Satoru Takahashi
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View article: Expression status transition of NOTCH1 accompanies chromatin remodeling in human early retinal progenitor cells
Expression status transition of NOTCH1 accompanies chromatin remodeling in human early retinal progenitor cells Open
Background The regulation of receptor expression is crucial for fine-tuned signal transduction. Notch signaling is a key signaling pathway involved in retinal development. Compared to the knowledge on this signaling pathway in the differe…
View article: Comparative Carcinogenicity of Double-Walled Carbon Nanotubes of Different Lengths Administered by Intratracheal Installation into Rat Lungs
Comparative Carcinogenicity of Double-Walled Carbon Nanotubes of Different Lengths Administered by Intratracheal Installation into Rat Lungs Open
We previously carried out an in vivo 2-year study to assess the potential toxicity/carcinogenicity of double-walled carbon nanotubes (DWCNTs) in a rat lung. We found that administration of DWCNTs by intratracheal–intrapulmonary spraying (T…
View article: Mycobacterium tuberculosis impairs protective cytokine production via transcription factor MafB manipulation
Mycobacterium tuberculosis impairs protective cytokine production via transcription factor MafB manipulation Open
Although an increased expression of the transcription factor v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B (MAFB) has been reported in patients with active tuberculosis (TB), its potential role in Mycobacterium tuberculosi…
View article: Computer identification of Notch3 in the neurogenic progenitor cells of mammalian early optic vesicles
Computer identification of Notch3 in the neurogenic progenitor cells of mammalian early optic vesicles Open
View article: <i>Mafb</i> Deficiency in Myeloid Cells Increases Susceptibility to <i>Mycobacterium tuberculosis</i> Infection in Mice
<i>Mafb</i> Deficiency in Myeloid Cells Increases Susceptibility to <i>Mycobacterium tuberculosis</i> Infection in Mice Open
v-Maf avian musculoaponeurotic fibrosarcoma oncogene homolog B ( MAFB ) is a candidate gene associated with early tuberculosis onset identified by a genome-wide association study. Here, we investigated the role of Mafb in susceptibility to…
View article: Feasibility of anticancer treatment using scalp cooling for patients with gynecological cancer in Japan: A case series study
Feasibility of anticancer treatment using scalp cooling for patients with gynecological cancer in Japan: A case series study Open
Aim To evaluate the safety and efficacy of scalp cooling in preventing chemotherapy‐induced alopecia among Japanese patients with gynecological cancer. Methods A retrospective study was conducted involving 16 patients with gynecological ca…
View article: Discordance Between Thyroid Function and Thyroid-Stimulating Hormone (TSH) Receptor Antibodies in Down Syndrome Patients With Autoimmune Thyroid Disease: A Long-Term Follow-Up Study of Two Cases
Discordance Between Thyroid Function and Thyroid-Stimulating Hormone (TSH) Receptor Antibodies in Down Syndrome Patients With Autoimmune Thyroid Disease: A Long-Term Follow-Up Study of Two Cases Open
Thyroid function in autoimmune thyroid disease (AITD) among patients with Down syndrome (DS) sometimes exhibits fluctuations over time, but the underlying cause of this variability remains unknown. Thyrotoxicosis is often associated with G…
View article: Hypothesis on the role of cholesterol crystals in spontaneously ruptured aortic plaques: Potential triggers for inflammation and systemic effects
Hypothesis on the role of cholesterol crystals in spontaneously ruptured aortic plaques: Potential triggers for inflammation and systemic effects Open
View article: A Review of the Carcinogenic Potential of Thick Rigid and Thin Flexible Multi-Walled Carbon Nanotubes in the Lung
A Review of the Carcinogenic Potential of Thick Rigid and Thin Flexible Multi-Walled Carbon Nanotubes in the Lung Open
The carcinogenic potential of MWCNTs is not well defined. Currently, IARC has classified MWCNT-7 as a Group 2 B material, possibly carcinogenic to humans, and all other MWCNTs as Group 3 materials, inadequate evidence in experimental anima…
