first-time suicide attempts Open
Objective Limited research exists in predicting first-time suicide attempts that account for two-thirds of suicide decedents. We aimed to predict first-time suicide attempts using a large data-driven approach that applies natural language …
View article: Effectiveness of a Brief Psychological Intervention Delivered by Nurse for Depression in Pregnancy: Study Protocol for a Multicentric Randomized Controlled Trial from India
Effectiveness of a Brief Psychological Intervention Delivered by Nurse for Depression in Pregnancy: Study Protocol for a Multicentric Randomized Controlled Trial from India Open
Background: Perinatal depression (PD) has important implications for maternal and infant well-being but largely goes undetected. There is a need to develop low-intensity psychosocial interventions applicable to obstetric health care facili…
View article: Emotional regulation neural circuitry abnormalities in adult bipolar disorder: dissociating effects of long-term depression history from relationships with present symptoms
Emotional regulation neural circuitry abnormalities in adult bipolar disorder: dissociating effects of long-term depression history from relationships with present symptoms Open
View article: White Matter Correlates of Suicidality in Adults With Bipolar Disorder Who Have Been Prospectively Characterized Since Childhood
White Matter Correlates of Suicidality in Adults With Bipolar Disorder Who Have Been Prospectively Characterized Since Childhood Open
View article: Using machine learning and surface reconstruction to accurately differentiate different trajectories of mood and energy dysregulation in youth
Using machine learning and surface reconstruction to accurately differentiate different trajectories of mood and energy dysregulation in youth Open
Difficulty regulating positive mood and energy is a feature that cuts across different pediatric psychiatric disorders. Yet, little is known regarding the neural mechanisms underlying different developmental trajectories of positive mood a…
View article: Prefrontal cortical activation during working memory task anticipation contributes to discrimination between bipolar and unipolar depression
Prefrontal cortical activation during working memory task anticipation contributes to discrimination between bipolar and unipolar depression Open