Satoshi Okawa
YOU?
Author Swipe
View article: Outcome and Prognostic Factors of Colorectal Endoscopic Submucosal Dissection in Patients Aged Over 75 Years
Outcome and Prognostic Factors of Colorectal Endoscopic Submucosal Dissection in Patients Aged Over 75 Years Open
Objectives We aimed to evaluate the safety and efficacy, and prognostic factors of colorectal endoscopic submucosal dissection (ESD) in patients aged ≥ 75 years. Methods We retrospectively collected cases of colorectal ESD performed betwee…
View article: Activated fatty acid synthesis pathway in macrophages propagates pathogenic fibroblast expansion after myocardial infarction
Activated fatty acid synthesis pathway in macrophages propagates pathogenic fibroblast expansion after myocardial infarction Open
Metabolic pathways, such as fatty acid oxidation and oxidative phosphorylation, can modulate inflammatory cells. However, little is known about the effects of the fatty acid synthesis pathway in macrophages on inflammation and cardiac remo…
View article: Community‐Level Compact City Design, Health Care Provision, and Outcomes of Patients With Stroke
Community‐Level Compact City Design, Health Care Provision, and Outcomes of Patients With Stroke Open
Background The optimal scale of urbanization for stroke health care provision and the potential impact of compact city design on stroke outcomes remain unclear. We investigated the impact of zip code area‐level compact city design using th…
View article: Mitochondrial iron transport via MFRN1 is required for erythroid cell cycle progression
Mitochondrial iron transport via MFRN1 is required for erythroid cell cycle progression Open
Iron metabolism drives key erythropoietic processes, including hemoglobinization, survival, and proliferation. Here, we developed in vivo methods to interrogate how iron regulates erythropoiesis and report that mitochondrial iron transport…
View article: <i>Etv5</i> Is Required for Peripheral Nerve Function and the Injury Response
<i>Etv5</i> Is Required for Peripheral Nerve Function and the Injury Response Open
The development of Schwann cells, which myelinate axons in the peripheral nervous system, is critically dependent on MEK/ERK signaling. While Ets-domain transcription factors ( Etv1 , Etv4 , Etv5 ) are downstream effectors of this pathway,…
View article: Combinatorial expression of glial transcription factors induces Schwann cell‐specific gene expression in mouse embryonic fibroblasts
Combinatorial expression of glial transcription factors induces Schwann cell‐specific gene expression in mouse embryonic fibroblasts Open
Background Schwann cells provide peripheral nerve trophic support, myelinate axons, and assist in repair. However, Schwann cell repair capacity is limited by chronic injury, disease, and aging. Schwann cell reprogramming is a cellular conv…
View article: Author response: Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling
Author response: Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling Open
View article: Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling
Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling Open
Metabolic pathways are remodeled in response to energy and other homeostatic demands and are dynamically regulated during embryonic development, suggesting a role in guiding cellular differentiation. Here, we show that glycolytic flux is r…
View article: Author response: Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling
Author response: Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling Open
View article: Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling
Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling Open
Metabolic pathways are remodeled in response to energy and other homeostatic demands and are dynamically regulated during embryonic development, suggesting a role in guiding cellular differentiation. Here, we show that glycolytic flux is r…
View article: Large‐Scale Clustered Transcriptional Silencing Associated With Cellular Senescence
Large‐Scale Clustered Transcriptional Silencing Associated With Cellular Senescence Open
Senescence is a cell fate associated with age‐related pathologies; however, senescence markers are not well‐defined. Using single cell multi‐isotope imaging mass spectrometry (MIMS), we identified hypercondensed, transcriptionally silent D…
View article: Identifying a Genetic Link Between Lung Function and Psoriasis
Identifying a Genetic Link Between Lung Function and Psoriasis Open
Introduction The common genetic underpinnings of psoriasis and pulmonary comorbidities have yet to be explored. Material and Methods In this cross‐sectional study, we investigated the single‐nucleotide polymorphisms (SNPs) associated with …
View article: Examining the NEUROG2 lineage and associated gene expression in human cortical organoids
Examining the NEUROG2 lineage and associated gene expression in human cortical organoids Open
Proneural genes are conserved drivers of neurogenesis across the animal kingdom. How their functions have adapted to guide human-specific neurodevelopmental features is poorly understood. Here, we mined transcriptomic data from human fetal…
View article: Post-transcriptional regulation of IFI16 promotes inflammatory endothelial pathophenotypes observed in pulmonary arterial hypertension
Post-transcriptional regulation of IFI16 promotes inflammatory endothelial pathophenotypes observed in pulmonary arterial hypertension Open
Our work establishes a paradigm of the regulatory role of the Wilms’ tumor 1-associated protein (WTAP)-interferon inducible protein 16 (IFI16) axis that uses m6A RNA methylation to drive endothelial inflammatory activation in pulmonary hyp…
View article: Health outcomes after national acute sleep deprivation events among the American public
Health outcomes after national acute sleep deprivation events among the American public Open
