Satoshi Matsusaka
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View article: Experimental and numerical investigation of wavelength and resolution dependency of dynamic optical coherence tomography signals
Experimental and numerical investigation of wavelength and resolution dependency of dynamic optical coherence tomography signals Open
The wavelength and system-resolution dependencies of dynamic optical coherence tomography (DOCT) are investigated experimentally and numerically. Experimental investigations demonstrate significant wavelength dependency for the DOCT values…
View article: Experimental and numerical investigation of wavelength and resolution dependency of dynamic optical coherence tomography signals
Experimental and numerical investigation of wavelength and resolution dependency of dynamic optical coherence tomography signals Open
The wavelength and system-resolution dependencies of dynamic optical coherence tomography (DOCT) are investigated experimentally and numerically. Experimental investigations demonstrate significant wavelength dependency for the DOCT values…
View article: Dynamic optical coherence tomography algorithm for label-free assessment of swiftness and occupancy of intratissue moving scatterers
Dynamic optical coherence tomography algorithm for label-free assessment of swiftness and occupancy of intratissue moving scatterers Open
Dynamic optical coherence tomography (DOCT) statistically analyzes fluctuations in time-sequential OCT signals, enabling label-free and three-dimensional visualization of intratissue and intracellular activities. Current DOCT methods, such…
View article: Detection of circulating tumor cells in patients with lung cancer using a rare cell sorter: a pilot study
Detection of circulating tumor cells in patients with lung cancer using a rare cell sorter: a pilot study Open
View article: Neural-network based high-speed volumetric dynamic optical coherence tomography
Neural-network based high-speed volumetric dynamic optical coherence tomography Open
We demonstrate deep-learning neural network (NN)-based dynamic optical coherence tomography (DOCT), which generates high-quality logarithmic-intensity-variance (LIV) DOCT images from only four OCT frames. The NN model is trained for tumor …
View article: Detection of circulating tumor cells in patients with lung cancer using a Rare Cell Sorter: a pilot study
Detection of circulating tumor cells in patients with lung cancer using a Rare Cell Sorter: a pilot study Open
Background We developed a Rare Cell Sorter (RCS) for collecting single cell including circulating tumor cells (CTCs). This single-institution pilot study evaluated the ability of this device to detect tumor-like cells in patients with lung…
View article: Label-free visualization and quantification of the drug-type-dependent response of tumor spheroids by dynamic optical coherence tomography
Label-free visualization and quantification of the drug-type-dependent response of tumor spheroids by dynamic optical coherence tomography Open
We demonstrate label-free dynamic optical coherence tomography (D-OCT)-based visualization and quantitative assessment of patterns of tumor spheroid response to three anti-cancer drugs. The study involved treating human breast adenocarcino…
View article: Neural-network based high-speed volumetric dynamic optical coherence tomography
Neural-network based high-speed volumetric dynamic optical coherence tomography Open
We demonstrate deep-learning neural network (NN)-based dynamic optical coherence tomography (DOCT), which generates high-quality logarithmic-intensity-variance (LIV) DOCT images from only four OCT frames. The NN model is trained for tumor …
View article: Deep convolutional neural networks-based scatterer density and resolution estimators in optical coherence tomography: erratum
Deep convolutional neural networks-based scatterer density and resolution estimators in optical coherence tomography: erratum Open
Errata are presented to correct the inconsistencies between the values and their units displayed in the figures and the texts in our published manuscript [ Biomed. Opt. Express 13 , 168 ( 2022 ) 10.1364/BOE.443343 ]. The errors were caused…
View article: Neural-network based high-speed volumetric dynamic optical coherence tomography
Neural-network based high-speed volumetric dynamic optical coherence tomography Open
We demonstrate deep-learning neural network (NN)-based dynamic optical coherence tomography (DOCT), which generates high-quality logarithmic-intensity-variance (LIV) DOCT images from only four OCT frames. The NN model is trained for tumor …
View article: Label-free visualization and quantification of the drug-type-dependent response of tumor spheroids by dynamic optical coherence tomography
Label-free visualization and quantification of the drug-type-dependent response of tumor spheroids by dynamic optical coherence tomography Open
We demonstrate label-free dynamic optical coherence tomography (D-OCT)-based visualization and quantitative assessment of patterns of tumor spheroid response to three anti-cancer drugs. The study involved treating human breast adenocarcino…
