Satoshi� Matsui
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View article: Comparative analysis of streptozocin-based regimen and capecitabine–temozolomide therapy in advanced pancreatic neuroendocrine neoplasms: influence of tumor grade and Ki-67 index
Comparative analysis of streptozocin-based regimen and capecitabine–temozolomide therapy in advanced pancreatic neuroendocrine neoplasms: influence of tumor grade and Ki-67 index Open
Background: Systemic therapy is a standard treatment option for pancreatic neuroendocrine neoplasms (Pan-NENs) with unresectable or metastatic disease. Streptozocin (STZ)-based chemotherapy is considered a standard treatment option for tum…
View article: MAPK/ERK signaling blocks ectopic H3K9me3 heterochromatin formation to confer mesoderm and endoderm developmental competence
MAPK/ERK signaling blocks ectopic H3K9me3 heterochromatin formation to confer mesoderm and endoderm developmental competence Open
During gastrulation, dynamic interplay among cell signaling pathways dictates cell fate decisions. While extensive studies have elucidated their critical roles in morphological regulation, how these signals orchestrate the epigenome to con…
View article: A Case of Curative Resection by Minimally Invasive Surgery in Two Stages Using the Hormonal Mapping Test for Pancreatic Head ACTHoma with Multiple Liver Metastases
A Case of Curative Resection by Minimally Invasive Surgery in Two Stages Using the Hormonal Mapping Test for Pancreatic Head ACTHoma with Multiple Liver Metastases Open
Hormonal mapping was effective in identifying hormone-producing lesions and guiding surgical strategies for ACTHomas with liver metastases.
View article: Late-Onset Para-Aortic Lymph Node Recurrence 11 Years after Resection of Pancreatic Cancer: Histological Reassessment Revealed Neuroendocrine Differentiation Amenable to Surgical Resection
Late-Onset Para-Aortic Lymph Node Recurrence 11 Years after Resection of Pancreatic Cancer: Histological Reassessment Revealed Neuroendocrine Differentiation Amenable to Surgical Resection Open
This case highlights the importance of tissue diagnosis when late-onset recurrence is observed in patients with a prior diagnosis of PDAC. It also underscores the potential for extremely delayed recurrence in Pan-NENs and the importance of…
View article: ZMYND11 Functions in Bimodal Regulation of Latent Genes and Brain-like Splicing to Safeguard Corticogenesis
ZMYND11 Functions in Bimodal Regulation of Latent Genes and Brain-like Splicing to Safeguard Corticogenesis Open
Despite the litany of pathogenic variants linked to neurodevelopmental disorders (NDD) including autism (ASD) and intellectual disability 1,2 , our understanding of the underlying mechanisms caused by risk genes remain unclear. Here, we le…
View article: Protocol for establishing inducible CRISPRd system for blocking transcription factor-binding sites in human pluripotent stem cells
Protocol for establishing inducible CRISPRd system for blocking transcription factor-binding sites in human pluripotent stem cells Open
Transcription factor (TF) gene knockout or knockdown experiments provide comprehensive downstream effects on gene regulation. However, distinguishing primary direct effects from secondary effects remains challenging. To assess the direct e…
View article: Protocol for establishing inducible CRISPR interference system for multiple-gene silencing in human pluripotent stem cells
Protocol for establishing inducible CRISPR interference system for multiple-gene silencing in human pluripotent stem cells Open