View article: Exploring experimental models of prostate cancer in chemoprevention: Oxidative stress as a key pathway to translational research
Exploring experimental models of prostate cancer in chemoprevention: Oxidative stress as a key pathway to translational research Open
Prostate cancer (PCa) is the second most common cancer in men globally. Its growth is driven by oxidative stress associated with inflammation, aging, and environmental factors, including diet and lifestyle. These factors contribute to mult…
View article: Supplementary Data from Cancer-Specific Targeting of Taurine-Upregulated Gene 1 Enhances the Effects of Chemotherapy in Pancreatic Cancer
Supplementary Data from Cancer-Specific Targeting of Taurine-Upregulated Gene 1 Enhances the Effects of Chemotherapy in Pancreatic Cancer Open
Figure S1-S8 & Table S1-S6
View article: A case of fetal diagnosis of partial anomalous pulmonary venous return
A case of fetal diagnosis of partial anomalous pulmonary venous return Open
View article: New high-precision measurement system for electron–positron pairs from sub-GeV/GeV gamma-rays in the emulsion telescope
New high-precision measurement system for electron–positron pairs from sub-GeV/GeV gamma-rays in the emulsion telescope Open
View article: Fullerene and fullerene whisker are not carcinogenic to the lungs and pleura in rat long-term study after 2-week intra-tracheal intrapulmonary administration
Fullerene and fullerene whisker are not carcinogenic to the lungs and pleura in rat long-term study after 2-week intra-tracheal intrapulmonary administration Open
View article: The role of <scp>DPYD</scp> and the effects of <scp>DPYD</scp> suppressor luteolin combined with 5‐<scp>FU</scp> in pancreatic cancer
The role of <span>DPYD</span> and the effects of <span>DPYD</span> suppressor luteolin combined with 5‐<span>FU</span> in pancreatic cancer Open
Background Despite advances in the treatment of cancer, pancreatic ductal adenocarcinoma (PDAC) remains highly lethal due to the lack of effective therapies. Our previous study showed that Luteolin (Lut), a flavonoid, suppressed pancreatoc…
View article: Development of deep learning model for diagnosing muscle-invasive bladder cancer on MRI with vision transformer
Development of deep learning model for diagnosing muscle-invasive bladder cancer on MRI with vision transformer Open
The DL model effectively diagnosed MIBC. The ViT-based model outperformed CNN-based models, highlighting its utility in medical image analysis.
View article: Characterisation of colorectal cancer by hierarchical clustering analyses for five stroma‐related markers
Characterisation of colorectal cancer by hierarchical clustering analyses for five stroma‐related markers Open
Evidence for the tumour‐supporting capacities of the tumour stroma has accumulated rapidly in colorectal cancer (CRC). Tumour stroma is composed of heterogeneous cells and components including cancer‐associated fibroblasts (CAFs), small ve…
View article: Estimating an embolic source in peripheral artery disease using non-obstructive general angioscopy and histopathology
Estimating an embolic source in peripheral artery disease using non-obstructive general angioscopy and histopathology Open
View article: Patient-derived castration-resistant prostate cancer model revealed CTBP2 upregulation mediated by OCT1 and androgen receptor
Patient-derived castration-resistant prostate cancer model revealed CTBP2 upregulation mediated by OCT1 and androgen receptor Open
View article: Revealing Mechanisms of Atherosclerosis and Atherosclerotic Diseases Using Angioscopy
Revealing Mechanisms of Atherosclerosis and Atherosclerotic Diseases Using Angioscopy Open
われわれは血管径を問わず観察可能な血流維持型汎用血管内視鏡(NOGA)システムを開発し,大動脈からの高頻度な自然破綻プラークを同定した。これは臓器の機能低下から老化にかかわると考えられた。コレステロール結晶を介した先天免疫によるプラークの進展,破綻についてin situで証明した。NOGAは急性大動脈解離の詳細な内膜傷害の同定や治療の補助手段として利用され,動脈硬化疾患の全体,さらに新しい治療の補助手段として有用である。
View article: Characterization of Pleural Mesothelioma by Hierarchical Clustering Analyses Using Immune Cells within Tumor Microenvironment
Characterization of Pleural Mesothelioma by Hierarchical Clustering Analyses Using Immune Cells within Tumor Microenvironment Open