View article: Label-free drug response evaluation of human derived tumor spheroids using three-dimensional dynamic optical coherence tomography
Label-free drug response evaluation of human derived tumor spheroids using three-dimensional dynamic optical coherence tomography Open
This study aims at demonstrating label-free drug-response-patterns assessment of different tumor spheroids and drug types by dynamic optical coherence tomography (D-OCT). The study involved human breast cancer (MCF-7) and colon cancer (HT-…
View article: Theoretical model for en face optical coherence tomography imaging and its application to volumetric differential contrast imaging
Theoretical model for en face optical coherence tomography imaging and its application to volumetric differential contrast imaging Open
A new formulation of the lateral imaging process of point-scanning optical coherence tomography (OCT) and a new differential contrast method designed by using this formulation are presented. The formulation is based on a mathematical sampl…
View article: Supplementary Figure S1 from Clinical Significance of <i>TLR1</i> I602S Polymorphism for Patients with Metastatic Colorectal Cancer Treated with FOLFIRI plus Bevacizumab
Supplementary Figure S1 from Clinical Significance of <i>TLR1</i> I602S Polymorphism for Patients with Metastatic Colorectal Cancer Treated with FOLFIRI plus Bevacizumab Open
This figure shows the signal pathway of TLR1, TLR2, and TLR6. TLR1 and TLR6, each of which forms a heterodimer with TLR2, initiate MAPK or NFκB pathway through TAK1. MyD88: myeloid differentiation factor88, TRAF: TNF receptor-associated f…
View article: Supplementary Figure S1 from Expression of Genes Involved in Vascular Morphogenesis and Maturation Predicts Efficacy of Bevacizumab-Based Chemotherapy in Patients Undergoing Liver Resection
Supplementary Figure S1 from Expression of Genes Involved in Vascular Morphogenesis and Maturation Predicts Efficacy of Bevacizumab-Based Chemotherapy in Patients Undergoing Liver Resection Open
Kaplan Meier curves for VEGFB mRNA levels in CLM for RFS (complete response, CR; not reached, NR)
View article: Supplementary Figure S8 from Expression of Genes Involved in Vascular Morphogenesis and Maturation Predicts Efficacy of Bevacizumab-Based Chemotherapy in Patients Undergoing Liver Resection
Supplementary Figure S8 from Expression of Genes Involved in Vascular Morphogenesis and Maturation Predicts Efficacy of Bevacizumab-Based Chemotherapy in Patients Undergoing Liver Resection Open
Kaplan Meier curves for VEGFB mRNA levels in CLM for OS (complete response, CR; standard error, SE)
View article: Supplementary Figure S4 from Expression of Genes Involved in Vascular Morphogenesis and Maturation Predicts Efficacy of Bevacizumab-Based Chemotherapy in Patients Undergoing Liver Resection
Supplementary Figure S4 from Expression of Genes Involved in Vascular Morphogenesis and Maturation Predicts Efficacy of Bevacizumab-Based Chemotherapy in Patients Undergoing Liver Resection Open
Kaplan Meier curves for KDR mRNA levels in CLM for RFS (complete response, CR)
View article: Supplementary Tables 1 and 2 from Polymorphisms in Genes Involved in EGFR Turnover Are Predictive for Cetuximab Efficacy in Colorectal Cancer
Supplementary Tables 1 and 2 from Polymorphisms in Genes Involved in EGFR Turnover Are Predictive for Cetuximab Efficacy in Colorectal Cancer Open
Supplemental Tables giving detailed information about rs985374 genotypes and efficacy in FIRE-3
View article: Supplementary Figure S6 from Expression of Genes Involved in Vascular Morphogenesis and Maturation Predicts Efficacy of Bevacizumab-Based Chemotherapy in Patients Undergoing Liver Resection
Supplementary Figure S6 from Expression of Genes Involved in Vascular Morphogenesis and Maturation Predicts Efficacy of Bevacizumab-Based Chemotherapy in Patients Undergoing Liver Resection Open
Kaplan Meier curves for EPHB4 mRNA levels in CLM for RFS (complete response, CR)
View article: Supplementary Figure S7 from Expression of Genes Involved in Vascular Morphogenesis and Maturation Predicts Efficacy of Bevacizumab-Based Chemotherapy in Patients Undergoing Liver Resection
Supplementary Figure S7 from Expression of Genes Involved in Vascular Morphogenesis and Maturation Predicts Efficacy of Bevacizumab-Based Chemotherapy in Patients Undergoing Liver Resection Open
Kaplan Meier curves for ACVRL1 mRNA levels in CLM for OS (complete response, CR; standard error, SE)
View article: Data from Polymorphisms in Genes Involved in EGFR Turnover Are Predictive for Cetuximab Efficacy in Colorectal Cancer
Data from Polymorphisms in Genes Involved in EGFR Turnover Are Predictive for Cetuximab Efficacy in Colorectal Cancer Open
Transmembrane receptors, such as the EGFR, are regulated by their turnover, which is dependent on the ubiquitin-proteasome system. We tested in two independent study cohorts whether SNPs in genes involved in EGFR turnover predict clinical …