Inducible loss-of-function strategies are crucial for understanding gene function. However, creating inducible, multiple-gene knockout models is challenging and time-consuming. Here, we present a protocol for establishing a doxycycline-ind…
View article: A Case of Congenital Biliary Dilatation Requiring Reoperation Due to Repeated Intrapancreatic Residual Cholangitis
A Case of Congenital Biliary Dilatation Requiring Reoperation Due to Repeated Intrapancreatic Residual Cholangitis Open
症例は21歳の女性で，10歳時に先天性胆道拡張症に対し肝外胆管切除，胆管空腸吻合，Roux-en-Y再建を施行された．術後11年目に上腹部痛を主訴に当院受診した．血液検査で炎症反応の上昇とCTで膵頭部に50 mm大の囊胞性病変を認め，遺残膵内胆管炎と診断した．前医の手術所見から拡張胆管の不十分な切除が原因と考え，遺残拡張胆管切除を施行した．手術は遺残拡張胆管前面の菲薄化した膵実質を一部切離して遺残胆管を同定し，膵実質との剥離を進め，膵管合流部の直上で切離し膵内遺残胆管を摘出…
View article: Pioneer transcription factors coordinate active and repressive gene expression states to regulate cell fate
Pioneer transcription factors coordinate active and repressive gene expression states to regulate cell fate Open
Pioneer transcription factors (TFs) regulate cell fate by establishing transcriptionally primed and active states. However, cell fate control requires the coordination of both lineage-specific gene activation and repression of alternative …
View article: A Case of “True Carcinosarcoma” Originating from the Bile Duct with a Morphology of Intrabiliary Polyp
A Case of “True Carcinosarcoma” Originating from the Bile Duct with a Morphology of Intrabiliary Polyp Open
症例は81歳の女性で,心窩部痛を主訴に当院救急外来を受診した.血液検査で肝胆道系酵素の上昇を認め,CTで総胆管結石もしくは胆管腫瘍による閉塞性黄疸を伴う胆管炎と診断され緊急入院となった.ERCPで総肝管から総胆管にかけて透亮像を認め,腫瘍も否定できない所見ではあったが,炎症極期であることを考慮し生検はせず,胆管ステントの留置にとどめた.後日症状軽快した段階で,再度ERCP下に生検を施行し,高分化から中分化管状腺癌の病理診断となった.胆管癌に対して肝外胆管切除,胆道再建,リン…
View article: Evaluation of histopathological heterogeneity of colorectal cancer liver metastasis sites after preoperative chemotherapy
Evaluation of histopathological heterogeneity of colorectal cancer liver metastasis sites after preoperative chemotherapy Open
Patients with liver metastases from colorectal cancer (CRLMs) frequently receive chemotherapy prior to liver resection. Histopathological assessment of the resected specimen can evaluate the response to chemotherapy. The present study anal…
View article: Pancreatic metastasis from renal cell carcinoma presenting as gastrointestinal hemorrhage: a case report
Pancreatic metastasis from renal cell carcinoma presenting as gastrointestinal hemorrhage: a case report Open
In some patients with metastatic renal cell carcinoma to the pancreas, gastrointestinal hemorrhages occur, but because of the rarity of this condition, treatment strategies have not been established. A 71-year-old man who had undergone a n…
View article: Evaluation of Histopathological Heterogeneity After Preoperative Chemotherapy in Patients With Liver Metastases from Colorectal Cancer
Evaluation of Histopathological Heterogeneity After Preoperative Chemotherapy in Patients With Liver Metastases from Colorectal Cancer Open
Background: Patients with liver metastases from colorectal cancer (CRLMs) frequently receive chemotherapy prior to liver resection. Histopathological assessment of the resected specimen can evaluate the response to chemotherapy. This study…
View article: A Case of Abscess of the Round Ligament of the Liver: Single-Port Laparoscopic Resection
A Case of Abscess of the Round Ligament of the Liver: Single-Port Laparoscopic Resection Open
症例は70歳の女性で，急な上腹部痛を自覚し近医を受診した．血液検査で炎症反応が異常高値であったため，当院を紹介受診した．腹部CTで肝円索内に長径66 mmのリング状に濃染される腫瘤を認め，肝円索膿瘍の診断で経皮的膿瘍ドレナージ術，抗生剤による保存的治療を行った．自覚症状，炎症反応は速やかに軽快したため，入院15日目に一時退院後，診断から約1か月後に単孔式腹腔鏡手術を施行した．右下腹部にポートを留置し，40 mm大の膿瘍瘢痕部分を含めた肝円索を切除した．本症例は歯周病を患って…
View article: A Case of Anal Canal Cancer with Pagetoid Spread Treated by Tri-Specialty Hybrid Surgery to Preserve Anal Function
A Case of Anal Canal Cancer with Pagetoid Spread Treated by Tri-Specialty Hybrid Surgery to Preserve Anal Function Open
