Saurabh Bhardwaj
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View article: Targeted and Surface-Engineered Nanocarriers: Precision Therapy in Alzheimer’s disease
Targeted and Surface-Engineered Nanocarriers: Precision Therapy in Alzheimer’s disease Open
Alzheimer's disease (AD) is a progressive neurological disorder, poses considerable treatment hurdles due to its complicated pathophysiology and the strong blood-brain barrier (BBB), which restricts central nervous system (CNS) medication …
View article: Eulerian–Lagrangian and thin film modeling of drug delivery under physiologically varying breathing in a realistic lung model
Eulerian–Lagrangian and thin film modeling of drug delivery under physiologically varying breathing in a realistic lung model Open
This work presents a computational approach to investigate antiviral aerosol deposition in anatomically realistic human airways under various physiological inhalation conditions. Antiviral drugs are represented as fine liquid droplets that…
View article: Corrigendum: Modeling flow in an in vitro anatomical cerebrovascular model with experimental validation
Corrigendum: Modeling flow in an in vitro anatomical cerebrovascular model with experimental validation Open
[This corrects the article DOI: 10.3389/fmedt.2023.1130201.].
View article: Evaluation of Correlation between C-reactive Protein (CRP) Levels in Synovial Lavage Fluid and Clinical Staging of Temporomandibular Joint Internal Derangement Disorders by Diagnostic Arthroscopy: A Prospective Study
Evaluation of Correlation between C-reactive Protein (CRP) Levels in Synovial Lavage Fluid and Clinical Staging of Temporomandibular Joint Internal Derangement Disorders by Diagnostic Arthroscopy: A Prospective Study Open
Introduction: Pain in the temporomandibular joint (TMJ) is thecommonsymptom in the patients with TMD. Unfortunately, the factors mediating pain are not sufficiently known to permitspecific treatment. Therefore the knowledge about themediat…
View article: Exploring the role of electrostatic deposition on inhaled aerosols in alveolated microchannels
Exploring the role of electrostatic deposition on inhaled aerosols in alveolated microchannels Open
Large amounts of net electrical charge are known to accumulate on inhaled aerosols during their generation using commonly-available inhalers. This effect often leads to superfluous deposition in the extra-thoracic airways at the cost of mo…
View article: In vitro–in silico correlation of three-dimensional turbulent flows in an idealized mouth-throat model
In vitro–in silico correlation of three-dimensional turbulent flows in an idealized mouth-throat model Open
There exists an ongoing need to improve the validity and accuracy of computational fluid dynamics (CFD) simulations of turbulent airflows in the extra-thoracic and upper airways. Yet, a knowledge gap remains in providing experimentally-res…
View article: A Novel Trans-Tracheostomal Retrograde Inhalation Technique Increases Subglottic Drug Deposition Compared to Traditional Trans-Oral Inhalation
A Novel Trans-Tracheostomal Retrograde Inhalation Technique Increases Subglottic Drug Deposition Compared to Traditional Trans-Oral Inhalation Open
Subglottic stenosis represents a challenging clinical condition in otolaryngology. Although patients often experience improvement following endoscopic surgery, recurrence rates remain high. Pursuing measures to maintain surgical results an…
View article: Modeling flow in an in vitro anatomical cerebrovascular model with experimental validation
Modeling flow in an in vitro anatomical cerebrovascular model with experimental validation Open
Acute ischemic stroke (AIS) is a leading cause of mortality that occurs when an embolus becomes lodged in the cerebral vasculature and obstructs blood flow in the brain. The severity of AIS is determined by the location and how extensively…
View article: Modeling Flow in an<i>In Vitro</i>Anatomical Cerebrovascular Model with Experimental Validation
Modeling Flow in an<i>In Vitro</i>Anatomical Cerebrovascular Model with Experimental Validation Open
Acute ischemic stroke (AIS) is a leading cause of mortality that occurs when an embolus becomes lodged in the cerebral vasculature and obstructs blood flow in the brain. The severity of AIS is determined by the location and how extensively…
View article: Retrieval of broken balloon from left anterior descending artery during percutaneous coronary intervention
Retrieval of broken balloon from left anterior descending artery during percutaneous coronary intervention Open
A 64-year-old male patient presented to the Emergency Room (ER) of our hospital with complaints of precordial pain associated with profuse sweating for the past 8 hours.
