Satoshi Sakai
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View article: Ponatinib/blinatumomab for relapsed Philadelphia chromosome-positive leukemia as a bridge to allogeneic transplantation
Ponatinib/blinatumomab for relapsed Philadelphia chromosome-positive leukemia as a bridge to allogeneic transplantation Open
We report three cases of ponatinib/blinatumomab (Pona/BLIN) combination therapy as a bridge to allogeneic hematopoietic cell transplantation (allo-HCT) in patients with relapsed/refractory Philadelphia chromosome-positive acute lymphoblast…
View article: Propargyl Amines as Simple Alkyne Initiators for Chain‐Growth Controlled/“Living” Click Polymerization
Propargyl Amines as Simple Alkyne Initiators for Chain‐Growth Controlled/“Living” Click Polymerization Open
Recently, we have reported chain‐growth controlled/“living” click polymerization as bi‐directional polyaddition employing copper‐catalyzed azide‐alkyne cycloaddition. In this study, we report simple propargyl amines as the initiator for co…
View article: Controlled/″Living″ Click Polymerization with Possible Bidirectional Chain-Growth Propagation during Polyaddition
Controlled/″Living″ Click Polymerization with Possible Bidirectional Chain-Growth Propagation during Polyaddition Open
In this work, we found a new class of controlled/″living″ polymerization system, which proceeds bidirectional fashion using click reaction of AB monomer bearing azide and alkyne functionalities in a single molecule. The click polymerizatio…
View article: CARM1/PRMT4 facilitates XPF–ERCC1 heterodimer assembly and maintains nucleotide excision repair activity
CARM1/PRMT4 facilitates XPF–ERCC1 heterodimer assembly and maintains nucleotide excision repair activity Open
The structure-specific endonuclease, XPF–ERCC1, plays a central role in DNA damage repair. This nuclease is known to be important for nucleotide excision repair, interstrand crosslink repair, and DNA double-strand repair. We found that the…
View article: RASL10A, a member of the RAS subfamily of small GTPases, suppresses the EMT and invasion of human lung adenocarcinoma A549 cells
RASL10A, a member of the RAS subfamily of small GTPases, suppresses the EMT and invasion of human lung adenocarcinoma A549 cells Open
Lung adenocarcinoma (LUAD) is the most frequently diagnosed form of non-small cell lung cancer and is known to develop distant metastases, such as brain and bone metastases, which can considerably affect the prognosis of patients. Therefor…
View article: Controlled/"Living" Click Polymerization with Possible Bi-Directional Chain-Growth Propagation during Polyaddition
Controlled/"Living" Click Polymerization with Possible Bi-Directional Chain-Growth Propagation during Polyaddition Open
In this work, we found a new class of controlled/"living" polymerization system, which proceeds bidirectional fashion using click reaction of AB monomer bearing azide and alkyne functionalities in a single molecule. The click polymerizatio…
View article: Controlled/"Living" Click Polymerization with Possible Bi-Directional Chain-Growth Propagation during Polyaddition
Controlled/"Living" Click Polymerization with Possible Bi-Directional Chain-Growth Propagation during Polyaddition Open
In this work, we found a new class of controlled/"living" polymerization system, which proceeds bidirectional fashion using click reaction of AB monomer bearing azide and alkyne functionalities in a single molecule. The click polymerizatio…
View article: Report of the AI Pathology Task Force, Non-clinical Evaluation Expert Committee, Japan Pharmaceutical Manufacturers Association: an overview of recent publications about AI pathology
Report of the AI Pathology Task Force, Non-clinical Evaluation Expert Committee, Japan Pharmaceutical Manufacturers Association: an overview of recent publications about AI pathology Open
The use of artificial intelligence (AI) in non-clinical pathology is rapidly expanding. In this study, we conducted a literature survey of articles published after 2017 that used AI to analyze the histopathological images of experimental a…
View article: FGF21 upregulation by hepatitis C virus via the eIF2α-ATF4 pathway: implications for interferon signaling suppression and TRIM31-mediated TSC degradation
FGF21 upregulation by hepatitis C virus via the eIF2α-ATF4 pathway: implications for interferon signaling suppression and TRIM31-mediated TSC degradation Open
Hepatitis C virus (HCV) infection is a major cause of chronic liver diseases and is known to induce endoplasmic reticulum (ER) stress, which alters cellular homeostasis and metabolic processes. While ER stress is implicated in HCV-related …
View article: Systemic Capillary Responses to Acute Exercise in Hypertensive Seniors: Insights from a Single-Center Pilot Study
Systemic Capillary Responses to Acute Exercise in Hypertensive Seniors: Insights from a Single-Center Pilot Study Open
Objective: The aim of this study was to investigate nailfold capillary parameters in community-dwelling individuals aged over 60 years who have hypertension and do not exercise regularly. Furthermore, the study examined the correlations be…
View article: Acute Exercise for the Hypertensive Elderly Affects the Whole-Body Capillary: A Single- Center Pilot Trial
Acute Exercise for the Hypertensive Elderly Affects the Whole-Body Capillary: A Single- Center Pilot Trial Open
Objective To investigate nailfold capillary parameters in community-dwelling individuals aged over 60 years who have hypertension and do not exercise regularly. Furthermore, the study examined the correlations between capillary function an…