症例は57歳の女性で，肛門右側の紅班を主訴に当院を受診した．皮膚生検で表皮にPaget細胞を認め，免疫組織化学染色で肛門管癌のPagetoid spreadと診断された．大腸内視鏡検査で直腸に腫瘤性病変を認めず，step biopsyでも陰性であった一方，直視下での肛門粘膜マッピング生検では陽性を示し，根治切除には肛門近傍の皮膚を含めた病変の切除が必要と考えた．深部浸潤を疑う所見はなく，粘膜下層での切除で根治性の確保と肛門温存が可能と考え，消化器外科・消化器内科・皮膚科合同…
View article: Intraductal Papillary Mucinous Carcinoma Penetrating the Colon in an Elderly Patient
Intraductal Papillary Mucinous Carcinoma Penetrating the Colon in an Elderly Patient Open
症例は85歳の女性で，腹部不快感で受診し，CTで横行結腸と連続する70 mm大の膵囊胞性病変と主膵管の拡張を認めた．ERCPで主乳頭開口部の開大と粘液漏出および主膵管内に乳頭状増殖を認めた．超音波内視鏡検査で囊胞性病変内に造影効果のある壁在結節を多数認めた．生検で膵管内乳頭粘液性腺癌（intraductal papillary mucinous carcinoma；以下，IPMCと略記）と診断した．膵実質は造影MRIで遅延性に造影され，拡散強調画像でびまん性に高信号を示した…
View article: Feasibility of the Reconstruction with Fascia Lata Patch on the Abdominal Wall Defect After Resection of the Abdominal Desmoid Tumor
Feasibility of the Reconstruction with Fascia Lata Patch on the Abdominal Wall Defect After Resection of the Abdominal Desmoid Tumor Open
Ayana Goto, Nobuhisa Matsuhashi, Takao Takahashi, Toshiyuki Tanahashi, Satoshi Matsui, Hisashi Imai, Yoshihiro Tanaka, Kazuya Yamaguchi, Kazuhiro Yoshida Department of Surgical Oncology, Gifu University School of Medicine, Gifu City 501-11…
View article: <p>Feasibility of the Reconstruction with Fascia Lata Patch on the Abdominal Wall Defect After Resection of the Abdominal Desmoid Tumor</p>
Feasibility of the Reconstruction with Fascia Lata Patch on the Abdominal Wall Defect After Resection of the Abdominal Desmoid Tumor Open
We encountered a case of abdominal wall desmoid tumor combined with a large abdominal incisional hernia. We selected the use of autologous fascia based on the risk of recurrence. The patient has not shown recurrence of incisional hernia or…
View article: Intranodal lymphangiography for chyle leakage after esophagectomy: A case report
Intranodal lymphangiography for chyle leakage after esophagectomy: A case report Open
Postoperative chylothorax after esophagectomy is a relatively rare complication, but treatment can sometimes be complicated. We report 3 cases of Lipiodol lymphangiography via inguinal lymph node puncture that was effective for chyle leaka…
View article: Primary Small Intestinal Cancer after Two Resections for Dissemination of Colon Cancer
Primary Small Intestinal Cancer after Two Resections for Dissemination of Colon Cancer Open
症例は73歳の女性で，2010年2月に上行結腸癌が先進部の腸重積，横行結腸穿孔，汎発性腹膜炎の診断で，当科にて拡大結腸右半切除術+D2リンパ節郭清術，回腸人工肛門造設術を施行した．病理学的診断は粘液癌でpSS，pN0，ly1，v1，pPM0，pDM0，pRM0，fStage IIであった．初回手術から4年，6年後に後腹膜再発を指摘され，いずれも摘出術を施行し，播種再発と診断した．初回手術から7年半後に腸閉塞のため当科紹介となり，CTにて狭窄部に腫瘍を認め，小腸部分切除術を施…
View article: Efficacy and Safety of Neoadjuvant Chemoradiotherapy with Docetaxel and 5-Fluorouracil Followed by Esophagectomy to Treat Advanced Esophageal Cancer
Efficacy and Safety of Neoadjuvant Chemoradiotherapy with Docetaxel and 5-Fluorouracil Followed by Esophagectomy to Treat Advanced Esophageal Cancer Open
目的：進行食道癌におけるdocetaxel・5-fluorouracil併用術前補助化学放射線療法（neoadjuvant chemoradiotherapy with docetaxel・5-fluorouracil；以下，DF-NACRTと略記）に対する有効性と安全性について検討した．方法：2007年12月～2017年8月までにDF-NACRTを行った進行食道癌12例を対象とした．結果：内訳はcStage II：2例，III：1例，IVA：8例，IVB：1例，年齢中央値…
View article: Transrectal EUS-FNA and Angiography Are Useful for the Treatment of Giant Small Intestine Gastrointestinal Stromal Tumors
Transrectal EUS-FNA and Angiography Are Useful for the Treatment of Giant Small Intestine Gastrointestinal Stromal Tumors Open
症例は55歳の男性で，主訴は頻尿であった．近医での腹部超音波検査において12 cm大の骨盤内腫瘤を指摘され，精査加療目的に紹介となった．経直腸超音波内視鏡下穿刺吸引細胞診（endoscopic ultrasound-guided fine needle aspiration；以下，EUS-FNAと略記）を行った結果，gastrointestinal stromal tumor（以下，GISTと略記）と診断された．血管造影検査では腫瘍は上腸間膜動脈，下腸間膜動脈，両側内腸骨動…