Saurabh S. Thosar
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View article: Endogenous Circadian System Attenuates Nighttime Vascular Endothelial Function in People With Untreated Obstructive Sleep Apnea
Endogenous Circadian System Attenuates Nighttime Vascular Endothelial Function in People With Untreated Obstructive Sleep Apnea Open
Background In people with obstructive sleep apnea (OSA), adverse cardiovascular events, such as myocardial infarction, occur more commonly in the middle of the night than at other times of the day. These events could occur as a result of t…
View article: Evaluating Nature-Based Versus Generic Physical Activity Programs to Address Chronic Health Conditions: Lessons from an Oregon (USA) Pilot Study
Evaluating Nature-Based Versus Generic Physical Activity Programs to Address Chronic Health Conditions: Lessons from an Oregon (USA) Pilot Study Open
Evidence appears to be building that direct exposure to natural landscapes characterized by significant green cover, such as forests, can help to reduce chronic health conditions such as obesity, stress, hypertension, chronic cardiovascula…
View article: Bedtime regularization as a potential adjunct therapy for hypertension: a proof-of-concept study.
Bedtime regularization as a potential adjunct therapy for hypertension: a proof-of-concept study. Open
In this proof-of-concept study, 2 weeks of bedtime regularization decreased 24-h and nighttime BP in people with hypertension, suggesting that this may be a simple, yet low-risk, adjunctive strategy to control BP in many people with hypert…
View article: Effectiveness and Durability of a Workplace Sedentary Behavior Intervention Based on the Total Worker Health® Approach
Effectiveness and Durability of a Workplace Sedentary Behavior Intervention Based on the Total Worker Health® Approach Open
We used the Total Worker Health® approach to develop a multi-component workplace sedentary behavior intervention and tested intervention effectiveness in a cluster randomized trial. Participants (n = 198; 75% female) were recruited from th…
View article: Bright light increases blood pressure and rate‐pressure product after a single session of aerobic exercise in men
Bright light increases blood pressure and rate‐pressure product after a single session of aerobic exercise in men Open
This study aimed to test whether bright light (BL) exposure attenuates the reduction in blood pressure (BP) postexercise compared to dim light (DL). Twenty healthy men (27 ± 5 years) randomly underwent two experimental sessions: one under …
View article: Transitioning to Working from Home Due to the COVID-19 Pandemic Significantly Increased Sedentary Behavior and Decreased Physical Activity: A Meta-Analysis
Transitioning to Working from Home Due to the COVID-19 Pandemic Significantly Increased Sedentary Behavior and Decreased Physical Activity: A Meta-Analysis Open
At the start of the COVID-19 pandemic, many workplaces transitioned to remote work, which altered lifestyle behaviors. We conducted a meta-analysis to understand if the transition to working from home due to the pandemic affected workers’ …
View article: Cardiovascular disease risk: it is complicated, but race and ethnicity are key, a Bayesian network analysis
Cardiovascular disease risk: it is complicated, but race and ethnicity are key, a Bayesian network analysis Open
Background Cardiovascular diseases are the leading cause of morbidity and mortality in the United States. Despite the complexity of cardiovascular disease etiology, we do not fully comprehend the interactions between non-modifiable factors…
View article: Obesity alters the circadian profiles of energy metabolism and glucose regulation in humans
Obesity alters the circadian profiles of energy metabolism and glucose regulation in humans Open
Objective Given the complex interaction among the circadian system, energy metabolism, and obesity, the authors tested whether having obesity impacts the circadian variation in energy and glucose metabolism in humans. Methods Participants …
View article: Chronological distribution of readings in ambulatory blood-pressure monitoring exams affects the nighttime average and the magnitude of blood-pressure dipping
Chronological distribution of readings in ambulatory blood-pressure monitoring exams affects the nighttime average and the magnitude of blood-pressure dipping Open
