Satoshi Hirakawa
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View article: A randomized, double-blind, placebo-controlled phase III study evaluating the preventive effect of diclofenac cream on capecitabine-related hand-foot syndrome: study protocol of J-SUPPORT2401/JORTC-SUP06 (J-DIRECT)
A randomized, double-blind, placebo-controlled phase III study evaluating the preventive effect of diclofenac cream on capecitabine-related hand-foot syndrome: study protocol of J-SUPPORT2401/JORTC-SUP06 (J-DIRECT) Open
Background Clinical evidence on preventive therapy for capecitabine-induced hand-foot syndrome (HFS) is limited, and moisturizing and avoiding local pressure are recommended in guidelines. Although the precise pathogenesis and mechanisms o…
View article: A randomized, double-blind, placebo-controlled phase III study evaluating the preventive effect of diclofenac cream on capecitabine-related hand-foot syndrome: Study protocol of J-SUPPORT2401/JORTC-SUP06 (J-DIRECT)
A randomized, double-blind, placebo-controlled phase III study evaluating the preventive effect of diclofenac cream on capecitabine-related hand-foot syndrome: Study protocol of J-SUPPORT2401/JORTC-SUP06 (J-DIRECT) Open
Background Clinical evidence on preventive therapy for capecitabine-induced hand-foot syndrome (HFS) is limited, and moisturizing and avoiding local pressure are recommended in guidelines. Although the precise pathogenesis and mechanisms o…
View article: Sirolimus treatment for intractable vascular anomalies (<scp>SIVA</scp>): An open‐label, single‐arm, multicenter, prospective trial
Sirolimus treatment for intractable vascular anomalies (<span>SIVA</span>): An open‐label, single‐arm, multicenter, prospective trial Open
Background Intractable vascular anomalies (VAs), including vascular tumors and venous, lymphatic, and mixed malformations, often have severe symptoms and a poor prognosis, highlighting the need for new treatments. We conducted a prospectiv…
View article: Operational performance and environmental satisfaction survey of a university building with large learning commons
Operational performance and environmental satisfaction survey of a university building with large learning commons Open
Learning Commons is being actively implemented in the design of university buildings to encourage diverse learning. Because the usage patterns of Learning Commons are different from those of regular classrooms, this design trend also has a…
View article: Sirolimus treatment for intractable lymphatic anomalies: an open-label, single-arm, multicenter, prospective trial
Sirolimus treatment for intractable lymphatic anomalies: an open-label, single-arm, multicenter, prospective trial Open
Introduction Intractable lymphatic anomalies (LAs) include cystic lymphatic malformation (LM; macrocystic, microcystic, or mixed), generalized lymphatic anomaly, and Gorham–Stout disease. LAs can present with severe symptoms and poor progn…
View article: Quality of life issues faced by patients with keratinocyte cancer: A systematic review
Quality of life issues faced by patients with keratinocyte cancer: A systematic review Open
Introduction: keratinocyte carcinomas (KC), including basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), represent the most prevalent malignancy worldwide with a rapidly increasing incidence. While KC and its treatmen…
View article: Multinational Association of Supportive Care in Cancer (MASCC) clinical practice guidance for the prevention of breast cancer-related arm lymphoedema (BCRAL): international Delphi consensus-based recommendations
Multinational Association of Supportive Care in Cancer (MASCC) clinical practice guidance for the prevention of breast cancer-related arm lymphoedema (BCRAL): international Delphi consensus-based recommendations Open
View article: Performance verification of pipe‐embedded wall system in school building and proposal of its optimal control strategy
Performance verification of pipe‐embedded wall system in school building and proposal of its optimal control strategy Open
In this study, a thermally activated building system (TABS) installed on the exterior wall as the pipe‐embedded wall (PEW) system in a school building was investigated. The basic performance of the PEW system utilizing well water cascade i…
View article: Changing Patterns of Infectious Diseases Among Hospitalized Children in Hokkaido, Japan, in the Post-COVID-19 Era, July 2019 to June 2022