View article: Coherent acoustic vibrations of Au nanoblocks and their modulation by Al2O3 layer deposition
Coherent acoustic vibrations of Au nanoblocks and their modulation by Al2O3 layer deposition Open
Coherent acoustic phonons induced in metallic nanostructures have attracted tremendous attention owing to their unique optomechanical characteristics. The frequency of the acoustic phonon vibration is highly sensitive to the material adsor…
View article: Natto consumption suppresses atherosclerotic plaque progression in LDL receptor-deficient mice transplanted with iRFP-expressing hematopoietic cells
Natto consumption suppresses atherosclerotic plaque progression in LDL receptor-deficient mice transplanted with iRFP-expressing hematopoietic cells Open
View article: Systematic <scp>observation‐based</scp> diagnosis of atrioventricular nodal reentrant tachycardia with a bystander concealed nodoventricular pathway
Systematic <span>observation‐based</span> diagnosis of atrioventricular nodal reentrant tachycardia with a bystander concealed nodoventricular pathway Open
Background This study aimed to establish a systematic method for diagnosing atrioventricular nodal reentrant tachycardia (AVNRT) with a bystander concealed nodoventricular pathway (cNVP). Methods We analyzed 13 cases of AVNRT with a bystan…
View article: Expression of Tumor Suppressor FHIT Is Regulated by the LINC00173-SNAIL Axis in Human Lung Adenocarcinoma
Expression of Tumor Suppressor FHIT Is Regulated by the LINC00173-SNAIL Axis in Human Lung Adenocarcinoma Open
Long non-coding RNAs (lncRNAs) play a critical role in a variety of human diseases such as cancer. Here, to elucidate a novel function of a lncRNA called LINC00173, we investigated its binding partner, target gene, and its regulatory mecha…
View article: Exercise training affects hemodynamics and exercise capacity in cases of heart failure with preserved ejection fraction: a non-randomized controlled trial in individuals aged 65–80 years
Exercise training affects hemodynamics and exercise capacity in cases of heart failure with preserved ejection fraction: a non-randomized controlled trial in individuals aged 65–80 years Open
Introduction Exercise training is an established intervention method for improving exercise capacity and survival rates in patients with heart failure with preserved ejection fraction (HFpEF). However, most reports have focused on European…
View article: CCIVR2 facilitates comprehensive identification of both overlapping and non-overlapping antisense transcripts within specified regions
CCIVR2 facilitates comprehensive identification of both overlapping and non-overlapping antisense transcripts within specified regions Open
View article: Role of hepcidin upregulation and proteolytic cleavage of ferroportin 1 in hepatitis C virus-induced iron accumulation
Role of hepcidin upregulation and proteolytic cleavage of ferroportin 1 in hepatitis C virus-induced iron accumulation Open
Hepatitis C virus (HCV) is a pathogen characterized not only by its persistent infection leading to the development of cirrhosis and hepatocellular carcinoma (HCC), but also by metabolic disorders such as lipid and iron dysregulation. Elev…
View article: Acute venodilation properties of low-dose intravenous nitroglycerine in pulmonary veno-occlusive disease: a case report
Acute venodilation properties of low-dose intravenous nitroglycerine in pulmonary veno-occlusive disease: a case report Open
Background The use of pulmonary vasodilators for pulmonary arterial hypertension (PAH) has led to a favourable prognosis. In contrast, pulmonary veno-occlusive disease (PVOD) is characterized by the possibility of severe pulmonary oedema a…
View article: Dynamic LCA of fuel cell-assisted bike in consideration of Pt catalyst degradation in various operating conditions
Dynamic LCA of fuel cell-assisted bike in consideration of Pt catalyst degradation in various operating conditions Open
Fuel cell (FC) systems have recently become increasingly popular in large applications, such as FC vehicles and stationary FC power systems for residences. The use of FC systems in smaller applications, such as electrically power-assisted …
View article: PO-05-227 DIAGNOSTIC OBSERVATIONS OF A BYSTANDER CONCEALED NODOVENTRICULAR PATHWAY DURING ATRIOVENTRICULAR NODAL REENTRANT TACHYCARDIA
PO-05-227 DIAGNOSTIC OBSERVATIONS OF A BYSTANDER CONCEALED NODOVENTRICULAR PATHWAY DURING ATRIOVENTRICULAR NODAL REENTRANT TACHYCARDIA Open
View article: Association of complication of type 2 diabetes mellitus with hemodynamics and exercise capacity in patients with heart failure with preserved ejection fraction: a case–control study in individuals aged 65–80 years
Association of complication of type 2 diabetes mellitus with hemodynamics and exercise capacity in patients with heart failure with preserved ejection fraction: a case–control study in individuals aged 65–80 years Open
View article: Table S1, Table S2, Table S3; Table S4 from Homeobox Transcription Factor NKX2-1 Promotes <i>Cyclin D1</i> Transcription in Lung Adenocarcinomas
Table S1, Table S2, Table S3; Table S4 from Homeobox Transcription Factor NKX2-1 Promotes <i>Cyclin D1</i> Transcription in Lung Adenocarcinomas Open
Table S1: Sequences of oligonucleotides, Table S2: Patient characteristics, Table S3: Univariate and Multivariate analysis of SCC; Supplementary Table S4. Correlation of NKX2-1 and YB-1 expression in NSCLCs.