Background Sleep is increasingly recognized as essential to human health, yet the adverse health consequences of acute sleep deprivation are unknown. Using actigraphic, genomic, and health data from the All of Us ( AoU ) Research Program, …
View article: Ice recrystallization inhibitors enable efficient cryopreservation of induced pluripotent stem cells: A functional and transcriptomic analysis
Ice recrystallization inhibitors enable efficient cryopreservation of induced pluripotent stem cells: A functional and transcriptomic analysis Open
The successful use of human induced pluripotent stem cells (iPSCs) for research or clinical applications requires the development of robust, efficient, and reproducible cryopreservation protocols. After cryopreservation, the survival rate …
View article: Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling
Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling Open
Metabolic pathways are remodeled in response to energy and other homeostatic demands and are dynamically regulated during embryonic development, suggestive of a role in guiding cellular differentiation. Here, we show that glycolytic flux i…
View article: Author response: Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling
Author response: Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling Open
View article: Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling
Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling Open
Metabolic pathways are remodeled in response to energy and other homeostatic demands and are dynamically regulated during embryonic development, suggesting a role in guiding cellular differentiation. Here, we show that glycolytic flux is r…
View article: Post-transcriptional regulation of IFI16 promotes inflammatory endothelial pathophenotypes observed in pulmonary arterial hypertension
Post-transcriptional regulation of IFI16 promotes inflammatory endothelial pathophenotypes observed in pulmonary arterial hypertension Open
Pulmonary arterial hypertension (PAH) is a progressive disease driven by endothelial cell inflammation and dysfunction, resulting in the pathological remodeling of the pulmonary vasculature. Innate immune activation has been linked to PAH …
View article: Reversal of inflammatory reprogramming by vasodilator agents in pulmonary hypertension
Reversal of inflammatory reprogramming by vasodilator agents in pulmonary hypertension Open
Background Pulmonary arterial hypertension (PAH) is a deadly disease without effective non-invasive diagnostic and prognostic testing. It remains unclear whether vasodilators reverse inflammatory activation, a part of PAH pathogenesis. Sin…
View article: Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling
Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling Open
Metabolic pathways are remodeled in response to energy and other homeostatic demands and are dynamically regulated during embryonic development, suggesting a role in guiding cellular differentiation. Here, we show that glycolytic flux is r…
View article: Deep learning-driven neuromorphogenesis screenings identify repurposable drugs for mitochondrial disease
Deep learning-driven neuromorphogenesis screenings identify repurposable drugs for mitochondrial disease Open
Summary Mitochondrial disease encompasses untreatable conditions affecting tissues with high energy demands. A severe manifestation of mitochondrial disease is Leigh syndrome (Leigh), which causes defects in basal ganglia and midbrain regi…
View article: Psoriasis and Pulmonary Function - Unveiling Genetic Connections
Psoriasis and Pulmonary Function - Unveiling Genetic Connections Open
Psoriasis, an immune-mediated skin disease characterized by erythematous plaques, is often associated with chronic lung diseases that impair pulmonary function. To investigate a potential genetic link between psoriasis and pulmonary functi…
View article: Pten regulates endocytic trafficking of cell adhesion and Wnt signaling molecules to pattern the retina
Pten regulates endocytic trafficking of cell adhesion and Wnt signaling molecules to pattern the retina Open
The retina is exquisitely patterned, with neuronal somata positioned at regular intervals to completely sample the visual field. Here, we show that phosphatase and tensin homolog (Pten) controls starburst amacrine cell spacing by modulatin…
View article: A molecular index for biological age identified from the metabolome and senescence‐associated secretome in humans
A molecular index for biological age identified from the metabolome and senescence‐associated secretome in humans Open
Unlike chronological age, biological age is a strong indicator of health of an individual. However, the molecular fingerprint associated with biological age is ill‐defined. To define a high‐resolution signature of biological age, we analyz…
View article: <i>NEUROG2</i>regulates a human-specific neurodevelopmental gene regulatory program
<i>NEUROG2</i>regulates a human-specific neurodevelopmental gene regulatory program Open
Unique hallmarks of human neocortical development include slower rates of neurogenesis and the establishment of an extracellular matrix-rich, outer-subventricular zone that supports basal neural progenitor cell expansion. How gene regulato…
View article: SinCMat: A single-cell-based method for predicting functional maturation transcription factors
SinCMat: A single-cell-based method for predicting functional maturation transcription factors Open
View article: Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension
Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension Open
Hypoxic reprogramming of vasculature relies on genetic, epigenetic, and metabolic circuitry, but the control points are unknown. In pulmonary arterial hypertension (PAH), a disease driven by hypoxia inducible factor (HIF)–dependent vascula…
View article: LEIGH SYNDROME DRUG DISCOVERY WITH INDUCED NEURONS AND MIDBRAIN ORGANOIDS UNVEILS A REPOSITIONABLE COMPOUND
LEIGH SYNDROME DRUG DISCOVERY WITH INDUCED NEURONS AND MIDBRAIN ORGANOIDS UNVEILS A REPOSITIONABLE COMPOUND Open