Changing Patterns of Infectious Diseases Among Hospitalized Children in Hokkaido, Japan, in the Post-COVID-19 Era, July 2019 to June 2022 Open
Background: Many reports have reported a reduction in respiratory infectious diseases and infectious gastroenteritis immediately after the coronavirus disease 2019 (COVID-19) pandemic, but data continuing into 2022 are very limited. We sou…
View article: Supplementary Figure Legend from Angiopoietin-like Protein 2 Accelerates Carcinogenesis by Activating Chronic Inflammation and Oxidative Stress
Supplementary Figure Legend from Angiopoietin-like Protein 2 Accelerates Carcinogenesis by Activating Chronic Inflammation and Oxidative Stress Open
PDF file - 109K
View article: Supplementary Figures 1 - 9 from Angiopoietin-like Protein 2 Accelerates Carcinogenesis by Activating Chronic Inflammation and Oxidative Stress
Supplementary Figures 1 - 9 from Angiopoietin-like Protein 2 Accelerates Carcinogenesis by Activating Chronic Inflammation and Oxidative Stress Open
PDF file - 1314K, Supp Fig 1. Oxidative stress-dependent formation of 4-HNE and HNE-modified proteins. Supp Fig 2. NAC treatment decreases susceptibility of wild-type mice to chemical skin carcinogenesis. Supp Fig 3. Chemical treatment of …
View article: Supplementary Figure Legend from Angiopoietin-like Protein 2 Accelerates Carcinogenesis by Activating Chronic Inflammation and Oxidative Stress
Supplementary Figure Legend from Angiopoietin-like Protein 2 Accelerates Carcinogenesis by Activating Chronic Inflammation and Oxidative Stress Open
PDF file - 109K
View article: Data from Angiopoietin-like Protein 2 Accelerates Carcinogenesis by Activating Chronic Inflammation and Oxidative Stress
Data from Angiopoietin-like Protein 2 Accelerates Carcinogenesis by Activating Chronic Inflammation and Oxidative Stress Open
Chronic inflammation has received much attention as a risk factor for carcinogenesis. We recently reported that Angiopoietin-like protein 2 (Angptl2) facilitates inflammatory carcinogenesis and metastasis in a chemically induced squamous c…
View article: Data from Angiopoietin-like Protein 2 Accelerates Carcinogenesis by Activating Chronic Inflammation and Oxidative Stress
Data from Angiopoietin-like Protein 2 Accelerates Carcinogenesis by Activating Chronic Inflammation and Oxidative Stress Open
Chronic inflammation has received much attention as a risk factor for carcinogenesis. We recently reported that Angiopoietin-like protein 2 (Angptl2) facilitates inflammatory carcinogenesis and metastasis in a chemically induced squamous c…
View article: Supplementary Figures 1 - 9 from Angiopoietin-like Protein 2 Accelerates Carcinogenesis by Activating Chronic Inflammation and Oxidative Stress
Supplementary Figures 1 - 9 from Angiopoietin-like Protein 2 Accelerates Carcinogenesis by Activating Chronic Inflammation and Oxidative Stress Open
PDF file - 1314K, Supp Fig 1. Oxidative stress-dependent formation of 4-HNE and HNE-modified proteins. Supp Fig 2. NAC treatment decreases susceptibility of wild-type mice to chemical skin carcinogenesis. Supp Fig 3. Chemical treatment of …
View article: Data from Angiopoietin-like Protein 2 Is an Important Facilitator of Inflammatory Carcinogenesis and Metastasis
Data from Angiopoietin-like Protein 2 Is an Important Facilitator of Inflammatory Carcinogenesis and Metastasis Open
Chronic inflammation plays important roles at different stages of cancer development, including carcinogenesis, tumor invasion, and metastasis, but molecular mechanisms linking inflammation to cancer development have not been fully clarifi…
View article: Supplementary Figures 1-19, Methods from Angiopoietin-like Protein 2 Is an Important Facilitator of Inflammatory Carcinogenesis and Metastasis
Supplementary Figures 1-19, Methods from Angiopoietin-like Protein 2 Is an Important Facilitator of Inflammatory Carcinogenesis and Metastasis Open
PDF file - 7.5MB
View article: Data from Angiopoietin-like Protein 2 Is an Important Facilitator of Inflammatory Carcinogenesis and Metastasis
Data from Angiopoietin-like Protein 2 Is an Important Facilitator of Inflammatory Carcinogenesis and Metastasis Open
Chronic inflammation plays important roles at different stages of cancer development, including carcinogenesis, tumor invasion, and metastasis, but molecular mechanisms linking inflammation to cancer development have not been fully clarifi…
View article: Supplementary Figures 1-19, Methods from Angiopoietin-like Protein 2 Is an Important Facilitator of Inflammatory Carcinogenesis and Metastasis