View article: Figure S1 from Homeobox Transcription Factor NKX2-1 Promotes <i>Cyclin D1</i> Transcription in Lung Adenocarcinomas
Figure S1 from Homeobox Transcription Factor NKX2-1 Promotes <i>Cyclin D1</i> Transcription in Lung Adenocarcinomas Open
Expression of NKX2-1 and cyclin D1 in NSCLCs.
View article: Data from Homeobox Transcription Factor NKX2-1 Promotes <i>Cyclin D1</i> Transcription in Lung Adenocarcinomas
Data from Homeobox Transcription Factor NKX2-1 Promotes <i>Cyclin D1</i> Transcription in Lung Adenocarcinomas Open
The known oncogene cyclin D1 (CCND1) participates in progression of the cell cycle from G1 to S-phase. Expression of cyclin D1 is frequently promoted in multiple human cancers including non–small cell lung cancer (NSCLC).…
View article: Table S1, Table S2, Table S3; Table S4 from Homeobox Transcription Factor NKX2-1 Promotes <i>Cyclin D1</i> Transcription in Lung Adenocarcinomas
Table S1, Table S2, Table S3; Table S4 from Homeobox Transcription Factor NKX2-1 Promotes <i>Cyclin D1</i> Transcription in Lung Adenocarcinomas Open
Table S1: Sequences of oligonucleotides, Table S2: Patient characteristics, Table S3: Univariate and Multivariate analysis of SCC; Supplementary Table S4. Correlation of NKX2-1 and YB-1 expression in NSCLCs.
View article: Figure S1 from Homeobox Transcription Factor NKX2-1 Promotes <i>Cyclin D1</i> Transcription in Lung Adenocarcinomas
Figure S1 from Homeobox Transcription Factor NKX2-1 Promotes <i>Cyclin D1</i> Transcription in Lung Adenocarcinomas Open
Expression of NKX2-1 and cyclin D1 in NSCLCs.
View article: Data from Homeobox Transcription Factor NKX2-1 Promotes <i>Cyclin D1</i> Transcription in Lung Adenocarcinomas
Data from Homeobox Transcription Factor NKX2-1 Promotes <i>Cyclin D1</i> Transcription in Lung Adenocarcinomas Open
The known oncogene cyclin D1 (CCND1) participates in progression of the cell cycle from G1 to S-phase. Expression of cyclin D1 is frequently promoted in multiple human cancers including non–small cell lung cancer (NSCLC).…
View article: Supplementary Figure S1-S10 from Long Noncoding RNA <i>ELIT-1</i> Acts as a Smad3 Cofactor to Facilitate TGFβ/Smad Signaling and Promote Epithelial–Mesenchymal Transition
Supplementary Figure S1-S10 from Long Noncoding RNA <i>ELIT-1</i> Acts as a Smad3 Cofactor to Facilitate TGFβ/Smad Signaling and Promote Epithelial–Mesenchymal Transition Open
FS1:Representative photographs of Fig. 1A; FS2:EMT-related gene expression; FS3:Snail induction by TGF-ß; FS4:Contribution of ELIT-1 on Snail expression; FS5:Effects on cell proliferation; FS6: EMT-related gene expression by ELIT-1; FS7:S…
View article: Supplementary Figure S1-S10 from Long Noncoding RNA <i>ELIT-1</i> Acts as a Smad3 Cofactor to Facilitate TGFβ/Smad Signaling and Promote Epithelial–Mesenchymal Transition
Supplementary Figure S1-S10 from Long Noncoding RNA <i>ELIT-1</i> Acts as a Smad3 Cofactor to Facilitate TGFβ/Smad Signaling and Promote Epithelial–Mesenchymal Transition Open
FS1:Representative photographs of Fig. 1A; FS2:EMT-related gene expression; FS3:Snail induction by TGF-ß; FS4:Contribution of ELIT-1 on Snail expression; FS5:Effects on cell proliferation; FS6: EMT-related gene expression by ELIT-1; FS7:S…