Satyan Lakshminrusimha
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View article: Neonatal SONography Assisted Resuscitation (NeoSONAR): Scoping review of the current literature and future directions
Neonatal SONography Assisted Resuscitation (NeoSONAR): Scoping review of the current literature and future directions Open
Ultrasound is increasingly utilized during cardiac arrest in adult populations. The European Society of Pediatric and Neonatal Intensive Care and the American Academy of Pediatrics have published guidelines on the use of point-of-care ultr…
View article: Respiratory Support prior to Cord Clamping in Very Preterm Infants: A Narrative Review with Pooled Results from Recent Studies
Respiratory Support prior to Cord Clamping in Very Preterm Infants: A Narrative Review with Pooled Results from Recent Studies Open
Background: Whether very preterm infants benefit from provision of respiratory support prior to cord clamping has been an important knowledge gap. Four randomised controlled trials have recently been published on this topic and have provid…
View article: Continuous Chest Compressions with Asynchronous Ventilation in Asphyxiated Preterm Lambs with Asystole
Continuous Chest Compressions with Asynchronous Ventilation in Asphyxiated Preterm Lambs with Asystole Open
Introduction: Gas exchange and perfusion are impaired during neonatal cardiopulmonary resuscitation. Continuous chest compressions with asynchronous ventilation (CCCaV) improve oxygenation and hemodynamics in term animal models compared to…
View article: Pulmonary Hemorrhage in Premature Infants: Pathophysiology, Risk Factors and Clinical Management
Pulmonary Hemorrhage in Premature Infants: Pathophysiology, Risk Factors and Clinical Management Open
Pulmonary hemorrhage (PH) is a life-threatening complication predominantly affecting preterm infants, particularly those with very low birth weight (VLBW) and fetal growth restriction (FGR). Typically occurring within the first 72 h of lif…
View article: Pulmonary Hemorrhage in Premature Infants: Pathophysiology, Risk Factors and Clinical Management
Pulmonary Hemorrhage in Premature Infants: Pathophysiology, Risk Factors and Clinical Management Open
Pulmonary hemorrhage (PH) is a life-threatening complication predominantly affecting preterm infants, particularly those with very low birth weight (VLBW) and fetal growth restriction (FGR). Typically occurring within the first 72 hours of…
View article: Hours based scheduling in neonatology: a practical approach
Hours based scheduling in neonatology: a practical approach Open
No standard work assignment exists for practicing neonatologists in the United States. Unlike other types of care providers in the neonatal intensive care unit who work under standard shift or work hour expectations, attending neonatologis…
View article: Impact of shift durations on sleep, fatigue, and wellness among neonatologists: a cross-sectional survey analysis
Impact of shift durations on sleep, fatigue, and wellness among neonatologists: a cross-sectional survey analysis Open
Objective To assess the effects of shift durations on sleep, fatigue, and wellness among U.S. neonatologists in diverse settings. Methods A cross-sectional survey of U.S. neonatologists yielded 810 responses from 4400 recipients. Statistic…
View article: Short Duration of Antenatal Corticosteroid Exposure and Outcomes in Extremely Preterm Infants
Short Duration of Antenatal Corticosteroid Exposure and Outcomes in Extremely Preterm Infants Open
Importance When preterm delivery is imminent, it remains unclear whether the timing from administration of antenatal betamethasone to birth may reduce mortality and morbidity among extremely preterm infants. Objective To evaluate the assoc…
View article: “Mission-Aligned Funds Flow”: Effect on Clinical Departments
“Mission-Aligned Funds Flow”: Effect on Clinical Departments Open
Problem Academic medical centers struggle with the high cost of care, reduced reimbursement, intense competition, and low profit margins. Many factors, including a high proportion of publicly insured patients, a model rewarding procedural …
View article: Perinatal Caffeine Administration Improves Outcomes in an Ovine Model of Neonatal Hypoxia-Ischemia
Perinatal Caffeine Administration Improves Outcomes in an Ovine Model of Neonatal Hypoxia-Ischemia Open
BACKGROUND: Neonatal hypoxic-ischemic encephalopathy disproportionately affects low- and middle-income countries, where ≈96% of affected infants reside. The current standard of care, therapeutic hypothermia, is frequently ineffective in th…
View article: Retrospective study of preterm infants exposed to inhaled nitric oxide in Kaiser Permanente Southern California: morbidity, mortality and follow-up
Retrospective study of preterm infants exposed to inhaled nitric oxide in Kaiser Permanente Southern California: morbidity, mortality and follow-up Open
Objective Describe characteristics of preterm infants exposed to inhaled nitric oxide (iNO) in Kaiser Permanente Southern California. Study design Case review of preterm infants <34-weeks exposed to iNO during 2010–2020 including respirato…
View article: Two-Year Outcomes of Umbilical Cord Milking in Nonvigorous Infants
Two-Year Outcomes of Umbilical Cord Milking in Nonvigorous Infants Open
Importance Compared with early cord clamping (ECC), umbilical cord milking (UCM) reduces delivery room cardiorespiratory support, hypoxic-ischemic encephalopathy, and therapeutic hypothermia in nonvigorous near-term and full-term infants. …
View article: Machine Learning–Based Critical Congenital Heart Disease Screening Using Dual‐Site Pulse Oximetry Measurements
Machine Learning–Based Critical Congenital Heart Disease Screening Using Dual‐Site Pulse Oximetry Measurements Open
Background Oxygen saturation (Sp o 2 ) screening has not led to earlier detection of critical congenital heart disease (CCHD). Adding pulse oximetry features (ie, perfusion data and radiofemoral pulse delay) may improve CCHD detection, esp…
View article: Meconium Aspiration Syndrome, Hypoxic-Ischemic Encephalopathy and Therapeutic Hypothermia—A Recipe for Severe Pulmonary Hypertension?
Meconium Aspiration Syndrome, Hypoxic-Ischemic Encephalopathy and Therapeutic Hypothermia—A Recipe for Severe Pulmonary Hypertension? Open
Hypoxic-ischemic encephalopathy (HIE) is the leading cause of mortality among term newborns globally. Infants born through meconium-stained amniotic fluid are at risk of developing meconium aspiration syndrome (MAS) and HIE. Simultaneous o…
View article: Hemodynamic assessment by neonatologist using echocardiography: Primary provider versus consultation model
Hemodynamic assessment by neonatologist using echocardiography: Primary provider versus consultation model Open
Hemodynamic instability is very common in sick neonates and the currently used traditional hemodynamic monitoring tools lack sensitivity and specificity. Hemodynamic evaluation on echocardiography can provide direct information regarding t…
View article: Direct Umbilical Vein Injection of Epinephrine with Cut-Cord Milking in an Ovine Model of Neonatal Resuscitation
Direct Umbilical Vein Injection of Epinephrine with Cut-Cord Milking in an Ovine Model of Neonatal Resuscitation Open
Background: An umbilical venous catheter (UVC) is the preferred route of epinephrine administration during neonatal resuscitation but requires specialized equipment, expertise, and time. Hypothesis: Direct injection of epinephrine into the…
View article: How long is too long? No added benefit with prolonged ventilation with intact cord in preterm infants
How long is too long? No added benefit with prolonged ventilation with intact cord in preterm infants Open
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View article: Paneth cell ontogeny in term and preterm ovine models
Paneth cell ontogeny in term and preterm ovine models Open
Introduction Paneth cells are critically important to intestinal health, including protecting intestinal stem cells, shaping the intestinal microbiome, and regulating host immunity. Understanding Paneth cell biology in the immature intesti…