Supplementary Figures 1-19, Methods from Angiopoietin-like Protein 2 Is an Important Facilitator of Inflammatory Carcinogenesis and Metastasis Open
PDF file - 7.5MB
View article: An analysis modality for vascular structures combining tissue-clearing technology and topological data analysis
An analysis modality for vascular structures combining tissue-clearing technology and topological data analysis Open
The blood and lymphatic vasculature networks are not yet fully understood even in mouse because of the inherent limitations of imaging systems and quantification methods. This study aims to evaluate the usefulness of the tissue-clearing te…
View article: An infant case of cervical purulent lymphadenitis caused by ST834 community-acquired methicillin-resistant Staphylococcus aureus with SCCmec-IVc in Japan
An infant case of cervical purulent lymphadenitis caused by ST834 community-acquired methicillin-resistant Staphylococcus aureus with SCCmec-IVc in Japan Open
View article: Surveillance in hospitalized children with infectious diseases in Japan: Pre- and post-coronavirus disease 2019
Surveillance in hospitalized children with infectious diseases in Japan: Pre- and post-coronavirus disease 2019 Open
View article: Mosaic Turner syndrome with improved Chiari type 1 malformation after growth hormone therapy: A case report
Mosaic Turner syndrome with improved Chiari type 1 malformation after growth hormone therapy: A case report Open
We described a three-year-old girl whose Chiari type 1 malformation associated with mosaic Turner syndrome disappeared after GH therapy. She was diagnosed with mosaic Turner syndrome at the age of 1 yr and 7 mo by a chromosomal analysis (G…
View article: Living Organisms under an Electron Microscope: the NanoSuit® Method aiming for Medical and Industrial Applications
Living Organisms under an Electron Microscope: the NanoSuit® Method aiming for Medical and Industrial Applications Open
Scanning electron microscopy (SEM) has made a remarkable progress and is an essential tool for observing biological materials at microscopic level. However, various complex procedures have precluded observation of living organisms to date.…
View article: Potential role of transforming growth factor‐beta 1/Smad signaling in secondary lymphedema after cancer surgery
Potential role of transforming growth factor‐beta 1/Smad signaling in secondary lymphedema after cancer surgery Open
Secondary lymphedema often develops after cancer surgery, and over 250 million patients suffer from this complication. A major symptom of secondary lymphedema is swelling with fibrosis, which lowers the patient's quality of life, even if c…
View article: Japanese clinical practice guidelines for vascular anomalies 2017
Japanese clinical practice guidelines for vascular anomalies 2017 Open
The objective was to prepare guidelines to perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas and vascular malformations, confirming the safety, and systematizing treatment, employing evid…
View article: Japanese Clinical Practice Guidelines for Vascular Anomalies 2017
Japanese Clinical Practice Guidelines for Vascular Anomalies 2017 Open
The objective was to prepare guidelines to perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas and vascular malformations, confirming the safety and systematizing treatment, employing evide…
View article: Japanese clinical practice guidelines for vascular anomalies 2017
Japanese clinical practice guidelines for vascular anomalies 2017 Open
The objective was to prepare guidelines to perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas and vascular malformations, confirming the safety, and systematizing treatment, employing evid…
View article: Aronia berry extract inhibits TNF-α-induced vascular endothelial inflammation through the regulation of STAT3
Aronia berry extract inhibits TNF-α-induced vascular endothelial inflammation through the regulation of STAT3 Open
Aronia berry extract could exert anti-atherosclerotic effects on TNF-α-induced inflammation through inhibition of STAT3/IRF1 pathway in vascular endothelial cells.
View article: Living Organisms under an Electron Microscope: the NanoSuit<sup>®</sup>
Living Organisms under an Electron Microscope: the NanoSuit<sup>®</sup> Open
Scanning electron microscopy (SEM) has made remarkable progress and has become an essential tool for observing biological materials at microscopic level. However, various complex procedures have precluded observation of living organisms to…