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View article: CD4<sup>+</sup> T cells from individuals with type 1 diabetes respond to a novel class of deamidated peptides formed in pancreatic islets
CD4<sup>+</sup> T cells from individuals with type 1 diabetes respond to a novel class of deamidated peptides formed in pancreatic islets Open
The β-cell plays a crucial role in the pathogenesis of type 1 diabetes, in part through the post-translational modification of self-proteins by biochemical processes such as deamidation. These neoantigens are potential triggers for breakin…
View article: CD4+ T Cells From Individuals With Type 1 Diabetes Respond to a Novel Class of Deamidated Peptides Formed in Pancreatic Islets
CD4+ T Cells From Individuals With Type 1 Diabetes Respond to a Novel Class of Deamidated Peptides Formed in Pancreatic Islets Open
The β-cell plays a crucial role in the pathogenesis of type 1 diabetes, in part through the posttranslational modification of self-proteins by biochemical processes such as deamidation. These neoantigens are potential triggers for breaking…
View article: CD4<sup>+</sup> T cells from individuals with type 1 diabetes respond to a novel class of deamidated peptides formed in pancreatic islets
CD4<sup>+</sup> T cells from individuals with type 1 diabetes respond to a novel class of deamidated peptides formed in pancreatic islets Open
The β-cell plays a crucial role in the pathogenesis of type 1 diabetes, in part through the post-translational modification of self-proteins by biochemical processes such as deamidation. These neoantigens are potential triggers for breakin…
View article: CD4<sup>+</sup> T cells from individuals with type 1 diabetes respond to a novel class of deamidated peptides formed in pancreatic islets
CD4<sup>+</sup> T cells from individuals with type 1 diabetes respond to a novel class of deamidated peptides formed in pancreatic islets Open
The β-cell plays a crucial role in the pathogenesis of type 1 diabetes, in part through the post-translational modification of self-proteins by biochemical processes such as deamidation. These neoantigens are potential triggers for breakin…
View article: Economic Hardship on Intensive Care Unit Managing COVID-Patients – A Retrospective Observational Study at a Tertiary Care Hospital in North India
Economic Hardship on Intensive Care Unit Managing COVID-Patients – A Retrospective Observational Study at a Tertiary Care Hospital in North India Open
Most elderly male with co-morbidities lost their battle after ventilator support in the ICU. Patients with co-morbidities and severe disease not only have a long duration of hospitalization and poor survival rate but also fetch an economic…
View article: Surgical training and tackling the elective backlog
Surgical training and tackling the elective backlog Open
How can we effectively ensure that surgical trainees are equipped with the skills and knowledge to tackle the backlog?
View article: ER stress promotes mitochondrial DNA mediated type-1 interferon response in beta-cells and interleukin-8 driven neutrophil chemotaxis
ER stress promotes mitochondrial DNA mediated type-1 interferon response in beta-cells and interleukin-8 driven neutrophil chemotaxis Open
Beta-cell destruction in type 1 diabetes (T1D) results from the combined effect of inflammation and recurrent autoimmunity. Accumulating evidence suggests the engagement of cellular stress during the initial stage of the disease, preceding…
View article: 29 The Surgical Trainee Personality: Selected or Shaped?
29 The Surgical Trainee Personality: Selected or Shaped? Open
Aim This study aims to describe the personality differences between trainees at different stages prior to and during surgical training. Method The Mental Muscle Diagram Indicator was distributed electronically to doctors in training in Sou…
View article: 817 Our Experience of Management of Nipple Discharge
817 Our Experience of Management of Nipple Discharge Open
Aim Evaluation of nipple discharge is a multidisciplinary practice requiring careful evaluation of the patient, their age and history. This study considers whether smoking is a contributory factor and if microdochectomy or Hadfield's proce…
View article: 856 The Croydon Elective Centre - Surgical Hub Supporting Patient Care and Surgical Training
856 The Croydon Elective Centre - Surgical Hub Supporting Patient Care and Surgical Training Open
Aim NHSE/I and the RCS England have advocated that the separation of elective and surgical care is fundamental in recovering surgical services. It is suggested that the separation is physical, and many Trusts are transforming pathways into…
View article: Surgical hubs and the use of technology
Surgical hubs and the use of technology Open
Yang et al discuss their importance in terms of tackling the backlog and providing an invaluable opportunity to train the workforce.
View article: 1358 Does A COVID Protected Hospital Within A COVID Hospital Enable Elective Care and Training Opportunities?
