Explanipedia

Unfolding the Mystery of Autoimmunity: The Environmental Determinants of Diabetes in the Young (TEDDY) Study Open

Marian Rewers, Daniel Agardh, Suzanne Bennett Johnson, Ezio Bonifacio, Helena Elding Larsson , et al. · 2025

In 2025, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health celebrates 75 years of leadership in diabetes research. The NIDDK serves people of the U.S. affected by or at risk f…

Early Appearance of Thyroid Autoimmunity in Children Followed From Birth for Type 1 Diabetes Risk Open

Berglind Jónsdóttir, Joanna Clasen, Kendra Vehik, Åke Lernmark, Markus Lundgren , et al. · 2024

Context Autoantibodies to thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) define preclinical autoimmune thyroid disease (AITD), which can progress to either clinical hypothyroidism or hyperthyroidism. Objective We determined the age at…

Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study Open

Leena Hakola, Lazarus K. Mramba, Ulla Uusitalo, Carin Andrén Aronsson, Sandra Hummel , et al. · 2024

Gastrointestinal Infections Modulate the Risk for Insulin Autoantibodies as the First-Appearing Autoantibody in the TEDDY Study Open

Maria Lönnrot, Kristian Lynch, Marian Rewers, Åke Lernmark, Kendra Vehik , et al. · 2023

OBJECTIVE To investigate gastrointestinal infection episodes (GIEs) in relation to the appearance of islet autoantibodies in The Environmental Determinants of Diabetes in the Young (TEDDY) cohort. RESEARCH DESIGN AND METHODS GIEs on risk o…

Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5- to 15-Year-Old Children Followed in the TEDDY Study Open

Xiang Liu, Suzanne Bennett Johnson, Kristian Lynch, Kerry Cordan, Russell R. Pate , et al. · 2023

OBJECTIVE This study investigated physical activity and its association with the development of islet autoimmunity and type 1 diabetes in genetically at-risk children aged 5–15 years. RESEARCH DESIGN AND METHODS As part of the longitudinal…

Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study Open

Steffen Ullitz Thorsen, Xiang Liu, Yachana Kataria, Thomas Mandrup‐Poulsen, Simranjeet Kaur , et al. · 2023

OBJECTIVE To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS In The Environmental …

Predictors of the Initiation of Islet Autoimmunity and Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study Open

Jeffrey P. Krischer, Xiang Liu, Åke Lernmark, William Hagopian, Marian Rewers , et al. · 2022

OBJECTIVE To distinguish among predictors of seroconversion, progression to multiple autoantibodies and from multiple autoantibodies to type 1 diabetes in young children. RESEARCH DESIGN AND METHODS Genetically high-risk newborns (n = 8,50…

Rising Hemoglobin A1c in the Nondiabetic Range Predicts Progression of Type 1 Diabetes As Well As Oral Glucose Tolerance Tests Open

Kendra Vehik, David Boulware, Michael Killian, Marian Rewers, Richard McIndoe , et al. · 2022

OBJECTIVE Biomarkers predicting risk of type 1 diabetes (stage 3) among children with islet autoantibodies are greatly needed to prevent diabetic ketoacidosis and facilitate prevention therapies. RESEARCH DESIGN AND METHODS Children in the…

Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study Open

Carina Törn, Xiang Liu, Suna Önengüt-Gümüşcü, Kevin Counts, Jose Leonardo Moreno , et al. · 2022

Author Correction: A combined risk score enhances prediction of type 1 diabetes among susceptible children Open

Lauric Ferrat, Kendra Vehik, Seth A. Sharp, Åke Lernmark, Marian Rewers , et al. · 2022

Is staff consistency important to parents’ satisfaction in a longitudinal study of children at risk for type 1 diabetes: the TEDDY study Open

Jessica Melin, Kristian Lynch, Markus Lundgren, Carin Andrén Aronsson, Helena Elding Larsson , et al. · 2022

Background Participants’ study satisfaction is important for both compliance with study protocols and retention, but research on parent study satisfaction is rare. This study sought to identify factors associated with parent study satisfac…

Dynamic changes in immune gene co-expression networks predict development of type 1 diabetes Open

Ingrid Brænne, Suna Önengüt-Gümüşcü, Ruoxi Chen, Ani Manichaikul, Stephen S. Rich , et al. · 2021

An Age-Related Exponential Decline in the Risk of Multiple Islet Autoantibody Seroconversion During Childhood Open

Ezio Bonifacio, Andreas Weiß, Christiane Winkler, Markus Hippich, Marian Rewers , et al. · 2021

OBJECTIVE Islet autoimmunity develops before clinical type 1 diabetes and includes multiple and single autoantibody phenotypes. The objective was to determine age-related risks of islet autoantibodies that reflect etiology and improve scre…

Children’s erythrocyte fatty acids are associated with the risk of islet autoimmunity Open

Sari Niinistö, Iris Erlund, Hye‐Seung Lee, Ulla Uusitalo, Irma Salminen , et al. · 2021

Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study Open

Maarit Oikarinen, Leena Puustinen, Jussi Lehtonen, Leena Hakola, Satu Simell , et al. · 2021

Enterovirus and adenovirus infections have been linked to the development of celiac disease. We evaluated this association in children who developed biopsy-proven celiac disease (N = 41) during prospective observation starting from birth, …

A combined risk score enhances prediction of type 1 diabetes among susceptible children Open

Lauric Ferrat, Kendra Vehik, Seth A. Sharp, Åke Lernmark, Marian Rewers , et al. · 2020

Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study Open

Kendra Vehik, Ezio Bonifacio, Åke Lernmark, Liping Yu, Alistair J.K. Williams , et al. · 2020

