Saundra S. Buys
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View article: Bridging Technology and Pretest Genetic Services: Quantitative Study of Chatbot Interaction Patterns, User Characteristics, and Genetic Testing Decisions
Bridging Technology and Pretest Genetic Services: Quantitative Study of Chatbot Interaction Patterns, User Characteristics, and Genetic Testing Decisions Open
Background Among the alternative solutions being tested to improve access to genetic services, chatbots (or conversational agents) are being increasingly used for service delivery. Despite the growing number of studies on the accessibility…
View article: Author Correction: Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus
Author Correction: Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus Open
View article: Importance of Prior Patient Interactions With the Healthcare System to Engaging With Pretest Cancer Genetic Services via Digital Health Tools Among Unaffected Primary Care Patients: Findings From the <scp>BRIDGE</scp> Trial
Importance of Prior Patient Interactions With the Healthcare System to Engaging With Pretest Cancer Genetic Services via Digital Health Tools Among Unaffected Primary Care Patients: Findings From the <span>BRIDGE</span> Trial Open
Objective To examine whether patient sociodemographic and clinical characteristics and prior interactions with the healthcare system were associated with opening patient portal messages related to cancer genetic services and beginning serv…
View article: Social vulnerability and genetic service utilization among unaffected BRIDGE trial patients with inherited cancer susceptibility
Social vulnerability and genetic service utilization among unaffected BRIDGE trial patients with inherited cancer susceptibility Open
Background Research on social determinants of genetic testing uptake is limited, particularly among unaffected patients with inherited cancer susceptibility. Methods We conducted a secondary analysis of the Broadening the Reach, Impact, an…
View article: Efficacy of a novel interstitial lung disease monitoring program in breast cancer patients undergoing treatment with trastuzumab-deruxtecan
Efficacy of a novel interstitial lung disease monitoring program in breast cancer patients undergoing treatment with trastuzumab-deruxtecan Open
An ILD monitoring protocol consisting of baseline PFTs and ongoing monitoring with PFTs and HRCT is a feasible approach as evidenced by a majority provider adherence rate. This type of protocol may be effective in preventing severe cases o…
View article: Table S3 from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years
Table S3 from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years Open
Average metabolic equivalents per week of recreational physical activity during adolescence and early adulthood by decade of birth year
View article: Figure S4 from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years
Figure S4 from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years Open
Figure S4 presents metabolic equivalents-per-week distribution of recreational physical activity by recreational activity quartiles and age group at enrollment.
View article: Table S1 from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years
Table S1 from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years Open
Characteristics of the full cohort by category of recreational physical activity during adolescence and early adulthood, n = 26,348
View article: Data from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years
Data from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years Open
Background:Breast cancer incidence is increasing in women under age 40, underscoring the need for research on breast cancer risk factors for younger women.Methods:We used data from an international family cohort (n = 26,348) to exam…
View article: Figure S5 from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years
Figure S5 from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years Open
Figure S5 presents the association of recreational physical activity during early adulthood with breast cancer risk before age 40 years stratified by recreational physical activity during adolescence in the restricted cohort, n = 10…
View article: Figure S3 from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years
Figure S3 from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years Open
Figure S3 provides four examples of how follow-up time was calculated in the study to incorporate both retrospective and prospective data collection.
View article: Figure S1 from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years
Figure S1 from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years Open
Figure S1 presents an overview of the selection criteria applied to identify the full cohort used in the main analyses.
View article: Table S2 from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years
Table S2 from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years Open
Cross-tabulation between recreational physical activity during adolescence and early adulthood in the full cohort (n = 26,348) and restricted cohort (n = 10,079)
View article: Table S6 from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years
Table S6 from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years Open
Hazard ratios and 95% confidence intervals for the joint association of recreational physical activity during adolescence and early adulthood with breast cancer risk before the age of 40 years in the full cohort, adjusted for breast cancer…
View article: Table S5 from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years
Table S5 from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years Open
Characteristics of the restricted cohort, n = 10,079
View article: Table S4 from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years
Table S4 from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years Open
Comparison of individuals included in versus excluded from the full cohort
View article: Figure S2 from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years
Figure S2 from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years Open
Figure S2 presents an overview of the selection criteria applied to identify the restricted cohort used in the secondary analyses.