1358 Does A COVID Protected Hospital Within A COVID Hospital Enable Elective Care and Training Opportunities? Open
Introduction Elective care in the UK came to a standstill with the advent of the COVID-19 pandemic. A restart could only be enabled with ‘green site’ separation and a ‘covid protected’ zone. A ‘hospital within the hospital’ concept was dev…
View article: 845 Diabetic Foot Care Services in COVID-19 Era – A University Hospital Multi specialty Team Experience
845 Diabetic Foot Care Services in COVID-19 Era – A University Hospital Multi specialty Team Experience Open
Introduction Multidisciplinary foot care services contribute to the reduction in amputations from foot ulceration secondary to diabetes. The COVID-19 pandemic pressurised services and required a pause of elective care. This study reports t…
View article: Working with ‘The Boss’, Sir Archibald McIndoe – an interview with Celia Liggins
Working with ‘The Boss’, Sir Archibald McIndoe – an interview with Celia Liggins Open
Holistic nursing in the Second World War.
View article: Zero tolerance to sexual harassment in surgical training in the UK
Zero tolerance to sexual harassment in surgical training in the UK Open
Sexual harassment exists within the surgical training community and environment. This is unprofessional behaviour and the surgical community must raise awareness of it as well as facilitating and encouraging reporting with robust investiga…
View article: 228 Resilience, Mindset and Burnout of Healthcare Workers During the COVID-19 Pandemic
228 Resilience, Mindset and Burnout of Healthcare Workers During the COVID-19 Pandemic Open
Introduction We investigated the impact of the Biopsychosocial challenges associated with the COVID-19 Pandemic on the Healthcare Workforce, exploring the impact on and relationship between Healthcare Workers’ Mindset, Resilience and Burno…
View article: Endoplasmic Reticulum-Mitochondria Crosstalk and Beta-Cell Destruction in Type 1 Diabetes
Endoplasmic Reticulum-Mitochondria Crosstalk and Beta-Cell Destruction in Type 1 Diabetes Open
Beta-cell destruction in type 1 diabetes (T1D) results from the combined effect of inflammation and recurrent autoimmunity. In response to inflammatory signals, beta-cells engage adaptive mechanisms where the endoplasmic reticulum (ER) and…
View article: Identification of Deamidated Peptides in Cytokine-Exposed MIN6 Cells through LC−MS/MS Using a Shortened Digestion Time and Inspection of MS2 Spectra
Identification of Deamidated Peptides in Cytokine-Exposed MIN6 Cells through LC−MS/MS Using a Shortened Digestion Time and Inspection of MS2 Spectra Open
Enzymatic deamidation, the conversion of glutamine (Gln) into glutamic acid (Glu) residues, mediated by tissue transglutaminase enzymes, can provoke autoimmunity by generating altered self-epitopes, a process well-known in celiac disease a…
View article: Sustainability in surgery
Sustainability in surgery Open
Facing the future: how the RCS is embedding sustainable approaches into surgical and dental practice.
View article: Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells
Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells Open
View article: Understanding type 1 diabetes through proteomics
Understanding type 1 diabetes through proteomics Open
Auto-immunity against pancreatic beta-cells leads to an absolute shortage of the hormone insulin, resulting in hyperglycemia and the onset of type 1 diabetes (T1D). Proteomic approaches have been used to elucidate the mechanisms of beta-ce…
View article: Aspiring to excellence in surgical training
Aspiring to excellence in surgical training Open
What do junior doctors think about surgical training?
View article: Early differences in islets from prediabetic NOD mice: combined microarray and proteomic analysis
Early differences in islets from prediabetic NOD mice: combined microarray and proteomic analysis Open
View article: Surgical learning activities for house officers - Do they improve the surgical experience?
Surgical learning activities for house officers - Do they improve the surgical experience? Open
To ascertain whether house officers (HOs) attain a more satisfactory surgical rotation experience when they perform basic surgical learning activities. We also sought to establish how many and which learning activities HOs achieve and the …
View article: The ‘weekend effect’ on patients with acute appendicitis - Comparing emergency laparoscopic appendicectomy outcomes in three London hospitals
The ‘weekend effect’ on patients with acute appendicitis - Comparing emergency laparoscopic appendicectomy outcomes in three London hospitals Open
View article: The relationship between grit and burnout: How do surgical trainees compare to other doctors?
The relationship between grit and burnout: How do surgical trainees compare to other doctors? Open
View article: Representation of surgeons as foundation training programme director’s in the United Kingdom
Representation of surgeons as foundation training programme director’s in the United Kingdom Open
View article: An audit cycle to improve an emergency surgery ambulatory clinic
An audit cycle to improve an emergency surgery ambulatory clinic Open
View article: Simulation in undergraduate medical education: Designing a programme to improve medical students’ non-technical skills
Simulation in undergraduate medical education: Designing a programme to improve medical students’ non-technical skills Open
View article: The role of surgical foundation placements in training
The role of surgical foundation placements in training Open