View article: <i>In vitro</i>−<i>in silico</i> correlation of three-dimensional turbulent flows in an idealized mouth-throat model
<i>In vitro</i>−<i>in silico</i> correlation of three-dimensional turbulent flows in an idealized mouth-throat model Open
There exists an ongoing need to improve the validity and accuracy of computational fluid dynamics (CFD) simulations of turbulent airflows in the extra-thoracic and upper airways. Yet, a knowledge gap remains in providing experimentally-res…
View article: Fate of inhaled aerosols under the influence of glottal motion in a realistic in silico human tracheobronchial tree model
Fate of inhaled aerosols under the influence of glottal motion in a realistic in silico human tracheobronchial tree model Open
Despite the prevalence of inhalation therapy in the treatment of various respiratory diseases, predicting and optimizing lung deposition fractions of inhaled drugs for maximal efficacy remains challenging due to the complex anatomical stru…
View article: Human Multi-Compartment Airways-on-Chip Platform for Emulating Respiratory Airborne Transmission: From Nose to Pulmonary Acini
Human Multi-Compartment Airways-on-Chip Platform for Emulating Respiratory Airborne Transmission: From Nose to Pulmonary Acini Open
The past decade has witnessed tremendous endeavors to deliver novel preclinical in vitro lung models for pulmonary research endpoints, including foremost with the advent of organ- and lung-on-chips . With growing interest in aerosol transm…
View article: Cow Dung – An Unusual Cause of Halitosis
Cow Dung – An Unusual Cause of Halitosis Open
View article: Ventilation‐induced epithelial injury drives biological onset of lung trauma in vitro and is mitigated with prophylactic anti‐inflammatory therapeutics
Ventilation‐induced epithelial injury drives biological onset of lung trauma in vitro and is mitigated with prophylactic anti‐inflammatory therapeutics Open
Mortality rates among patients suffering from acute respiratory failure remain perplexingly high despite the maintenance of blood oxygen homeostasis during ventilatory support. The biotrauma hypothesis advocates that mechanical forces from…
View article: Author response for "Ventilation‐induced epithelial injury drives biological onset of lung trauma in vitro and is mitigated with prophylactic anti‐inflammatory therapeutics"
Author response for "Ventilation‐induced epithelial injury drives biological onset of lung trauma in vitro and is mitigated with prophylactic anti‐inflammatory therapeutics" Open
View article: Homocysteinemia-Induced Upper-Extremity Deep-Vein Thrombosis
Homocysteinemia-Induced Upper-Extremity Deep-Vein Thrombosis Open
Hyperhomocysteinemia is a rare condition which predisposes to arterial and venous thrombosis. Plasma homocysteine levels are influenced by many genetic factors and environmental factors. Increased levels of homocysteine at high-altitude ar…
View article: A Study on Sequential µ-EDM and its Advantages
A Study on Sequential µ-EDM and its Advantages Open
The use of sequential traditional and non-traditional µmachining methods associated with µ-EDM have been thoroughly addressed in this paper, along with their applicability in current research and industrial domains. The requirement as well…
View article: Ventilation-induced epithelial injury drives biological onset of lung trauma<i>in vitro</i>and is mitigated with anti-inflammatory therapeutics
Ventilation-induced epithelial injury drives biological onset of lung trauma<i>in vitro</i>and is mitigated with anti-inflammatory therapeutics Open
Mortality rates among patients suffering from acute respiratory failure remain perplexingly high despite maintenance of blood homeostasis. The biotrauma hypothesis advances that mechanical forces from invasive ventilation trigger immunolog…
View article: In silico optimization of targeted aerosol delivery in upper airways via Inhaled Volume Tracking
In silico optimization of targeted aerosol delivery in upper airways via Inhaled Volume Tracking Open
View article: Avalung: A saviour in avalanche
Avalung: A saviour in avalanche Open
View article: Effect of Yoga in Post-Myocardial Infarction Cases
Effect of Yoga in Post-Myocardial Infarction Cases Open
Introduction: The prevalence of coronary artery disease (CAD) has progressively -increased in India and is the major cause of morbidity and mortality burden in the world. Several strategies are available to reduce morbidity and mortality, …
View article: In Silico Optimization of Fiber-Shaped Aerosols in Inhalation Therapy for Augmented Targeting and Deposition across the Respiratory Tract
In Silico Optimization of Fiber-Shaped Aerosols in Inhalation Therapy for Augmented Targeting and Deposition across the Respiratory Tract Open
Motivated by a desire to uncover new opportunities for designing the size and shape of fiber-shaped aerosols towards improved pulmonary drug delivery deposition outcomes, we explore the transport and deposition characteristics of fibers un…
View article: Dentigerous Cyst: A Review of Literature
Dentigerous Cyst: A Review of Literature Open
A dentigerous cyst is a developmental cyst of odontogenic origin which develops around the fully-formed crown of an unerupted tooth. The significance of keratinization in odontogenic cysts is not fully known, but keratinization is the fina…
View article: NAFLD is a marker of severity of coronary artery disease
NAFLD is a marker of severity of coronary artery disease Open
View article: A study of prevalence of non-alcoholic fatty liver disease in patients of coronary artery disease and their clinical correlation
A study of prevalence of non-alcoholic fatty liver disease in patients of coronary artery disease and their clinical correlation Open
Background: Currently, the importance of non alcoholic fatty liver disease (NAFLD) and its relationship with coronary artery disease (CAD) is being increasingly recognized and this has stimulated an interest in the possible role of NAFLD i…
View article: Diabetes Mellitus Type II: Correlation between HBA1C Level and Left Ventricular Diastolic Dysfunction
Diabetes Mellitus Type II: Correlation between HBA1C Level and Left Ventricular Diastolic Dysfunction Open
Background: Diabetes is a metabolic disease which affects various organs of the body like heart, eye, kidney, skin and peripheral nerves. Diabetic cardiomyopathy is defined as the appearance of the symptoms of Congestive heart failure in d…