The distribution of ambulatory blood-pressure monitoring (ABPM) readings affects the reproducibility of average blood pressure (BP) values as well as dipping percentage and dipping diagnoses. Our data suggest that the placement of measurem…
View article: Effectiveness of worksite wellness programs based on physical activity to improve workers’ health and productivity: a systematic review
Effectiveness of worksite wellness programs based on physical activity to improve workers’ health and productivity: a systematic review Open
Background Although the scientific literature has previously described the impact of worksite programs based on physical activity (WPPAs) on employees’ productivity and health in different contexts, the effect of these programs has not bee…
View article: 0821 Nighttime Average and Dipping Blood Pressure Can Differ Based on the Temporal Distribution of Ambulatory Measurements at Nighttime
0821 Nighttime Average and Dipping Blood Pressure Can Differ Based on the Temporal Distribution of Ambulatory Measurements at Nighttime Open
Introduction Ambulatory blood pressure (BP) monitoring is recommended in preference to office BP as it enables BP assessments across the night and quantification of the degree of nocturnal BP dipping (dipping” = nighttime/daytime BP of <…
View article: 0843 Identifying the Minimum Number of Ambulatory Blood Pressure Measurements to Classify a Reliable Blood Pressure Dipping Status
0843 Identifying the Minimum Number of Ambulatory Blood Pressure Measurements to Classify a Reliable Blood Pressure Dipping Status Open
Introduction Ambulatory blood pressure monitoring (ABPM) is recommended over office BP assessment as it enables quantification of the degree of nocturnal BP dipping (classifications: “dipping” = nighttime/daytime BP of < 0.9; “non-dippi…
View article: 0017 Obstructive sleep apnea is associated with altered circadian rhythms in systolic blood pressure at rest and during exercise
0017 Obstructive sleep apnea is associated with altered circadian rhythms in systolic blood pressure at rest and during exercise Open
Introduction Obstructive sleep apnea (OSA) is associated with an increased risk for major adverse cardiovascular events (MACE), such as sudden cardiac death. MACE is more frequent in the morning in the general population but more frequent …
View article: Rest–activity rhythm as a clinical biomarker: what are the next steps?
Rest–activity rhythm as a clinical biomarker: what are the next steps? Open
View article: 0008 The endogenous circadian system provides for enhanced coronary microvascular function in the morning
0008 The endogenous circadian system provides for enhanced coronary microvascular function in the morning Open
Introduction Major adverse cardiovascular events occur most commonly in the morning compared to other times of the day or night. Evaluation of coronary microvascular reserve perfusion can be used to reflect the anatomic and functional stat…
View article: Endogenous Circadian System Increases Capacity for Enhanced Coronary Microvascular Function in the Morning
Endogenous Circadian System Increases Capacity for Enhanced Coronary Microvascular Function in the Morning Open
View article: Resting coronary flow drives the daily pattern in coronary flow reserve in patients with chest pain without obstructive epicardial stenosis
Resting coronary flow drives the daily pattern in coronary flow reserve in patients with chest pain without obstructive epicardial stenosis Open
Objectives Ischemia with no obstructive coronary artery disease (INOCA) is a risk factor for major adverse cardiovascular events and is characterized by abnormal coronary microvascular tone. In patients with INOCA, adverse cardiovascular e…
View article: The circadian system modulates the cortisol awakening response in humans
The circadian system modulates the cortisol awakening response in humans Open
Background In humans, circulating cortisol usually peaks 30–60 min after awakening from nocturnal sleep, this is commonly referred to as the cortisol awakening response (CAR). We examined the extent to which the CAR is influenced by the ci…
View article: Chronobiology of Exercise: Evaluating the Best Time to Exercise for Greater Cardiovascular and Metabolic Benefits
Chronobiology of Exercise: Evaluating the Best Time to Exercise for Greater Cardiovascular and Metabolic Benefits Open