Introduction: Over the past decade, classifications using immune cell infiltration have been applied to many types of tumors; however, mesotheliomas have been less frequently evaluated. Methods: In this study, 60 well-characterized pleural…
View article: Flare phenomenon visualized by 99mTc-bone scintigraphy has prognostic value for patients with metastatic castration-resistant prostate cancer
Flare phenomenon visualized by 99mTc-bone scintigraphy has prognostic value for patients with metastatic castration-resistant prostate cancer Open
View article: Simultaneous Expression of CD70 and POSTN in Cancer-Associated Fibroblasts Predicts Worse Survival of Colorectal Cancer Patients
Simultaneous Expression of CD70 and POSTN in Cancer-Associated Fibroblasts Predicts Worse Survival of Colorectal Cancer Patients Open
Colorectal cancer (CRC) is one of the most common gastrointestinal cancers worldwide, with high morbidity and mortality rates. The evidence for the tumor-supporting capacities of cancer-associated fibroblasts (CAFs) that modulate cancer ce…
View article: Different Characteristics and Interleukin-6 Ratios of Scattering-Type Aortic Plaques
Different Characteristics and Interleukin-6 Ratios of Scattering-Type Aortic Plaques Open
Background Cholesterol crystals (CCs) are related to innate inflammation in spontaneously ruptured aortic plaques (SRAPs), and variability exists in the CCs and interleukin (IL)-6 ratio in SRAPs. Methods The prevalence of scattering-type r…
View article: Successful Retrieval of Filter Embolic Protection Device Fragment Trapped by a Carotid Stent: A Case Report
Successful Retrieval of Filter Embolic Protection Device Fragment Trapped by a Carotid Stent: A Case Report Open
The edge of a carotid stent can potentially trap devices. When trapping or fragmentation of a device is suspected, it is necessary to evaluate the situation and cause, and the device should be appropriately retrieved without using force.
View article: Hexane insoluble fraction from purple rice extract improves steatohepatitis and fibrosis <i>via</i> inhibition of NF-κB and JNK signaling
Hexane insoluble fraction from purple rice extract improves steatohepatitis and fibrosis <i>via</i> inhibition of NF-κB and JNK signaling Open
Inhibition of NF-κB and JNK signaling by PRE-HIF contributes to decreased expression of cytokines and improved histological changes in NASH.
View article: Incidence of Pancreatic Injury and Pancreatitis in Patients Treated With Immune Checkpoint Inhibitors
Incidence of Pancreatic Injury and Pancreatitis in Patients Treated With Immune Checkpoint Inhibitors Open
INTRODUCTION: Immune checkpoint inhibitors (ICIs) are being increasingly used to treat advanced malignancies. ICI-induced pancreatic injury (ICI-PI), which is an immune-related adverse event that may be a risk factor of ICI-associated panc…
View article: Severe esophageal stricture after perforation and necrotizing esophagitis: unusual presentation of a duodenal gastrinoma
Severe esophageal stricture after perforation and necrotizing esophagitis: unusual presentation of a duodenal gastrinoma Open
Gastrinomas are pancreatic or duodenal endocrine tumors that secrete excess gastrin, which causes gastroesophageal reflux disease, peptic ulcers, and chronic diarrhea. Due to the rarity of the disease, nonspecific symptoms, and the outstan…
View article: Switching mechanism from AR to EGFR signaling via 3-O-sulfated heparan sulfate in castration-resistant prostate cancer
Switching mechanism from AR to EGFR signaling via 3-O-sulfated heparan sulfate in castration-resistant prostate cancer Open
Androgen deprivation therapy is given to suppress prostate cancer growth; however, some cells continue to grow hormone-independently as castration-resistant prostate cancer (CRPC). Sulfated glycosaminoglycans promote ligand binding to rece…
View article: Atherosclerosis of the aorta before blue toe syndrome: Spontaneously ruptured aortic plaques revealed by non-obstructive general angioscopy
Atherosclerosis of the aorta before blue toe syndrome: Spontaneously ruptured aortic plaques revealed by non-obstructive general angioscopy Open