Saurabh Thapliyal
YOU?
Author Swipe
View article: Cohesin forms fountains at active enhancers in C. elegans
Cohesin forms fountains at active enhancers in C. elegans Open
Transcriptional enhancers must locate target genes with precision. In mammals, topologically associating domains (TADs) guide this process, but the C. elegans genome lacks such organization despite containing over 30,000 putative enhancers…
View article: Starvation transforms signal encoding in C. elegans thermoresponsive neurons and suppresses heat avoidance via bidirectional glutamatergic and peptidergic signaling
Starvation transforms signal encoding in C. elegans thermoresponsive neurons and suppresses heat avoidance via bidirectional glutamatergic and peptidergic signaling Open
Animals must continuously adapt their behavioral outputs in response to changes in internal state, including nutritional state. Here, we show that starvation induces a profound and progressive suppression of thermonociceptive behavior in C…
View article: Starvation transforms signal encoding in C. elegans thermoresponsive neurons and suppresses heat avoidance via bidirectional glutamatergic and peptidergic signaling
Starvation transforms signal encoding in C. elegans thermoresponsive neurons and suppresses heat avoidance via bidirectional glutamatergic and peptidergic signaling Open
Animals must continuously adapt their behavioral outputs in response to changes in internal state, including nutritional state. Here, we show that starvation induces a profound and progressive suppression of thermonociceptive behavior in C…
View article: Starvation transforms signal encoding in <i>C. elegans</i> thermoresponsive neurons and suppresses heat avoidance via bidirectional glutamatergic and peptidergic signaling
Starvation transforms signal encoding in <i>C. elegans</i> thermoresponsive neurons and suppresses heat avoidance via bidirectional glutamatergic and peptidergic signaling Open
Animals must continuously adapt their behavioral outputs in response to changes in internal state, including nutritional state. Here, we show that starvation induces a profound and progressive suppression of thermonociceptive behavior in C…
View article: N-glycan core tri-fucosylation requires Golgi α-mannosidase III activity that impacts nematode growth and behavior
N-glycan core tri-fucosylation requires Golgi α-mannosidase III activity that impacts nematode growth and behavior Open
N-glycans with complex core chitobiose modifications are observed in various free-living and parasitic nematodes but are absent in mammals. Using Caenorhabditis elegans as a model, we demonstrated that the core N-acetylglucosamine (GlcNAc)…
View article: Cohesin forms fountains at active enhancers in <i>C. elegans</i>
Cohesin forms fountains at active enhancers in <i>C. elegans</i> Open
Transcriptional enhancers must locate their target genes with both precision and efficiency. In mammals, this specificity is facilitated by topologically associated domains (TADs), which restrict the enhancer search space through three-dim…
View article: Multisite regulation integrates multimodal context in sensory circuits to control persistent behavioral states in C. elegans
Multisite regulation integrates multimodal context in sensory circuits to control persistent behavioral states in C. elegans Open
Maintaining or shifting between behavioral states according to context is essential for animals to implement fitness-promoting strategies. How the integration of internal state, past experience and sensory inputs orchestrates persistent mu…
View article: Multisite gating in tonic sensory circuits integrates multimodal context to control persistent behavioral states
Multisite gating in tonic sensory circuits integrates multimodal context to control persistent behavioral states Open
Maintaining or shifting between behavioral states according to context is essential for animals to implement fitness-promoting strategies. How integration of internal state, past experience and sensory inputs orchestrate persistent multidi…
View article: Ca2+/CaM binding to CaMKI promotes IMA-3 importin binding and nuclear translocation in sensory neurons to control behavioral adaptation
Ca2+/CaM binding to CaMKI promotes IMA-3 importin binding and nuclear translocation in sensory neurons to control behavioral adaptation Open
Sensory and behavioral plasticity are essential for animals to thrive in changing environments. As key effectors of intracellular calcium signaling, Ca 2+ /calmodulin-dependent protein kinases (CaMKs) can bridge neural activation with the …
View article: Author response: Ca2+/CaM binding to CaMKI promotes IMA-3 importin binding and nuclear translocation in sensory neurons to control behavioral adaptation
Author response: Ca2+/CaM binding to CaMKI promotes IMA-3 importin binding and nuclear translocation in sensory neurons to control behavioral adaptation Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Sensory and…
View article: Tissue-specific isoforms of the single C. elegans Ryanodine receptor gene unc-68 control specific functions
Tissue-specific isoforms of the single C. elegans Ryanodine receptor gene unc-68 control specific functions Open
Ryanodine receptors (RyR) are essential regulators of cellular calcium homeostasis and signaling. Vertebrate genomes contain multiple RyR gene isoforms, expressed in different tissues and executing different functions. In contrast, inverte…
View article: Specific Ion Channels Control Sensory Gain, Sensitivity, and Kinetics in a Tonic Thermonociceptor
Specific Ion Channels Control Sensory Gain, Sensitivity, and Kinetics in a Tonic Thermonociceptor Open
View article: FLP-18 Functions through the G-Protein-Coupled Receptors NPR-1 and NPR-4 to Modulate Reversal Length in<i>Caenorhabditis elegans</i>
FLP-18 Functions through the G-Protein-Coupled Receptors NPR-1 and NPR-4 to Modulate Reversal Length in<i>Caenorhabditis elegans</i> Open
Animal behavior is critically dependent on the activity of neuropeptides. Reversals, one of the most conspicuous behaviors in Caenorhabditis elegans , plays an important role in determining the navigation strategy of the animal. Our experi…