Physiological function fluctuates across 24 h due to ongoing daily patterns of behaviors and environmental changes, including the sleep/wake, rest/activity, light/dark, and daily temperature cycles. The internal circadian system prepares t…
View article: 0153 Bright light exposition potentiates the vasodilation promoted by dynamic handgrip exercise
0153 Bright light exposition potentiates the vasodilation promoted by dynamic handgrip exercise Open
Introduction Bright light (~5000 lux) directed at human skin increases plasma nitric oxide concentration promoting vasodilation, with increased skeletal muscle blood flow (BF) and decreased blood pressure (BP). The same stimulus directed a…
View article: Can Overnight Sleep Efficiency Impact Cardiovascular Risk in the Morning? [Response to Letter]
Can Overnight Sleep Efficiency Impact Cardiovascular Risk in the Morning? [Response to Letter] Open
Response to Letter in regards to Sleep Efficiency is Inversely Associated with Brachial Artery Diameter and Morning Blood Pressure in Midlife Adults, with a Potential Sex-Effect: A Short Comment [Letter]
View article: Sleep Efficiency is Inversely Associated with Brachial Artery Diameter and Morning Blood Pressure in Midlife Adults, with a Potential Sex-Effect
Sleep Efficiency is Inversely Associated with Brachial Artery Diameter and Morning Blood Pressure in Midlife Adults, with a Potential Sex-Effect Open
In midlife adults, poor sleep efficiency is associated with increased brachial artery diameter and blood pressure, effects that were primarily driven by significant associations in women. These associations could underlie the observed incr…
View article: Shorter Sleep Predicts Longer Subsequent Day Sedentary Duration in Healthy Midlife Adults, but Not in Those with Sleep Apnea
Shorter Sleep Predicts Longer Subsequent Day Sedentary Duration in Healthy Midlife Adults, but Not in Those with Sleep Apnea Open
In healthy adults, short nighttime sleep predicts a longer duration of sedentary behavior on a subsequent day, but we did not observe this relationship in people with OSA. The mechanisms underlying this association in healthy individuals a…
View article: 068 Morning Cardiovascular Function in Chronic Cannabis Users and Healthy Controls
068 Morning Cardiovascular Function in Chronic Cannabis Users and Healthy Controls Open
Introduction In the US cannabis is recreationally legal in 15 states and medically legal in 34 states. Preclinical studies suggest beneficial effects of cannabis on the cardiovascular system (e.g., vasorelaxation). Yet, acute cases of hosp…
View article: Sedentary Work and Physiological Markers of Health
Sedentary Work and Physiological Markers of Health Open
The purpose of this study is to examine associations between objectively measured workplace sedentary behavior and physiological markers of health. We hypothesize that increased sedentary time and more frequent bouts of uninterrupted sitti…
View article: Circadian control of human cardiovascular function
Circadian control of human cardiovascular function Open
View article: Biological pathways underlying the association between habitual long-sleep and elevated cardiovascular risk in adults
Biological pathways underlying the association between habitual long-sleep and elevated cardiovascular risk in adults Open
View article: Circadian rhythm in negative affect: Implications for mood disorders
Circadian rhythm in negative affect: Implications for mood disorders Open
View article: 0035 Resting Metabolism and the Metabolic Response to Exercise Follow Circadian Patterns with Day/Night Differences in Substrate Utilization Between Lean and Obese Adults
0035 Resting Metabolism and the Metabolic Response to Exercise Follow Circadian Patterns with Day/Night Differences in Substrate Utilization Between Lean and Obese Adults Open
Introduction Resting energy expenditure (EE) follows a circadian rhythm in healthy lean participants, with a nadir in the early morning hours. We determined: (1) whether this pattern persists (or how substrate utilization may change), when…
View article: 0570 Apnea-Hypopnea Index is Positively Correlated with Mood Disturbance
0570 Apnea-Hypopnea Index is Positively Correlated with Mood Disturbance Open
Introduction The prevalence of mood disorders such as depression is higher in individuals with obstructive sleep apnea (OSA). Previous studies have found no significant correlation between the apnea-hypopnea index (AHI) and measures of moo…