View article: Table S7 from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years
Table S7 from Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years Open
Hazard ratios and 95% confidence intervals for the association of recreational physical activity during both adolescence and early adulthood with breast cancer risk before the age of 40 years in the restricted cohort, n = 10,079
View article: Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years
Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years Open
Background: Breast cancer incidence is increasing in women under age 40, underscoring the need for research on breast cancer risk factors for younger women. Methods: We used data from an international family cohort (n = 26,348) to examine …
View article: Hormonal Contraception and Breast Cancer Risk for Carriers of Germline Mutations in <i>BRCA1</i> and <i>BRCA2</i>
Hormonal Contraception and Breast Cancer Risk for Carriers of Germline Mutations in <i>BRCA1</i> and <i>BRCA2</i> Open
PURPOSE It is uncertain whether, and to what extent, hormonal contraceptives increase breast cancer (BC) risk for germline BRCA1 or BRCA2 mutation carriers. METHODS Using pooled observational data from four prospective cohort studies, asso…
View article: Uptake of Cancer Genetic Services for Chatbot vs Standard-of-Care Delivery Models
Uptake of Cancer Genetic Services for Chatbot vs Standard-of-Care Delivery Models Open
Importance Increasing numbers of unaffected individuals could benefit from genetic evaluation for inherited cancer susceptibility. Automated conversational agents (ie, chatbots) are being developed for cancer genetics contexts; however, ra…
View article: Pregnancy-Related Factors and Breast Cancer Risk for Women Across a Range of Familial Risk
Pregnancy-Related Factors and Breast Cancer Risk for Women Across a Range of Familial Risk Open
Importance Few studies have investigated whether the associations between pregnancy-related factors and breast cancer (BC) risk differ by underlying BC susceptibility. Evidence regarding variation in BC risk is critical to understanding BC…
View article: TOWARDS Study: Patient-Derived Xenograft Engraftment Predicts Poor Survival in Patients With Newly Diagnosed Triple-Negative Breast Cancer
TOWARDS Study: Patient-Derived Xenograft Engraftment Predicts Poor Survival in Patients With Newly Diagnosed Triple-Negative Breast Cancer Open
PURPOSE Assessing risk of recurrence for nonmetastatic triple-negative breast cancer (TNBC) is a key determinant of therapeutic strategy. The best predictor of recurrence risk is failure to achieve a pathologic complete response after preo…
View article: The psychosocial impact of prostate cancer screening for <i>BRCA1</i> and <i>BRCA2</i> carriers
The psychosocial impact of prostate cancer screening for <i>BRCA1</i> and <i>BRCA2</i> carriers Open
Objectives To report the long‐term outcomes from a longitudinal psychosocial study that forms part of the ‘Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted Screening in men at higher genetic risk and control…
View article: Large-scale genome-wide association study of 398,238 women unveils seven novel loci associated with high-grade serous epithelial ovarian cancer risk
Large-scale genome-wide association study of 398,238 women unveils seven novel loci associated with high-grade serous epithelial ovarian cancer risk Open
Background Nineteen genomic regions have been associated with high-grade serous ovarian cancer (HGSOC). We used data from the Ovarian Cancer Association Consortium (OCAC), Consortium of Investigators of Modifiers of BRCA1 / BRCA2 (CIMBA), …
View article: Childhood physical activity and pubertal timing: findings from the LEGACY girls study
Childhood physical activity and pubertal timing: findings from the LEGACY girls study Open
Background There is limited research on whether physical activity (PA) in early childhood is associated with the timing of pubertal events in girls. Methods We used data collected over 2011–16 from the LEGACY Girls Study (n = 984; primaril…
View article: NCCN Guidelines® Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2024
NCCN Guidelines® Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2024 Open
The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic focus primarily on assessment of pathogenic/likely pathogenic (P/LP) variants associated with increased risk of breast, ovarian, pancreatic, and…
View article: A Likelihood Ratio Approach for Utilizing Case-Control Data in the Clinical Classification of Rare Sequence Variants: Application to BRCA1 and BRCA2
A Likelihood Ratio Approach for Utilizing Case-Control Data in the Clinical Classification of Rare Sequence Variants: Application to BRCA1 and BRCA2 Open
A large number of variants identified through clinical genetic testing in disease susceptibility genes are of uncertain significance (VUS). Following the recommendations of the American College of Medical Genetics and Genomics (ACMG) and A…
View article: Association of Breast Cancer Odds with Background Parenchymal Enhancement Quantified Using a Fully Automated Method at MRI: The IMAGINE Study
Association of Breast Cancer Odds with Background Parenchymal Enhancement Quantified Using a Fully Automated Method at MRI: The IMAGINE Study Open
Background Background parenchymal enhancement (BPE) at breast MRI has been associated with increased breast cancer risk in several independent studies. However, variability of subjective BPE assessments have precluded its use in clinical p…
View article: Association of the <scp> <i>CHEK2</i> </scp> c. <scp>1100delC</scp> variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer‐specific survival
Association of the <span> <i>CHEK2</i> </span> c. <span>1100delC</span> variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer‐specific survival Open
Background Breast cancer (BC) patients with a germline CHEK2 c.1100delC variant have an increased risk of contralateral BC (CBC) and worse BC‐specific survival (BCSS) compared to non‐carriers. Aim To assessed the associations of CHEK2 c.11…