OBJECTIVE The first-appearing β-cell autoantibody has been shown to influence risk of type 1 diabetes (T1D). Here, we assessed the risk of autoantibody spreading to the second-appearing autoantibody and further progression to clinical dise…

Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study Open

Qian Li, Hemang Parikh, Martha Butterworth, Åke Lernmark, William Hagopian , et al. · 2020

Children at increased genetic risk for type 1 diabetes (T1D) after environmental exposures may develop pancreatic islet autoantibodies (IA) at a very young age. Metabolic profile changes over time may imply responses to exposures and signa…

Distinct Growth Phases in Early Life Associated With the Risk of Type 1 Diabetes: The TEDDY Study Open

Xiang Liu, Kendra Vehik, Yangxin Huang, Helena Elding Larsson, Jorma Toppari , et al. · 2020

OBJECTIVE This study investigates two-phase growth patterns in early life and their association with development of islet autoimmunity (IA) and type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS The Environmental Determinants of Diabetes i…

Metabolite-related dietary patterns and the development of islet autoimmunity Open

Randi K. Johnson, Lauren A. Vanderlinden, Brian C. DeFelice, Katerina Kechris, Ulla Uusitalo , et al. · 2019

The role of diet in type 1 diabetes development is poorly understood. Metabolites, which reflect dietary response, may help elucidate this role. We explored metabolomics and lipidomics differences between 352 cases of islet autoimmunity (I…

Persistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease Open

Partho Sen, Cecilia Carlsson, Suvi Μ. Virtanen, Satu Simell, Heikki Hyöty , et al. · 2019

OBJECTIVES: Celiac disease (CD) is a chronic enteropathy characterized by an autoimmune reaction in the small intestine of genetically susceptible individuals. The underlying causes of autoimmune reaction and its effect on host metabolism …

Predicting Islet Cell Autoimmunity and Type 1 Diabetes: An 8-Year TEDDY Study Progress Report Open

Jeffrey P. Krischer, Xiang Liu, Kendra Vehik, Beena Akolkar, William Hagopian , et al. · 2019

OBJECTIVE Assessment of the predictive power of The Environmental Determinants of Diabetes in the Young (TEDDY)-identified risk factors for islet autoimmunity (IA), the type of autoantibody appearing first, and type 1 diabetes (T1D). RESEA…

Persistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease Open

Partho Sen, Cecilia Carlsson, Suvi Μ. Virtanen, Satu Simell, Heikki Hyöty , et al. · 2019

OBJECTIVES:Celiac disease (CD) is a chronic enteropathy characterized by an autoimmune reaction in the small intestine of genetically susceptible individuals. The underlying causes of autoimmune reaction and its effect on host metabolism r…

Metabolite-related dietary patterns and the development of islet autoimmunity Open

Randi K. Johnson, Lauren A. Vanderlinden, Brian C. DeFelice, Katerina Kechris, Ulla Uusitalo , et al. · 2019

The role of diet in type 1 diabetes development is poorly understood. Metabolites, which reflect dietary response, may help elucidate this role. We explored metabolomics and lipidomics differences between 352 cases of islet autoimmunity (I…

Early Probiotic Supplementation and the Risk of Celiac Disease in Children at Genetic Risk Open

Ulla Uusitalo, Carin Andrén Aronsson, Xiang Liu, Kalle Kurppa, Jimin Yang , et al. · 2019

Probiotics are linked to positive regulatory effects on the immune system. The aim of the study was to examine the association between the exposure of probiotics via dietary supplements or via infant formula by the age of 1 year and the d…

Time-Resolved Autoantibody Profiling Facilitates Stratification of Preclinical Type 1 Diabetes in Children Open

David Endesfelder, Wolfgang zu Castell, Ezio Bonifacio, Marian Rewers, William Hagopian , et al. · 2018

Progression to clinical type 1 diabetes varies among children who develop β-cell autoantibodies. Differences in autoantibody patterns could relate to disease progression and etiology. Here we modeled complex longitudinal autoantibody profi…

Persistent alterations in plasma lipid profiles prior to introduction of gluten in the diet associate with progression to celiac disease Open

Partho Sen, Cecilia Carlsson, Suvi Μ. Virtanen, Satu Simell, Heikki Hyöty , et al. · 2018

Background and Aims Celiac disease (CD) is a chronic enteropathy characterized by an autoimmune reaction in the small intestine in genetically-susceptible individuals. Gluten is the required environmental trigger of clinical CD, but the un…

Reduction in White Blood Cell, Neutrophil, and Red Blood Cell Counts Related to Sex, HLA, and Islet Autoantibodies in Swedish TEDDY Children at Increased Risk for Type 1 Diabetes Open

Falastin Salami, Hye Seung Lee, Eva Freyhult, Helena Elding Larsson, Åke Lernmark , et al. · 2018

Islet autoantibodies (IAs) precede the clinical onset of type 1 diabetes (T1D); however, the knowledge is limited about whether the prodrome affects complete blood counts (CBCs) in 4- to 12-year-old children with increased genetic risk for…

Early Infant Diet and Islet Autoimmunity in the TEDDY Study Open

Ulla Uusitalo, Hye‐Seung Lee, Carin Andrén Aronsson, Kendra Vehik, Jimin Yang , et al. · 2018

OBJECTIVE To examine duration of breastfeeding and timing of complementary foods and risk of islet autoimmunity (IA). RESEARCH DESIGN AND METHODS The Environmental Determinants of Diabetes in the Young (TEDDY) study prospectively follows 8…

Correction: Vol. 18, No. 2 Open

Mira Meriluoto, Lea Hedman, Laura M. Tanner, Ville Simell, Marjaana Mäkinen , et al. · 2016

Satu Simell YOU? Author Swipe