View article: Supplementary Table 1, Supplementary Table 2A, Supplementary Table 2B, Supplementary Table 3, Supplementary Table 4, or Supplementary Table 5 from <i>TWIST1</i> Polymorphisms Predict Survival in Patients with Metastatic Colorectal Cancer Receiving First-Line Bevacizumab plus Oxaliplatin-Based Chemotherapy
Supplementary Table 1, Supplementary Table 2A, Supplementary Table 2B, Supplementary Table 3, Supplementary Table 4, or Supplementary Table 5 from <i>TWIST1</i> Polymorphisms Predict Survival in Patients with Metastatic Colorectal Cancer Receiving First-Line Bevacizumab plus Oxaliplatin-Based Chemotherapy Open
Supplementary Table 1. Summary of EMT-related SNPs Supplementary Table 2A. Association between baseline characteristics and clinical outcomes in the bevacizumab cohort Supplementary Table 2B. Association between baseline characteristics an…
View article: Data from Polymorphisms in Genes Involved in EGFR Turnover Are Predictive for Cetuximab Efficacy in Colorectal Cancer
Data from Polymorphisms in Genes Involved in EGFR Turnover Are Predictive for Cetuximab Efficacy in Colorectal Cancer Open
Transmembrane receptors, such as the EGFR, are regulated by their turnover, which is dependent on the ubiquitin-proteasome system. We tested in two independent study cohorts whether SNPs in genes involved in EGFR turnover predict clinical …
View article: Data from Cytokeratin-20 and Survivin-Expressing Circulating Tumor Cells Predict Survival in Metastatic Colorectal Cancer Patients by a Combined Immunomagnetic qRT-PCR Approach
Data from Cytokeratin-20 and Survivin-Expressing Circulating Tumor Cells Predict Survival in Metastatic Colorectal Cancer Patients by a Combined Immunomagnetic qRT-PCR Approach Open
Circulating tumor cells (CTC) express epithelial and stem cell–like genes, though current approved detection methods mainly use epithelial markers. We optimized a CTC isolation method that could capture their molecular heterogeneity and pr…
View article: Supplementary Figure S3 from Expression of Genes Involved in Vascular Morphogenesis and Maturation Predicts Efficacy of Bevacizumab-Based Chemotherapy in Patients Undergoing Liver Resection
Supplementary Figure S3 from Expression of Genes Involved in Vascular Morphogenesis and Maturation Predicts Efficacy of Bevacizumab-Based Chemotherapy in Patients Undergoing Liver Resection Open
Kaplan Meier curves for HIF1A mRNA levels in CLM for RFS (complete response, CR; not reached, NR)
View article: Supplementary Figure 1 from Cytokeratin-20 and Survivin-Expressing Circulating Tumor Cells Predict Survival in Metastatic Colorectal Cancer Patients by a Combined Immunomagnetic qRT-PCR Approach
Supplementary Figure 1 from Cytokeratin-20 and Survivin-Expressing Circulating Tumor Cells Predict Survival in Metastatic Colorectal Cancer Patients by a Combined Immunomagnetic qRT-PCR Approach Open
ROC curve stratified by combination of CK20 and Survivin gene expression: An optimal cutoff value of either 0.16 for CK20 or 0.15 for Survivin yields a sensitivity of 79.6% and specificity of 85%.
View article: Supplementary Figure S5 from Expression of Genes Involved in Vascular Morphogenesis and Maturation Predicts Efficacy of Bevacizumab-Based Chemotherapy in Patients Undergoing Liver Resection
Supplementary Figure S5 from Expression of Genes Involved in Vascular Morphogenesis and Maturation Predicts Efficacy of Bevacizumab-Based Chemotherapy in Patients Undergoing Liver Resection Open
Kaplan Meier curves for EGFL7 mRNA levels in CLM for RFS (complete response, CR)
View article: Supplementary Figure S2 from Expression of Genes Involved in Vascular Morphogenesis and Maturation Predicts Efficacy of Bevacizumab-Based Chemotherapy in Patients Undergoing Liver Resection
Supplementary Figure S2 from Expression of Genes Involved in Vascular Morphogenesis and Maturation Predicts Efficacy of Bevacizumab-Based Chemotherapy in Patients Undergoing Liver Resection Open
Kaplan Meier curves for VEGFC mRNA levels in CLM for RFS (complete response, CR; not reached, NR)
View article: Supplementary Figure 1 from Cytokeratin-20 and Survivin-Expressing Circulating Tumor Cells Predict Survival in Metastatic Colorectal Cancer Patients by a Combined Immunomagnetic qRT-PCR Approach
Supplementary Figure 1 from Cytokeratin-20 and Survivin-Expressing Circulating Tumor Cells Predict Survival in Metastatic Colorectal Cancer Patients by a Combined Immunomagnetic qRT-PCR Approach Open
ROC curve stratified by combination of CK20 and Survivin gene expression: An optimal cutoff value of either 0.16 for CK20 or 0.15 for Survivin yields a sensitivity of 79.6% and specificity of 85%.
View article: Data from <i>TWIST1</i> Polymorphisms Predict Survival in Patients with Metastatic Colorectal Cancer Receiving First-Line Bevacizumab plus Oxaliplatin-Based Chemotherapy
Data from <i>TWIST1</i> Polymorphisms Predict Survival in Patients with Metastatic Colorectal Cancer Receiving First-Line Bevacizumab plus Oxaliplatin-Based Chemotherapy Open
The epithelial–mesenchymal transition (EMT) is an important mechanism of resistance to angiogenesis inhibition. The ability of EMT pathway genetic variants to predict the efficacy of antiangiogenic therapy is unknown. We analyzed associati…